Fundamental molecular biology:
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| Main Author: | |
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| Format: | Book |
| Language: | English |
| Published: |
Malden, MA [u.a.]
Blackwell
2007
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| Edition: | 1. publ. |
| Subjects: | |
| Online Access: | Table of contents only Inhaltsverzeichnis |
| Item Description: | Includes bibliographical references and index |
| Physical Description: | XXI, 725 S. zahlr. Ill. 1 CD-ROM (12 cm) |
| ISBN: | 1405103795 9781405103794 |
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| 100 | 1 | |a Allison, Lizabeth A. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Fundamental molecular biology |c Lizabeth A. Allison |
| 250 | |a 1. publ. | ||
| 264 | 1 | |a Malden, MA [u.a.] |b Blackwell |c 2007 | |
| 300 | |a XXI, 725 S. |b zahlr. Ill. |e 1 CD-ROM (12 cm) | ||
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| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Includes bibliographical references and index | ||
| 650 | 7 | |a Moleculaire biologie |2 gtt | |
| 650 | 4 | |a Molecular biology |v Textbooks | |
| 650 | 4 | |a Molecular Biology | |
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| _version_ | 1804136320910491648 |
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| adam_text | FUNDAMENTAL MOLECULAR BIOLOGY LIZABETH A. ALLISON DEPARTMENT OF BIOLOGY
COLLEGE OF WILLIAM AND MARY WILLIAMSBURG VA 23185, USA BLACKWELL
PUBLISHING CONTENTS PREFACE, XVIII 1 THE BEGINNINGS OF MOLECULAR
BIOLOGY, 1 1.1 INTRODUCTION 1 2 HISTORICAL PERSPECTIVE INSIGHTS INTO
HEREDITY FROM ROUND AND WRINKLED PEAS: MENDELIAN GENETICS INSIGHTS INTO
THE NATURE OF HEREDITARY MATERIAL: THE TRANSFORMING PRINCIPLE IS DNA
CREATIVITY IN APPROACH LEADS TO THE ONE GENE-ONE ENZYME HYPOTHESIS THE
IMPORTANCE OF TECHNOLOGICAL ADVANCES: THE HERSHEY-CHASE EXPERIMENT A
MODEL FOR THE STRUCTURE OF DNA: THE DNA DOUBLE HELIX CHAPTER SUMMARY
ANALYTICAL QUESTIONS SUGGESTIONS FOR FURTHER READING 2 THE STRUCTURE OF
DNA, 13 2.1 INTRODUCTION 2 2 PRIMARY STRUCTURE: THE COMPONENTS OF
NUCLEIC ACIDS FIVE-CARBON SUGARS NITROGENOUS BASES THE PHOSPHATE
FUNCTIONAL GROUP NUCLEOSIDES AND NUCLEOTIDES 2.3 SIGNIFICANCE OF 5 AND
3 7A NOMENCLATURE OF NUCLEOTIDES 2 5 THE LENGTH OF RNA AND DNA 2.6
SECONDARY STRUCTURE OF DNA HYDROGEN BONDS FORM BETWEEN THE BASES BASE
STACKING PROVIDES CHEMICAL STABILITY TO THE DNA DOUBLE HELIX STRUCTURE
OF THE WATSON-CRICK DNA DOUBLE HELIX DISTINGUISHING BETWEEN FEATURES OF
ALTERNATIVE DOUBLE-HELICAL STRUCTURES DNA CAN UNDERGO REVERSIBLE STRAND
SEPARATION 2 7 UNUSUAL DNA SECONDARY STRUCTURES SLIPPED STRUCTURES
CRUCIFORM STRUCTURES TRIPLE HELIX DNA DISEASE BOX 2.1 FRIEDREICH S
ATAXIA AND TRIPLE HELIX DNA 2 8 TERTIARY STRUCTURE OF DNA SUPERCOILING
OF DNA TOPOISOMERASES RELAX SUPERCOILED DNA WHAT IS THE SIGNIFICANCE OF
SUPERCOILING IN VIVO? DISEASE BOX 2.2 TOPOISOMERASE-TARGETED ANTICANCER
DRUGS CHAPTER SUMMARY ANALYTICAL QUESTIONS SUGGESTIONS FOR FURTHER
READING 3 GENOME ORGANIZATION: FROM NUCLEOTIDES TO CHROMATIN, 37 3.1
INTRODUCTION 3.2 EUKARYOTIC GENOME CONTENTS CHROMATIN STRUCTURE:
HISTORICAL PERSPECTIVE HISTONES NUCLEOSOMES BEADS-ON-A-STRING: THE 10 NM
FIBER THE 30 NM FIBER LOOP DOMAINS METAPHASE CHROMOSOMES ALTERNATIVE
CHROMATIN STRUCTURES 3.3 BACTERIAL GENOME 3.4 PLASMIDS 3.5
BACTERIOPHAGES AND MAMMALIAN DNA VIRUSES BACTERIOPHAGES MAMMALIAN DNA
VIRUSES 3.6 ORGANELLE GENOMES: CHLOROPLASTS AND MITOCHONDRIA CHLOROPLAST
DNA [CPDNA] MITOCHONDRIAL DNA (MTDNAL DISEASE BOX 3.1 MITOCHONDRIAL DNA
AND DISEASE 3.7 RNA-BASED GENOMES EUKARYOTIC RNA VIRUSES RETROVIRUSES
VIROIDS OTHER SUBVIRAL PATHOGENS DISEASE BOX 3.2 AVIAN FLU CHAPTER
SUMMARY ANALYTICAL QUESTIONS SUGGESTIONS FOR FURTHER READING 4 THE
VERSATILITY OF RNA, 54 4.1 INTRODUCTION 4.2 SECONDARY STRUCTURE OF RNA
SECONDARY STRUCTURE MOTIFS IN RNA BASE-PAIRED RNA ADOPTS AN A-TYPE
DOUBLE HELIX RNA HELICES OFTEN CONTAIN NONCANONICAL BASE PAIRS 4.3
TERTIARY STRUCTURE OF RNA TRNA STRUCTURE: IMPORTANT INSIGHTS INTO RNA
STRUCTURAL MOTIFS COMMON TERTIARY STRUCTURE MOTIFS IN RNA 4 4 KINETICS
OF RNA FOLDING 4.5 RNA IS INVOLVED IN A WIDE RANGE OF CELLULAR PROCESSES
4 6 HISTORICAL PERSPECTIVE: THE DISCOVERY OF RNA CATALYSIS TETRAHYMENA
GROUP I INTRON NBOZYME RNASE P RIBOZYME FOCUS BOX 4.1: THE RNA WORLD 4.7
RIBOZYMES CATALYZE A VARIETY OF CHEMICAL REACTIONS MODE OF NBOZYME
ACTION LARGE RIBOZYMES SMALL RIBOZYMES CHAPTER SUMMARY ANALYTICAL
QUESTIONS SUGGESTIONS FOR FURTHER READING CONTENTS 5 FROM GENE TO
PROTEIN, 79 5.1 INTRODUCTIO N 5 2 THE CENTRAL DOGMA 5 3 THE GENETIC CODE
TRANSLATING THE GENETIC CODE THE 21ST AND 22ND GENETICALLY ENCODED AMINO
ACIDS ROLE OF MODIFIED NUCLEOTIDES IN DECODING IMPLICATIONS OF CODON
BIAS FOR MOLECULAR BIOLOGISTS 5 4 PROTEIN STRUCTURE PRIMARY STRUCTURE
SECONDARY STRUCTURE TERTIARY STRUCTURE QUATERNARY STRUCTURE SIZE AND
COMPLEXITY OF PROTEINS PROTEINS CONTAIN MULTIPLE FUNCTIONAL DOMAINS
PREDICTION OF PROTEIN STRUCTURE 5.5 PROTEIN FUNCTION ENZYMES ARE
BIOLOGICAL CATALYSTS REGULATION OF PROTEIN ACTIVITY BY
POST-TRANSLATIONAL MODIFICATIONS ALLOSTERIC REGULATION OF PROTEIN
