The polycystic ovary syndrome: current concepts on pathogenesis and clinical care
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York
Springer
2007
|
| Schriftenreihe: | Endocrine updates
27 |
| Schlagworte: | |
| Online-Zugang: | Inhaltstext Inhaltsverzeichnis |
| Beschreibung: | X, 134 S. Ill., graph. Darst. |
| ISBN: | 9780387692463 0387692460 |
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| 245 | 1 | 0 | |a The polycystic ovary syndrome |b current concepts on pathogenesis and clinical care |c ed. by Ricardo Azziz |
| 264 | 1 | |a New York |b Springer |c 2007 | |
| 300 | |a X, 134 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Endocrine updates |v 27 | |
| 650 | 4 | |a Polycystic Ovary Syndrome |x physiopathology | |
| 650 | 4 | |a Polycystic ovary syndrome | |
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Datensatz im Suchindex
| _version_ | 1805088754885459968 |
|---|---|
| adam_text |
Contents
Contributors
ix
Chapter
1:
Definition, Diagnosis, and Epidemiology
of the Polycystic Ovary Syndrome
Ricardo
Azziz (azzizr® cshs. org)
1
1.
Defining PCOS: Basics
1
2.
Specific Criteria for PCOS
2
3.
Diagnosis of PCOS
6
4.
Prevalence of PCOS
9
5.
Conclusions
11
Chapter
2:
Clinical Evaluation of PCOS
Richard S.
Legro
(RSLl@psu.edu)
17
1.
Features of PCOS
17
2.
Differential Diagnosis of PCOS
19
3.
Evaluation for Insulin Resistance in PCOS
21
4.
Summary
24
Chapter
3:
Genetics of PCOS
Mark O. Goodarzi (Mark.Goodarzi@cshs.org)
29
1.
The Inherited Basis of PCOS and Its Component Phenotypes
29
2.
The Candidate Gene Approach as Applied to PCOS Genetics
30
3.
Epigenetics: A New Avenue in PCOS Genetics
39
4.
Conclusions
40
Chapter
4:
Insulin Action in Polycystic Ovary Syndrome:
In Vivo and In Vitro
Jean-Patrice Baillargeon (JP.Baillargeon@usherbrooke.ca)
43
1.
Introduction
43
2.
Insulin Action in PCOS
44
3.
Androgenic Actions of Insulin in PCOS
46
4.
Insulin Actions and Ovulatory Dysfunction in PCOS
54
5.
Conclusions
59
6.
Future Avenues of Investigation
61
vi
Contents
Chapter
5:
Ovarian Steroidogenic Abnormalities in PCOS
Jessica K. Wickenheisser and Jan M. McAllister
(jmcallister@psu.edu)
69
1.
Ovarian
Androgen
and Estrogen Biosynthesis
70
2.
Dysregulated Estrogen Biosynthesis in PCOS
72
3.
Dysregulated
Androgen
Biosynthesis in PCOS
73
4.
Increases in CYP17 and CYP11A1 Gene Transcription and mRNA
Stability in PCOS
75
5.
Insulin Sensitivity and the PCOS Ovary
77
6.
Mitogen Activated Protein Kinase Signaling and Altered Steroid
Biosynthesis in PCOS
77
7.
Gene Expression Profiling and Candidate Gene Analysis in PCOS
78
8.
Paracrine and
Autocrine
Regulators that May Impact Ovarian
Steroid Abnormalities and Follicular Growth in the PCOS Ovary
80
9.
Summary
82
Chapter
6:
Role of Obesity and Adiposity in PCOS
Renato Pasquali,
Laura
Patton,
Evanthia Diamanti-Kandarakis,
and
Alessandra
Gambineri
(renato.pasquali
@ unibo. it)
85
1.
Prevalence of Obesity in PCOS
86
2.
Pattern and Implications of Body Fat Distribution
in Women with PCOS
87
3.
Pathophysiology of Obesity on the Hyperandrogenic, Ovulatory,
and Metabolic Alterations of PCOS
88
4.
Summary and Perspectives
96
Chapter
7:
Strategies for
Ovulation
Induction in the Management
of Anovulatory Polycystic Ovary Syndrome
Adam
Balen
(adam.balen@leedsth.nhs.uk)
99
1.
PCOS and Anovulatory Infertility: The Basics
99
2.
Lifestyle and Weight Loss in PCOS
101
3.
CC Therapy
102
4.
Aromatase Inhibitors
104
5.
Gonadotropi
Therapy
104
6.
Surgical
Ovulation
Induction
105
7.
The Role of Metformin and Other Insulin Sensitizers
107
8.
IVF
in Women with Polycystic Ovaries
110
9.
IVMofOocytes
112
10.
Summary
112
Contents
vii
Chapter
8:
Long-Term
Morbidity of PCOS
Ricardo Azziz
(azzizr@ cshs. org)
117
1.
Introduction
117
2.
Prevalence of Principal Morbidities Associated with PCOS
117
3.
Estimating the Economic Burden of PCOS
124
4.
Conclusions
124
Index
131 |
| adam_txt |
Contents
Contributors
ix
Chapter
1:
Definition, Diagnosis, and Epidemiology
of the Polycystic Ovary Syndrome
Ricardo
Azziz (azzizr® cshs. org)
1
1.
Defining PCOS: Basics
1
2.
Specific Criteria for PCOS
2
3.
Diagnosis of PCOS
6
4.
Prevalence of PCOS
9
5.
Conclusions
11
Chapter
2:
Clinical Evaluation of PCOS
Richard S.
