Protein misfolding in neurodegenerative diseases: mechanisms and therapeutic strategies
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Boca Raton, Fla. [u.a.]
CRC Press
2008
|
| Series: | CRC enzyme inhibitors series
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XXIV, 565 S. Ill., graph. Darst. |
| ISBN: | 9780849373107 |
Staff View
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| 650 | 4 | |a Nervous system |x Degeneration |x Etiology | |
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| 650 | 4 | |a Neurodegenerative Diseases |x etiology | |
| 650 | 4 | |a Neurodegenerative Diseases |x physiopathology | |
| 650 | 4 | |a Neurodegenerative Diseases |x therapy | |
| 650 | 4 | |a Protein Folding | |
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Record in the Search Index
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| adam_text | Contents
Series Preface ix
Preface xi
Editors xiii
Contributors xv
Abbreviations xix
Chapter 1 Protein Folding and Misfolding, Relevance
to Disease, and Biological Function 1
Massimo Stefani
PARTI
ALZHEIMER S DISEASE
Chapter 2 Alzheimer s Disease 69
Charlotte E. Teunissen and Tischa J.M. van der Cammen
Chapter 3 Improving Cholinergic Transmission 95
3.1 Cholinergic Transmission and Acetylcholine Release Enhancers 96
Pierre Francotte, Pascal de Tullio, and Bernard Pirotte
3.2 AChE and Its Inhibition 103
Jure Stojan
3.3 AChE Inhibitors and Their Clinical Assessment 114
Pierre Francotte, Pascal de Tullio, and Bernard Pirotte
Chapter 4 Reduction in Plaque Formation 145
4.1 Secretase and APP Processing 147
Christian Czech, Helmut Jacobsen, and Celine Adessi
4.2 Mechanism of Plaque Formation and Ap Aggregation Inhibitors... 156
Christian Czech, Helmut Jacobsen, and Celine Adessi
4.3 Nonsteroidal Anti-Inflammatory Drugs 163
Bruno P. Imbimbo and Francesco Speroni
4.4 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors ....192
Dario Cattaneo
v
vi
4.5 A3 Polymerization Reduction 209
Harry LeVine III and Corinne E. Augelli-Szafran
Chapter 5 Carbonic Anhydrase Activators as Potential Anti-Alzheimer s
Disease Agents 265
Claudia T. Supuran and Andrea Scozzafava
Chapter 6 Detection and Reduction of Neurofibrillary Lesions 289
JeffKuret
Chapter 7 Protein Misfolding in Alzheimer s Disease:
Pathogenic or Protective? 327
Rudy J. Castellani, Hyoung-Gon Lee, Akihiko Nunomura,
Xiongwei Zhu, George Perry, and Mark A. Smith
Chapter 8 Enhancement of Brain Retinoic Acid Levels 337
Ann B. Goodman, Peter McCaffery, Joana A. Palha,
Claire Simons, and Arthur B. Pardee
PART II
PARKINSON S DISEASE
Chapter 9 Parkinson s Disease: What Is It? What Causes It?
And How Can It Be Cured? 381
Tom Foltynie, Andrew W. Michell, and Roger A. Barker
Chapter 10 Restoring Dopamine Levels 415
P. Nuno Palma, Maria Jodo Bonifacio, Luis Almeida,
and Patricio Soares-da-Silva
PART III
HUNTINGTON S DISEASE
Chapter 11 Huntington s Disease 449
Claire-Anne Gutekunst and Fran Norflus
PART IV
AMYOTROPHIC LATERAL SCLEROSIS
Chapter 12 Amyotrophic Lateral Sclerosis (Motor Neuron Disease) 479
Teresa Sanelli, Janice Robertson, Avi Chakabartty, and
Michael J. Strong
vii
PARTV
TRANSMISSIBLE SPONCIFORM
ENCEPHALOPA THIES
Chapter 13 Transmissible Spongiform Encephalopathies 517
Michael D. Geschwind and Giuseppe Legname
PART VI
OVERVIEW
Chapter 14 Overview 547
H. John Smith, Robert D.E. Sew ell, and Claire Simons
Index 557
|
| adam_txt |
Contents
Series Preface ix
Preface xi
Editors xiii
Contributors xv
Abbreviations xix
Chapter 1 Protein Folding and Misfolding, Relevance
to Disease, and Biological Function 1
Massimo Stefani
PARTI
ALZHEIMER'S DISEASE
Chapter 2 Alzheimer's Disease 69
Charlotte E. Teunissen and Tischa J.M. van der Cammen
Chapter 3 Improving Cholinergic Transmission 95
3.1 Cholinergic Transmission and Acetylcholine Release Enhancers 96
Pierre Francotte, Pascal de Tullio, and Bernard Pirotte
3.2 AChE and Its Inhibition 103
Jure Stojan
3.3 AChE Inhibitors and Their Clinical Assessment 114
Pierre Francotte, Pascal de Tullio, and Bernard Pirotte
Chapter 4 Reduction in Plaque Formation 145
4.1 Secretase and APP Processing 147
Christian Czech, Helmut Jacobsen, and Celine Adessi
4.2 Mechanism of Plaque Formation and Ap Aggregation Inhibitors. 156
Christian Czech, Helmut Jacobsen, and Celine Adessi
4.3 Nonsteroidal Anti-Inflammatory Drugs 163
Bruno P. Imbimbo and Francesco Speroni
4.4 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors .192
Dario Cattaneo
v
vi
4.5 A3 Polymerization Reduction 209
Harry LeVine III and Corinne E. Augelli-Szafran
Chapter 5 Carbonic Anhydrase Activators as Potential Anti-Alzheimer's
Disease Agents 265
Claudia T. Supuran and Andrea Scozzafava
Chapter 6 Detection and Reduction of Neurofibrillary Lesions 289
JeffKuret
Chapter 7 Protein Misfolding in Alzheimer's Disease:
Pathogenic or Protective? 327
Rudy J. Castellani, Hyoung-Gon Lee, Akihiko Nunomura,
Xiongwei Zhu, George Perry, and Mark A. Smith
Chapter 8 Enhancement of Brain Retinoic Acid Levels 337
Ann B. Goodman, Peter McCaffery, Joana A. Palha,
Claire Simons, and Arthur B. Pardee
PART II
PARKINSON'S DISEASE
Chapter 9 Parkinson's Disease: What Is It? What Causes It?
