Transgenic animal mutagenicity assays:
This document provides an introduction to the field of transgenic mutagenicity assays and assesses the possible role of these assays in toxicology testing and mechanistic research. Part I gives a short overview of in vivo genotoxicity testing. Part II gives an overview of the data produced by variou...
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Geneva
World Health Organization
2006
|
| Schriftenreihe: | Environmental health criteria
233 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Zusammenfassung: | This document provides an introduction to the field of transgenic mutagenicity assays and assesses the possible role of these assays in toxicology testing and mechanistic research. Part I gives a short overview of in vivo genotoxicity testing. Part II gives an overview of the data produced by various assays. Part III discusses the use of the assays in research. Part IV evaluates the role and potential added value of transgenic mutation assays in toxicology and risk assessment. This document is directed at toxicologists, research scientists and risk assessors.--Publisher's description. |
| Beschreibung: | XXV, 298 S. Ill., graph. Darst. |
| ISBN: | 9241572337 |
Internformat
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| 245 | 1 | 0 | |a Transgenic animal mutagenicity assays |c first draft prep. by Ulrich Wahnschaffe ... |
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| 490 | 1 | |a Environmental health criteria |v 233 | |
| 520 | 3 | |a This document provides an introduction to the field of transgenic mutagenicity assays and assesses the possible role of these assays in toxicology testing and mechanistic research. Part I gives a short overview of in vivo genotoxicity testing. Part II gives an overview of the data produced by various assays. Part III discusses the use of the assays in research. Part IV evaluates the role and potential added value of transgenic mutation assays in toxicology and risk assessment. This document is directed at toxicologists, research scientists and risk assessors.--Publisher's description. | |
| 650 | 4 | |a Animaux transgéniques | |
| 650 | 7 | |a Camundongos (genética) |2 larpcal | |
| 650 | 7 | |a Exposição ambiental |2 larpcal | |
| 650 | 7 | |a Medição de risco |2 larpcal | |
| 650 | 7 | |a Mutageniteit |2 gtt | |
| 650 | 4 | |a Mutagénicité | |
| 650 | 7 | |a Mutagênese (testes) |2 larpcal | |
| 650 | 4 | |a Risques pour la santé - Évaluation | |
| 650 | 7 | |a Tests |2 gtt | |
| 650 | 4 | |a Toxicologie génétique | |
| 650 | 7 | |a Transgene organismen |2 gtt | |
| 650 | 4 | |a Animals, Genetically Modified |x genetics | |
| 650 | 4 | |a Genetic toxicology | |
| 650 | 4 | |a Health risk assessment | |
| 650 | 4 | |a Mutagenicity Tests | |
| 650 | 4 | |a Mutagenicity testing | |
| 650 | 4 | |a Mutagens |x toxicity | |
| 650 | 4 | |a Risk Assessment | |
| 650 | 4 | |a Transgenic animals | |
| 650 | 0 | 7 | |a Versuchstiere |0 (DE-588)4078861-1 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Transgene Tiere |0 (DE-588)4279021-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Mutagenitätstest |0 (DE-588)4261911-7 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Transgene Tiere |0 (DE-588)4279021-9 |D s |
| 689 | 0 | 1 | |a Versuchstiere |0 (DE-588)4078861-1 |D s |
| 689 | 0 | 2 | |a Mutagenitätstest |0 (DE-588)4261911-7 |D s |
| 689 | 0 | |C b |5 DE-604 | |
| 700 | 1 | |a Wahnschaffe, Ulrich |e Sonstige |4 oth | |
