Essential hypertension and its causes: neural and non-neural mechanisms
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| Format: | Book |
| Language: | English |
| Published: |
New York, NY
Oxford Univ. Press
2007
|
| Subjects: | |
| Online Access: | Table of contents only Inhaltsverzeichnis |
| Item Description: | Includes bibliographical references and index |
| Physical Description: | XXVI, 690 S. Ill., zahlr. graph. Darst. |
| ISBN: | 0195094832 9780195094831 |
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| 100 | 1 | |a Korner, Paul I. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Essential hypertension and its causes |b neural and non-neural mechanisms |c Paul Korner |
| 264 | 1 | |a New York, NY |b Oxford Univ. Press |c 2007 | |
| 300 | |a XXVI, 690 S. |b Ill., zahlr. graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Includes bibliographical references and index | ||
| 650 | 4 | |a Essential hypertension | |
| 650 | 4 | |a Essential hypertension | |
| 650 | 4 | |a Hypertension |x etiology | |
| 650 | 0 | 7 | |a Essenzielle Hypertonie |0 (DE-588)4153048-2 |2 gnd |9 rswk-swf |
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Record in the Search Index
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| adam_text | Contents
Abbreviations xxiii
I Introduction
1 A Short History and Some Clinical Aspects 3
A Short History 3
Clinical Hypertension 5
Severity of Hypertension and Future Risk 7
Concluding Remarks 12
II Biological Control
2 The Nature of the Cardiovascular Control System 15
Man-Made Control Systems 15
The Mammalian Circulatory Control System 20
Finding One s Way Around the Circulatory Control System in EH 25
Page s Mosaic Theory and Cuyton s Theory of Long-Term
Blood Pressure Control 31
What Matters in Cardiovascular Systems Analysis? 37
3 Blood Pressure Genetics 39
Background 39
xviii CONTENTS
Effect of Genes and Environment on Human Blood Pressure 47
Genetic Basis for Trait Differences Between
Hypertensives and Normotensives 50
Molecular Genetics: Current Approaches to High-BP Genes 59
Genetics and Systems Analysis 67
III Input-Output Analysis: Pointers to Neural Involvement
4 Human Arterial Pressure 71
Blood Pressure Epidemiology 71
Diurnal Variation in Blood Pressure 79
Some Factors Causing Long-Term Blood Pressure Changes 81
Redevelopment of Hypertension After Stopping Treatment 92
Arterial Blood Pressure as a Pointer to the Causes of EH 93
5 Output Patterns in Nonobese Hypertensives 95
Central and Regional Hemodynamics 95
Blood Volume and Viscosity in EH 105
Autonomic Outflow Patterns 109
Plasma Renin Activity 118
Steroid Hormones 119
EH Is a Largely Constrictor Type of High BP 121
IV Intrinsic Cardiovascular Properties in Hypertension
6 The Peripheral Vascular Integrator 127
Some Features of the Normal Vasculature 127
Myogenic Regulation and Related Factors 132
Metabolic Regulation 141
Nitric Oxide and Other Endothelial Autacoids in
Hypertension 144
Role of Structural Changes in Chronic Hypertension 150
Integrative Vascular Regulation and Its Impairment in EH 167
7 Cardiac Performance 170
Background Physiology 170
Left Ventricular Geometry in EH 179
Intrinsic Mechanical Performance in LVH 184
Contractile and Pump Performance in EH 190
Coronary and Myocyte Factors 191
Cellular Mechanisms in Cardiac Hypertrophy 195
How the Heart Maintains Contractile Performance 202
CONTENTS xix
V Integrative Aspects of Neural Circulatory Control
8 CNS Cardiovascular Pathways: Role of Fast and
Slow Transmitters 207
CNS Cardiovascular Pathways 208
Determinants of Resting Sympathetic Tone 212
Synoptic Transmission 213
Strengthening of Synoptic Transmission (Sensitization) in Aplysia,
Drosophila, and Humans 216
Role of Monoaminergic Neurons 219
