Development of the nervous system:
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
ElsevierAcad. Press
2006
|
| Ausgabe: | 2. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIII, 373 S. Ill., graph. Darst. 1 CD-ROM (12 cm) |
| ISBN: | 0126186219 9780126186215 0123694477 9780123694478 |
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| 245 | 1 | 0 | |a Development of the nervous system |c Dan H. Sanes ; Thomas A. Reh ; William A. Harris |
| 250 | |a 2. ed. | ||
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Datensatz im Suchindex
| _version_ | 1804136453745147904 |
|---|---|
| adam_text | Cor
Preface for the First Edition xi
Preface for the Second Edition xiii
1. Neural Induction 1
Development and Evolution of Neurons 1
Early Embryology of Metazoans 1
Derivation of Neural Tissue 3
Interactions with Neighboring Tissues in Making Neural
Tissue 9
The Molecular Nature of the Neural Inducer 13
Conservation of Neural Induction 16
Interactions Among the Ectodermal Cells in Controlling
Neuroblast Segregation 20
Notch, Delta, and Achaete Scute Genes in Vertebrates 25
Linking Induction to Proneural Activity 27
Summary 28
2. Polarity and Segmentation 29
Regional Identity of the Nervous System 29
The Anterior Posterior Axis and HOX Genes 30
HOX Gene Function in the Nervous System 33
Signaling Molecules that Pattern the Anterior Posterior
Axis in Vertebrates: Heads or Tails 36
Organizing Centers in the Developing Brain 39
Forebrain Development, Prosomeres, and PAX Genes 42
Dorsal Ventral Polarity in the Neural Tube 46
Dorsal Neural Tube and Neural Crest 50
Patterning the Cerebral Cortex 52
Summary 55
3. Genesis and Migration 57
Cell Cycle Genes Control the Number of Neurons
Generated during Development 62
v
itents
Cell Interactions Control the Number of Cells Made by
Progenitors 63
The Generation of Neurons and GLIA 69
Cerebral Cortex Histogenesis 71
The Subventricular Zone: A Secondary Zone of
Neurogenesis 75
Cerebellar Cortex Histogenesis 76
Molecular Mechanisms of Neuronal Migration 78
Postembryonic and Adult Neurogenesis 82
Summary 85
4 Determination and Differentiation 87
Transcriptional Hierarchies in Invariant Lineages 88
Spatial and Temporal Coordinates of Determination 91
Asymmetric Cell Divisions and Asymmetric Fate 93
Generating Complexity through Cellular Interactions 94
Specification and Differentiation through Cellular
Interactions and Interactions with the Local
Environment 97
Competence and Histogenesis 100
The Interplay of Intrinsic and Extrinsic Influences in
Histogenesis 102
Interpreting Gradients and the Spatial Organization of
Cell Types 106
Summary 109
5. Axon Growth and Guidance 111
The Growth Cone 114
The Dynamic Cytoskeleton 116
What Do Growth Cones Grow On? 121
What Provides Directional Information to Growth
Cones? 123
Cell Adhesion and Labeled Pathways 124
Repulsive Guidance 127
ii
cc
Chemotaxis, Gradients, and Local Information 130
The Optic Pathway 133
The Midline 134
Attraction and Repulsion: Desensitization and
Adaptation 134
Signal Transduction 137
Summary 138
6. Target Selection 145
Defasiculation 145
Target Recognition and Entry 147
Slowing Down and Branching 148
Border Patrol and Prevention of Inappropriate
Targeting 149
Topographic Mapping 152
Chemospecificity and Ephrins 153
Shifting and Fine Tuning of Connections 158
The Third Dimension, Lamina Specific
Termination 162
Cellular and Synaptic Targeting 164
Sniffing Out Targets 166
Summary 170
7. Naturally Occurring Neuron Death 173
What does Neuron Death Look Like? 173
Early Elimination of Progenitor Cells 174
How Many Differentiated Neurons Die? 174
Survival Depends on the Synaptic Target 176
NGF: A Target Derived Survival Factor 180
The Neurotrophin Family 182
The TRK Family of Neurotrophin Receptors 184
How does the Neurotrophin Signal Reach the
Soma? 186
The P75 Neurotrophin Receptor 186
The Expanding World of Survival Factors 188
Endocrine Control of Cell Survival 190
Cell Death Requires Protein Synthesis 192
Intracellular Signaling 193
Caspases: Agents of Death 196
BCL 2 Proteins: Regulators ot Apoptosis 200