| 830 | 0 | |a Environmental health criteria |v 233 |w (DE-604)BV000011459 |9 233 | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-015429794 | ||
Datensatz im Suchindex
| _version_ | 1804136200965980160 |
|---|---|
| adam_text | CONTENTS
ENVIRONMENTAL HEALTH CRITERIA FOR
TRANSGENIC ANIMAL MUTAGENICITY ASSAYS
PREAMBLE x
ACRONYMS AND ABBREVIATIONS xix
GLOSSARY xxii
1. SUMMARY 1
PART I: OVERVIEW OF GENOTOXICITY TESTING AND
TRANSGENIC ANIMAL MUTAGENICITY SYSTEMS 7
2. OVERVIEW OF GENOTOXICITY TESTING 8
2.1 Gene mutation assays in vivo using endogenous
genes 8
2.2 Gene mutation assays in vivo using transgenes 8
3. CONSTRUCTION/PRODUCTION OF TRANSGENIC
ANIMALS USING AS EXAMPLES THE LACI AND
LACZ MUTATION MODELS 10
3.1 The foreign gene construct 10
3.2 Generation of transgenic animals with shuttle
vectors: the transfer method 10
3.3 Strains and species used 12
3.4 Target or reporter genes — the lac operon 12
3.5 Transgene shuttle vectors 13
3.6 Transgenic animal models 14
3.6.1 lad transgenic model — the Big Blue*
construct 14
3.6.2 lacZ transgenic mouse model — the
Muta™Mouse construct 15
EHC 233: Transgenic Animal Mutagenicity Assays
4. THE TRANSGENIC MUTAGENICITY ASSAY —
METHODOLOGY USING AS EXAMPLES LACI AND
LACZ MUTATION MODELS 16
4.1 Treatment schemes 16
4.2 Collection of (target) tissues and isolation of DNA 16
4.3 Recovery of the DNA construct of the shuttle vector
from the genomic DNA and in vitro packaging 16
4.4 Infection into bacteria and plating 18
4.5 Detection and quantification of mutations 18
4.5.1 Big Blue® system 18
4.5.2 Muta™Mouse system 19
5. FURTHER TRANSGENIC MUTAGENICITY ASSAYS 21
5.1 MI assay (Big Blue® and Muta™Mouse) 21
5.2 gpt delta model 24
5.2.1 gpt delta rodents 24
5.2.2 6 TG selection 24
5.2.3 Spf selection 24
5.3 The /acZ plasmid model 26
5.4 Upcoming transgenic models for which no extensive
data are available 27
5.4.1 1 X174 transgenic mouse model 27
5.4.2 XsupF transgenic mouse 28
5.4.3 pKZl transgenic recombination model 28
5.4.4 rpsL transgenic mouse model 29
6. PARAMETERS AND CRITERIA FOR VALID
EXPERIMENTAL DESIGN 30
6.1 Determinants studied using transgenic mutation
assays 30
6.1.1 Types of mutations 30
6.1.2 Overall mutant/mutation frequency 30
6.1.3 Spontaneous mutant frequency 31
6.1.4 Sequence analysis 31
6.2 Criteria for valid experimental design of transgenic
mutation assays 32
6.2.1 Selection of the most suitable model 32
6.2.2 Duration of exposure 32
6.2.3 Selection of the dose 33
EHC 233: Transgenic Animal Mutagenicity Assays
, 6.2.4 Post treatment manifestation time 33
6.2.5 Significance of a negative result 35
6.2.6 Factors to consider when comparing the
performance of mutation assays 35
6.2.7 Positive control 36
6.2.8 Sensitivity 36
6.2.9 Statistics 37
6.2.10 Analysis of DNA sequence 3 7
6.2.11 Use of transgenic assays in the detection of
gene mutations in germ cells 38
PART II: COMPARISON OF THE LACI MODEL AND THE
LACZ MODEL WITH CONVENTIONAL TEST SYSTEMS 39
7. INTRODUCTION TO PART II 40
7.1 Aim of the comparison and criteria for the selection
of data 40
7.2 Choice and limitations of data 41
7.3 Validity of data on transgenic animal mutation assays 42
7.4 Criteria for predictivity of transgenic assays 43
8. COMPARISON OF THE MUTA™MOUSE AND BIG
BLUE® ASSAYS 44
9. TRANSGENIC ASSAYS — COMPARISON WITH
OTHER ASSAYS 46
9.1 The Muta™Mouse assay and the Big Blue® mouse
assay versus the mouse bone marrow micronucleus
test 46
9.1.1 The mouse bone marrow micronucleus test:
principles and procedures 61
9.1.2 Comparison of data from the mouse bone
marrow micronucleus test and transgenic
mouse test 61
9.1.2.1 Bone marrow 61