ACTIVITY CYCLIN-DEPENDENT KINASE ACTIVATION MACROMOLECULAR ASSEMBLAGES
5.6 PROTEIN FOLDING AND MISFOLDING MOLECULAR CHAPERONES
UBIQUITIN-MEDIATED PROTEIN DEGRADATION PROTEIN MISFOLDING DISEASES
DISEASE BOX 5.1 PRIONS CHAPTER SUMMARY ANALYTICAL QUESTIONS SUGGESTIONS
FOR FURTHER READING 6 DNA REPLICATION AND TELOMERE MAINTENANCE, 108 6.1
INTRODUCTION 6 2 HISTORICAL PERSPECTIVE INSIGHT INTO THE MODE OF DNA
REPLICATION: THE MESELSON-STAHL EXPERIMENT INSIGHT INTO THE MODE OF DNA
REPLICATION: VISUALIZATION OF REPLICATING BACTERIAL DNA 6 3 DNA
SYNTHESIS OCCURS FROM 5 -» 3 6 4 DNA POLYMERASES ARE THE ENZYMES THAT
CATALYZE DNA SYNTHESIS FOCUS BOX 6.1 BACTERIAL DNA POLYMERASES 6 5
SEMIDISCONTINUOUS DNA REPLICATION LEADING STRAND SYNTHESIS IS CONTINUOUS
LAGGING STRAND SYNTHESIS IS DISCONTINUOUS 6 6 NUCLEAR DNA REPLICATION IN
EUKARYOTIC CELLS REPLICATION FACTORIES HISTONE REMOVAL AT THE ORIGINS OF
REPLICATION PREREPLICATION COMPLEX FORMATION AT THE ORIGINS OF
REPLICATION REPLICATION LICENSING: DNA ONLY REPLICATES ONCE PER CELL
CYCLE DUPLEX UNWINDING AT REPLICATION FORKS RNA PRIMING OF LEADING
STRAND AND LAGGING STRAND DNA SYNTHESIS CONTENTS POLYMERASE SWITCHING
ELONGATION OF LEADING STRANDS AND LAGGING STRANDS PROOFREADING
MATURATION OF NASCENT DNA STRANDS TERMINATION HISTONE DEPOSITION FOCUS
BOX 6.2 THE NAMING OF GENES INVOLVED IN DNA REPLICATION DISEASE BOX 6.1
SYSTEMIC LUPUS ERYTHEMATOSUS AND PCNA 6.7 REPLICATION OF ORGANELLE DNA
MODELS FOR MTDNA REPLICATION REPLICATION OF CPDNA DISEASE BOX 6.2 RNASE
MRP AND CARTILAGE-HAIR HYPOPLASIA 6.8 ROLLING CIRCLE REPLICATION 6 9
TELOMERE MAINTENANCE: THE ROLE OF TELOMERASE IN DNA REPLICATION, AGING,
AND CANCER TELOMERES SOLUTION TO THE END REPLICATION PROBLEM MAINTENANCE
OF TELOMERES BY TELOMERASE OTHER MODES OF TELOMERE MAINTENANCE
REGULATION OF TELOMERASE ACTIVITY TELOMERASE, AGING, AND CANCER DISEASE
BOX 6.3 DYSKERATOSIS CONGENITA: LOSS OF TELOMERASE FUNCTION CHAPTER
SUMMARY ANALYTICAL QUESTIONS SUGGESTIONS FOR FURTHER READING 7 DNA
REPAIR AND RECOMBINATION, 152 7.1 INTRODUCTION 7 2 TYPES OF MUTATIONS
AND THEIR PHENOTYPIC CONSEQUENCES TRANSITIONS AND TRANSVERSIONS CAN LEAD
TO SILENT, MISSENSE, OR NONSENSE MUTATIONS INSERTIONS OR DELETIONS CAN
CAUSE FRAMESHIFT MUTATIONS EXPANSION OF TNNUCLEOTIDE REPEATS LEADS TO
GENETIC INSTABILITY 7.3 GENERAL CLASSES OF DNA DAMAGE SINGLE BASE
CHANGES STRUCTURAL DISTORTION DNA BACKBONE DAMAGE CELLULAR RESPONSE TO
DNA DAMAGE 7 4 LESION BYPASS 7 5 DIRECT REVERSAL OF DNA DAMAGE 7.6
REPAIR OF SINGLE BASE CHANGES AND STRUCTURAL DISTORTIONS BY REMOVAL OF
DNA DAMAGE BASE EXCISION REPAIR MISMATCH REPAIR NUCLEOTIDE EXCISION
REPAIR DISEASE BOX 7.1 HEREDITARY NONPOLYPOSIS COLORECTAL CANCER: A
DEFECT IN MISMATCH REPAIR 7 7 DOUBLE-STRAND BREAK REPAIR BY REMOVAL OF
DNA DAMAGE HOMOLOGOUS RECOMBINATION NONHOMOLOGOUS END-JOINING DISEASE
BOX 7.2 XERODERMA PIGMENTOSUM AND RELATED DISORDERS: DEFECTS IN
NUCLEOTIDE EXCISION REPAIR DISEASE BOX 7.3 HEREDITARY BREAST CANCER
SYNDROMES: MUTATIONS IN BRCA1 AND BRCA2 CONTENTS CHAPTER SUMMARY
ANALYTICAL QUESTIONS SUGGESTIONS FOR FURTHER READING 8 RECOMBINANT DNA
TECHNOLOGY AND MOLECULAR CLONING, 180 8 1 INTRODUCTION 8.2 HISTORICAL
PERSPECTIVE INSIGHTS FROM BACTENOPHAGE LAMBDA (A| COHESIVE SITES
INSIGHTS FROM BACTERIAL RESTRICTION AND MODIFICATION SYSTEMS THE FIRST
CLONING EXPERIMENTS 8.3 CUTTING AND JOINING DNA MAJOR CLASSES OF
RESTRICTION ENDONUCLEASES RESTRICTION ENDONUCLEASE NOMENCLATURE
RECOGNITION SEGUENCES FOR TYPE II RESTRICTION ENDONUCLEASES DNA LIGASE
FOCUS BOX 8.1 FEAR OF RECOMBINANT DNA MOLECULES 8.4 MOLECULAR CLONING
VECTOR DNA CHOICE OF VECTOR IS DEPENDENT ON INSERT SIZE AND APPLICATION
PLASMID DNA AS A VECTOR BACTERIOPHAGE LAMBDA (A) AS A VECTOR ARTIFICIAL
CHROMOSOME VECTORS SOURCES OF DNA FOR CLONING FOCUS BOX 8.2 ECORI:
KINKING AND CUTTING DNA TOOL BOX 8.1 LIGUID CHROMATOGRAPHY 8.5
CONSTRUCTING DNA LIBRARIES GENOMIC LIBRARY CDNA LIBRARY 8.6 PROBES
HETEROLOGOUS PROBES HOMOLOGOUS PROBES TOOL BOX 8.2 COMPLEMENTARY DNA
(CDNA) SYNTHESIS TOOL BOX 8.3 POLYMERASE CHAIN REACTION (PCR) TOOL BOX
8.4 RADIOACTIVE AND NONRADIOACTIVE LABELING METHODS TOOL BOX 8.5 NUCLEIC
ACID LABELING 8.7 LIBRARY SCREENING TRANSFER OF COLONIES TO A
DNA-BINDING MEMBRANE COLONY HYBRIDIZATION DETECTION OF POSITIVE COLONIES
8 8 EXPRESSION LIBRARIES 8 9 RESTRICTION MAPPING 8 10 RESTRICTION
FRAGMENT LENGTH POLYMORPHISM (RFLP) RFLPS CAN SERVE AS MARKERS OF
GENETIC DISEASES TOOL BOX 8.6 ELECTROPHORESIS TOOL BOX 8.7 SOUTHERN BLOT
DISEASE BOX 8.1 PCR-RFLP ASSAY FOR MAPLE SYRUP URINE DISEASE 8 11 DNA
SEQUENCING MANUAL DNA SEQUENCING BY THE SANGER DIDEOXY DNA METHOD
AUTOMATED DNA SEQUENCING CONTENTS 11.5 TRANSCRIPTION FACTORS
TRANSCRIPTION FACTORS MEDIATE GENE-SPECIFIC TRANSCNPTIONAL ACTIVATION OR
REPRESSION TRANSCRIPTION FACTORS ARE MODULAR PROTEINS DNA-BINDING DOMAIN
MOTIFS TRANSACTIVATION DOMAIN DIMENZATION DOMAIN FOCUS BOX 11.4
HOMEOBOXES AND HOMEODOMAINS DISEASE BOX 11.2 GREIG CEPHALOPOLYSYNDACTYLY
SYNDROME AND SONIC HEDGEHOG SIGNALING DISEASE BOX 11.3 DEFECTIVE HISTONE
ACETYLTRANSFERASES IN RUBINSTEIN-TAYBI SYNDROME 116 TRANSCRIPTIONAL
