Diversity in the neuronal machine: order and variability in interneuronal microcircuits
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| Main Author: | |
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| Format: | Book |
| Language: | English |
| Published: |
Oxford
Oxford University Press
2006
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| Subjects: | |
| Online Access: | Publisher description Inhaltsverzeichnis |
| Item Description: | Literaturverzeichnis: Seite 203-233 |
| Physical Description: | xvii, 238 Seiten Illustrationen, Diagramme 25 cm |
| ISBN: | 9780195177015 0195177010 |
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| 245 | 1 | 0 | |a Diversity in the neuronal machine |b order and variability in interneuronal microcircuits |c Ivan Soltesz |
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Contents
1: Introduction 3
A Walk in the Neuronal Forest 3
Historical Roots: Nuts and Bolts of a Neuronal Machine 5
Great Victories of Cajal's "Rational Psychology" Paradigm 14
The Janus Face of Order and Variability, and the Dangers of Typology 22
Back to the Future: Early Notions on Variability 24
Defining Interneurons 27
2: Developmental Origins of Interneuronal Heterogeneity 29
Ontogenetic Differences between Glutamatergic Neurons versus
Interneurons 29
Molecular Carrots and Sticks for Interneuronal Migration 32
Distinct Interneurons from Different Sources? 35
A Case Study: Migration of Interneurons Toward the Hippocampus 38
Long Road to Tipperary: Consequences of Distant Progenitor Zones for
Interneuronal Specification 40
When Things Go Wrong: Interneuron Migrations and Neurological
Disorders 42
3: Order in Diversity: From Phenomenology to Function 45
Diversity at Multiple Levels of Neuronal Organization 45
Linnean Order in Diversity: A Modern Compendium of Interneuronal
Species 47
Cogwheels of Understanding: Functions of Interneuronal Subtypes 55
Basket Cells: Division of Labor 62
Canonical Microcircuits, Cortical Columns, and Their Stereotyped
Inhabitants 66
Crusade for the Great Synthesis and the End of Neuroscience 69
XV
xvi Contents
4: Cracks in the Crystal: Elusive Neurospecies and the Great Correlation
Hunt 72
Neuronal Species: Can't Live with Them, Can't Live without Them 72
Getting Lost in Parameter Space: The Mirage of Blind Phenotypic
Correlations 75
Imperfect Correlations: Experimenter's Errors or Reality? 78
The Other Extreme: Each Interneuron as an Unclassifiable Individual 84
5: Functions of Heterogeneity: Meaning of Means and Variability
of Variances 87
Reconciling Order and Variability: Distinct Subtypes and Cell to Cell
Heterogeneity as Simultaneously Existing Reality 87
Definitions: Heterogeneity, Variance and Diversity 88
First Look at Variability and Function: Interneuronal Covering of
Principal Cells Both in Space and Time 91
Simulations of Interneuronal Variance and Synchrony 93
Toward Rules that Underlie the Modulation of Postsynaptic Behavior
by Interneuronal Variability 98
6: Interneuronal Variability: Plasticity and Regulation 105
Dynamic Clamp Down on Interneuronal Variance 105
Alterations in Variance: Neuromodulators, Neurological Diseases, and
Development 112
Statistical Methods of Measuring Changes in Variance 116
Transfer of Interneuronal Variability to Principal Cells: Potential for
More Functional States? 117
Heterogeneity in the Outside World and Its Reflection in the Circuit 119
Variations for the Advanced Age: Intra Species Variance in Interneuronal
Populations dirough Somatic Mutations? 120
7: Diversity Beyond Variance 125
Species Number and Relative Abundance: Entropy Based Measures
of Diversity 125
Plasticity of Interneuronal Diversity: Birth and Loss of Cellular
Species 127
Effects of Changed Diversity on Firing Rates 130
Modulation of Synchrony by Alterations in Diversity 135
Equitability, and Alpha, Beta and Gamma Diversity 139
Molecular Dragnets Cast Wide: Interneuronal Species from Unsupervised
Clustering 140
Emerging Order in the Molecular Pandora's Box 145
Ontogenetic Cladistics for Interneurons 148
Interneuronal Diversity and Evolution 149