9.1.2.2 All organs 63
9.1.3 Predictivity of the transgenic animal
mutagenicity assays and the mouse bone
marrow micronucleus test for carcinogenicity 63
EHC 233: Transgenic Animal Mutagenicity Assays
9.1.4 Comparison of both test systems 66
9.1.5 Conclusions 68
9.2 The Muta™Mouse assay and the Big Blue® mouse
or rat assay versus assays using endogenous reporter
genes 70
9.2.1 Results in the mouse spot test compared with
those from transgenic animals 70
9.2.1.1 Description of the mouse spot test 71
9.2.1.2 Comparison of the mouse spot test
with transgenic mouse model systems 71
9.2.1.3 Predictivity of the transgenic animal
mutagenicity assays and the mouse
spot test for carcinogenicity 78
9.2.1.4 Advantages and disadvantages of
both test systems 79
9.2.1.5 Conclusions 80
9.2.2 Transgenic animal mutagenicity assay versus
Hprt and other endogenous genes 82
9.2.2.1 Description of endogenous gene
animal models 87
9.2.2.2 Comparative studies 89
9.2.2.3 Conclusion 93
9.3 Transgenic animal mutagenicity assays and indirect
measure of DNA damage using UDS in vivo assay 94
9.4 Results of transgenic animal mutagenicity assays
compared with results of genotoxicity assays in vitro 94
9.4.1 Gene mutation 95
9.4.2 Chromosomal aberration 95
9.4.3 Direct or indirect measure of DNA damage 103
9.4.4 Conclusion 103
10. TRANSGENIC ASSAYS AND CARCINOGENICITY
TESTING 104
10.1 Comparison of target organs in carcinogenicity
studies with target organs in transgenic animal
mutation assays 104
10.1.1 Pattern of target organs 104
10.1.2 Analysis of the predictivity for the liver as
target organ 121
10.1.3 Conclusion 127
EHC 233: Transgenic Animal Mutagenicity Assays
10.2 Comparison of results of carcinogenicity studies with
results from transgenic animal mutagenicity assays 128
10.2.1 Non genotoxic carcinogens 139
10.2.2 Validity of data on transgenic animal
mutation assays 139
10.2.3 Evaluation of the predictivity for
carcinogenicity in mice 140
10.2.4 Conclusion 148
PART III: APPLICATIONS OF TRANSGENIC ANIMAL
MUTAGENICITY STUDIES 149_
11. MUTATION FREQUENCIES AND SEQUENCING DATA
AND APPLICATIONS OF THIS INFORMATION IN
MECHANISTIC STUDIES 150
11.1 Studies on spontaneous mutant/mutation frequencies
(in organs of non exposed transgenic animals) 150
11.1.1 Sources of spontaneous mutations 150
11.1.2 Spontaneous mutation data: sequence data in
organs of non exposed transgenic animals 151
11.1.3 The frequency and nature of spontaneous
mutations versus age in multiple tissues 152
11.2 Examination of fundamental paradigms in genetic
toxicology 154
11.2.1 Dose response relationships 155
11.2.2 Correlation of dose with mutation frequency
and carcinogenicity 157
11.2.3 Relationship between DNA adducts, cell
proliferation and gene mutations 158
11.3 Studies into the mechanism of action of
mutagenicity/carcinogenicity using sequence data 161
11.3.1 Clonal correction and correction for ex vivo
mutations 161
11.3.2 Premutagenic lesions 162
11.3.3 Tissue specific responses 164
11.3.4 Evaluation of genotoxicants that do not
appear to interact with DNA 166
11.3.5 Active components of mixtures 166
11.3.6 Active metabolites 166
11.3.7 Investigations into the mechanisms of
deletion mutations in vivo 167
EHC 233: Transgenic Animal Mutagenicity Assays
11.4 Importance of the transgenic mutation assays for
studies other than genetic toxicology 169
PART IV: EVALUATION, CONCLUSIONS AND
RECOMMENDATIONS 171_
12. EVALUATION OF THE TRANSGENIC ANIMAL
MUTAGENICITY ASSAYS BASED ON THIS
REVIEW OF THE CURRENT LITERATURE 172
12.1 Features of the assay 172
