A computer scientist's guide to cell biology: a travelogue from a stranger in a strange land
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| Format: | Book |
| Language: | English |
| Published: |
New York
Springer
2007
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| Subjects: | |
| Online Access: | Inhaltstext Inhaltsverzeichnis |
| Physical Description: | XIV, 99 S. Ill., graph. Darst. |
| ISBN: | 9780387482750 |
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Table of Contents
List of Figures xi
Introduction xiii
How Cells Work 1
Prokaryotes: the simplest living things 1
Even simpler "living" things: viruses and plasmids 4
All complex living things are eukaryotes 6
Cells cooperate 9
Cells divide and multiply 14
The Complexity of Living Things 19
Complexes and pathways 19
Individual interactions can be complicated 21
Energy and pathways 29
Amplification and pathways 31
Modularity and locality in biology 33
Looking at Very Small Things 37
Limitations of optical microscopes 37
viii A Computer Scientist's Guide to Cell Biology
Special types of microscopes 39
Electron microscopes 42
Manipulation of the Very Small 45
Taking small things apart 45
Parallelism, automation, and re use in biology 53
Classifying small things by taking them apart 55
Reprogramming Cells 59
Our colleagues, the microorganisms 59
Restriction enzymes and restriction methylase systems 59
Constructing recombinant DNA with REs and DNA ligase 60
Inserting foreign DNA into a cell 62
Genomic DNA libraries 64
Creating novel proteins: tagging and phage display 65
Yeast two hybrid assays using fusion proteins 67
Other Ways to Use Biology for Biological Experiments 71
Replicating DNA in a test tube 71
Sequencing DNA by partial replication and sorting 75
Other in vitro systems: translation and reverse transcription 76
Exploiting the natural defenses of a cell: Antibodies 77
William W. Cohen ix
Exploiting the natural defenses of a cell: RNA interference 78
Serial analysis of gene expression 79
Bioinformatics 83
Where to go from here? 91
Acknowledgements 94
Index 95
List of Figures
Figure 1. The "central dogma" of biology 2
Figure 2. Relative sizes of various biological objects 6
Figure 3. Internal organization of a eukaryotic animal cell 8
Figure 4. Voltage gated ion channels in neurons 10
Figure 5. How signals propagate along a neuron 11
Figure 6. A transmitter gated ion channel 12
Figure 7. A G protein coupled receptor protein 13
Figure 8. Meiosis produces haploid cells 16
Figure 9. The bacterial flagellum 20
Figure 10. How£. coli responds to nutrients 21
Figure 11. How enzymes work 23
Figure 12. Saturation kinetics for enzymes 24
Figure 13. Derivation of Michaelis Menten saturation kinetics 25
Figure 14. Interpreting Michaelis Menten saturation kinetics 26
Figure 15. An enzyme with a sigmoidal concentration velocity curve 28
Figure 16. A coupled reaction 29
Figure 17. Part of an energy producing pathway 30
Figure 18. How light is detected by rhodopsin 31
Figure 19. Amplification rates of two biological processes 32
Figure 20. Behavior of particles moving by diffusion 36
Figure 21. The Abbe model of resolution 38
Figure 22. How a DIC microscope works 39
Figure 23. How a fluorescence microscope works 40
Figure 24. Fluorescent microscope images 41
Figure 25. Electron microscope images 43
Figure 26. An article on reverse engineering PCs 45
Figure 27. Using SDS PAGE to separate components of a mixture 48
Figure 28. Structure and nomenclature of protein molecules 67
Figure 29. The yeast two hybrid system 68
Figure 30. Structure and nomenclature of DNA molecules 73
Figure 31. DNA duplication in nature and with PCR 74
Figure 32. Procedure for sequencing DNA 76
Figure 33. Serial analysis of gene expression (SAGE) 81
Figure 34. Computing a simple edit distance 85
Figure 35. The Smith Waterman edit distance method 86
Figure 36. Two possible evolutionary trees 87
Please visit the book's homepage at www.springer.com for color images of
some figures. |
| adam_txt |
Table of Contents
List of Figures xi
Introduction xiii
How Cells Work 1
Prokaryotes: the simplest living things 1
Even simpler "living" things: viruses and plasmids 4
All complex living things are eukaryotes 6
Cells cooperate 9
Cells divide and multiply 14
The Complexity of Living Things 19
Complexes and pathways 19
Individual interactions can be complicated 21
Energy and pathways 29
Amplification and pathways 31
Modularity and locality in biology 33
Looking at Very Small Things 37
Limitations of optical microscopes 37
viii A Computer Scientist's Guide to Cell Biology
Special types of microscopes 39
Electron microscopes 42
Manipulation of the Very Small 45
Taking small things apart 45
Parallelism, automation, and re use in biology 53
Classifying small things by taking them apart 55
Reprogramming Cells 59
Our colleagues, the microorganisms 59
Restriction enzymes and restriction methylase systems 59