Constraints on Interneuronal Diversity 153
Contents xvii
8: Fifty Ways to Be a Basket Cell: Self Tuning Interneurons with Multiple
Solutions for Their Tasks 156
The "Ideal" Basket Cell 156
Unbearable Multiplicity of Being a Specialized Neuron 157
Failure of Averaging 158
Homeostatic Regulation and Activity Sensors 161
Homeostasis in GABAergic Systems 165
Wanted, Alive: Interneuronal Heterogeneity in Naturalistic
Environments 167
9: Interneuronal Diversity and Small World Neuronal Networks 171
Building Complex Machines with Minimal Wiring 171
Real World Small Worlds: Worming Up to the Hippocampus 179
Attack Tolerance of Small World Networks: Hippocampal Sclerosis
as a Natural Experiment 183
Scale Free Networks: Interneurons as Hubs 186
Interneuronal Heterogeneity in Small World Networks 191
10: Closing Thoughts: The Stucture of Cortical Microcircuit
Theory 195
Resolution of the Diversity Debate 195
Building a Complex Machine from Variable Parts 196
Phenogenetic Perspective for Interneuronal Research and the Role of
Chance 198
Cajal's Functional Neuroanatomy in the 21st Century 201
Bibliography 203
Index 235 |
| adam_txt |
Contents
1: Introduction 3
A Walk in the Neuronal Forest 3
Historical Roots: Nuts and Bolts of a Neuronal Machine 5
Great Victories of Cajal's "Rational Psychology" Paradigm 14
The Janus Face of Order and Variability, and the Dangers of Typology 22
Back to the Future: Early Notions on Variability 24
Defining Interneurons 27
2: Developmental Origins of Interneuronal Heterogeneity 29
Ontogenetic Differences between Glutamatergic Neurons versus
Interneurons 29
Molecular Carrots and Sticks for Interneuronal Migration 32
Distinct Interneurons from Different Sources? 35
A Case Study: Migration of Interneurons Toward the Hippocampus 38
Long Road to Tipperary: Consequences of Distant Progenitor Zones for
Interneuronal Specification 40
When Things Go Wrong: Interneuron Migrations and Neurological
Disorders 42
3: Order in Diversity: From Phenomenology to Function 45
Diversity at Multiple Levels of Neuronal Organization 45
Linnean Order in Diversity: A Modern Compendium of Interneuronal
Species 47
Cogwheels of Understanding: Functions of Interneuronal Subtypes 55
Basket Cells: Division of Labor 62
Canonical Microcircuits, Cortical Columns, and Their Stereotyped
Inhabitants 66
Crusade for the Great Synthesis and the End of Neuroscience 69
XV
xvi Contents
4: Cracks in the Crystal: Elusive Neurospecies and the Great Correlation
Hunt 72
Neuronal Species: Can't Live with Them, Can't Live without Them 72
Getting Lost in Parameter Space: The Mirage of Blind Phenotypic
Correlations 75
Imperfect Correlations: Experimenter's Errors or Reality? 78
The Other Extreme: Each Interneuron as an Unclassifiable Individual 84
5: Functions of Heterogeneity: Meaning of Means and Variability
of Variances 87
Reconciling Order and Variability: Distinct Subtypes and Cell to Cell
Heterogeneity as Simultaneously Existing Reality 87
Definitions: Heterogeneity, Variance and Diversity 88
First Look at Variability and Function: Interneuronal Covering of
Principal Cells Both in Space and Time 91
Simulations of Interneuronal Variance and Synchrony 93
Toward Rules that Underlie the Modulation of Postsynaptic Behavior
by Interneuronal Variability 98
6: Interneuronal Variability: Plasticity and Regulation 105
Dynamic Clamp Down on Interneuronal Variance 105
Alterations in Variance: Neuromodulators, Neurological Diseases, and
Development 112
Statistical Methods of Measuring Changes in Variance 116
Transfer of Interneuronal Variability to Principal Cells: Potential for
More Functional States? 117
Heterogeneity in the Outside World and Its Reflection in the Circuit 119
Variations for the Advanced Age: Intra Species Variance in Interneuronal
Populations dirough Somatic Mutations? 120
7: Diversity Beyond Variance 125
Species Number and Relative Abundance: Entropy Based Measures
of Diversity 125
Plasticity of Interneuronal Diversity: Birth and Loss of Cellular
Species 127
Effects of Changed Diversity on Firing Rates 130
Modulation of Synchrony by Alterations in Diversity 135