12.2 Gene mutation assay — implications for testing 172
12.2.1 Reliability of a negative result 173
12.3 Comparison with endogenous genes 174
12.4 Molecular analysis and mechanistic studies 174
12.5 Animal welfare and economy 175
13. CONCLUSIONS 177
14. RECOMMENDATIONS 178
REFERENCES 179
APPENDIX 1: MASTER TABLE 215
APPENDIX 2: THE CII ASSAY IN TRANSGENIC
RODENT STUDIES 279
RESUME 287
RESUMEN 293
vtt
|
| adam_txt |
CONTENTS
ENVIRONMENTAL HEALTH CRITERIA FOR
TRANSGENIC ANIMAL MUTAGENICITY ASSAYS
PREAMBLE x
ACRONYMS AND ABBREVIATIONS xix
GLOSSARY xxii
1. SUMMARY 1
PART I: OVERVIEW OF GENOTOXICITY TESTING AND
TRANSGENIC ANIMAL MUTAGENICITY SYSTEMS 7
2. OVERVIEW OF GENOTOXICITY TESTING 8
2.1 Gene mutation assays in vivo using endogenous
genes 8
2.2 Gene mutation assays in vivo using transgenes 8
3. CONSTRUCTION/PRODUCTION OF TRANSGENIC
ANIMALS USING AS EXAMPLES THE LACI AND
LACZ MUTATION MODELS 10
3.1 The foreign gene construct 10
3.2 Generation of transgenic animals with shuttle
vectors: the transfer method 10
3.3 Strains and species used 12
3.4 Target or reporter genes — the lac operon 12
3.5 Transgene shuttle vectors 13
3.6 Transgenic animal models 14
3.6.1 lad transgenic model — the Big Blue*
construct 14
3.6.2 lacZ transgenic mouse model — the
Muta™Mouse construct 15
EHC 233: Transgenic Animal Mutagenicity Assays
4. THE TRANSGENIC MUTAGENICITY ASSAY —
METHODOLOGY USING AS EXAMPLES LACI AND
LACZ MUTATION MODELS 16
4.1 Treatment schemes 16
4.2 Collection of (target) tissues and isolation of DNA 16
4.3 Recovery of the DNA construct of the shuttle vector
from the genomic DNA and in vitro packaging 16
4.4 Infection into bacteria and plating 18
4.5 Detection and quantification of mutations 18
4.5.1 Big Blue® system 18
4.5.2 Muta™Mouse system 19
5. FURTHER TRANSGENIC MUTAGENICITY ASSAYS 21
5.1 MI assay (Big Blue® and Muta™Mouse) 21
5.2 gpt delta model 24
5.2.1 gpt delta rodents 24
5.2.2 6 TG selection 24
5.2.3 Spf selection 24
5.3 The /acZ plasmid model 26
5.4 Upcoming transgenic models for which no extensive
data are available 27
5.4.1 1 X174 transgenic mouse model 27
5.4.2 XsupF transgenic mouse 28
5.4.3 pKZl transgenic recombination model 28
5.4.4 rpsL transgenic mouse model 29
6. PARAMETERS AND CRITERIA FOR VALID
EXPERIMENTAL DESIGN 30
6.1 Determinants studied using transgenic mutation
assays 30
6.1.1 Types of mutations 30
6.1.2 Overall mutant/mutation frequency 30
6.1.3 Spontaneous mutant frequency 31
6.1.4 Sequence analysis 31
6.2 Criteria for valid experimental design of transgenic
mutation assays 32
6.2.1 Selection of the most suitable model 32
6.2.2 Duration of exposure 32
6.2.3 Selection of the dose 33
EHC 233: Transgenic Animal Mutagenicity Assays
, 6.2.4 Post treatment manifestation time 33
6.2.5 Significance of a negative result 35
6.2.6 Factors to consider when comparing the
performance of mutation assays 35
6.2.7 Positive control 36
6.2.8 Sensitivity 36
6.2.9 Statistics 37
6.2.10 Analysis of DNA sequence 3 7
6.2.11 Use of transgenic assays in the detection of
gene mutations in germ cells 38
PART II: COMPARISON OF THE LACI MODEL AND THE
LACZ MODEL WITH CONVENTIONAL TEST SYSTEMS 39
7. INTRODUCTION TO PART II 40
7.1 Aim of the comparison and criteria for the selection
of data 40
7.2 Choice and limitations of data 41
7.3 Validity of data on transgenic animal mutation assays 42
7.4 Criteria for predictivity of transgenic assays 43
8. COMPARISON OF THE MUTA™MOUSE AND BIG
BLUE® ASSAYS 44
9. TRANSGENIC ASSAYS — COMPARISON WITH
OTHER ASSAYS 46
9.1 The Muta™Mouse assay and the Big Blue® mouse
