Networking of chaperones by co-chaperones:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Austin, Tex.
Landes Bioscience/Eurekah.com [u.a.]
2007
|
| Series: | Molecular biology intelligence unit
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | 139 S. Ill., graph. Darst. |
| ISBN: | 9780387493084 |
Staff View
MARC
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| 245 | 1 | 0 | |a Networking of chaperones by co-chaperones |c Gregory L. Batch [ed.] |
| 264 | 1 | |a Austin, Tex. |b Landes Bioscience/Eurekah.com [u.a.] |c 2007 | |
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Record in the Search Index
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|---|---|
| adam_text | I CONTENTS |
Preface xiii
Acknowledgements xv
1. Nucleotide Exchange Factors for Hsp70 Molecular Chaperones 1
Jeffrey L. Brodsky and Andreas Bracher
GrpE: The Bacterial Nucleotide Exchange Factor for Hsp70 2
The Discovery of Hsp70 Nucleotide Exchange Factors
in Eukaryotes: Fishing Pays Off 2
Hsp70 NEFs in Eukaryotes Exhibit Diverse Functions 4
The Mechanism of Action of Hsp70 Nucleotide Exchange Factors:
Results from Structural and Biochemical Studies 5
2. Functions of the Hsp90 Binding FKBP Immunophilins 13
Marc B. Cox and David F. Smith
Structure/Function Relationships of Steroid
Receptor Associated FKBPs 15
Cellular and Physiological Functions of Hsp90 Associated FKBPs 16
Functional Interactions between FKBP52 and FKBP51 19
Xap2 and FKBP6 20
Plant FKBPs 21
3. Hop: An Hsp70/Hsp90 Co Chaperone That Functions
within and beyond Hsp70/Hsp90 Protein Folding Pathways 26
Sheril Daniel, Csaba Soti, Peter Csermely, Graeme Bradley
and Gregory L. Blatch
Hop (Hsp70/Hsp90 Organizing Protein) 28
Hop Modulates the Activities of Hsp70 and Hsp90 28
Hop Interactions Go Beyond Hsp70 and Hsp90 32
Subcellular Localization of Hop Affects Its Activities 33
4. Do Hsp40s Act as Chaperones or Co Chaperones? 38
Meredith F.N. Rosser and Douglas M. Cyr
Hsp70 Co Chaperone Activity of Hsp40s 40
Do Hsp40s Act as Chaperones? 40
Determination of Specificity 43
The G/F Region 43
Central Domains 43
Substrate Binding Domains 44
Hsp40 Quaternary Structure 46
5. The Chaperone and Co Chaperone Activities of Cdc37
during Protein Kinase Maturation 52
AvromJ. Caplan
Cdc37 Structure 53
Cdc37 as a Co Chaperone of Hsp90 54
Chaperone Actions of Cdc37 in Protein Kinase Maturation 56
6. UNC 45: A Chaperone for Myosin and a Co Chaperone for Hsp90.... 62
Odutayo O. Odunuga and Henry F. Epstein
UNC 45 and Myosin Folding, Assembly and Function 63
UNC 45 and the Molecular Chaperone Hsp90 65
UNC 45 Proteins in Invertebrates: C. elegans and D. melanogaster 67
UNC 45 Proteins in Vertebrates: Mouse and Human 68
Structure of UNC 45 Proteins 69
Fungal UCS Containing Proteins 69
7. The Roles of GroES as a Co Chaperone for GroEL 75
Han Liu and Peter A. Lund
A Note on Nomenclature 75
The in Vivo Roles of the GroEL and GroES Proteins 76
The Roles of GroES in die Chaperonin Mechanism 77
Future Research Directions 85
8. Co Chaperones of the Endoplasmic Reticulum 88
Johanna Dudek, Martin Jung, Andreas Weitzmann, Markus Greiner
and Richard Zimmermann
The Chaperone Network of the ER 90
The Hsp70/Hsp40 Network of the ER 90
The Role of Co Chaperones of BiP/Kar2p in Protein Transport
into the ER 94
Open Questions Related to die Networking of ER Chaperones
by Co Chaperones 96
9. The Evolution and Function of Co Chaperones in Mitochondria 99
