Cerebral ischemic tolerance: from bench-to-bedside
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | German |
| Published: |
München
Verl. Dr. Hut
2006
|
| Edition: | 1. Aufl. |
| Series: | Biochemie
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | 135 S. graph. Darst. 22 cm, 300 gr. |
| ISBN: | 9783899634433 3899634438 |
Staff View
MARC
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| 264 | 1 | |a München |b Verl. Dr. Hut |c 2006 | |
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| 650 | 4 | |a Brain Ischemia |x physiopathology | |
| 650 | 4 | |a Brain Ischemia |x therapy | |
| 650 | 4 | |a Disease Models, Animal | |
| 650 | 4 | |a Ischemic Preconditioning | |
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Record in the Search Index
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Table of content
In memoriam 4
Main abbrevations 5
Abstract 6
1. Introduction g
2. Aims of the study 12
2.1. Purpose 13
2.2. Main questions 13
3. Methodology 15
4. Definition of ischemic tolerance 17
5. Pathophysiology of focal cerebral ischemia 20
5.1. The core and penumbral region of infarction 21
5.2. Process of cerebral infarction and cellular death 22
6. Ischemic tolerance: An archetypical non-specific stress-response? 28
7. Experimental models of ischemic tolerance 31
8. Animal models of cerebral ischemic tolerance 35
8.1. Global-global ischemia animal models 36
8.2. Focal-global ischemia animal models 36
8.3. Global-focal ischemia animal models 37
8.4. Focal-focal ischemia animal models 38
9. In vitro models of cerebral ischemic tolerance 39
10. Mechanisms of ischemic tolerance in the brain 41
10.1. Ischemic tolerance in the heart 47
10.2. Ischemic tolerance in the brain 47
10.2.1. Activation of adenosine receptors 49
10.2.2. Activation of phospholipase C 49
10.2.3. Activation of phosphokinase C 50
10.2.4. Activation of Katp channels 52
11. Adenosine-induced signal transduction pathway 54
12. Ischemic tolerance and postischemic functional recovery 58
13. Necrosis, apoptosis and ischemic tolerance - the same pathways, but a different kind
of stimulus? 60
14. Stress proteins and ischemic tolerance 62
-2-
15. Cross tolerance 65
16. Different experimental induction of ischemic tolerance 68
16.1. Pharmacological preconditioning 69
16.2. Thrombin preconditioning 69
16.3. Erythropoetin preconditioning 70
16.4. Hypothermia preconditioning 71
16.5. Other substances 72
17. From animal experiments to clinical practice 74
18. Clinical aspects of cerebral ischemic tolerance 76
18.1. Prestroke transient ischemic attack 77
18.2. Reperfusion 79
18.3. Chronic mild reduction of perfusion pressure 80
19. Remote preconditioning 82
20. Postconditioning 84
20.1. Mechanism of postconditioning 86
21. Remote postconditioning 88
22. Time window 90
23. Postconditioning vs. preconditioning 92
24. Controversies in the experimental and clinical application of preconditioning 95
25. Therapeutic implications of ischemic tolerance 97
25.1. Preconditioning 98
25.2. Anesthetics 100
25.3. Postconditioning 103
26. Prospects to the future 104
26.1. Preconditioning 105
26.2. Postconditioning 107
27. Conclusion 108
28. References 111
|
| adam_txt |
-1 -
Table of content
In memoriam 4
Main abbrevations 5
Abstract 6
1. Introduction g
2. Aims of the study 12
2.1. Purpose 13
2.2. Main questions 13
3. Methodology 15
4. Definition of ischemic tolerance 17
5. Pathophysiology of focal cerebral ischemia 20
5.1. The core and penumbral region of infarction 21
5.2. Process of cerebral infarction and cellular death 22
6. Ischemic tolerance: An archetypical non-specific stress-response? 28
7. Experimental models of ischemic tolerance 31
8. Animal models of cerebral ischemic tolerance 35
8.1. Global-global ischemia animal models 36
8.2. Focal-global ischemia animal models 36
8.3. Global-focal ischemia animal models 37
8.4. Focal-focal ischemia animal models 38
9. In vitro models of cerebral ischemic tolerance 39
10. Mechanisms of ischemic tolerance in the brain 41
10.1. Ischemic tolerance in the heart 47
10.2. Ischemic tolerance in the brain 47
10.2.1. Activation of adenosine receptors 49
10.2.2. Activation of phospholipase C 49
10.2.3. Activation of phosphokinase C 50
10.2.4. Activation of Katp channels 52