Legro
(RSLl@psu.edu)
17
1.
Features of PCOS
17
2.
Differential Diagnosis of PCOS
19
3.
Evaluation for Insulin Resistance in PCOS
21
4.
Summary
24
Chapter
3:
Genetics of PCOS
Mark O. Goodarzi (Mark.Goodarzi@cshs.org)
29
1.
The Inherited Basis of PCOS and Its Component Phenotypes
29
2.
The Candidate Gene Approach as Applied to PCOS Genetics
30
3.
Epigenetics: A New Avenue in PCOS Genetics
39
4.
Conclusions
40
Chapter
4:
Insulin Action in Polycystic Ovary Syndrome:
In Vivo and In Vitro
Jean-Patrice Baillargeon (JP.Baillargeon@usherbrooke.ca)
43
1.
Introduction
43
2.
Insulin Action in PCOS
44
3.
Androgenic Actions of Insulin in PCOS
46
4.
Insulin Actions and Ovulatory Dysfunction in PCOS
54
5.
Conclusions
59
6.
Future Avenues of Investigation
61
vi
Contents
Chapter
5:
Ovarian Steroidogenic Abnormalities in PCOS
Jessica K. Wickenheisser and Jan M. McAllister
(jmcallister@psu.edu)
69
1.
Ovarian
Androgen
and Estrogen Biosynthesis
70
2.
Dysregulated Estrogen Biosynthesis in PCOS
72
3.
Dysregulated
Androgen
Biosynthesis in PCOS
73
4.
Increases in CYP17 and CYP11A1 Gene Transcription and mRNA
Stability in PCOS
75
5.
Insulin Sensitivity and the PCOS Ovary
77
6.
Mitogen Activated Protein Kinase Signaling and Altered Steroid
Biosynthesis in PCOS
77
7.
Gene Expression Profiling and Candidate Gene Analysis in PCOS
78
8.
Paracrine and
Autocrine
Regulators that May Impact Ovarian
Steroid Abnormalities and Follicular Growth in the PCOS Ovary
80
9.
Summary
82
Chapter
6:
Role of Obesity and Adiposity in PCOS
Renato Pasquali,
Laura
Patton,
Evanthia Diamanti-Kandarakis,
and
Alessandra
Gambineri
(renato.pasquali
@ unibo. it)
85
1.
Prevalence of Obesity in PCOS
86
2.
Pattern and Implications of Body Fat Distribution
in Women with PCOS
87
3.
Pathophysiology of Obesity on the Hyperandrogenic, Ovulatory,
and Metabolic Alterations of PCOS
88
4.
Summary and Perspectives
96
Chapter
7:
Strategies for
Ovulation
Induction in the Management
of Anovulatory Polycystic Ovary Syndrome
Adam
Balen
(adam.balen@leedsth.nhs.uk)
99
1.
PCOS and Anovulatory Infertility: The Basics
99
2.
Lifestyle and Weight Loss in PCOS
101
3.
CC Therapy
102
4.
Aromatase Inhibitors
104
5.
Gonadotropi
Therapy
104
6.
Surgical
Ovulation
Induction
105
7.
The Role of Metformin and Other Insulin Sensitizers
107
8.
IVF
in Women with Polycystic Ovaries
110
9.
IVMofOocytes
112
10.
Summary
112
Contents
vii
Chapter
8:
Long-Term
Morbidity of PCOS
Ricardo Azziz
(azzizr@ cshs. org)
117
1.
Introduction
117
2.
Prevalence of Principal Morbidities Associated with PCOS
117
3.
Estimating the Economic Burden of PCOS
124
4.
Conclusions
124
Index
131 |
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| spelling | The polycystic ovary syndrome current concepts on pathogenesis and clinical care ed. by Ricardo Azziz New York Springer 2007 X, 134 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Endocrine updates 27 Polycystic Ovary Syndrome physiopathology Polycystic ovary syndrome Stein-Leventhal-Syndrom (DE-588)4246279-4 gnd rswk-swf Stein-Leventhal-Syndrom (DE-588)4246279-4 s DE-604 Azziz, Ricardo Sonstige oth Endocrine updates 27 (DE-604)BV012381937 27 text/html http://deposit.dnb.de/cgi-bin/dokserv?id=2887524&prov=M&dok_var=1&dok_ext=htm Inhaltstext Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015507473&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
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| title | The polycystic ovary syndrome current concepts on pathogenesis and clinical care |
| title_auth | The polycystic ovary syndrome current concepts on pathogenesis and clinical care |
| title_exact_search | The polycystic ovary syndrome current concepts on pathogenesis and clinical care |
| title_exact_search_txtP | The polycystic ovary syndrome current concepts on pathogenesis and clinical care |
| title_full | The polycystic ovary syndrome current concepts on pathogenesis and clinical care ed. by Ricardo Azziz |
| title_fullStr | The polycystic ovary syndrome current concepts on pathogenesis and clinical care ed. by Ricardo Azziz |
| title_full_unstemmed | The polycystic ovary syndrome current concepts on pathogenesis and clinical care ed. by Ricardo Azziz |
| title_short | The polycystic ovary syndrome |
| title_sort | the polycystic ovary syndrome current concepts on pathogenesis and clinical care |
| title_sub | current concepts on pathogenesis and clinical care |
| topic | Polycystic Ovary Syndrome physiopathology Polycystic ovary syndrome Stein-Leventhal-Syndrom (DE-588)4246279-4 gnd |
| topic_facet | Polycystic Ovary Syndrome physiopathology Polycystic ovary syndrome Stein-Leventhal-Syndrom |
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