Dejan Bursac and Trevor Lithgow
The Mitochondrial Homologue of DnaKand Its Co Chaperones 99
Mitochondrial Protein Import with a Highly Advanced
Hsp70 Machine at Its Core 100
Molecular Chaperones and FeS Cluster Assembly 103
Ziml7, a Uniquely Mitochondria] Regulator of Hsp70 104
10. From Creator to Terminator: Co Chaperones That Link
Molecular Chaperones to the Ubiquitin/Proteasome System 109
Jorg Hb hfeld, Karsten Bbhse, Markus Genau and Britta Westhoff
The Ubiquitin/Proteasome System 110
Co Chaperones That Link Chaperones
to the Ubiquitin/Proteasome System 112
A Novel Concept for Protein Quality Control 116
Substrate Selection 118
Regulating the Balance between Chaperone Assisted Folding
and Degradation 118
Outlook 119
11. The Role of Hsp70 and Its Co Chaperones in Protein Misfolding,
Aggregation and Disease 122
Jacqueline van der Spuy, Michael E. Cheetham and]. Paul Chappie
Hsp70 and Its Co Chaperones in Neurodegenerative Disease 124
Mutations in Putative Hsp70 Co Chaperones which Cause
Inherited Disease 127
Index 137
|
| adam_txt |
I CONTENTS |
Preface xiii
Acknowledgements xv
1. Nucleotide Exchange Factors for Hsp70 Molecular Chaperones 1
Jeffrey L. Brodsky and Andreas Bracher
GrpE: The Bacterial Nucleotide Exchange Factor for Hsp70 2
The Discovery of Hsp70 Nucleotide Exchange Factors
in Eukaryotes: Fishing Pays Off 2
Hsp70 NEFs in Eukaryotes Exhibit Diverse Functions 4
The Mechanism of Action of Hsp70 Nucleotide Exchange Factors:
Results from Structural and Biochemical Studies 5
2. Functions of the Hsp90 Binding FKBP Immunophilins 13
Marc B. Cox and David F. Smith
Structure/Function Relationships of Steroid
Receptor Associated FKBPs 15
Cellular and Physiological Functions of Hsp90 Associated FKBPs 16
Functional Interactions between FKBP52 and FKBP51 19
Xap2 and FKBP6 20
Plant FKBPs 21
3. Hop: An Hsp70/Hsp90 Co Chaperone That Functions
within and beyond Hsp70/Hsp90 Protein Folding Pathways 26
Sheril Daniel, Csaba Soti, Peter Csermely, Graeme Bradley
and Gregory L. Blatch
Hop (Hsp70/Hsp90 Organizing Protein) 28
Hop Modulates the Activities of Hsp70 and Hsp90 28
Hop Interactions Go Beyond Hsp70 and Hsp90 32
Subcellular Localization of Hop Affects Its Activities 33
4. Do Hsp40s Act as Chaperones or Co Chaperones? 38
Meredith F.N. Rosser and Douglas M. Cyr
Hsp70 Co Chaperone Activity of Hsp40s 40
Do Hsp40s Act as Chaperones? 40
Determination of Specificity 43
The G/F Region 43
Central Domains 43
Substrate Binding Domains 44
Hsp40 Quaternary Structure 46
5. The Chaperone and Co Chaperone Activities of Cdc37
during Protein Kinase Maturation 52
AvromJ. Caplan
Cdc37 Structure 53
Cdc37 as a Co Chaperone of Hsp90 54
Chaperone Actions of Cdc37 in Protein Kinase Maturation 56
6. UNC 45: A Chaperone for Myosin and a Co Chaperone for Hsp90. 62
Odutayo O. Odunuga and Henry F. Epstein
UNC 45 and Myosin Folding, Assembly and Function 63
UNC 45 and the Molecular Chaperone Hsp90 65
UNC 45 Proteins in Invertebrates: C. elegans and D. melanogaster 67
UNC 45 Proteins in Vertebrates: Mouse and Human 68
Structure of UNC 45 Proteins 69
Fungal UCS Containing Proteins 69
7. The Roles of GroES as a Co Chaperone for GroEL 75
Han Liu and Peter A. Lund
A Note on Nomenclature 75
The in Vivo Roles of the GroEL and GroES Proteins 76
The Roles of GroES in die Chaperonin Mechanism 77
Future Research Directions 85
8. Co Chaperones of the Endoplasmic Reticulum 88
