Renal physiology:
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Book |
| Language: | German |
| Published: |
Philadelphia
Mosby
2007
|
| Edition: | 4. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | Getr. Zählung graph. Darst. |
| ISBN: | 0323034470 9780323034470 |
Staff View
MARC
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| 245 | 1 | 0 | |a Renal physiology |c Bruce M. Koeppen ; Bruce A. Stanton |
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Record in the Search Index
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| adam_text | CONTENTS
INTRODUCTION TO THE KIDNEY 1
1
PHYSIOLOGY OF BODY FLUIDS 5
Objectives, 5
Physicochemical Properties of Electrolyte
Solutions, 5
Molarity and Equivalence, 5
Osmosis and Osmotic Pressure, 6
Osmolarity and Osmolality, 7
Tonicity, 7
One otic Pressure, 8
Specific Gravity, 8
Volumes of Body Fluid Compartments, 9
Composition of Body Fluid
Compartments, 10
Fluid Exchange Between Body Fluid
Compartments, 11
Capillary Fluid Exchange, 11
Cellular Fluid Exchange, 13
Summary, 15
Key Words and Concepts, 15
Self Study Problems, 16
2
STRUCTURE AND FUNCTION
OFTHE KIDNEYS 19
Objectives, 19
Structure of the Kidneys, 19
Gross Anatomy, 19
Ultrastructure of the Nephron, 20
infrastructure of the Renal
Corpuscle, 24
Ultrastructure of the Juxtaglomerular
Apparatus, 28
Innervation of the Kidneys, 28
Summary, 29
Key Words and Concepts, 29
Self Study Problems, 30
3
GLOMERULAR FILTRATION
AND RENAL BLOOD FLOW 31
Objectives, 31
Renal Clearance, 31
Glomendar Filtration Rate, 32
Glomerular Filtration, 34
Determinants of Ultrafiltrate
Composition, 35
Dynamics of Ultrafiltration, 36
Renal Blood Flow, 37
Regulation of Renal Blood Flow and
Glomerular Filtration Rate, 41
Sympathetic Nerves, 41
Angiotensin II, 42
Prostaglandins, 42
Nitric Oxide, 43
Endothelin, 44
Bradykinin, 44
Adenosine, 44
Natriuretic Peptides, 44
ATP, 44
Glucocorticoids, 44
Histamine, 44
Dopamine, 44
Summary, 45
Key Words and Concepts, 46
Self Study Problems, 46
4
RENAL TRANSPORT MECHANISMS:
NaCl AND WATER REABSORPTION
ALONG THE NEPHRON 47
Objectives, 47
General Principles of Membrane
Transport, 48
General Principles of Transepithelial Solute
and Water Transport, 50
NaCl, Solute, and Water Reabsorption Along
the Nephron, 52
Proximal Tubule, 52
Henle s Loop, 61
Distal Tubule and Collecting
Duct, 63
Regulation of NaCl and Water
Reabsorption, 64
Summary, 69
Key Words and Concepts, 70
Self Study Problems, 70
5
REGULATION OF BODY FLUID
OSMOLALITY: REGULATION OF
WATER BALANCE 71
Objectives, 71
Antidiuretic Hormone, 73
Osmotic Control ofADH Secretion, 74
Hemodynamic Control ofADH
Secretion, 75
ADH Actions on the Kidneys, 76
Thirst, 79
Renal Mechanisms for Dilution and
Concentration of the Urine, 80
Medullary Interstitium, 85
Vasa Recta Function, 86
Assessment of Renal Diluting
and Concentrating Ability, 87
Summary, 89
Key Words And Concepts, 89
Self Study Problems, 90
6
REGULATION OF EXTRACELLULAR
FLUID VOLUME AND NaCI
BALANCE 91
Objectives, 91
Concept of Effective Circulating
Volume, 92
Volume Sensing Systems, 93
Vascular Low Pressure Volume
Sensors, 94
Vascular High Pressure Volume
Sensors, 94
Hepatic Sensors, 95
Central Nervous System Na+
Sensors, 95
Volume Sensor Signals, 95
Renal Sympathetic Nerves, 95
Renin Angiotensin Aldosterone
System, 96
Natriuretic Peptides, 98
Antidiuretic Hormone, 99
Control of Renal NaCl Excretion During
Euvolemia, 99
Mechanisms for Maintaining the
Delivery of Na+ to the Distal Tubule
Constant, 101
Regulation of Distal Tubule and Collecting
Duct Na+ Reabsorption, 101
Control of Na+ Excretion with Volume
Expansion, 102
Control of Na+ Excretion with Volume
Contraction, 104