COACTIVATORS AND COREPRESSORS CHROMATIN MODIFICATION COMPLEXES LINKER
HISTONE VARIANTS CHROMATIN REMODELING COMPLEXES FOCUS BOX 11.5 IS THERE
A HISTONE CODE? 11.7 TRANSCRIPTION COMPLEX ASSEMBLY: THE ENHANCEOSOME
MODEL VERSUS THE HIT AND RUN MODEL ORDER OF RECRUITMENT OF VARIOUS
PROTEINS THAT REGULATE TRANSCRIPTION ENHANCEOSOME MODEL HIT AND RUN
MODEL MERGING OF MODELS 11.8 MECHANISM OF RNA POLYMERASE II
TRANSCRIPTION PROMOTER CLEARANCE ELONGATION: POLYMERIZATION OF RNA
PROOFREADING AND BACKTRACKING TRANSCRIPTION ELONGATION THROUGH THE
NUCLEOSOMAL BARRIER DISEASE BOX 11.4 DEFECTS IN ELONGATOR AND FAMILIAL
DYSAUTONOMIA 11.9 NUCLEAR IMPORT AND EXPORT OF PROTEINS KARYOPHERMS
NUCLEAR LOCALIZATION SEQUENCES (NLSS) NUCLEAR EXPORT SEQUENCES (NESS)
NUCLEAR IMPORT PATHWAY NUCLEAR EXPORT PATHWAY FOCUS BOX 11.6 THE NUCLEAR
PORE COMPLEX FOCUS BOX 11.7 CHARACTERIZATION OF THE FIRST NUCLEAR
LOCALIZATION SEQUENCE 1110 REGULATED NUCLEAR IMPORT AND SIGNAL
TRANSDUCTION PATHWAYS REGULATED NUCLEAR IMPORT OF NF-KB REGULATED
NUCLEAR IMPORT OF THE GLUCOCORTICOID RECEPTOR CHAPTER SUMMARY ANALYTICAL
QUESTIONS SUGGESTIONS FOR FURTHER READING 12 EPIGENETICS AND MONOALLELIC
GENE EXPRESSION, 392 12.1 INTRODUCTION 12 2 EPIGENETIC MARKERS CYTOSINE
DNA METHYLATION MARKS GENES FOR SILENCING STABLE MAINTENANCE OF HISTONE
MODIFICATIONS DISEASE BOX 12.1 CANCER AND EPIGENETICS 12 3 GENOMIC
IMPRINTING ESTABLISHING AND MAINTAINING THE IMPRINT MECHANISMS OF
MONOALLELIC EXPRESSION GENOMIC IMPRINTING IS ESSENTIAL FOR NORMAL
DEVELOPMENT CONTENTS ORIGINS OF GENOMIC IMPRINTING DISEASE BOX 12.2
FRAGILE X MENTAL RETARDATION AND ABERRANT DNA METHYLATION DISEASE BOX
12.3 GENOMIC IMPRINTING AND NEURODEVELOPMENTAL DISORDERS 12.4 X
CHROMOSOME INACTIVATION RANDOM X CHROMOSOME INACTIVATION IN MAMMALS
MOLECULAR MECHANISMS FOR STABLE MAINTENANCE OF X CHROMOSOME INACTIVATION
IS THERE MONOALLELIC EXPRESSION OF ALL X-LINKED GENES 7 12.5 PHENOTYPIC
CONSEQUENCES OF TRANSPOSABLE ELEMENTS HISTORICAL PERSPECTIVE: BARBARA
MCCLINTOCK S DISCOVERY OF MOBILE GENETIC ELEMENTS IN MAIZE DNA
TRANSPOSONS HAVE A WIDE HOST RANGE DNA TRANSPOSONS MOVE BY A CUT AND
PASTE MECHANISM RETROTRANSPOSONS MOVE BY A COPY AND PASTE MECHANISM
SOME LTR RETROTRANSPOSONS ARE ACTIVE IN THE MAMMALIAN GENOME NON-LTR
RETROTRANSPOSONS INCLUDE LINES AND SINES TOOL BOX 12.1 TRANSPOSON
TAGGING DISEASE BOX 12.4 JUMPING GENES AND HUMAN DISEASE 12.6 EPIGENETIC
CONTROL OF TRANSPOSABLE ELEMENTS METHYLATION OF TRANSPOSABLE ELEMENTS
HETEROCHROMATIN FORMATION MEDIATED BY RNAI AND RNA-DIRECTED DNA
METHYLATION 12.7 ALLELIC EXCLUSION YEAST MATING-TYPE SWITCHING AND
SILENCING ANTIGEN SWITCHING IN TRYPANOSOMES V(D)J RECOMBINATION AND THE
ADAPTIVE IMMUNE RESPONSE DISEASE BOX 12.5 TRYPANOSOMIASIS: HUMAN
SLEEPING SICKNESS FOCUS BOX 12.1 DID THE V[D)J SYSTEM EVOLVE FROM A
TRANSPOSON ? CHAPTER SUMMARY ANALYTICAL QUESTIONS SUGGESTIONS FOR
FURTHER READING 13 RNA PROCESSING AND POST-TRANSCRIPTIONAL GENE
REGULATION, 452 13.1 INTRODUCTION 13 2 RNA SPLICING: HISTORICAL
PERSPECTIVE AND OVERVIEW 13 3 GROUP I AND GROUP II SELF-SPLICING INTRONS
GROUP I INTRONS REQUIRE AN EXTERNAL G COFACTOR FOR SPLICING GROUP II
INTRONS REQUIRE AN INTERNAL BULGED A FOR SPLICING MOBILE GROUP I AND II
INTRONS FOCUS BOX 13.1 INTRON-ENCODED SMALL NUCLEOLAR RNA AND
INSIDE-OUT GENES 13 4 ARCHAEL AND NUCLEAR TRANSFER RNA INTRONS ARCHAET
INTRONS ARE SPLICED BY AN ENDONBONUCLEASE SOME NUCLEAR TRNA GENES
CONTAIN AN MTRON 13 5 COTRANSCRIPTIONAL PROCESSING OF NUCLEAR PRE-MRNA
ADDITION OF THE 5 -7-METHYLGUANOSINE CAP TERMINATION AND POLYADENYLATION
SPLICING DISEASE BOX 13.1 OCULOPHARYNGEAL MUSCULAR DYSTROPHY
TNNUCLEOTIDE REPEAT EXPANSION M A POLY(A]-BINDING PROTEIN GENE DISEASE
BOX 13.2 SPINAL MUSCULAR ATROPHY: DEFECTS IN SNRNP BIOGENESIS DISEASE
BOX 13.3 PRP8 GENE MUTATIONS CAUSE RETIMTIS PIGMENTOSA 13.6 ALTERNATIVE
SPLICING EFFECTS OF ALTERNATIVE SPLICING ON GENE EXPRESSION CONTENTS
REGULATION OF ALTERNATIVE SPLICING FOCUS BOX 13.2 THE DSCAM GENE:
EXTREME ALTERNATIVE SPLICING 13 7 TRANS-SPLICING DISCONTINUOUS GROUP II
FRANS-SPLICING SPLICED LEADER FRANS-SPLICING TRNA FRANS-SPLICING FOCUS
BOX 13.3 APOPTOSIS 13 8 RNA EDITING RNA EDITING IN TRYPANOSOMES RNA
EDITING IN MAMMALS DISEASE BOX 13.4 AMYOTROPHIC LATERAL SCLEROSIS: A
DEFECT IN RNA EDITING? 13 9 BASE MODIFICATION GUIDED BY SMALL NUCLEOLAR
RNA MOLECULES 13 10 POST-TRANSCRIPTIONAL GENE REGULATION BY MICRORNA
HISTORICAL PERSPECTIVE: THE DISCOVERY OF MIRNA IN CAENORHABDITIS ETEGANS
PROCESSING OF MIRNAS MIRNAS TARGET MRNA FOR DEGRADATION AND
TRANSLATIONAL INHIBITION 13 11 RNA TURNOVER IN THE NUCLEUS AND CYTOPLASM
NUCLEAR EXOSOMES AND QUALITY CONTROL QUALITY CONTROL AND THE FORMATION
OF NUCLEAR EXPORT-COMPETENT RNPS CYTOPLASMIC RNA TURNOVER CHAPTER
SUMMARY ANALYTICAL QUESTIONS SUGGESTIONS FOR FURTHER READING 14 THE
MECHANISM OF TRANSLATION, 512 14.1 INTRODUCTION 14.2 RIBOSOME STRUCTURE
AND ASSEMBLY STRUCTURE OF RIBOSOMES THE NUCLEOLUS RIBOSOME BIOGENESIS
FOCUS BOX 14.1 WHAT IS S ? 14 3 AMINOACYL-TRNA SYNTHETASES
AMINOACYL-TRNA CHARGING PROOFREADING ACTIVITY OF AMINOACYL-TRNA
SYNTHETASES 14 4 INITIATION OF TRANSLATION TERNARY COMPLEX FORMATION AND
