Glutathione response to cadmium in fish cells in vitro and in vivo: relation to metallothionein, cadmium accumulation and cadmium cytotoxicity
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| Language: | English |
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Leipzig [u.a.]
UFZ - Umweltforschungszentrum Leipzig-Halle
2002
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| Series: | UFZ-Bericht
2002,3 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Zugl.: Halle-Wittenberg, Univ., Diss., 2002. -Zsfassung in dt. Sprache |
| Physical Description: | III, 145 S. graph. Darst. |
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| adam_text | Titel: Glutathione response to cadmium in fish cells in vitro and in vivo
Autor: Lange, Anke
Jahr: 2002
CONTENTS
Contents..................................................................................................................................I
List of abbreviations...........................................................................................................IV
GENERAL INTRODUCTION_______________________________________________1
1.1 Metal uptake and toxicity in fish..........................................................................................1
1.2 Cellular defense mechanisms against metal toxicity...........................................................3
1.3 Glutathione...........................................................................................................................4
1.4 Metallothionein....................................................................................................................6
1.4.1 Characterization of metallothionein.............................................................................6
1.4.2 Induction and synthesis of metallothionein..................................................................7
1.4.3 Physiological role of metallothionein...........................................................................9
1.5 Glutathione and metallothionein in the intracellular fate of heavy metals........................10
1.6 Aims of the thesis...............................................................................................................11
1.7 References..........................................................................................................................14
CHAPTER 1: Aterations of tissue glutathione levels and metallothionein mRNA in
rainbow trout during single and combined exposure to cadmium and zinc____..19
1.1 Abstract..............................................................................................................................20
1.2 Introduction........................................................................................................................20
1.3 Materials and Methods.......................................................................................................22
1.4 Results................................................................................................................................26
1.5 Discussion..........................................................................................................................34
1.6 References..........................................................................................................................39
CHAPTER 2: Glutathione response offish cells in vitro to cadmium exposure:
The influence of the cellular thiol status_____..__________.______..........______.43
2.1 Abstract..............................................................................................................................44
2.2 Introduction........................................................................................................................45
2.3 Material and Methods........................................................................................................49
2.4 Results................................................................................................................................57
2.4.1 Characterization of cellular models............................................................................57
2.4.1.1 Levels of total GSH and cysteine after different pretreatments....................................57
2.4.1.2 Recovery of total GSH in RTG-2 cells after GSH depletion........................................58
2.4.1.3 Induction ofMT gene transcription after Zn pre-exposure...........................................59
I
2.4.1.4 Cd cytotoxicity in RTG-2 and CHSE-214 cells with different thiol status...................59
2.4.2 Time- and concentration-dependent effects of Cd on intracellular levels of total
GSH, cysteine and glutathione disulfide in RTG-2 and CHSE-214 cells with
different thiol status....................................................................................................60
2.4.2.1 Response of total GSH to time- and concentration-dependent Cd exposure................61
2.4.2.2 Response of total cysteine to time- and concentration-dependent Cd exposure...........63
2.4.2.3 Response of GSSG to time- and concentration-dependent Cd exposure......................65
2.4.2.4 The GSSG/GSH-ratio after time- and concentration-dependent Cd exposure..............66
2.4.3 Time- and concentration-dependent effects of Cd on cellular levels of MT mRNA
in differently pretreated RTG-2 and CHSE-214 cells................................................68
2.4.4 Effects of Cd on cellular levels of total GSH, cysteine, GSSG and MT mRNA in
carp hepatocytes.........................................................................................................70
2.5 Discussion..........................................................................................................................71
2.5.1 Characterization of the cellular models......................................................................72
2.5.1.1 Effects of GSH depletion on cellular thiols..................................................................72
2.5.1.2 Effects of Zn pretreatment on cellular thiols.................................................................73