Johanna Dudek, Martin Jung, Andreas Weitzmann, Markus Greiner
and Richard Zimmermann
The Chaperone Network of the ER 90
The Hsp70/Hsp40 Network of the ER 90
The Role of Co Chaperones of BiP/Kar2p in Protein Transport
into the ER 94
Open Questions Related to die Networking of ER Chaperones
by Co Chaperones 96
9. The Evolution and Function of Co Chaperones in Mitochondria 99
Dejan Bursac and Trevor Lithgow
The Mitochondrial Homologue of DnaKand Its Co Chaperones 99
Mitochondrial Protein Import with a Highly Advanced
Hsp70 Machine at Its Core 100
Molecular Chaperones and FeS Cluster Assembly 103
Ziml7, a Uniquely Mitochondria] Regulator of Hsp70 104
10. From Creator to Terminator: Co Chaperones That Link
Molecular Chaperones to the Ubiquitin/Proteasome System 109
Jorg Hb'hfeld, Karsten Bbhse, Markus Genau and Britta Westhoff
The Ubiquitin/Proteasome System 110
Co Chaperones That Link Chaperones
to the Ubiquitin/Proteasome System 112
A Novel Concept for Protein Quality Control 116
Substrate Selection 118
Regulating the Balance between Chaperone Assisted Folding
and Degradation 118
Outlook 119
11. The Role of Hsp70 and Its Co Chaperones in Protein Misfolding,
Aggregation and Disease 122
Jacqueline van der Spuy, Michael E. Cheetham and]. Paul Chappie
Hsp70 and Its Co Chaperones in Neurodegenerative Disease 124
Mutations in Putative Hsp70 Co Chaperones which Cause
Inherited Disease 127
Index 137 |
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| isbn | 9780387493084 |
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| publisher | Landes Bioscience/Eurekah.com [u.a.] |
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| series2 | Molecular biology intelligence unit |
| spelling | Networking of chaperones by co-chaperones Gregory L. Batch [ed.] Austin, Tex. Landes Bioscience/Eurekah.com [u.a.] 2007 139 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molecular biology intelligence unit Molecular Chaperones Molecular chaperones Protein Folding Polypeptidketten bindende Proteine (DE-588)4311255-9 gnd rswk-swf Polypeptidketten bindende Proteine (DE-588)4311255-9 s DE-604 Blatch, Gregory L. Sonstige (DE-588)173905323 oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015484260&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Networking of chaperones by co-chaperones Molecular Chaperones Molecular chaperones Protein Folding Polypeptidketten bindende Proteine (DE-588)4311255-9 gnd |
| subject_GND | (DE-588)4311255-9 |
| title | Networking of chaperones by co-chaperones |
| title_auth | Networking of chaperones by co-chaperones |
| title_exact_search | Networking of chaperones by co-chaperones |
| title_exact_search_txtP | Networking of chaperones by co-chaperones |
| title_full | Networking of chaperones by co-chaperones Gregory L. Batch [ed.] |
| title_fullStr | Networking of chaperones by co-chaperones Gregory L. Batch [ed.] |
| title_full_unstemmed | Networking of chaperones by co-chaperones Gregory L. Batch [ed.] |
| title_short | Networking of chaperones by co-chaperones |
| title_sort | networking of chaperones by co chaperones |
| topic | Molecular Chaperones Molecular chaperones Protein Folding Polypeptidketten bindende Proteine (DE-588)4311255-9 gnd |
| topic_facet | Molecular Chaperones Molecular chaperones Protein Folding Polypeptidketten bindende Proteine |
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