LOADING ONTO THE 40S RIBOSOMAL SUBUNIT LOADING THE MRNA ON THE 40S
RIBOSOMAL SUBUNIT SCANNING AND AUG RECOGNITION JOINING OF THE 40S AND
60S RIBOSOMAL SUBUNITS TOOL BOX 14.1 TRANSLATION TOEPRINTING ASSAYS
DISEASE BOX 14.1 EUKARYOTIC INITIATION FACTOR 2B AND VANISHING WHITE
MATTER 14 5 ELONGATION DECODING PEPTIDE BOND FORMATION AND TRANSLOCATION
PEPTIDYL TRANSFERASE ACTIVITY EVENTS IN THE RIBOSOME TUNNEL 14 6
TERMINATION 14 7 TRANSLATIONAL AND POST-TRANSLATIONAL CONTROL
PHOSPHORYLATION OF ELF2A BLOCKS TERNARY COMPLEX FORMATION ELF2A
PHOSPHORYLATION IS MEDIATED BY FOUR DISTINCT PROTEIN KINASES CONTENTS
CHAPTER SUMMARY ANALYTICAL QUESTIONS SUGGESTIONS FOR FURTHER READING 15
GENETICALLY MODIFIED ORGANISMS: USE IN BASIC AND APPLIED RESEARCH, 545
15 1 INTRODUCTION 15.2 TRANSGENIC MICE HOW TO MAKE A TRANSGENIC MOUSE
INDUCIBLE TRANSGENIC MICE FOCUS BOX 15.1 ONCOMOUSE PATENT 15.3
GENE-TARGETED MOUSE MODELS KNOCKOUT MICE KNOCKIN MICE KNOCKDOWN MICE
CONDITIONAL KNOCKOUT AND KNOCKIN MICE FOCUS BOX 15.2 A MOUSE FOR EVERY
NEED 15.4 OTHER APPLICATIONS OF TRANSGENIC ANIMAL TECHNOLOGY TRANSGENIC
PRIMATES TRANSGENIC LIVESTOCK GENE PHARMING FOCUS BOX 15.3 TRANSGENIC
ARTWORK: THE GFP BUNNY 15.5 CLONING BY NUCLEAR TRANSFER GENETIC
EQUIVALENCE OF SOMATIC CELL NUCLEI: FROG CLONING EXPERIMENTS CLONING OF
MAMMALS BY NUCLEAR TRANSFER BREAKTHROUGH OF THE YEAR : THE CLONING OF
DOLLY METHOD FOR CLONING BY NUCLEAR TRANSFER SOURCE OF MTDNA IN CLONES
WHY IS CLONING BY NUCLEAR TRANSFER INEFFICIENT 7 APPLICATIONS OF CLONING
BY NUCLEAR TRANSFER FOCUS BOX 15.4 GENETICALLY MANIPULATED PETS 15 6
TRANSGENIC PLANTS T-DNA-MEDIATED GENE DELIVERY ELECTROPORATION AND
MICROBALLISTICS FOCUS BOX 15.5 GENETICALLY MODIFIED CROPS: ARE YOU
EATING GENETICALLY ENGINEERED TOMATOES CHAPTER SUMMARY ANALYTICAL
QUESTIONS SUGGESTIONS FOR FURTHER READING H GENOME ANALYSIS: DNA TYPING,
GENOMICS, AND BEYOND, 581 16.1 INTRODUCTION 16 2 DNA TYPING DNA
POLYMORPHISMS: THE BASIS OF DNA TYPING MINISATELLITE ANALYSIS POLYMERASE
CHAIN REACTION-BASED ANALYSIS SHORT TANDEM REPEAT ANALYSIS MITOCHONDRIAL
DNA ANALYSIS Y CHROMOSOME ANALYSIS RANDOMLY AMPLIFIED POLYMORPHIC DNA
FRAPD! ANALYSIS FOCUS BOX 16.1 DNA PROFILES OF MARIJUANA FOCUS BOX 16.2
NONHUMAN DNA TYPING CONTENTS 16 3 GENOMICS AND BEYOND WHAT IS
BIOMFORMATICS 7 GENOMICS PROTEOMICS THE AGE OF OMICS 16 4 THE HUMAN
GENOME PROJECT CLONE BY CLONE GENOME ASSEMBLY APPROACH WHOLE-GENOME
SHOTGUN APPROACH ROUGH DRAFTS VERSUS FINISHED SEQUENCES 16 5 OTHER
SEQUENCED GENOMES WHAT IS A GENE AND HOW MANY ARE THERE IN THE HUMAN
GENOME? FOCUS BOX 16.3 COMPARATIVE ANALYSIS OF GENOMES: INSIGHTS FROM
PUFFERFISH AND CHICKENS 16 6 HIGH-THROUGHPUT ANALYSIS OF GENE FUNCTION
DNA MICROARRAYS PROTEIN ARRAYS MASS SPECTROMETRY 16 7 SINGLE NUCLEOTIDE
POLYMORPHISMS FOCUS BOX 16.4 THE NUCLEOLAR PROTEOME DISEASE BOX 16.1
MAPPING DISEASE-ASSOCIATED SNPS: ALZHEIMER S DISEASE CHAPTER SUMMARY
ANALYTICAL QUESTIONS SUGGESTIONS FOR FURTHER READING 17 MEDICAL
MOLECULAR BIOLOGY, 618 17 1 INTRODUCTION 17 2 MOLECULAR BIOLOGY OF
CANCER ACTIVATION OF ONCOGENES INACTIVATION OF TUMOR SUPPRESSOR GENES
INAPPROPRIATE EXPRESSION OF MICRORNAS IN CANCER CHROMOSOMAL
REARRANGEMENTS AND CANCER VIRUSES AND CANCER CHEMICAL CARCINOGENESIS
FOCUS BOX 17.1 HOW CANCER CELLS METASTASIZE: THE ROLE OF SRC DISEASE BOX
17.1 KNUDSON S TWO-HIT HYPOTHESIS AND RETINOBLASTOMA DISEASE BOX 17.2
CANCER GENE THERAPY: A MAGIC BULLET 9 FOCUS BOX 17.2 THE DISCOVERY OF
P53 DISEASE BOX 17.3 HUMAN PAPILLOMA VIRUS (HPV] AND CERVICAL CANCER 17
3 GENE THERAPY VECTORS FOR SOMATIC CELL GENE THERAPY ENHANCEMENT GENETIC
ENGINEERING GENE THERAPY FOR INHERITED IMMUNODEFICIENCY SYNDROMES CYSTIC
FIBROSIS GENE THERAPY HIV-1 GENE THERAPY FOCUS BOX 17.3
RETROVIRAL-MEDIATED GENE TRANSFER: HOW TO MAKE A SAFE VECTOR FOCUS BOX
17.4 THE FIRST GENE THERAPY FATALITY FOCUS BOX 17.5 HIV-1 LIFE CYCLE 17
4 GENES AND HUMAN BEHAVIOR AGGRESSIVE, IMPULSIVE, AND VIOLENT BEHAVIOR
SCHIZOPHRENIA SUSCEPTIBILITY LOCI CONTENTS CHAPTER SUMMARY ANALYTICAL
QUESTIONS SUGGESTIONS FOR FURTHER READING GLOSSARY, 668 INDEX, 711
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FUNDAMENTAL MOLECULAR BIOLOGY LIZABETH A. ALLISON DEPARTMENT OF BIOLOGY
COLLEGE OF WILLIAM AND MARY WILLIAMSBURG VA 23185, USA BLACKWELL
PUBLISHING CONTENTS PREFACE, XVIII 1 THE BEGINNINGS OF MOLECULAR
BIOLOGY, 1 1.1 INTRODUCTION 1 2 HISTORICAL PERSPECTIVE INSIGHTS INTO
HEREDITY FROM ROUND AND WRINKLED PEAS: MENDELIAN GENETICS INSIGHTS INTO
THE NATURE OF HEREDITARY MATERIAL: THE TRANSFORMING PRINCIPLE IS DNA
CREATIVITY IN APPROACH LEADS TO THE ONE GENE-ONE ENZYME HYPOTHESIS THE
IMPORTANCE OF TECHNOLOGICAL ADVANCES: THE HERSHEY-CHASE EXPERIMENT A
MODEL FOR THE STRUCTURE OF DNA: THE DNA DOUBLE HELIX CHAPTER SUMMARY
ANALYTICAL QUESTIONS SUGGESTIONS FOR FURTHER READING 2 THE STRUCTURE OF
DNA, 13 2.1 INTRODUCTION 2 2 PRIMARY STRUCTURE: THE COMPONENTS OF
NUCLEIC ACIDS FIVE-CARBON SUGARS NITROGENOUS BASES THE PHOSPHATE
FUNCTIONAL GROUP NUCLEOSIDES AND NUCLEOTIDES 2.3 SIGNIFICANCE OF 5' AND
3' 7A NOMENCLATURE OF NUCLEOTIDES 2 5 THE LENGTH OF RNA AND DNA 2.6
SECONDARY STRUCTURE OF DNA HYDROGEN BONDS FORM BETWEEN THE BASES BASE