Edema, 106
Alterations in Starling Forces, 106
The Role of the Kidneys, 107
Summary, 108
Key Words and Concepts, 109
Self Study Problems, 109
7
REGULATION OF POTASSIUM
BALANCE 113
Objectives, 113
Overview of K+ Homeostasis, 113
Regulation of Plasma [KT], 115
Epinephrine, 116
Insulin, 116
Aldosterone, 117
Alterations of Plasma [K+], 117
Acid Base Balance, 117
Plasma Osmolality, 117
Cell Lysis, 118
Exercise, 118
K+Excretion by the Kidneys, 118
Cellular Mechanisms of K+ Secretion by
Principal Cells in the Distal Tubule and
Collecting Duct, 120
Regulation of K+ Secretion by the Distal
Tubule and Collecting Duct, 120
Plasma [K+], 120
Aldosterone, 122
Antidiuretic Hormone, 123
Factors that Perturb K+ Excretion, 124
Flow of Tubular Fluid, 124
Acid Base Balance, 125
Glucocorticoids, 127
Summary, 128
Key Words and Concepts, 128
Self Study Problems, 128
8
REGULATION OF ACID BASE
BALANCE 129
Objectives, 129
The HCO; Buffer System, 130
Overview of Acid Base Balance, 130
Net Acid Excretion by the Kidneys, 131
HCOT Reabsorption Along the Nephron, 132
Regulation of H* Secretion, 135
Formation of New HCOj, 137
Response to Acid Base Disorders, 141
Extracellular and Intracellular
Buffers, 141
Respiratory Compensation, 142
Renal Compensation, 142
Simple Acid Base Disorders, 143
Metabolic Acidosis, 143
Metabolic Alkalosis, 144
Respiratory Acidosis, 144
Respiratory Alkalosis, 145
Analysis of Acid Base Disorders, 145
Summary, 147
Key Words and Concepts, 147
Self Study Problems, 147
9
REGULATION OF CALCIUM
AND PHOSPHATE
HOMEOSTASIS 149
Objectives, 149
Calcium, 150
Overview ofG?++ Homeostasis, 150
Ca++ Transport along the
Nephron, 152
Regulation of Urinary Ca++
Excretion, 154
Calcium Sensing Receptor, 155
Phosphate, 155
Overview of Pi Homeostasis, 156
Pi Transport along the Nephron, 157
Regulation of Urinary Pi
Excretion, 157
Integrative Review of Parathyroid Hormone,
Calcitriol, and Calcitonin on Ca++ and
Pi Homeostasis, 159
Summary, 161
Key Words and Concepts, 161
Self Study Problems, 161
10
PHYSIOLOGY OF DIURETIC
ACTION, 163
Objectives, 163
General Principles of Diuretic Action, 163
Sites of Action of Diuretics, 164
Response of Other Nephron
Segments, 164
Adequate Delivery of Diuretics to
Their Site of Action, 164
Volume of the Extracellular Fluid, 165
Diuretic Braking Phenomenon, 165
Mechanisms of Action of Diuretics, 166
Osmotic Diuretics, 166
Carbonic Anhydrase Inhibitors, 167
Loop Diuretics, 167
Thiazide Diuretics, 168
K+ Sparing Diuretics, 168
Aquaretics, 169
Effect of Diuretics on the Excretion of Water
and other Solutes, 169
Solute Free Water, 169
K+ Excretion, 170
HCOj Excretion, 170
Ca++ and Pi Excretion, 171
Summary, 172
Key Words and Concepts, 173
Self Study Problems, 173
ADDITIONAL READING, 175
A
INTEGRATIVE CASE STUDIES . . .179
B
NORMAL LABORATORY
VALUES 183
C
NEPHRON FUNCTION 185
D
ANSWERS TO SELF STUDY
POBLEMS 189
E
ANSWERS TO INTEGRATIVE
CASE STUDIES 203
F
REVIEW EXAMINATION 209
INDEX 223
|
| adam_txt |
CONTENTS
INTRODUCTION TO THE KIDNEY 1
1
PHYSIOLOGY OF BODY FLUIDS 5
Objectives, 5
Physicochemical Properties of Electrolyte
Solutions, 5
Molarity and Equivalence, 5
Osmosis and Osmotic Pressure, 6
Osmolarity and Osmolality, 7
Tonicity, 7
One otic Pressure, 8
Specific Gravity, 8
Volumes of Body Fluid Compartments, 9
Composition of Body Fluid
Compartments, 10
Fluid Exchange Between Body Fluid
Compartments, 11
Capillary Fluid Exchange, 11
Cellular Fluid Exchange, 13
Summary, 15
Key Words and Concepts, 15
Self Study Problems, 16
2
STRUCTURE AND FUNCTION
OFTHE KIDNEYS 19
Objectives, 19
Structure of the Kidneys, 19
Gross Anatomy, 19
Ultrastructure of the Nephron, 20
infrastructure of the Renal