assay versus the mouse bone marrow micronucleus
test 46
9.1.1 The mouse bone marrow micronucleus test:
principles and procedures 61
9.1.2 Comparison of data from the mouse bone
marrow micronucleus test and transgenic
mouse test 61
9.1.2.1 Bone marrow 61
9.1.2.2 All organs 63
9.1.3 Predictivity of the transgenic animal
mutagenicity assays and the mouse bone
marrow micronucleus test for carcinogenicity 63
EHC 233: Transgenic Animal Mutagenicity Assays
9.1.4 Comparison of both test systems 66
9.1.5 Conclusions 68
9.2 The Muta™Mouse assay and the Big Blue® mouse
or rat assay versus assays using endogenous reporter
genes 70
9.2.1 Results in the mouse spot test compared with
those from transgenic animals 70
9.2.1.1 Description of the mouse spot test 71
9.2.1.2 Comparison of the mouse spot test
with transgenic mouse model systems 71
9.2.1.3 Predictivity of the transgenic animal
mutagenicity assays and the mouse
spot test for carcinogenicity 78
9.2.1.4 Advantages and disadvantages of
both test systems 79
9.2.1.5 Conclusions 80
9.2.2 Transgenic animal mutagenicity assay versus
Hprt and other endogenous genes 82
9.2.2.1 Description of endogenous gene
animal models 87
9.2.2.2 Comparative studies 89
9.2.2.3 Conclusion 93
9.3 Transgenic animal mutagenicity assays and indirect
measure of DNA damage using UDS in vivo assay 94
9.4 Results of transgenic animal mutagenicity assays
compared with results of genotoxicity assays in vitro 94
9.4.1 Gene mutation 95
9.4.2 Chromosomal aberration 95
9.4.3 Direct or indirect measure of DNA damage 103
9.4.4 Conclusion 103
10. TRANSGENIC ASSAYS AND CARCINOGENICITY
TESTING 104
10.1 Comparison of target organs in carcinogenicity
studies with target organs in transgenic animal
mutation assays 104
10.1.1 Pattern of target organs 104
10.1.2 Analysis of the predictivity for the liver as
target organ 121
10.1.3 Conclusion 127
EHC 233: Transgenic Animal Mutagenicity Assays
10.2 Comparison of results of carcinogenicity studies with
results from transgenic animal mutagenicity assays 128
10.2.1 Non genotoxic carcinogens 139
10.2.2 Validity of data on transgenic animal
mutation assays 139
10.2.3 Evaluation of the predictivity for
carcinogenicity in mice 140
10.2.4 Conclusion 148
PART III: APPLICATIONS OF TRANSGENIC ANIMAL
MUTAGENICITY STUDIES 149_
11. MUTATION FREQUENCIES AND SEQUENCING DATA
AND APPLICATIONS OF THIS INFORMATION IN
MECHANISTIC STUDIES 150
11.1 Studies on spontaneous mutant/mutation frequencies
(in organs of non exposed transgenic animals) 150
11.1.1 Sources of spontaneous mutations 150
11.1.2 Spontaneous mutation data: sequence data in
organs of non exposed transgenic animals 151
11.1.3 The frequency and nature of spontaneous
mutations versus age in multiple tissues 152
11.2 Examination of fundamental paradigms in genetic
toxicology 154
11.2.1 Dose response relationships 155
11.2.2 Correlation of dose with mutation frequency
and carcinogenicity 157
11.2.3 Relationship between DNA adducts, cell
proliferation and gene mutations 158
11.3 Studies into the mechanism of action of
mutagenicity/carcinogenicity using sequence data 161
11.3.1 Clonal correction and correction for ex vivo
mutations 161
11.3.2 Premutagenic lesions 162
11.3.3 Tissue specific responses 164
11.3.4 Evaluation of genotoxicants that do not
appear to interact with DNA 166
11.3.5 Active components of mixtures 166
11.3.6 Active metabolites 166
11.3.7 Investigations into the mechanisms of
deletion mutations in vivo 167
EHC 233: Transgenic Animal Mutagenicity Assays