STACKING PROVIDES CHEMICAL STABILITY TO THE DNA DOUBLE HELIX STRUCTURE
OF THE WATSON-CRICK DNA DOUBLE HELIX DISTINGUISHING BETWEEN FEATURES OF
ALTERNATIVE DOUBLE-HELICAL STRUCTURES DNA CAN UNDERGO REVERSIBLE STRAND
SEPARATION 2 7 UNUSUAL DNA SECONDARY STRUCTURES SLIPPED STRUCTURES
CRUCIFORM STRUCTURES TRIPLE HELIX DNA DISEASE BOX 2.1 FRIEDREICH'S
ATAXIA AND TRIPLE HELIX DNA 2 8 TERTIARY STRUCTURE OF DNA SUPERCOILING
OF DNA TOPOISOMERASES RELAX SUPERCOILED DNA WHAT IS THE SIGNIFICANCE OF
SUPERCOILING IN VIVO? DISEASE BOX 2.2 TOPOISOMERASE-TARGETED ANTICANCER
DRUGS CHAPTER SUMMARY ANALYTICAL QUESTIONS SUGGESTIONS FOR FURTHER
READING 3 GENOME ORGANIZATION: FROM NUCLEOTIDES TO CHROMATIN, 37 3.1
INTRODUCTION 3.2 EUKARYOTIC GENOME CONTENTS CHROMATIN STRUCTURE:
HISTORICAL PERSPECTIVE HISTONES NUCLEOSOMES BEADS-ON-A-STRING: THE 10 NM
FIBER THE 30 NM FIBER LOOP DOMAINS METAPHASE CHROMOSOMES ALTERNATIVE
CHROMATIN STRUCTURES 3.3 BACTERIAL GENOME 3.4 PLASMIDS 3.5
BACTERIOPHAGES AND MAMMALIAN DNA VIRUSES BACTERIOPHAGES MAMMALIAN DNA
VIRUSES 3.6 ORGANELLE GENOMES: CHLOROPLASTS AND MITOCHONDRIA CHLOROPLAST
DNA [CPDNA] MITOCHONDRIAL DNA (MTDNAL DISEASE BOX 3.1 MITOCHONDRIAL DNA
AND DISEASE 3.7 RNA-BASED GENOMES EUKARYOTIC RNA VIRUSES RETROVIRUSES
VIROIDS OTHER SUBVIRAL PATHOGENS DISEASE BOX 3.2 AVIAN FLU CHAPTER
SUMMARY ANALYTICAL QUESTIONS SUGGESTIONS FOR FURTHER READING 4 THE
VERSATILITY OF RNA, 54 4.1 INTRODUCTION 4.2 SECONDARY STRUCTURE OF RNA
SECONDARY STRUCTURE MOTIFS IN RNA BASE-PAIRED RNA ADOPTS AN A-TYPE
DOUBLE HELIX RNA HELICES OFTEN CONTAIN NONCANONICAL BASE PAIRS 4.3
TERTIARY STRUCTURE OF RNA TRNA STRUCTURE: IMPORTANT INSIGHTS INTO RNA
STRUCTURAL MOTIFS COMMON TERTIARY STRUCTURE MOTIFS IN RNA 4 4 KINETICS
OF RNA FOLDING 4.5 RNA IS INVOLVED IN A WIDE RANGE OF CELLULAR PROCESSES
4 6 HISTORICAL PERSPECTIVE: THE DISCOVERY OF RNA CATALYSIS TETRAHYMENA
GROUP I INTRON NBOZYME RNASE P RIBOZYME FOCUS BOX 4.1: THE RNA WORLD 4.7
RIBOZYMES CATALYZE A VARIETY OF CHEMICAL REACTIONS MODE OF NBOZYME
ACTION LARGE RIBOZYMES SMALL RIBOZYMES CHAPTER SUMMARY ANALYTICAL
QUESTIONS SUGGESTIONS FOR FURTHER READING CONTENTS 5 FROM GENE TO
PROTEIN, 79 5.1 INTRODUCTIO N 5 2 THE CENTRAL DOGMA 5 3 THE GENETIC CODE
TRANSLATING THE GENETIC CODE THE 21ST AND 22ND GENETICALLY ENCODED AMINO
ACIDS ROLE OF MODIFIED NUCLEOTIDES IN DECODING IMPLICATIONS OF CODON
BIAS FOR MOLECULAR BIOLOGISTS 5 4 PROTEIN STRUCTURE PRIMARY STRUCTURE
SECONDARY STRUCTURE TERTIARY STRUCTURE QUATERNARY STRUCTURE SIZE AND
COMPLEXITY OF PROTEINS PROTEINS CONTAIN MULTIPLE FUNCTIONAL DOMAINS
PREDICTION OF PROTEIN STRUCTURE 5.5 PROTEIN FUNCTION ENZYMES ARE
BIOLOGICAL CATALYSTS REGULATION OF PROTEIN ACTIVITY BY
POST-TRANSLATIONAL MODIFICATIONS ALLOSTERIC REGULATION OF PROTEIN
ACTIVITY CYCLIN-DEPENDENT KINASE ACTIVATION MACROMOLECULAR ASSEMBLAGES
5.6 PROTEIN FOLDING AND MISFOLDING MOLECULAR CHAPERONES
UBIQUITIN-MEDIATED PROTEIN DEGRADATION PROTEIN MISFOLDING DISEASES
DISEASE BOX 5.1 PRIONS CHAPTER SUMMARY ANALYTICAL QUESTIONS SUGGESTIONS
FOR FURTHER READING 6 DNA REPLICATION AND TELOMERE MAINTENANCE, 108 6.1
INTRODUCTION 6 2 HISTORICAL PERSPECTIVE INSIGHT INTO THE MODE OF DNA
REPLICATION: THE MESELSON-STAHL EXPERIMENT INSIGHT INTO THE MODE OF DNA
REPLICATION: VISUALIZATION OF REPLICATING BACTERIAL DNA 6 3 DNA
SYNTHESIS OCCURS FROM 5' -» 3' 6 4 DNA POLYMERASES ARE THE ENZYMES THAT
CATALYZE DNA SYNTHESIS FOCUS BOX 6.1 BACTERIAL DNA POLYMERASES 6 5
SEMIDISCONTINUOUS DNA REPLICATION LEADING STRAND SYNTHESIS IS CONTINUOUS
LAGGING STRAND SYNTHESIS IS DISCONTINUOUS 6 6 NUCLEAR DNA REPLICATION IN
EUKARYOTIC CELLS REPLICATION FACTORIES HISTONE REMOVAL AT THE ORIGINS OF
REPLICATION PREREPLICATION COMPLEX FORMATION AT THE ORIGINS OF
REPLICATION REPLICATION LICENSING: DNA ONLY REPLICATES ONCE PER CELL
CYCLE DUPLEX UNWINDING AT REPLICATION FORKS RNA PRIMING OF LEADING
STRAND AND LAGGING STRAND DNA SYNTHESIS CONTENTS POLYMERASE SWITCHING
ELONGATION OF LEADING STRANDS AND LAGGING STRANDS PROOFREADING
MATURATION OF NASCENT DNA STRANDS TERMINATION HISTONE DEPOSITION FOCUS
BOX 6.2 THE NAMING OF GENES INVOLVED IN DNA REPLICATION DISEASE BOX 6.1
SYSTEMIC LUPUS ERYTHEMATOSUS AND PCNA 6.7 REPLICATION OF ORGANELLE DNA
MODELS FOR MTDNA REPLICATION REPLICATION OF CPDNA DISEASE BOX 6.2 RNASE
MRP AND CARTILAGE-HAIR HYPOPLASIA 6.8 ROLLING CIRCLE REPLICATION 6 9
TELOMERE MAINTENANCE: THE ROLE OF TELOMERASE IN DNA REPLICATION, AGING,
AND CANCER TELOMERES SOLUTION TO THE END REPLICATION PROBLEM MAINTENANCE
OF TELOMERES BY TELOMERASE OTHER MODES OF TELOMERE MAINTENANCE
REGULATION OF TELOMERASE ACTIVITY TELOMERASE, AGING, AND CANCER DISEASE
BOX 6.3 DYSKERATOSIS CONGENITA: LOSS OF TELOMERASE FUNCTION CHAPTER
SUMMARY ANALYTICAL QUESTIONS SUGGESTIONS FOR FURTHER READING 7 DNA
REPAIR AND RECOMBINATION, 152 7.1 INTRODUCTION 7 2 TYPES OF MUTATIONS
AND THEIR PHENOTYPIC CONSEQUENCES TRANSITIONS AND TRANSVERSIONS CAN LEAD
TO SILENT, MISSENSE, OR NONSENSE MUTATIONS INSERTIONS OR DELETIONS CAN
CAUSE FRAMESHIFT MUTATIONS EXPANSION OF TNNUCLEOTIDE REPEATS LEADS TO
GENETIC INSTABILITY 7.3 GENERAL CLASSES OF DNA DAMAGE SINGLE BASE