2.5.1.3 Effect of cellular thiol status on Cd cytotoxicity...........................................................74
2.5.2 Effects of Cd on cellular levels of total GSH: Importance of the cellular
thiol status...................................................................................................................76
2.5.3 Effects of Cd on cellular levels of total cysteine: Importance of the cellular
thiol status...................................................................................................................78
2.5.4 Effects of Cd on cellular MT mRNA: Importance of the cellular thiol status............79
2.5.5 Effects of Cd on cellular thiol levels of carp hepatocytes..........................................81
2.6 Conclusions........................................................................................................................83
2.7 References..........................................................................................................................84
CHAPTER 3: The role of glutathione and sulfhydryl groups in cadmium uptake
by cultures of the rainbow trout RTG-2 cell line------------------------------------------90
3.1 Abstract..............................................................................................................................91
3.2 Introduction........................................................................................................................91
3.3 Material and Methods........................................................................................................94
3.4 Results................................................................................................................................98
3.4.1 Time course of cadmium uptake and effects on total GSH and cysteine...................98
3.4.2 Effects of a sulfhydryl group blocker on Cd uptake and total GSH...........................99
3.4.3 Effect of intracellular GSH on Cd uptake.................................................................100
3.5 Discussion........................................................................................................................102
3.5.1 Interrelation of Cd uptake and intracellular thiol response.......................................102
3.5.2 Role of sulfhydryl groups in Cd uptake....................................................................104
n
3.5.3 Possible mechanisms for sulfhydiyl-mediated Cd uptake........................................106
3.6 References........................................................................................................................107
GENERAL DISCUSSION______________......._______________________________109
4.1 Introduction......................................................................................................................109
4.2 Cellular response of total GSH to in vivo and in vitro metal exposure...........................110
4.3 Effects of in vivo and in vitro heavy metal exposure on MT gene transcription.............113
4.4 Comparison of the cellular total GSH and MT responses to in vivo and
in vitro metal stress..........................................................................................................115
4.5 Do the two thiol pools, GSH and MT, influence each other?..........................................117
4.6 The role cellular thiols in cytoprotection against metal toxicity related to intracellular
metal concentrations........................................................................................................119
4.7 Effects of GSH (and sulfhydryl groups in general) on cellular metal uptake..................121
4.8 General Conclusions........................................................................................................122
4.9 Perspectives......................................................................................................................122
4.10References........................................................................................................................124
SUMMARY________________________________________________________127
ZUSAMMENFASSUNG______________________________________________133
Appendix...............................................................................................................................137
Acknowledgements............................................................................................................142
List of publications............................................................................................................143
Curriculum Vitae...............................................................................................................144
ffl
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| adam_txt |
Titel: Glutathione response to cadmium in fish cells in vitro and in vivo
Autor: Lange, Anke
Jahr: 2002
CONTENTS
Contents.I
List of abbreviations.IV
GENERAL INTRODUCTION_1
1.1 Metal uptake and toxicity in fish.1
1.2 Cellular defense mechanisms against metal toxicity.3
1.3 Glutathione.4
1.4 Metallothionein.6
1.4.1 Characterization of metallothionein.6
1.4.2 Induction and synthesis of metallothionein.7
1.4.3 Physiological role of metallothionein.9
1.5 Glutathione and metallothionein in the intracellular fate of heavy metals.10
1.6 Aims of the thesis.11
1.7 References.14
CHAPTER 1: Aterations of tissue glutathione levels and metallothionein mRNA in
rainbow trout during single and combined exposure to cadmium and zinc_.19
1.1 Abstract.20
1.2 Introduction.20
1.3 Materials and Methods.22
1.4 Results.26
1.5 Discussion.34
1.6 References.39
CHAPTER 2: Glutathione response offish cells in vitro to cadmium exposure:
The influence of the cellular thiol status_._._._.43
2.1 Abstract.44
2.2 Introduction.45
2.3 Material and Methods.49
2.4 Results.57
2.4.1 Characterization of cellular models.57
2.4.1.1 Levels of total GSH and cysteine after different pretreatments.57
2.4.1.2 Recovery of total GSH in RTG-2 cells after GSH depletion.58
2.4.1.3 Induction ofMT gene transcription after Zn pre-exposure.59
I
2.4.1.4 Cd cytotoxicity in RTG-2 and CHSE-214 cells with different thiol status.59