Catecholaminergic Modulation in Hypertension 233
Central Actions of a-Methyldopa 235
Integration and Communication within the Central Controller 237
Concluding Comments 240
9 Whole-Organism Baroreflexes 241
Cardiovascular Baroreceptors 242
Cardiac Baroreflexes in Hypertension 246
Sympathetic Constrictor Baroreflexes 264
Disturbances That Engage the ANS Mainly Through Baroreflexes 267
Determinants of BP Variability in EH 276
Does Baroreflex Dysfunction Cause Hypertension? 276
Baroreflexes, Adaptive Circulatory Control, and EH 280
10 Exercise Training and Its Long-Term Effects on Blood Pressure:
Linkage to Somatic Movement 284
Circulatory and Respiratory Changes during Exercise 284
Mechanisms of Circulatory Control during Exercise 288
long-Term Effects of Regular Exercise Training 298
Circulatory Regulation during and after Exercise:
A Role for the Cerebellum? 307
Regular Exercise Training: Potential for Preventing EH 314
VI The Brain as the Source of Lifestyle-Related Hypertension
11 Psychosocial Stress and Hypertension 317
CNS Pathways Mediating Responses to Psychosocial Stress 318
Cardiovascular Effects of Chronic Stress in Animals 340
Psychosocial and Mental Stress in Humans 347
A Hypothesis on How Psychosocial Stress Initiates EH 354
12 Salt, Other Dietary Factors, and Blood Pressure 359
Regulatory Mechanisms 360
XX CONTENTS
Definitions of Human Salt Sensitivity and Salt Resistance 375
Salt Sensitivity Is Enhanced in Hypertension 378
Other Determinants of Salt Sensitivity 387
Other Dietary Factors and Their Relation to Salt 390
Role of Salt in the Pathogenesis of EH 3 92
13 Normotensive and Hypertensive Obesity 395
Definitions, Cardiovascular Risk, and Role of Genetic and
Environmental Factors 396
Energy Balance 397
Circulatory Effects of Obesity 407
Mechanisms Underlying Impairment of Glucose Transport 414
Autonomic Mechanisms and Human Obesity 420
Obesity and Its Relationship to EH 425
14 Obstructive Sleep Apnea 429
Epidemiological Links between Obesity, OSA, and Hypertension 429
Cardiorespiratory and Autonomic Changes in OSA Patients 430
Effects of Apnea and Arterial Hypoxia in Different Species 435
A Schema for Cardiorespiratory Control in OSA 450
Relationship between OSA and Essential Hypertension 453
VII Causes and Mechanisms of Renal and SHR Hypertension
15 More About the Kidney in Hypertension 457
Interpreting Renal Transplantation Experiments 458
Are Low Nephron Numbers a Consequence or a Cause of EH? 461
Human Renal Hypertension 465
The Kidney and Sympathetic Neural Activity 469
Experimental Renal Hypertension 475
One Kidney, One Clip Hypertension 476
Goldblatt Two Kidney, One Clip Hypertension 487
Cellophane Wrap Hypertension 489
Renal Antihypertensive Humoral Mechanisms 4 94
The Kidney in Renal and Essential Hypertension 496
16 SHR Hypertension and Its Causes 501
Output Patterns 502
Prevention and Attenuation of SHR Hypertension 517
The Koletsky Obese SHR 523
Renal Hypertension in SHR 524
BP Genetics 526
The Pathogenesis of SHR Hypertension 527
Concluding Remarks 5 31
CONTENTS xxi
VIII Synthesis
17 Two Syndromes of Essential Hypertension 535
Central Autonomic Regulation and the Initiation of EH 536
The Two Syndromes 539
Prevention and Treatment 545
Concluding Remarks 550
Notes 551
References 561
Index 677
|
| adam_txt |
Contents
Abbreviations xxiii
I Introduction
1 A Short History and Some Clinical Aspects 3
A Short History 3
Clinical Hypertension 5
Severity of Hypertension and Future Risk 7
Concluding Remarks 12
II Biological Control
2 The Nature of the Cardiovascular Control System 15
Man-Made Control Systems 15
The Mammalian Circulatory Control System 20
Finding One's Way Around the Circulatory Control System in EH 25
Page's Mosaic Theory and Cuyton's Theory of Long-Term