CHANGES STRUCTURAL DISTORTION DNA BACKBONE DAMAGE CELLULAR RESPONSE TO
DNA DAMAGE 7 4 LESION BYPASS 7 5 DIRECT REVERSAL OF DNA DAMAGE 7.6
REPAIR OF SINGLE BASE CHANGES AND STRUCTURAL DISTORTIONS BY REMOVAL OF
DNA DAMAGE BASE EXCISION REPAIR MISMATCH REPAIR NUCLEOTIDE EXCISION
REPAIR DISEASE BOX 7.1 HEREDITARY NONPOLYPOSIS COLORECTAL CANCER: A
DEFECT IN MISMATCH REPAIR 7 7 DOUBLE-STRAND BREAK REPAIR BY REMOVAL OF
DNA DAMAGE HOMOLOGOUS RECOMBINATION NONHOMOLOGOUS END-JOINING DISEASE
BOX 7.2 XERODERMA PIGMENTOSUM AND RELATED DISORDERS: DEFECTS IN
NUCLEOTIDE EXCISION REPAIR DISEASE BOX 7.3 HEREDITARY BREAST CANCER
SYNDROMES: MUTATIONS IN BRCA1 AND BRCA2 CONTENTS CHAPTER SUMMARY
ANALYTICAL QUESTIONS SUGGESTIONS FOR FURTHER READING 8 RECOMBINANT DNA
TECHNOLOGY AND MOLECULAR CLONING, 180 8 1 INTRODUCTION 8.2 HISTORICAL
PERSPECTIVE INSIGHTS FROM BACTENOPHAGE LAMBDA (A| COHESIVE SITES
INSIGHTS FROM BACTERIAL RESTRICTION AND MODIFICATION SYSTEMS THE FIRST
CLONING EXPERIMENTS 8.3 CUTTING AND JOINING DNA MAJOR CLASSES OF
RESTRICTION ENDONUCLEASES RESTRICTION ENDONUCLEASE NOMENCLATURE
RECOGNITION SEGUENCES FOR TYPE II RESTRICTION ENDONUCLEASES DNA LIGASE
FOCUS BOX 8.1 FEAR OF RECOMBINANT DNA MOLECULES 8.4 MOLECULAR CLONING
VECTOR DNA CHOICE OF VECTOR IS DEPENDENT ON INSERT SIZE AND APPLICATION
PLASMID DNA AS A VECTOR BACTERIOPHAGE LAMBDA (A) AS A VECTOR ARTIFICIAL
CHROMOSOME VECTORS SOURCES OF DNA FOR CLONING FOCUS BOX 8.2 ECORI:
KINKING AND CUTTING DNA TOOL BOX 8.1 LIGUID CHROMATOGRAPHY 8.5
CONSTRUCTING DNA LIBRARIES GENOMIC LIBRARY CDNA LIBRARY 8.6 PROBES
HETEROLOGOUS PROBES HOMOLOGOUS PROBES TOOL BOX 8.2 COMPLEMENTARY DNA
(CDNA) SYNTHESIS TOOL BOX 8.3 POLYMERASE CHAIN REACTION (PCR) TOOL BOX
8.4 RADIOACTIVE AND NONRADIOACTIVE LABELING METHODS TOOL BOX 8.5 NUCLEIC
ACID LABELING 8.7 LIBRARY SCREENING TRANSFER OF COLONIES TO A
DNA-BINDING MEMBRANE COLONY HYBRIDIZATION DETECTION OF POSITIVE COLONIES
8 8 EXPRESSION LIBRARIES 8 9 RESTRICTION MAPPING 8 10 RESTRICTION
FRAGMENT LENGTH POLYMORPHISM (RFLP) RFLPS CAN SERVE AS MARKERS OF
GENETIC DISEASES TOOL BOX 8.6 ELECTROPHORESIS TOOL BOX 8.7 SOUTHERN BLOT
DISEASE BOX 8.1 PCR-RFLP ASSAY FOR MAPLE SYRUP URINE DISEASE 8 11 DNA
SEQUENCING MANUAL DNA SEQUENCING BY THE SANGER "DIDEOXY" DNA METHOD
AUTOMATED DNA SEQUENCING CONTENTS 11.5 TRANSCRIPTION FACTORS
TRANSCRIPTION FACTORS MEDIATE GENE-SPECIFIC TRANSCNPTIONAL ACTIVATION OR
REPRESSION TRANSCRIPTION FACTORS ARE MODULAR PROTEINS DNA-BINDING DOMAIN
MOTIFS TRANSACTIVATION DOMAIN DIMENZATION DOMAIN FOCUS BOX 11.4
HOMEOBOXES AND HOMEODOMAINS DISEASE BOX 11.2 GREIG CEPHALOPOLYSYNDACTYLY
SYNDROME AND SONIC HEDGEHOG SIGNALING DISEASE BOX 11.3 DEFECTIVE HISTONE
ACETYLTRANSFERASES IN RUBINSTEIN-TAYBI SYNDROME 116 TRANSCRIPTIONAL
COACTIVATORS AND COREPRESSORS CHROMATIN MODIFICATION COMPLEXES LINKER
HISTONE VARIANTS CHROMATIN REMODELING COMPLEXES FOCUS BOX 11.5 IS THERE
A HISTONE CODE? 11.7 TRANSCRIPTION COMPLEX ASSEMBLY: THE ENHANCEOSOME
MODEL VERSUS THE "HIT AND RUN" MODEL ORDER OF RECRUITMENT OF VARIOUS
PROTEINS THAT REGULATE TRANSCRIPTION ENHANCEOSOME MODEL HIT AND RUN
MODEL MERGING OF MODELS 11.8 MECHANISM OF RNA POLYMERASE II
TRANSCRIPTION PROMOTER CLEARANCE ELONGATION: POLYMERIZATION OF RNA
PROOFREADING AND BACKTRACKING TRANSCRIPTION ELONGATION THROUGH THE
NUCLEOSOMAL BARRIER DISEASE BOX 11.4 DEFECTS IN ELONGATOR AND FAMILIAL
DYSAUTONOMIA 11.9 NUCLEAR IMPORT AND EXPORT OF PROTEINS KARYOPHERMS
NUCLEAR LOCALIZATION SEQUENCES (NLSS) NUCLEAR EXPORT SEQUENCES (NESS)
NUCLEAR IMPORT PATHWAY NUCLEAR EXPORT PATHWAY FOCUS BOX 11.6 THE NUCLEAR
PORE COMPLEX FOCUS BOX 11.7 CHARACTERIZATION OF THE FIRST NUCLEAR
LOCALIZATION SEQUENCE 1110 REGULATED NUCLEAR IMPORT AND SIGNAL
TRANSDUCTION PATHWAYS REGULATED NUCLEAR IMPORT OF NF-KB REGULATED
NUCLEAR IMPORT OF THE GLUCOCORTICOID RECEPTOR CHAPTER SUMMARY ANALYTICAL
QUESTIONS SUGGESTIONS FOR FURTHER READING 12 EPIGENETICS AND MONOALLELIC
GENE EXPRESSION, 392 12.1 INTRODUCTION 12 2 EPIGENETIC MARKERS CYTOSINE
DNA METHYLATION MARKS GENES FOR SILENCING STABLE MAINTENANCE OF HISTONE
MODIFICATIONS DISEASE BOX 12.1 CANCER AND EPIGENETICS 12 3 GENOMIC
IMPRINTING ESTABLISHING AND MAINTAINING THE IMPRINT MECHANISMS OF
MONOALLELIC EXPRESSION GENOMIC IMPRINTING IS ESSENTIAL FOR NORMAL
DEVELOPMENT CONTENTS ORIGINS OF GENOMIC IMPRINTING DISEASE BOX 12.2
FRAGILE X MENTAL RETARDATION AND ABERRANT DNA METHYLATION DISEASE BOX
12.3 GENOMIC IMPRINTING AND NEURODEVELOPMENTAL DISORDERS 12.4 X
CHROMOSOME INACTIVATION RANDOM X CHROMOSOME INACTIVATION IN MAMMALS
MOLECULAR MECHANISMS FOR STABLE MAINTENANCE OF X CHROMOSOME INACTIVATION
IS THERE MONOALLELIC EXPRESSION OF ALL X-LINKED GENES 7 12.5 PHENOTYPIC
CONSEQUENCES OF TRANSPOSABLE ELEMENTS HISTORICAL PERSPECTIVE: BARBARA
MCCLINTOCK'S DISCOVERY OF MOBILE GENETIC ELEMENTS IN MAIZE DNA
TRANSPOSONS HAVE A WIDE HOST RANGE DNA TRANSPOSONS MOVE BY A "CUT AND
PASTE" MECHANISM RETROTRANSPOSONS MOVE BY A "COPY AND PASTE" MECHANISM
SOME LTR RETROTRANSPOSONS ARE ACTIVE IN THE MAMMALIAN GENOME NON-LTR
RETROTRANSPOSONS INCLUDE LINES AND SINES TOOL BOX 12.1 TRANSPOSON
TAGGING DISEASE BOX 12.4 JUMPING GENES AND HUMAN DISEASE 12.6 EPIGENETIC