Synaptic Transmission at the Target 201
Afferent Regulation of Cell Survival 202
Summary 206
8. Synapse Formation and Function 207
What Do Newly Formed Synapses Look Like? 211
The First Signs ot Synapse Function 215
The Decision to Form a Synapse 218
The Sticky Synapse 220
INTENTS
Converting Growth Cones to Presynaptic Terminals 221
Receptor Clustering Signifies Postsynaptic Differentiation
at NMJ 222
Presynaptic Terminals Induce Receptor Aggregation 224
Agrin, a Transynaptic Clustering Signal 226
Postsynaptic Response to Agrin 227
Receptor Clustering Signals in the CNS 229
Internal Membrane Proteins and Receptor Aggregation in
the CNS 230
The Expression and Insertion of New Receptors 233
Neuronal Activity Regulates Receptor Expression 235
Neuregulin, a Regulator of Postsynaptic
Transcription 236
Maturation of Transmission and Receptor Isoform
Transitions 238
Maturation of Transmitter Reuptake 241
Short Term Plasticity 242
Appearance of Synaptic Inhibition 243
Is Inhibition Really Inhibitory during Development? 243
Summary 244
9. Refinement of Synaptic Connections 247
The Early Pattern of Connections 247
Functional Synapses are Eliminated 249
Axonal Arbors are Refined or Eliminated 250
Some Terminals Expand or Remain Stable 255
Neural Activity Regulates Synaptic Connections 255
Sensory Coding Properties Reflect Synapse
Rearrangement 262
Activity Contributes to the Alignment of Sensory
Maps 265
Spontaneous Activity and Afferent Segregation 267
Many Forms of Plasticity have a Time Limit 271
Synapses Interact Over a Short Distance 271
Heterosynaptic Depression 272
Postsynaptic Receptors are Eliminated 274
Involvement of Intracellular Calcium 276
NMDA Receptors and Calcium Signaling 276
The Role of Second Messenger Systems 278
Metabotropic Receptors 279
Gain Control 280
Silent Synapses 282
Homeostasis: The More Things Change, the More They
Stay the Same 283
Plasticity of Inhibitory Connections 284
Synaptic Influence on Neuron Morphology 285
Summary 287
10. Behavioral Development 289
Behavioral Ontogeny 289
Genetic and Environmental Mechanisms 290
CO
Environmental Determinants of Behavioral
Development 291
The First Movements 291
The Mechanism of Spontaneous Movements 293
Embryonic Movements: Uncoordinated or Integrated? 294
The Role of Activity in the Emergence of Coordinated
Behavior 296
Stage Specific Behaviors 297
Beginning to Make Sense of the World 299
Asking Babies Questions 300
Sharp Eyesight 301
Acute Hearing 302
Sex Specific Behavior 305
Genetic Sex 306
JTENTS I
Hormonal Signals 306
Hormonal Control of Brain Gender 307
Genetic Control of Brain Gender 308
Singing in the Brain 309
From Gonads to Brain? 310
Learning to Remember 311
Where s Mamma? 312
Fear and Loathing 314
Getting Information from One Brain to Another 317
Language 319
Summary 321
References 323
Index 361
|
| adam_txt |
Cor
Preface for the First Edition xi
Preface for the Second Edition xiii
1. Neural Induction 1
Development and Evolution of Neurons 1
Early Embryology of Metazoans 1
Derivation of Neural Tissue 3
Interactions with Neighboring Tissues in Making Neural
Tissue 9
The Molecular Nature of the Neural Inducer 13
Conservation of Neural Induction 16
Interactions Among the Ectodermal Cells in Controlling
Neuroblast Segregation 20
Notch, Delta, and Achaete Scute Genes in Vertebrates 25
Linking Induction to Proneural Activity 27
Summary 28
2. Polarity and Segmentation 29
Regional Identity of the Nervous System 29
The Anterior Posterior Axis and HOX Genes 30
HOX Gene Function in the Nervous System 33
Signaling Molecules that Pattern the Anterior Posterior
Axis in Vertebrates: Heads or Tails 36
Organizing Centers in the Developing Brain 39
Forebrain Development, Prosomeres, and PAX Genes 42
Dorsal Ventral Polarity in the Neural Tube 46
Dorsal Neural Tube and Neural Crest 50
Patterning the Cerebral Cortex 52
Summary 55
3. Genesis and Migration 57
Cell Cycle Genes Control the Number of Neurons
Generated during Development 62
v
itents
Cell Interactions Control the Number of Cells Made by
Progenitors 63
The Generation of Neurons and GLIA 69