Corpuscle, 24
Ultrastructure of the Juxtaglomerular
Apparatus, 28
Innervation of the Kidneys, 28
Summary, 29
Key Words and Concepts, 29
Self Study Problems, 30
3
GLOMERULAR FILTRATION
AND RENAL BLOOD FLOW 31
Objectives, 31
Renal Clearance, 31
Glomendar Filtration Rate, 32
Glomerular Filtration, 34
Determinants of Ultrafiltrate
Composition, 35
Dynamics of Ultrafiltration, 36
Renal Blood Flow, 37
Regulation of Renal Blood Flow and
Glomerular Filtration Rate, 41
Sympathetic Nerves, 41
Angiotensin II, 42
Prostaglandins, 42
Nitric Oxide, 43
Endothelin, 44
Bradykinin, 44
Adenosine, 44
Natriuretic Peptides, 44
ATP, 44
Glucocorticoids, 44
Histamine, 44
Dopamine, 44
Summary, 45
Key Words and Concepts, 46
Self Study Problems, 46
4
RENAL TRANSPORT MECHANISMS:
NaCl AND WATER REABSORPTION
ALONG THE NEPHRON 47
Objectives, 47
General Principles of Membrane
Transport, 48
General Principles of Transepithelial Solute
and Water Transport, 50
NaCl, Solute, and Water Reabsorption Along
the Nephron, 52
Proximal Tubule, 52
Henle's Loop, 61
Distal Tubule and Collecting
Duct, 63
Regulation of NaCl and Water
Reabsorption, 64
Summary, 69
Key Words and Concepts, 70
Self Study Problems, 70
5
REGULATION OF BODY FLUID
OSMOLALITY: REGULATION OF
WATER BALANCE 71
Objectives, 71
Antidiuretic Hormone, 73
Osmotic Control ofADH Secretion, 74
Hemodynamic Control ofADH
Secretion, 75
ADH Actions on the Kidneys, 76
Thirst, 79
Renal Mechanisms for Dilution and
Concentration of the Urine, 80
Medullary Interstitium, 85
Vasa Recta Function, 86
Assessment of Renal Diluting
and Concentrating Ability, 87
Summary, 89
Key Words And Concepts, 89
Self Study Problems, 90
6
REGULATION OF EXTRACELLULAR
FLUID VOLUME AND NaCI
BALANCE 91
Objectives, 91
Concept of Effective Circulating
Volume, 92
Volume Sensing Systems, 93
Vascular Low Pressure Volume
Sensors, 94
Vascular High Pressure Volume
Sensors, 94
Hepatic Sensors, 95
Central Nervous System Na+
Sensors, 95
Volume Sensor Signals, 95
Renal Sympathetic Nerves, 95
Renin Angiotensin Aldosterone
System, 96
Natriuretic Peptides, 98
Antidiuretic Hormone, 99
Control of Renal NaCl Excretion During
Euvolemia, 99
Mechanisms for Maintaining the
Delivery of Na+ to the Distal Tubule
Constant, 101
Regulation of Distal Tubule and Collecting
Duct Na+ Reabsorption, 101
Control of Na+ Excretion with Volume
Expansion, 102
Control of Na+ Excretion with Volume
Contraction, 104
Edema, 106
Alterations in Starling Forces, 106
The Role of the Kidneys, 107
Summary, 108
Key Words and Concepts, 109
Self Study Problems, 109
7
REGULATION OF POTASSIUM
BALANCE 113
Objectives, 113
Overview of K+ Homeostasis, 113
Regulation of Plasma [KT], 115
Epinephrine, 116
Insulin, 116
Aldosterone, 117
Alterations of Plasma [K+], 117
Acid Base Balance, 117
Plasma Osmolality, 117
Cell Lysis, 118
Exercise, 118
K+Excretion by the Kidneys, 118
Cellular Mechanisms of K+ Secretion by
Principal Cells in the Distal Tubule and
Collecting Duct, 120
Regulation of K+ Secretion by the Distal
Tubule and Collecting Duct, 120
Plasma [K+], 120
Aldosterone, 122
Antidiuretic Hormone, 123
Factors that Perturb K+ Excretion, 124
Flow of Tubular Fluid, 124
Acid Base Balance, 125
Glucocorticoids, 127
Summary, 128
Key Words and Concepts, 128
Self Study Problems, 128
8
REGULATION OF ACID BASE
BALANCE 129
Objectives, 129
The HCO; Buffer System, 130
Overview of Acid Base Balance, 130
Net Acid Excretion by the Kidneys, 131
HCOT Reabsorption Along the Nephron, 132
Regulation of H* Secretion, 135
Formation of New HCOj, 137
Response to Acid Base Disorders, 141
Extracellular and Intracellular
Buffers, 141
Respiratory Compensation, 142
Renal Compensation, 142
Simple Acid Base Disorders, 143