Constructing recombinant DNA with REs and DNA ligase 60
Inserting foreign DNA into a cell 62
Genomic DNA libraries 64
Creating novel proteins: tagging and phage display 65
Yeast two hybrid assays using fusion proteins 67
Other Ways to Use Biology for Biological Experiments 71
Replicating DNA in a test tube 71
Sequencing DNA by partial replication and sorting 75
Other in vitro systems: translation and reverse transcription 76
Exploiting the natural defenses of a cell: Antibodies 77
William W. Cohen ix
Exploiting the natural defenses of a cell: RNA interference 78
Serial analysis of gene expression 79
Bioinformatics 83
Where to go from here? 91
Acknowledgements 94
Index 95
List of Figures
Figure 1. The "central dogma" of biology 2
Figure 2. Relative sizes of various biological objects 6
Figure 3. Internal organization of a eukaryotic animal cell 8
Figure 4. Voltage gated ion channels in neurons 10
Figure 5. How signals propagate along a neuron 11
Figure 6. A transmitter gated ion channel 12
Figure 7. A G protein coupled receptor protein 13
Figure 8. Meiosis produces haploid cells 16
Figure 9. The bacterial flagellum 20
Figure 10. How£. coli responds to nutrients 21
Figure 11. How enzymes work 23
Figure 12. Saturation kinetics for enzymes 24
Figure 13. Derivation of Michaelis Menten saturation kinetics 25
Figure 14. Interpreting Michaelis Menten saturation kinetics 26
Figure 15. An enzyme with a sigmoidal concentration velocity curve 28
Figure 16. A coupled reaction 29
Figure 17. Part of an energy producing pathway 30
Figure 18. How light is detected by rhodopsin 31
Figure 19. Amplification rates of two biological processes 32
Figure 20. Behavior of particles moving by diffusion 36
Figure 21. The Abbe model of resolution 38
Figure 22. How a DIC microscope works 39
Figure 23. How a fluorescence microscope works 40
Figure 24. Fluorescent microscope images 41
Figure 25. Electron microscope images 43
Figure 26. An article on reverse engineering PCs 45
Figure 27. Using SDS PAGE to separate components of a mixture 48
Figure 28. Structure and nomenclature of protein molecules 67
Figure 29. The yeast two hybrid system 68
Figure 30. Structure and nomenclature of DNA molecules 73
Figure 31. DNA duplication in nature and with PCR 74
Figure 32. Procedure for sequencing DNA 76
Figure 33. Serial analysis of gene expression (SAGE) 81
Figure 34. Computing a simple edit distance 85
Figure 35. The Smith Waterman edit distance method 86
Figure 36. Two possible evolutionary trees 87
Please visit the book's homepage at www.springer.com for color images of
some figures. |
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| spelling | Cohen, William W. Verfasser aut A computer scientist's guide to cell biology a travelogue from a stranger in a strange land William W. Cohen New York Springer 2007 XIV, 99 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Cytologie - Informatique Datenverarbeitung Cytology Data processing Cytologie (DE-588)4070177-3 gnd rswk-swf (DE-588)4151278-9 Einführung gnd-content Cytologie (DE-588)4070177-3 s DE-604 text/html http://deposit.dnb.de/cgi-bin/dokserv?id=2858134&prov=M&dok_var=1&dok_ext=htm Inhaltstext HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015512534&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Cohen, William W. A computer scientist's guide to cell biology a travelogue from a stranger in a strange land Cytologie - Informatique Datenverarbeitung Cytology Data processing Cytologie (DE-588)4070177-3 gnd |
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| title | A computer scientist's guide to cell biology a travelogue from a stranger in a strange land |
| title_auth | A computer scientist's guide to cell biology a travelogue from a stranger in a strange land |
| title_exact_search | A computer scientist's guide to cell biology a travelogue from a stranger in a strange land |
| title_exact_search_txtP | A computer scientist's guide to cell biology a travelogue from a stranger in a strange land |
| title_full | A computer scientist's guide to cell biology a travelogue from a stranger in a strange land William W. Cohen |
| title_fullStr | A computer scientist's guide to cell biology a travelogue from a stranger in a strange land William W. Cohen |
| title_full_unstemmed | A computer scientist's guide to cell biology a travelogue from a stranger in a strange land William W. Cohen |
| title_short | A computer scientist's guide to cell biology |
| title_sort | a computer scientist s guide to cell biology a travelogue from a stranger in a strange land |
| title_sub | a travelogue from a stranger in a strange land |
| topic | Cytologie - Informatique Datenverarbeitung Cytology Data processing Cytologie (DE-588)4070177-3 gnd |
| topic_facet | Cytologie - Informatique Datenverarbeitung Cytology Data processing Cytologie Einführung |
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