Cerebral Cortex Histogenesis 71
The Subventricular Zone: A Secondary Zone of
Neurogenesis 75
Cerebellar Cortex Histogenesis 76
Molecular Mechanisms of Neuronal Migration 78
Postembryonic and Adult Neurogenesis 82
Summary 85
4 Determination and Differentiation 87
Transcriptional Hierarchies in Invariant Lineages 88
Spatial and Temporal Coordinates of Determination 91
Asymmetric Cell Divisions and Asymmetric Fate 93
Generating Complexity through Cellular Interactions 94
Specification and Differentiation through Cellular
Interactions and Interactions with the Local
Environment 97
Competence and Histogenesis 100
The Interplay of Intrinsic and Extrinsic Influences in
Histogenesis 102
Interpreting Gradients and the Spatial Organization of
Cell Types 106
Summary 109
5. Axon Growth and Guidance 111
The Growth Cone 114
The Dynamic Cytoskeleton 116
What Do Growth Cones Grow On? 121
What Provides Directional Information to Growth
Cones? 123
Cell Adhesion and Labeled Pathways 124
Repulsive Guidance 127
ii
cc
Chemotaxis, Gradients, and Local Information 130
The Optic Pathway 133
The Midline 134
Attraction and Repulsion: Desensitization and
Adaptation 134
Signal Transduction 137
Summary 138
6. Target Selection 145
Defasiculation 145
Target Recognition and Entry 147
Slowing Down and Branching 148
Border Patrol and Prevention of Inappropriate
Targeting 149
Topographic Mapping 152
Chemospecificity and Ephrins 153
Shifting and Fine Tuning of Connections 158
The Third Dimension, Lamina Specific
Termination 162
Cellular and Synaptic Targeting 164
Sniffing Out Targets 166
Summary 170
7. Naturally Occurring Neuron Death 173
What does Neuron Death Look Like? 173
Early Elimination of Progenitor Cells 174
How Many Differentiated Neurons Die? 174
Survival Depends on the Synaptic Target 176
NGF: A Target Derived Survival Factor 180
The Neurotrophin Family 182
The TRK Family of Neurotrophin Receptors 184
How does the Neurotrophin Signal Reach the
Soma? 186
The P75 Neurotrophin Receptor 186
The Expanding World of Survival Factors 188
Endocrine Control of Cell Survival 190
Cell Death Requires Protein Synthesis 192
Intracellular Signaling 193
Caspases: Agents of Death 196
BCL 2 Proteins: Regulators ot Apoptosis 200
Synaptic Transmission at the Target 201
Afferent Regulation of Cell Survival 202
Summary 206
8. Synapse Formation and Function 207
What Do Newly Formed Synapses Look Like? 211
The First Signs ot Synapse Function 215
The Decision to Form a Synapse 218
The Sticky Synapse 220
INTENTS
Converting Growth Cones to Presynaptic Terminals 221
Receptor Clustering Signifies Postsynaptic Differentiation
at NMJ 222
Presynaptic Terminals Induce Receptor Aggregation 224
Agrin, a Transynaptic Clustering Signal 226
Postsynaptic Response to Agrin 227
Receptor Clustering Signals in the CNS 229
Internal Membrane Proteins and Receptor Aggregation in
the CNS 230
The Expression and Insertion of New Receptors 233
Neuronal Activity Regulates Receptor Expression 235
Neuregulin, a Regulator of Postsynaptic
Transcription 236
Maturation of Transmission and Receptor Isoform
Transitions 238
Maturation of Transmitter Reuptake 241
Short Term Plasticity 242
Appearance of Synaptic Inhibition 243
Is Inhibition Really Inhibitory during Development? 243
Summary 244
9. Refinement of Synaptic Connections 247
The Early Pattern of Connections 247
Functional Synapses are Eliminated 249
Axonal Arbors are Refined or Eliminated 250
Some Terminals Expand or Remain Stable 255
Neural Activity Regulates Synaptic Connections 255
Sensory Coding Properties Reflect Synapse
Rearrangement 262
Activity Contributes to the Alignment of Sensory
Maps 265
Spontaneous Activity and Afferent Segregation 267
Many Forms of Plasticity have a Time Limit 271
Synapses Interact Over a Short Distance 271
Heterosynaptic Depression 272
Postsynaptic Receptors are Eliminated 274
Involvement of Intracellular Calcium 276
NMDA Receptors and Calcium Signaling 276
The Role of Second Messenger Systems 278
Metabotropic Receptors 279
Gain Control 280
Silent Synapses 282