Metabolic Acidosis, 143
Metabolic Alkalosis, 144
Respiratory Acidosis, 144
Respiratory Alkalosis, 145
Analysis of Acid Base Disorders, 145
Summary, 147
Key Words and Concepts, 147
Self Study Problems, 147
9
REGULATION OF CALCIUM
AND PHOSPHATE
HOMEOSTASIS 149
Objectives, 149
Calcium, 150
Overview ofG?++ Homeostasis, 150
Ca++ Transport along the
Nephron, 152
Regulation of Urinary Ca++
Excretion, 154
Calcium Sensing Receptor, 155
Phosphate, 155
Overview of Pi Homeostasis, 156
Pi Transport along the Nephron, 157
Regulation of Urinary Pi
Excretion, 157
Integrative Review of Parathyroid Hormone,
Calcitriol, and Calcitonin on Ca++ and
Pi Homeostasis, 159
Summary, 161
Key Words and Concepts, 161
Self Study Problems, 161
10
PHYSIOLOGY OF DIURETIC
ACTION, 163
Objectives, 163
General Principles of Diuretic Action, 163
Sites of Action of Diuretics, 164
Response of Other Nephron
Segments, 164
Adequate Delivery of Diuretics to
Their Site of Action, 164
Volume of the Extracellular Fluid, 165
Diuretic Braking Phenomenon, 165
Mechanisms of Action of Diuretics, 166
Osmotic Diuretics, 166
Carbonic Anhydrase Inhibitors, 167
Loop Diuretics, 167
Thiazide Diuretics, 168
K+ Sparing Diuretics, 168
Aquaretics, 169
Effect of Diuretics on the Excretion of Water
and other Solutes, 169
Solute Free Water, 169
K+ Excretion, 170
HCOj Excretion, 170
Ca++ and Pi Excretion, 171
Summary, 172
Key Words and Concepts, 173
Self Study Problems, 173
ADDITIONAL READING, 175
A
INTEGRATIVE CASE STUDIES . . .179
B
NORMAL LABORATORY
VALUES 183
C
NEPHRON FUNCTION 185
D
ANSWERS TO SELF STUDY
POBLEMS 189
E
ANSWERS TO INTEGRATIVE
CASE STUDIES 203
F
REVIEW EXAMINATION 209
INDEX 223 |
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| id | DE-604.BV022404446 |
| illustrated | Illustrated |
| index_date | 2024-07-02T17:19:29Z |
| indexdate | 2024-07-09T20:56:52Z |
| institution | BVB |
| isbn | 0323034470 9780323034470 |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-015613032 |
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| spelling | Koeppen, Bruce M. Verfasser aut Renal physiology Bruce M. Koeppen ; Bruce A. Stanton 4. ed. Philadelphia Mosby 2007 Getr. Zählung graph. Darst. txt rdacontent n rdamedia nc rdacarrier Reins - Physiologie Kidney physiology Kidneys Physiology Physiologie (DE-588)4045981-0 gnd rswk-swf Niere (DE-588)4042270-7 gnd rswk-swf Niere (DE-588)4042270-7 s Physiologie (DE-588)4045981-0 s DE-604 Stanton, Bruce A. Verfasser aut HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015613032&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Koeppen, Bruce M. Stanton, Bruce A. Renal physiology Reins - Physiologie Kidney physiology Kidneys Physiology Physiologie (DE-588)4045981-0 gnd Niere (DE-588)4042270-7 gnd |
| subject_GND | (DE-588)4045981-0 (DE-588)4042270-7 |
| title | Renal physiology |
| title_auth | Renal physiology |
| title_exact_search | Renal physiology |
| title_exact_search_txtP | Renal physiology |
| title_full | Renal physiology Bruce M. Koeppen ; Bruce A. Stanton |
| title_fullStr | Renal physiology Bruce M. Koeppen ; Bruce A. Stanton |
| title_full_unstemmed | Renal physiology Bruce M. Koeppen ; Bruce A. Stanton |
| title_short | Renal physiology |
| title_sort | renal physiology |
| topic | Reins - Physiologie Kidney physiology Kidneys Physiology Physiologie (DE-588)4045981-0 gnd Niere (DE-588)4042270-7 gnd |
| topic_facet | Reins - Physiologie Kidney physiology Kidneys Physiology Physiologie Niere |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015613032&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT koeppenbrucem renalphysiology AT stantonbrucea renalphysiology |