Blood Pressure Control 31
What Matters in Cardiovascular Systems Analysis? 37
3 Blood Pressure Genetics 39
Background 39
xviii CONTENTS
Effect of Genes and Environment on Human Blood Pressure 47
Genetic Basis for Trait Differences Between
Hypertensives and Normotensives 50
Molecular Genetics: Current Approaches to High-BP Genes 59
Genetics and Systems Analysis 67
III Input-Output Analysis: Pointers to Neural Involvement
4 Human Arterial Pressure 71
Blood Pressure Epidemiology 71
Diurnal Variation in Blood Pressure 79
Some Factors Causing Long-Term Blood Pressure Changes 81
Redevelopment of Hypertension After Stopping Treatment 92
Arterial Blood Pressure as a Pointer to the Causes of EH 93
5 Output Patterns in Nonobese Hypertensives 95
Central and Regional Hemodynamics 95
Blood Volume and Viscosity in EH 105
Autonomic Outflow Patterns 109
Plasma Renin Activity 118
Steroid Hormones 119
EH Is a Largely Constrictor Type of High BP 121
IV Intrinsic Cardiovascular Properties in Hypertension
6 The Peripheral Vascular Integrator 127
Some Features of the Normal Vasculature 127
Myogenic Regulation and Related Factors 132
Metabolic Regulation 141
Nitric Oxide and Other Endothelial Autacoids in
Hypertension 144
Role of Structural Changes in Chronic Hypertension 150
Integrative Vascular Regulation and Its Impairment in EH 167
7 Cardiac Performance 170
Background Physiology 170
Left Ventricular Geometry in EH 179
Intrinsic Mechanical Performance in LVH 184
Contractile and Pump Performance in EH 190
Coronary and Myocyte Factors 191
Cellular Mechanisms in Cardiac Hypertrophy 195
How the Heart Maintains Contractile Performance 202
CONTENTS xix
V Integrative Aspects of Neural Circulatory Control
8 CNS Cardiovascular Pathways: Role of Fast and
Slow Transmitters 207
CNS Cardiovascular Pathways 208
Determinants of Resting Sympathetic Tone 212
Synoptic Transmission 213
Strengthening of Synoptic Transmission (Sensitization) in Aplysia,
Drosophila, and Humans 216
Role of Monoaminergic Neurons 219
Catecholaminergic Modulation in Hypertension 233
Central Actions of a-Methyldopa 235
Integration and Communication within the Central Controller 237
Concluding Comments 240
9 Whole-Organism Baroreflexes 241
Cardiovascular Baroreceptors 242
Cardiac Baroreflexes in Hypertension 246
Sympathetic Constrictor Baroreflexes 264
Disturbances That Engage the ANS Mainly Through Baroreflexes 267
Determinants of BP Variability in EH 276
Does Baroreflex Dysfunction Cause Hypertension? 276
Baroreflexes, Adaptive Circulatory Control, and EH 280
10 Exercise Training and Its Long-Term Effects on Blood Pressure:
Linkage to Somatic Movement 284
Circulatory and Respiratory Changes during Exercise 284
Mechanisms of Circulatory Control during Exercise 288
long-Term Effects of Regular Exercise Training 298
Circulatory Regulation during and after Exercise:
A Role for the Cerebellum? 307
Regular Exercise Training: Potential for Preventing EH 314
VI The Brain as the Source of Lifestyle-Related Hypertension
11 Psychosocial Stress and Hypertension 317
CNS Pathways Mediating Responses to Psychosocial Stress 318
Cardiovascular Effects of Chronic Stress in Animals 340
Psychosocial and Mental Stress in Humans 347
A Hypothesis on How Psychosocial Stress Initiates EH 354
12 Salt, Other Dietary Factors, and Blood Pressure 359
Regulatory Mechanisms 360
XX CONTENTS
Definitions of Human Salt Sensitivity and Salt Resistance 375
Salt Sensitivity Is Enhanced in Hypertension 378
Other Determinants of Salt Sensitivity 387
Other Dietary Factors and Their Relation to Salt 390
Role of Salt in the Pathogenesis of EH 3 92
13 Normotensive and Hypertensive Obesity 395
Definitions, Cardiovascular Risk, and Role of Genetic and
Environmental Factors 396
Energy Balance 397