Homeostasis: The More Things Change, the More They
Stay the Same 283
Plasticity of Inhibitory Connections 284
Synaptic Influence on Neuron Morphology 285
Summary 287
10. Behavioral Development 289
Behavioral Ontogeny 289
Genetic and Environmental Mechanisms 290
CO
Environmental Determinants of Behavioral
Development 291
The First Movements 291
The Mechanism of Spontaneous Movements 293
Embryonic Movements: Uncoordinated or Integrated? 294
The Role of Activity in the Emergence of Coordinated
Behavior 296
Stage Specific Behaviors 297
Beginning to Make Sense of the World 299
Asking Babies Questions 300
Sharp Eyesight 301
Acute Hearing 302
Sex Specific Behavior 305
Genetic Sex 306
JTENTS I \
Hormonal Signals 306
Hormonal Control of Brain Gender 307
Genetic Control of Brain Gender 308
Singing in the Brain 309
From Gonads to Brain? 310
Learning to Remember 311
Where's Mamma? 312
Fear and Loathing 314
Getting Information from One Brain to Another 317
Language 319
Summary 321
References 323
Index 361 |
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| dewey-search | 612.8 |
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| discipline | Biologie Psychologie Medizin |
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| edition | 2. ed. |
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| illustrated | Illustrated |
| index_date | 2024-07-02T17:15:56Z |
| indexdate | 2024-07-09T20:56:39Z |
| institution | BVB |
| isbn | 0126186219 9780126186215 0123694477 9780123694478 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-015603073 |
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| physical | XIII, 373 S. Ill., graph. Darst. 1 CD-ROM (12 cm) |
| publishDate | 2006 |
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| publisher | ElsevierAcad. Press |
| record_format | marc |
| spelling | Sanes, Dan H. Verfasser aut Development of the nervous system Dan H. Sanes ; Thomas A. Reh ; William A. Harris 2. ed. Amsterdam [u.a.] ElsevierAcad. Press 2006 XIII, 373 S. Ill., graph. Darst. 1 CD-ROM (12 cm) txt rdacontent n rdamedia nc rdacarrier Neurophysiologie du développement Developmental neurophysiology Zentralnervensystem (DE-588)4067637-7 gnd rswk-swf Neurogenese (DE-588)4331352-8 gnd rswk-swf Entwicklung (DE-588)4113450-3 gnd rswk-swf Zentralnervensystem (DE-588)4067637-7 s Entwicklung (DE-588)4113450-3 s DE-604 Neurogenese (DE-588)4331352-8 s Reh, Thomas A. Verfasser aut Harris, William A. Verfasser aut HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015603073&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Sanes, Dan H. Reh, Thomas A. Harris, William A. Development of the nervous system Neurophysiologie du développement Developmental neurophysiology Zentralnervensystem (DE-588)4067637-7 gnd Neurogenese (DE-588)4331352-8 gnd Entwicklung (DE-588)4113450-3 gnd |
| subject_GND | (DE-588)4067637-7 (DE-588)4331352-8 (DE-588)4113450-3 |
| title | Development of the nervous system |
| title_auth | Development of the nervous system |
| title_exact_search | Development of the nervous system |
| title_exact_search_txtP | Development of the nervous system |
| title_full | Development of the nervous system Dan H. Sanes ; Thomas A. Reh ; William A. Harris |
| title_fullStr | Development of the nervous system Dan H. Sanes ; Thomas A. Reh ; William A. Harris |
| title_full_unstemmed | Development of the nervous system Dan H. Sanes ; Thomas A. Reh ; William A. Harris |
| title_short | Development of the nervous system |
| title_sort | development of the nervous system |
| topic | Neurophysiologie du développement Developmental neurophysiology Zentralnervensystem (DE-588)4067637-7 gnd Neurogenese (DE-588)4331352-8 gnd Entwicklung (DE-588)4113450-3 gnd |
| topic_facet | Neurophysiologie du développement Developmental neurophysiology Zentralnervensystem Neurogenese Entwicklung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015603073&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT sanesdanh developmentofthenervoussystem AT rehthomasa developmentofthenervoussystem AT harriswilliama developmentofthenervoussystem |