11.4 Importance of the transgenic mutation assays for
studies other than genetic toxicology 169
PART IV: EVALUATION, CONCLUSIONS AND
RECOMMENDATIONS 171_
12. EVALUATION OF THE TRANSGENIC ANIMAL
MUTAGENICITY ASSAYS BASED ON THIS
REVIEW OF THE CURRENT LITERATURE 172
12.1 Features of the assay 172
12.2 Gene mutation assay — implications for testing 172
12.2.1 Reliability of a negative result 173
12.3 Comparison with endogenous genes 174
12.4 Molecular analysis and mechanistic studies 174
12.5 Animal welfare and economy 175
13. CONCLUSIONS 177
14. RECOMMENDATIONS 178
REFERENCES 179
APPENDIX 1: MASTER TABLE 215
APPENDIX 2: THE CII ASSAY IN TRANSGENIC
RODENT STUDIES 279
RESUME 287
RESUMEN 293
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| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02984nam a2200649 cb4500</leader><controlfield tag="001">BV022218544</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20070122 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">070109s2006 ad|| |||| 00||| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9241572337</subfield><subfield code="9">92-4-157233-7</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="z">9879241572337</subfield><subfield code="9">987-92-4-157233-7</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)77516640</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV022218544</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-12</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RA1224.4.M86</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">636.0821</subfield><subfield code="2">22</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Transgenic animal mutagenicity assays</subfield><subfield code="c">first draft prep. by Ulrich Wahnschaffe ...</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Geneva</subfield><subfield code="b">World Health Organization</subfield><subfield code="c">2006</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XXV, 298 S.</subfield><subfield code="b">Ill., graph. 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Part IV evaluates the role and potential added value of transgenic mutation assays in toxicology and risk assessment. 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| id | DE-604.BV022218544 |
| illustrated | Illustrated |
| index_date | 2024-07-02T16:28:20Z |
| indexdate | 2024-07-09T20:52:38Z |
| institution | BVB |
| isbn | 9241572337 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-015429794 |
| oclc_num | 77516640 |
| open_access_boolean | |
| owner | DE-12 |
| owner_facet | DE-12 |
| physical | XXV, 298 S. Ill., graph. Darst. |
| publishDate | 2006 |
| publishDateSearch | 2006 |
| publishDateSort | 2006 |
| publisher | World Health Organization |
| record_format | marc |
| series | Environmental health criteria |
| series2 | Environmental health criteria |
| spelling | Transgenic animal mutagenicity assays first draft prep. by Ulrich Wahnschaffe ... Geneva World Health Organization 2006 XXV, 298 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Environmental health criteria 233 This document provides an introduction to the field of transgenic mutagenicity assays and assesses the possible role of these assays in toxicology testing and mechanistic research. Part I gives a short overview of in vivo genotoxicity testing. Part II gives an overview of the data produced by various assays. Part III discusses the use of the assays in research. Part IV evaluates the role and potential added value of transgenic mutation assays in toxicology and risk assessment. This document is directed at toxicologists, research scientists and risk assessors.