Circulatory Effects of Obesity 407
Mechanisms Underlying Impairment of Glucose Transport 414
Autonomic Mechanisms and Human Obesity 420
Obesity and Its Relationship to EH 425
14 Obstructive Sleep Apnea 429
Epidemiological Links between Obesity, OSA, and Hypertension 429
Cardiorespiratory and Autonomic Changes in OSA Patients 430
Effects of Apnea and Arterial Hypoxia in Different Species 435
A Schema for Cardiorespiratory Control in OSA 450
Relationship between OSA and Essential Hypertension 453
VII Causes and Mechanisms of Renal and SHR Hypertension
15 More About the Kidney in Hypertension 457
Interpreting Renal Transplantation Experiments 458
Are Low Nephron Numbers a Consequence or a Cause of EH? 461
Human Renal Hypertension 465
The Kidney and Sympathetic Neural Activity 469
Experimental Renal Hypertension 475
One Kidney, One Clip Hypertension 476
Goldblatt Two Kidney, One Clip Hypertension 487
Cellophane Wrap Hypertension 489
Renal Antihypertensive Humoral Mechanisms 4 94
The Kidney in Renal and Essential Hypertension 496
16 SHR Hypertension and Its Causes 501
Output Patterns 502
Prevention and Attenuation of SHR Hypertension 517
The Koletsky Obese SHR 523
Renal Hypertension in SHR 524
BP Genetics 526
The Pathogenesis of SHR Hypertension 527
Concluding Remarks 5 31
CONTENTS xxi
VIII Synthesis
17 Two Syndromes of Essential Hypertension 535
Central Autonomic Regulation and the Initiation of EH 536
The Two Syndromes 539
Prevention and Treatment 545
Concluding Remarks 550
Notes 551
References 561
Index 677 |
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| index_date | 2024-07-02T17:25:54Z |
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| isbn | 0195094832 9780195094831 |
| language | English |
| lccn | 2006023747 |
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| spelling | Korner, Paul I. Verfasser aut Essential hypertension and its causes neural and non-neural mechanisms Paul Korner New York, NY Oxford Univ. Press 2007 XXVI, 690 S. Ill., zahlr. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Essential hypertension Hypertension etiology Essenzielle Hypertonie (DE-588)4153048-2 gnd rswk-swf Essenzielle Hypertonie (DE-588)4153048-2 s DE-604 http://www.loc.gov/catdir/toc/ecip0617/2006023747.html Table of contents only HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015630076&sequence=000006&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Korner, Paul I. Essential hypertension and its causes neural and non-neural mechanisms Essential hypertension Hypertension etiology Essenzielle Hypertonie (DE-588)4153048-2 gnd |
| subject_GND | (DE-588)4153048-2 |
| title | Essential hypertension and its causes neural and non-neural mechanisms |
| title_auth | Essential hypertension and its causes neural and non-neural mechanisms |
| title_exact_search | Essential hypertension and its causes neural and non-neural mechanisms |
| title_exact_search_txtP | Essential hypertension and its causes neural and non-neural mechanisms |
| title_full | Essential hypertension and its causes neural and non-neural mechanisms Paul Korner |
| title_fullStr | Essential hypertension and its causes neural and non-neural mechanisms Paul Korner |
| title_full_unstemmed | Essential hypertension and its causes neural and non-neural mechanisms Paul Korner |
| title_short | Essential hypertension and its causes |
| title_sort | essential hypertension and its causes neural and non neural mechanisms |
| title_sub | neural and non-neural mechanisms |
| topic | Essential hypertension Hypertension etiology Essenzielle Hypertonie (DE-588)4153048-2 gnd |
| topic_facet | Essential hypertension Hypertension etiology Essenzielle Hypertonie |
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