CONTROL OF TRANSPOSABLE ELEMENTS METHYLATION OF TRANSPOSABLE ELEMENTS
HETEROCHROMATIN FORMATION MEDIATED BY RNAI AND RNA-DIRECTED DNA
METHYLATION 12.7 ALLELIC EXCLUSION YEAST MATING-TYPE SWITCHING AND
SILENCING ANTIGEN SWITCHING IN TRYPANOSOMES V(D)J RECOMBINATION AND THE
ADAPTIVE IMMUNE RESPONSE DISEASE BOX 12.5 TRYPANOSOMIASIS: HUMAN
"SLEEPING SICKNESS" FOCUS BOX 12.1 DID THE V[D)J SYSTEM EVOLVE FROM A
TRANSPOSON"? CHAPTER SUMMARY ANALYTICAL QUESTIONS SUGGESTIONS FOR
FURTHER READING 13 RNA PROCESSING AND POST-TRANSCRIPTIONAL GENE
REGULATION, 452 13.1 INTRODUCTION 13 2 RNA SPLICING: HISTORICAL
PERSPECTIVE AND OVERVIEW 13 3 GROUP I AND GROUP II SELF-SPLICING INTRONS
GROUP I INTRONS REQUIRE AN EXTERNAL G COFACTOR FOR SPLICING GROUP II
INTRONS REQUIRE AN INTERNAL BULGED A FOR SPLICING MOBILE GROUP I AND II
INTRONS FOCUS BOX 13.1 INTRON-ENCODED SMALL NUCLEOLAR RNA AND
"INSIDE-OUT" GENES 13 4 ARCHAEL AND NUCLEAR TRANSFER RNA INTRONS ARCHAET
INTRONS ARE SPLICED BY AN ENDONBONUCLEASE SOME NUCLEAR TRNA GENES
CONTAIN AN MTRON 13 5 COTRANSCRIPTIONAL PROCESSING OF NUCLEAR PRE-MRNA
ADDITION OF THE 5'-7-METHYLGUANOSINE CAP TERMINATION AND POLYADENYLATION
SPLICING DISEASE BOX 13.1 OCULOPHARYNGEAL MUSCULAR DYSTROPHY
TNNUCLEOTIDE REPEAT EXPANSION M A POLY(A]-BINDING PROTEIN GENE DISEASE
BOX 13.2 SPINAL MUSCULAR ATROPHY: DEFECTS IN SNRNP BIOGENESIS DISEASE
BOX 13.3 PRP8 GENE MUTATIONS CAUSE RETIMTIS PIGMENTOSA 13.6 ALTERNATIVE
SPLICING EFFECTS OF ALTERNATIVE SPLICING ON GENE EXPRESSION CONTENTS
REGULATION OF ALTERNATIVE SPLICING FOCUS BOX 13.2 THE DSCAM GENE:
EXTREME ALTERNATIVE SPLICING 13 7 TRANS-SPLICING DISCONTINUOUS GROUP II
FRANS-SPLICING SPLICED LEADER FRANS-SPLICING TRNA FRANS-SPLICING FOCUS
BOX 13.3 APOPTOSIS 13 8 RNA EDITING RNA EDITING IN TRYPANOSOMES RNA
EDITING IN MAMMALS DISEASE BOX 13.4 AMYOTROPHIC LATERAL SCLEROSIS: A
DEFECT IN RNA EDITING? 13 9 BASE MODIFICATION GUIDED BY SMALL NUCLEOLAR
RNA MOLECULES 13 10 POST-TRANSCRIPTIONAL GENE REGULATION BY MICRORNA
HISTORICAL PERSPECTIVE: THE DISCOVERY OF MIRNA IN CAENORHABDITIS ETEGANS
PROCESSING OF MIRNAS MIRNAS TARGET MRNA FOR DEGRADATION AND
TRANSLATIONAL INHIBITION 13 11 RNA TURNOVER IN THE NUCLEUS AND CYTOPLASM
NUCLEAR EXOSOMES AND QUALITY CONTROL QUALITY CONTROL AND THE FORMATION
OF NUCLEAR EXPORT-COMPETENT RNPS CYTOPLASMIC RNA TURNOVER CHAPTER
SUMMARY ANALYTICAL QUESTIONS SUGGESTIONS FOR FURTHER READING 14 THE
MECHANISM OF TRANSLATION, 512 14.1 INTRODUCTION 14.2 RIBOSOME STRUCTURE
AND ASSEMBLY STRUCTURE OF RIBOSOMES THE NUCLEOLUS RIBOSOME BIOGENESIS
FOCUS BOX 14.1 WHAT IS "S"? 14 3 AMINOACYL-TRNA SYNTHETASES
AMINOACYL-TRNA CHARGING PROOFREADING ACTIVITY OF AMINOACYL-TRNA
SYNTHETASES 14 4 INITIATION OF TRANSLATION TERNARY COMPLEX FORMATION AND
LOADING ONTO THE 40S RIBOSOMAL SUBUNIT LOADING THE MRNA ON THE 40S
RIBOSOMAL SUBUNIT SCANNING AND AUG RECOGNITION JOINING OF THE 40S AND
60S RIBOSOMAL SUBUNITS TOOL BOX 14.1 TRANSLATION TOEPRINTING ASSAYS
DISEASE BOX 14.1 EUKARYOTIC INITIATION FACTOR 2B AND VANISHING WHITE
MATTER 14 5 ELONGATION DECODING PEPTIDE BOND FORMATION AND TRANSLOCATION
PEPTIDYL TRANSFERASE ACTIVITY EVENTS IN THE RIBOSOME TUNNEL 14 6
TERMINATION 14 7 TRANSLATIONAL AND POST-TRANSLATIONAL CONTROL
PHOSPHORYLATION OF ELF2A BLOCKS TERNARY COMPLEX FORMATION ELF2A
PHOSPHORYLATION IS MEDIATED BY FOUR DISTINCT PROTEIN KINASES CONTENTS
CHAPTER SUMMARY ANALYTICAL QUESTIONS SUGGESTIONS FOR FURTHER READING 15
GENETICALLY MODIFIED ORGANISMS: USE IN BASIC AND APPLIED RESEARCH, 545
15 1 INTRODUCTION 15.2 TRANSGENIC MICE HOW TO MAKE A TRANSGENIC MOUSE
INDUCIBLE TRANSGENIC MICE FOCUS BOX 15.1 ONCOMOUSE PATENT 15.3
GENE-TARGETED MOUSE MODELS KNOCKOUT MICE KNOCKIN MICE KNOCKDOWN MICE
CONDITIONAL KNOCKOUT AND KNOCKIN MICE FOCUS BOX 15.2 A MOUSE FOR EVERY
NEED 15.4 OTHER APPLICATIONS OF TRANSGENIC ANIMAL TECHNOLOGY TRANSGENIC
PRIMATES TRANSGENIC LIVESTOCK GENE PHARMING FOCUS BOX 15.3 TRANSGENIC
ARTWORK: THE GFP BUNNY 15.5 CLONING BY NUCLEAR TRANSFER GENETIC
EQUIVALENCE OF SOMATIC CELL NUCLEI: FROG CLONING EXPERIMENTS CLONING OF
MAMMALS BY NUCLEAR TRANSFER "BREAKTHROUGH OF THE YEAR": THE CLONING OF
DOLLY METHOD FOR CLONING BY NUCLEAR TRANSFER SOURCE OF MTDNA IN CLONES
WHY IS CLONING BY NUCLEAR TRANSFER INEFFICIENT 7 APPLICATIONS OF CLONING
BY NUCLEAR TRANSFER FOCUS BOX 15.4 GENETICALLY MANIPULATED PETS 15 6
TRANSGENIC PLANTS T-DNA-MEDIATED GENE DELIVERY ELECTROPORATION AND
MICROBALLISTICS FOCUS BOX 15.5 GENETICALLY MODIFIED CROPS: ARE YOU
EATING GENETICALLY ENGINEERED TOMATOES CHAPTER SUMMARY ANALYTICAL
QUESTIONS SUGGESTIONS FOR FURTHER READING H GENOME ANALYSIS: DNA TYPING,
GENOMICS, AND BEYOND, 581 16.1 INTRODUCTION 16 2 DNA TYPING DNA
POLYMORPHISMS: THE BASIS OF DNA TYPING MINISATELLITE ANALYSIS POLYMERASE
CHAIN REACTION-BASED ANALYSIS SHORT TANDEM REPEAT ANALYSIS MITOCHONDRIAL
DNA ANALYSIS Y CHROMOSOME ANALYSIS RANDOMLY AMPLIFIED POLYMORPHIC DNA
FRAPD! ANALYSIS FOCUS BOX 16.1 DNA PROFILES OF MARIJUANA FOCUS BOX 16.2
NONHUMAN DNA TYPING CONTENTS 16 3 GENOMICS AND BEYOND WHAT IS
BIOMFORMATICS 7 GENOMICS PROTEOMICS THE AGE OF "OMICS" 16 4 THE HUMAN
GENOME PROJECT CLONE BY CLONE GENOME ASSEMBLY APPROACH WHOLE-GENOME