--Publisher's description. Animaux transgéniques Camundongos (genética) larpcal Exposição ambiental larpcal Medição de risco larpcal Mutageniteit gtt Mutagénicité Mutagênese (testes) larpcal Risques pour la santé - Évaluation Tests gtt Toxicologie génétique Transgene organismen gtt Animals, Genetically Modified genetics Genetic toxicology Health risk assessment Mutagenicity Tests Mutagenicity testing Mutagens toxicity Risk Assessment Transgenic animals Versuchstiere (DE-588)4078861-1 gnd rswk-swf Transgene Tiere (DE-588)4279021-9 gnd rswk-swf Mutagenitätstest (DE-588)4261911-7 gnd rswk-swf Transgene Tiere (DE-588)4279021-9 s Versuchstiere (DE-588)4078861-1 s Mutagenitätstest (DE-588)4261911-7 s b DE-604 Wahnschaffe, Ulrich Sonstige oth Environmental health criteria 233 (DE-604)BV000011459 233 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015429794&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Transgenic animal mutagenicity assays Environmental health criteria Animaux transgéniques Camundongos (genética) larpcal Exposição ambiental larpcal Medição de risco larpcal Mutageniteit gtt Mutagénicité Mutagênese (testes) larpcal Risques pour la santé - Évaluation Tests gtt Toxicologie génétique Transgene organismen gtt Animals, Genetically Modified genetics Genetic toxicology Health risk assessment Mutagenicity Tests Mutagenicity testing Mutagens toxicity Risk Assessment Transgenic animals Versuchstiere (DE-588)4078861-1 gnd Transgene Tiere (DE-588)4279021-9 gnd Mutagenitätstest (DE-588)4261911-7 gnd |
| subject_GND | (DE-588)4078861-1 (DE-588)4279021-9 (DE-588)4261911-7 |
| title | Transgenic animal mutagenicity assays |
| title_auth | Transgenic animal mutagenicity assays |
| title_exact_search | Transgenic animal mutagenicity assays |
| title_exact_search_txtP | Transgenic animal mutagenicity assays |
| title_full | Transgenic animal mutagenicity assays first draft prep. by Ulrich Wahnschaffe ... |
| title_fullStr | Transgenic animal mutagenicity assays first draft prep. by Ulrich Wahnschaffe ... |
| title_full_unstemmed | Transgenic animal mutagenicity assays first draft prep. by Ulrich Wahnschaffe ... |
| title_short | Transgenic animal mutagenicity assays |
| title_sort | transgenic animal mutagenicity assays |
| topic | Animaux transgéniques Camundongos (genética) larpcal Exposição ambiental larpcal Medição de risco larpcal Mutageniteit gtt Mutagénicité Mutagênese (testes) larpcal Risques pour la santé - Évaluation Tests gtt Toxicologie génétique Transgene organismen gtt Animals, Genetically Modified genetics Genetic toxicology Health risk assessment Mutagenicity Tests Mutagenicity testing Mutagens toxicity Risk Assessment Transgenic animals Versuchstiere (DE-588)4078861-1 gnd Transgene Tiere (DE-588)4279021-9 gnd Mutagenitätstest (DE-588)4261911-7 gnd |
| topic_facet | Animaux transgéniques Camundongos (genética) Exposição ambiental Medição de risco Mutageniteit Mutagénicité Mutagênese (testes) Risques pour la santé - Évaluation Tests Toxicologie génétique Transgene organismen Animals, Genetically Modified genetics Genetic toxicology Health risk assessment Mutagenicity Tests Mutagenicity testing Mutagens toxicity Risk Assessment Transgenic animals Versuchstiere Transgene Tiere Mutagenitätstest |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015429794&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000011459 |
| work_keys_str_mv | AT wahnschaffeulrich transgenicanimalmutagenicityassays |