Equitability, and Alpha, Beta and Gamma Diversity 139
Molecular Dragnets Cast Wide: Interneuronal Species from Unsupervised
Clustering 140
Emerging Order in the Molecular Pandora's Box 145
Ontogenetic Cladistics for Interneurons 148
Interneuronal Diversity and Evolution 149
Constraints on Interneuronal Diversity 153
Contents xvii
8: Fifty Ways to Be a Basket Cell: Self Tuning Interneurons with Multiple
Solutions for Their Tasks 156
The "Ideal" Basket Cell 156
Unbearable Multiplicity of Being a Specialized Neuron 157
Failure of Averaging 158
Homeostatic Regulation and Activity Sensors 161
Homeostasis in GABAergic Systems 165
Wanted, Alive: Interneuronal Heterogeneity in Naturalistic
Environments 167
9: Interneuronal Diversity and Small World Neuronal Networks 171
Building Complex Machines with Minimal Wiring 171
Real World Small Worlds: Worming Up to the Hippocampus 179
Attack Tolerance of Small World Networks: Hippocampal Sclerosis
as a Natural Experiment 183
Scale Free Networks: Interneurons as Hubs 186
Interneuronal Heterogeneity in Small World Networks 191
10: Closing Thoughts: The Stucture of Cortical Microcircuit
Theory 195
Resolution of the Diversity Debate 195
Building a Complex Machine from Variable Parts 196
Phenogenetic Perspective for Interneuronal Research and the Role of
Chance 198
Cajal's Functional Neuroanatomy in the 21st Century 201
Bibliography 203
Index 235 |
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| spelling | Soltesz, Ivan ca. 20./21. Jh. Verfasser (DE-588)1336590467 aut Diversity in the neuronal machine order and variability in interneuronal microcircuits Ivan Soltesz Oxford Oxford University Press 2006 xvii, 238 Seiten Illustrationen, Diagramme 25 cm txt rdacontent n rdamedia nc rdacarrier Literaturverzeichnis: Seite 203-233 Interneurons Neural networks (Neurobiology) Interneurons classification Hippocampus Interneurons physiology Nerve Net physiology Nervennetz (DE-588)4041638-0 gnd rswk-swf Interneuron (DE-588)4314951-0 gnd rswk-swf Nervennetz (DE-588)4041638-0 s Interneuron (DE-588)4314951-0 s DE-604 http://www.loc.gov/catdir/enhancements/fy0636/2005009389-d.html Publisher description HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015625036&sequence=000010&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Soltesz, Ivan ca. 20./21. Jh Diversity in the neuronal machine order and variability in interneuronal microcircuits Interneurons Neural networks (Neurobiology) Interneurons classification Hippocampus Interneurons physiology Nerve Net physiology Nervennetz (DE-588)4041638-0 gnd Interneuron (DE-588)4314951-0 gnd |
| subject_GND | (DE-588)4041638-0 (DE-588)4314951-0 |
| title | Diversity in the neuronal machine order and variability in interneuronal microcircuits |
| title_auth | Diversity in the neuronal machine order and variability in interneuronal microcircuits |
| title_exact_search | Diversity in the neuronal machine order and variability in interneuronal microcircuits |
| title_exact_search_txtP | Diversity in the neuronal machine order and variability in interneuronal microcircuits |
| title_full | Diversity in the neuronal machine order and variability in interneuronal microcircuits Ivan Soltesz |
| title_fullStr | Diversity in the neuronal machine order and variability in interneuronal microcircuits Ivan Soltesz |
| title_full_unstemmed | Diversity in the neuronal machine order and variability in interneuronal microcircuits Ivan Soltesz |
| title_short | Diversity in the neuronal machine |
| title_sort | diversity in the neuronal machine order and variability in interneuronal microcircuits |
| title_sub | order and variability in interneuronal microcircuits |
| topic | Interneurons Neural networks (Neurobiology) Interneurons classification Hippocampus Interneurons physiology Nerve Net physiology Nervennetz (DE-588)4041638-0 gnd Interneuron (DE-588)4314951-0 gnd |
| topic_facet | Interneurons Neural networks (Neurobiology) Interneurons classification Hippocampus Interneurons physiology Nerve Net physiology Nervennetz Interneuron |
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