SHOTGUN APPROACH ROUGH DRAFTS VERSUS FINISHED SEQUENCES 16 5 OTHER
SEQUENCED GENOMES WHAT IS A GENE AND HOW MANY ARE THERE IN THE HUMAN
GENOME? FOCUS BOX 16.3 COMPARATIVE ANALYSIS OF GENOMES: INSIGHTS FROM
PUFFERFISH AND CHICKENS 16 6 HIGH-THROUGHPUT ANALYSIS OF GENE FUNCTION
DNA MICROARRAYS PROTEIN ARRAYS MASS SPECTROMETRY 16 7 SINGLE NUCLEOTIDE
POLYMORPHISMS FOCUS BOX 16.4 THE NUCLEOLAR PROTEOME DISEASE BOX 16.1
MAPPING DISEASE-ASSOCIATED SNPS: ALZHEIMER'S DISEASE CHAPTER SUMMARY
ANALYTICAL QUESTIONS SUGGESTIONS FOR FURTHER READING 17 MEDICAL
MOLECULAR BIOLOGY, 618 17 1 INTRODUCTION 17 2 MOLECULAR BIOLOGY OF
CANCER ACTIVATION OF ONCOGENES INACTIVATION OF TUMOR SUPPRESSOR GENES
INAPPROPRIATE EXPRESSION OF MICRORNAS IN CANCER CHROMOSOMAL
REARRANGEMENTS AND CANCER VIRUSES AND CANCER CHEMICAL CARCINOGENESIS
FOCUS BOX 17.1 HOW CANCER CELLS METASTASIZE: THE ROLE OF SRC DISEASE BOX
17.1 KNUDSON'S TWO-HIT HYPOTHESIS AND RETINOBLASTOMA DISEASE BOX 17.2
CANCER GENE THERAPY: A "MAGIC BULLET 9 " FOCUS BOX 17.2 THE DISCOVERY OF
P53 DISEASE BOX 17.3 HUMAN PAPILLOMA VIRUS (HPV] AND CERVICAL CANCER 17
3 GENE THERAPY VECTORS FOR SOMATIC CELL GENE THERAPY ENHANCEMENT GENETIC
ENGINEERING GENE THERAPY FOR INHERITED IMMUNODEFICIENCY SYNDROMES CYSTIC
FIBROSIS GENE THERAPY HIV-1 GENE THERAPY FOCUS BOX 17.3
RETROVIRAL-MEDIATED GENE TRANSFER: HOW TO MAKE A "SAFE VECTOR" FOCUS BOX
17.4 THE FIRST GENE THERAPY FATALITY FOCUS BOX 17.5 HIV-1 LIFE CYCLE 17
4 GENES AND HUMAN BEHAVIOR AGGRESSIVE, IMPULSIVE, AND VIOLENT BEHAVIOR
SCHIZOPHRENIA SUSCEPTIBILITY LOCI CONTENTS CHAPTER SUMMARY ANALYTICAL
QUESTIONS SUGGESTIONS FOR FURTHER READING GLOSSARY, 668 INDEX, 711 |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| author | Allison, Lizabeth A. |
| author_facet | Allison, Lizabeth A. |
| author_role | aut |
| author_sort | Allison, Lizabeth A. |
| author_variant | l a a la laa |
| building | Verbundindex |
| bvnumber | BV022302606 |
| callnumber-first | Q - Science |
| callnumber-label | QH506 |
| callnumber-raw | QH506 |
| callnumber-search | QH506 |
| callnumber-sort | QH 3506 |
| callnumber-subject | QH - Natural History and Biology |
| classification_rvk | WD 4150 |
| classification_tum | BIO 220f |
| ctrlnum | (OCoLC)70929247 (DE-599)BVBBV022302606 |
| dewey-full | 572.8 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 572 - Biochemistry |
| dewey-raw | 572.8 |
| dewey-search | 572.8 |
| dewey-sort | 3572.8 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| discipline_str_mv | Biologie |
| edition | 1. publ. |
| format | Book |
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| genre_facet | Lehrbuch |
| id | DE-604.BV022302606 |
| illustrated | Illustrated |
| index_date | 2024-07-02T16:55:34Z |
| indexdate | 2024-07-09T20:54:32Z |
| institution | BVB |
| isbn | 1405103795 9781405103794 |
| language | English |
| lccn | 2006026641 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-015512575 |
| oclc_num | 70929247 |
| open_access_boolean | |
| owner | DE-M49 DE-BY-TUM DE-634 DE-11 DE-188 |
| owner_facet | DE-M49 DE-BY-TUM DE-634 DE-11 DE-188 |
| physical | XXI, 725 S. zahlr. Ill. 1 CD-ROM (12 cm) |
| publishDate | 2007 |
| publishDateSearch | 2007 |
| publishDateSort | 2007 |
| publisher | Blackwell |
| record_format | marc |
| spelling | Allison, Lizabeth A. Verfasser aut Fundamental molecular biology Lizabeth A. Allison 1. publ. Malden, MA [u.a.] Blackwell 2007 XXI, 725 S. zahlr. Ill. 1 CD-ROM (12 cm) txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Moleculaire biologie gtt Molecular biology Textbooks Molecular Biology Molekularbiologie (DE-588)4039983-7 gnd rswk-swf (DE-588)4123623-3 Lehrbuch gnd-content Molekularbiologie (DE-588)4039983-7 s DE-604 http://www.loc.gov/catdir/toc/ecip0619/2006026641.html Table of contents only GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015512575&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Allison, Lizabeth A. Fundamental molecular biology Moleculaire biologie gtt Molecular biology Textbooks Molecular Biology Molekularbiologie (DE-588)4039983-7 gnd |
| subject_GND | (DE-588)4039983-7 (DE-588)4123623-3 |
| title | Fundamental molecular biology |
| title_auth | Fundamental molecular biology |
| title_exact_search | Fundamental molecular biology |
| title_exact_search_txtP | Fundamental molecular biology |
| title_full | Fundamental molecular biology Lizabeth A. Allison |
| title_fullStr | Fundamental molecular biology Lizabeth A. Allison |
| title_full_unstemmed | Fundamental molecular biology Lizabeth A. Allison |
| title_short | Fundamental molecular biology |
| title_sort | fundamental molecular biology |
| topic | Moleculaire biologie gtt Molecular biology Textbooks Molecular Biology Molekularbiologie (DE-588)4039983-7 gnd |
| topic_facet | Moleculaire biologie Molecular biology Textbooks Molecular Biology Molekularbiologie Lehrbuch |
| url | http://www.loc.gov/catdir/toc/ecip0619/2006026641.html http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015512575&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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