2.4.2 Time- and concentration-dependent effects of Cd on intracellular levels of total
GSH, cysteine and glutathione disulfide in RTG-2 and CHSE-214 cells with
different thiol status.60
2.4.2.1 Response of total GSH to time- and concentration-dependent Cd exposure.61
2.4.2.2 Response of total cysteine to time- and concentration-dependent Cd exposure.63
2.4.2.3 Response of GSSG to time- and concentration-dependent Cd exposure.65
2.4.2.4 The GSSG/GSH-ratio after time- and concentration-dependent Cd exposure.66
2.4.3 Time- and concentration-dependent effects of Cd on cellular levels of MT mRNA
in differently pretreated RTG-2 and CHSE-214 cells.68
2.4.4 Effects of Cd on cellular levels of total GSH, cysteine, GSSG and MT mRNA in
carp hepatocytes.70
2.5 Discussion.71
2.5.1 Characterization of the cellular models.72
2.5.1.1 Effects of GSH depletion on cellular thiols.72
2.5.1.2 Effects of Zn pretreatment on cellular thiols.73
2.5.1.3 Effect of cellular thiol status on Cd cytotoxicity.74
2.5.2 Effects of Cd on cellular levels of total GSH: Importance of the cellular
thiol status.76
2.5.3 Effects of Cd on cellular levels of total cysteine: Importance of the cellular
thiol status.78
2.5.4 Effects of Cd on cellular MT mRNA: Importance of the cellular thiol status.79
2.5.5 Effects of Cd on cellular thiol levels of carp hepatocytes.81
2.6 Conclusions.83
2.7 References.84
CHAPTER 3: The role of glutathione and sulfhydryl groups in cadmium uptake
by cultures of the rainbow trout RTG-2 cell line------------------------------------------90
3.1 Abstract.91
3.2 Introduction.91
3.3 Material and Methods.94
3.4 Results.98
3.4.1 Time course of cadmium uptake and effects on total GSH and cysteine.98
3.4.2 Effects of a sulfhydryl group blocker on Cd uptake and total GSH.99
3.4.3 Effect of intracellular GSH on Cd uptake.100
3.5 Discussion.102
3.5.1 Interrelation of Cd uptake and intracellular thiol response.102
3.5.2 Role of sulfhydryl groups in Cd uptake.104
n
3.5.3 Possible mechanisms for sulfhydiyl-mediated Cd uptake.106
3.6 References.107
GENERAL DISCUSSION_._109
4.1 Introduction.109
4.2 Cellular response of total GSH to in vivo and in vitro metal exposure.110
4.3 Effects of in vivo and in vitro heavy metal exposure on MT gene transcription.113
4.4 Comparison of the cellular total GSH and MT responses to in vivo and
in vitro metal stress.115
4.5 Do the two thiol pools, GSH and MT, influence each other?.117
4.6 The role cellular thiols in cytoprotection against metal toxicity related to intracellular
metal concentrations.119
4.7 Effects of GSH (and sulfhydryl groups in general) on cellular metal uptake.121
4.8 General Conclusions.122
4.9 Perspectives.122
4.10References.124
SUMMARY_127
ZUSAMMENFASSUNG_133
Appendix.137
Acknowledgements.142
List of publications.143
Curriculum Vitae.144
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| spelling | Lange, Anke Verfasser aut Glutathione response to cadmium in fish cells in vitro and in vivo relation to metallothionein, cadmium accumulation and cadmium cytotoxicity Leipzig [u.a.] UFZ - Umweltforschungszentrum Leipzig-Halle 2002 III, 145 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier UFZ-Bericht 2002,3 Zugl.: Halle-Wittenberg, Univ., Diss., 2002. -Zsfassung in dt. Sprache Bioakkumulation (DE-588)4275028-3 gnd rswk-swf Fische (DE-588)4017269-7 gnd rswk-swf Primärstoffwechsel (DE-588)4175700-2 gnd rswk-swf Cadmium (DE-588)4009274-4 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Cadmium (DE-588)4009274-4 s DE-604 Fische (DE-588)4017269-7 s Primärstoffwechsel (DE-588)4175700-2 s Bioakkumulation (DE-588)4275028-3 s UFZ-Bericht 2002,3 (DE-604)BV010126205 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015383336&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Lange, Anke Glutathione response to cadmium in fish cells in vitro and in vivo relation to metallothionein, cadmium accumulation and cadmium cytotoxicity UFZ-Bericht Bioakkumulation (DE-588)4275028-3 gnd Fische (DE-588)4017269-7 gnd Primärstoffwechsel (DE-588)4175700-2 gnd Cadmium (DE-588)4009274-4 gnd |
| subject_GND | (DE-588)4275028-3 (DE-588)4017269-7 (DE-588)4175700-2 (DE-588)4009274-4 (DE-588)4113937-9 |
| title | Glutathione response to cadmium in fish cells in vitro and in vivo relation to metallothionein, cadmium accumulation and cadmium cytotoxicity |
| title_auth | Glutathione response to cadmium in fish cells in vitro and in vivo relation to metallothionein, cadmium accumulation and cadmium cytotoxicity |
| title_exact_search | Glutathione response to cadmium in fish cells in vitro and in vivo relation to metallothionein, cadmium accumulation and cadmium cytotoxicity |
| title_exact_search_txtP | Glutathione response to cadmium in fish cells in vitro and in vivo relation to metallothionein, cadmium accumulation and cadmium cytotoxicity |
| title_full | Glutathione response to cadmium in fish cells in vitro and in vivo relation to metallothionein, cadmium accumulation and cadmium cytotoxicity |
| title_fullStr | Glutathione response to cadmium in fish cells in vitro and in vivo relation to metallothionein, cadmium accumulation and cadmium cytotoxicity |
| title_full_unstemmed | Glutathione response to cadmium in fish cells in vitro and in vivo relation to metallothionein, cadmium accumulation and cadmium cytotoxicity |
| title_short | Glutathione response to cadmium in fish cells in vitro and in vivo |
| title_sort | glutathione response to cadmium in fish cells in vitro and in vivo relation to metallothionein cadmium accumulation and cadmium cytotoxicity |
| title_sub | relation to metallothionein, cadmium accumulation and cadmium cytotoxicity |
| topic | Bioakkumulation (DE-588)4275028-3 gnd Fische (DE-588)4017269-7 gnd Primärstoffwechsel (DE-588)4175700-2 gnd Cadmium (DE-588)4009274-4 gnd |
| topic_facet | Bioakkumulation Fische Primärstoffwechsel Cadmium Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015383336&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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| work_keys_str_mv | AT langeanke glutathioneresponsetocadmiuminfishcellsinvitroandinvivorelationtometallothioneincadmiumaccumulationandcadmiumcytotoxicity |