11. Adenosine-induced signal transduction pathway 54
12. Ischemic tolerance and postischemic functional recovery 58
13. Necrosis, apoptosis and ischemic tolerance - the same pathways, but a different kind
of stimulus? 60
14. Stress proteins and ischemic tolerance 62
-2-
15. Cross tolerance 65
16. Different experimental induction of ischemic tolerance 68
16.1. Pharmacological preconditioning 69
16.2. Thrombin preconditioning 69
16.3. Erythropoetin preconditioning 70
16.4. Hypothermia preconditioning 71
16.5. Other substances 72
17. From animal experiments to clinical practice 74
18. Clinical aspects of cerebral ischemic tolerance 76
18.1. Prestroke transient ischemic attack 77
18.2. Reperfusion 79
18.3. Chronic mild reduction of perfusion pressure 80
19. Remote preconditioning 82
20. Postconditioning 84
20.1. Mechanism of postconditioning 86
21. Remote postconditioning 88
22. Time window 90
23. Postconditioning vs. preconditioning 92
24. Controversies in the experimental and clinical application of preconditioning 95
25. Therapeutic implications of ischemic tolerance 97
25.1. Preconditioning 98
25.2. Anesthetics 100
25.3. Postconditioning 103
26. Prospects to the future 104
26.1. Preconditioning 105
26.2. Postconditioning 107
27. Conclusion 108
28. References 111 |
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| id | DE-604.BV022226768 |
| illustrated | Illustrated |
| index_date | 2024-07-02T16:31:12Z |
| indexdate | 2024-07-09T20:52:49Z |
| institution | BVB |
| isbn | 9783899634433 3899634438 |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-015437907 |
| oclc_num | 181358994 |
| open_access_boolean | |
| owner | DE-12 DE-19 DE-BY-UBM |
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| physical | 135 S. graph. Darst. 22 cm, 300 gr. |
| publishDate | 2006 |
| publishDateSearch | 2006 |
| publishDateSort | 2006 |
| publisher | Verl. Dr. Hut |
| record_format | marc |
| series2 | Biochemie |
| spelling | Schaller, Bernhard Verfasser aut Cerebral ischemic tolerance from bench-to-bedside Bernhard J. Schaller 1. Aufl. München Verl. Dr. Hut 2006 135 S. graph. Darst. 22 cm, 300 gr. txt rdacontent n rdamedia nc rdacarrier Biochemie Brain Ischemia physiopathology Brain Ischemia therapy Disease Models, Animal Ischemic Preconditioning Ischämie (DE-588)4162456-7 gnd rswk-swf Toleranz Biologie (DE-588)4308830-2 gnd rswk-swf Hirnkrankheit (DE-588)4025013-1 gnd rswk-swf Hirnkrankheit (DE-588)4025013-1 s Ischämie (DE-588)4162456-7 s Toleranz Biologie (DE-588)4308830-2 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015437907&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Schaller, Bernhard Cerebral ischemic tolerance from bench-to-bedside Brain Ischemia physiopathology Brain Ischemia therapy Disease Models, Animal Ischemic Preconditioning Ischämie (DE-588)4162456-7 gnd Toleranz Biologie (DE-588)4308830-2 gnd Hirnkrankheit (DE-588)4025013-1 gnd |
| subject_GND | (DE-588)4162456-7 (DE-588)4308830-2 (DE-588)4025013-1 |
| title | Cerebral ischemic tolerance from bench-to-bedside |
| title_auth | Cerebral ischemic tolerance from bench-to-bedside |
| title_exact_search | Cerebral ischemic tolerance from bench-to-bedside |
| title_exact_search_txtP | Cerebral ischemic tolerance from bench-to-bedside |
| title_full | Cerebral ischemic tolerance from bench-to-bedside Bernhard J. Schaller |
| title_fullStr | Cerebral ischemic tolerance from bench-to-bedside Bernhard J. Schaller |
| title_full_unstemmed | Cerebral ischemic tolerance from bench-to-bedside Bernhard J. Schaller |
| title_short | Cerebral ischemic tolerance |
| title_sort | cerebral ischemic tolerance from bench to bedside |
| title_sub | from bench-to-bedside |
| topic | Brain Ischemia physiopathology Brain Ischemia therapy Disease Models, Animal Ischemic Preconditioning Ischämie (DE-588)4162456-7 gnd Toleranz Biologie (DE-588)4308830-2 gnd Hirnkrankheit (DE-588)4025013-1 gnd |
| topic_facet | Brain Ischemia physiopathology Brain Ischemia therapy Disease Models, Animal Ischemic Preconditioning Ischämie Toleranz Biologie Hirnkrankheit |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015437907&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT schallerbernhard cerebralischemictolerancefrombenchtobedside |