And How Can It Be Cured? 381
Tom Foltynie, Andrew W. Michell, and Roger A. Barker
Chapter 10 Restoring Dopamine Levels 415
P. Nuno Palma, Maria Jodo Bonifacio, Luis Almeida,
and Patricio Soares-da-Silva
PART III
HUNTINGTON'S DISEASE
Chapter 11 Huntington's Disease 449
Claire-Anne Gutekunst and Fran Norflus
PART IV
AMYOTROPHIC LATERAL SCLEROSIS
Chapter 12 Amyotrophic Lateral Sclerosis (Motor Neuron Disease) 479
Teresa Sanelli, Janice Robertson, Avi Chakabartty, and
Michael J. Strong
vii
PARTV
TRANSMISSIBLE SPONCIFORM
ENCEPHALOPA THIES
Chapter 13 Transmissible Spongiform Encephalopathies 517
Michael D. Geschwind and Giuseppe Legname
PART VI
OVERVIEW
Chapter 14 Overview 547
H. John Smith, Robert D.E. Sew ell, and Claire Simons
Index 557 |
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| spelling | Protein misfolding in neurodegenerative diseases mechanisms and therapeutic strategies ed. by H. John Smith ... Boca Raton, Fla. [u.a.] CRC Press 2008 XXIV, 565 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier CRC enzyme inhibitors series Nervous system Degeneration Etiology Nervous system Degeneration Pathophysiology Nervous system Degeneration Treatment Neurodegenerative Diseases etiology Neurodegenerative Diseases physiopathology Neurodegenerative Diseases therapy Protein Folding Protein folding Huntington-Chorea (DE-588)4026223-6 gnd rswk-swf Proteinfaltung (DE-588)4324567-5 gnd rswk-swf Parkinson-Krankheit (DE-588)4044683-9 gnd rswk-swf Alzheimerkrankheit (DE-588)4112510-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Alzheimerkrankheit (DE-588)4112510-1 s Proteinfaltung (DE-588)4324567-5 s DE-604 Parkinson-Krankheit (DE-588)4044683-9 s Huntington-Chorea (DE-588)4026223-6 s Smith, Harold John Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015618216&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Protein misfolding in neurodegenerative diseases mechanisms and therapeutic strategies Nervous system Degeneration Etiology Nervous system Degeneration Pathophysiology Nervous system Degeneration Treatment Neurodegenerative Diseases etiology Neurodegenerative Diseases physiopathology Neurodegenerative Diseases therapy Protein Folding Protein folding Huntington-Chorea (DE-588)4026223-6 gnd Proteinfaltung (DE-588)4324567-5 gnd Parkinson-Krankheit (DE-588)4044683-9 gnd Alzheimerkrankheit (DE-588)4112510-1 gnd |
| subject_GND | (DE-588)4026223-6 (DE-588)4324567-5 (DE-588)4044683-9 (DE-588)4112510-1 (DE-588)4143413-4 |
| title | Protein misfolding in neurodegenerative diseases mechanisms and therapeutic strategies |
| title_auth | Protein misfolding in neurodegenerative diseases mechanisms and therapeutic strategies |
| title_exact_search | Protein misfolding in neurodegenerative diseases mechanisms and therapeutic strategies |
| title_exact_search_txtP | Protein misfolding in neurodegenerative diseases mechanisms and therapeutic strategies |
| title_full | Protein misfolding in neurodegenerative diseases mechanisms and therapeutic strategies ed. by H. John Smith ... |
| title_fullStr | Protein misfolding in neurodegenerative diseases mechanisms and therapeutic strategies ed. by H. John Smith ... |
| title_full_unstemmed | Protein misfolding in neurodegenerative diseases mechanisms and therapeutic strategies ed. by H. John Smith ... |
| title_short | Protein misfolding in neurodegenerative diseases |
| title_sort | protein misfolding in neurodegenerative diseases mechanisms and therapeutic strategies |
| title_sub | mechanisms and therapeutic strategies |
| topic | Nervous system Degeneration Etiology Nervous system Degeneration Pathophysiology Nervous system Degeneration Treatment Neurodegenerative Diseases etiology Neurodegenerative Diseases physiopathology Neurodegenerative Diseases therapy Protein Folding Protein folding Huntington-Chorea (DE-588)4026223-6 gnd Proteinfaltung (DE-588)4324567-5 gnd Parkinson-Krankheit (DE-588)4044683-9 gnd Alzheimerkrankheit (DE-588)4112510-1 gnd |
| topic_facet | Nervous system Degeneration Etiology Nervous system Degeneration Pathophysiology Nervous system Degeneration Treatment Neurodegenerative Diseases etiology Neurodegenerative Diseases physiopathology Neurodegenerative Diseases therapy Protein Folding Protein folding Huntington-Chorea Proteinfaltung Parkinson-Krankheit Alzheimerkrankheit Aufsatzsammlung |
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