Basic statistics and pharmaceutical statistical applications:
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Boca Raton [u.a.]
Chapman & Hall
2006
|
| Edition: | 2. ed. |
| Series: | Biostatistics
16 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | 714 S. Ill., graph. Darst. |
| ISBN: | 0849337992 |
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MARC
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| 100 | 1 | |a De Muth, James E. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Basic statistics and pharmaceutical statistical applications |c James E. De Muth |
| 250 | |a 2. ed. | ||
| 264 | 1 | |a Boca Raton [u.a.] |b Chapman & Hall |c 2006 | |
| 300 | |a 714 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Biostatistics |v 16 | |
| 650 | 7 | |a Estatística aplicada |2 larpcal | |
| 650 | 7 | |a Estatística |2 larpcal | |
| 650 | 7 | |a Farmácia (métodos estatísticos) |2 larpcal | |
| 650 | 4 | |a Pharmacie - Méthodes statistiques | |
| 650 | 4 | |a Statistiques | |
| 650 | 4 | |a Statistik | |
| 650 | 4 | |a Pharmacy |x Statistical methods | |
| 650 | 4 | |a Pharmacy |x methods |v Statistics | |
| 650 | 4 | |a Statistics | |
| 830 | 0 | |a Biostatistics |v 16 |w (DE-604)BV013101415 |9 16 | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-015036621 | ||
Record in the Search Index
| _version_ | 1804135751517995008 |
|---|---|
| adam_text | BASIC STATISTICS AND PHARMACEUTICAL STATISTICAL APPLICATIONS SECOND
EDITION JAMES E. DE MUTH JJCHAPMAN & HALL/CRC ^ ^ 0 1 TAYLORS.FRANCIS
GROUP BOCA RATON LONDON NEW YORK CHAPMAN & HALL/CRC IS AN IMPRINT OF THE
TAYLOR & FRANCIS GROUP, AN INFORMA BUSINESS CONTENTS 1. INTRODUCTION 1
TYPES OF STATISTICS 1 PARAMETERS AND STATISTICS 2 SAMPLING AND
INDEPENDENT OBSERVATIONS 3 TYPES OF VARIABLES 4 INDEPENDENT AND
DEPENDENT VARIABLES 8 SELECTION OF THE APPROPRIATE STATISTICAL TEST 8
PROCEDURES FOR INFERENTIAL STATISTICAL TESTS 9 REFERENCES 11 SUGGESTED
SUPPLEMENTAL READINGS 11 EXAMPLE PROBLEMS 11 ANSWERS TO PROBLEMS 14 2.
PROBABILITY 17 CLASSIC PROBABILITY 17 PROBABILITY INVOLVING TWO
VARIABLES 20 CONDITIONAL PROBABILITY 22 PROBABILITY DISTRIBUTION 24
COUNTING TECHNIQUES 27 BINOMIAL DISTRIBUTION 30 POISSON DISTRIBUTION 34
REFERENCES 36 SUGGESTED SUPPLEMENTAL READINGS 36 EXAMPLE PROBLEMS 36
ANSWERS TO PROBLEMS 38 3. SAMPLING 41 RANDOM SAMPLING 42 OTHER
PROBABILITY SAMPLING PROCEDURES 44 PRECISION, ACCURACY, AND BIAS 45
RELIABILITY AND VALIDITY 46 SUGGESTED SUPPLEMENTAL READINGS 47 EXAMPLE
PROBLEMS 47 ANSWERS TO PROBLEMS 48 CONTENTS 4. PRESENTATION MODES 49
TABULATIONOFDATA 49 VISUAL DISPLAYS FOR DISCRETE VARIABLES 51 VISUAL
DISPLAYS FOR CONTINUOUS VARIABLES 53 VISUAL DISPLAYS FOR TWO OR MORE
CONTINUOUS VARIABLES 62 REFERENCES 62 SUGGESTED SUPPLEMENTAL READINGS 63
EXAMPLE PROBLEMS 64 ANSWERS TO PROBLEMS 65 5. MEASURES OF CENTRAL
TENDENCY 69 CENTERS OF A CONTINUOUS DISTRIBUTION 69 DISPERSION WITHIN A
CONTINUOUS DISTRIBUTION 73 POPULATION VERSUS SAMPLE MEASURES OF CENTRAL
TENDENCY 78 MEASUREMENTS RELATED TO THE SAMPLE STANDARD DEVIATION 79
TRIMMED MEAN 81 ALTERNATIVE COMPUTATIONAL METHODS FOR CALCULATING
CENTRAL TENDENCY... 83 REFERENCES 89 SUGGESTED SUPPLEMENTAL READINGS 89
EXAMPLE PROBLEMS 89 ANSWERS TO PROBLEMS 90 6. THE NORMAL DISTRIBUTION
AND DATA TRANSFORMATION 95 THE NORMAL DISTRIBUTION 95 DETERMINING IF THE
DISTRIBUTION IS NORMAL 103 DATA TRANSFORMATIONS: AN OVERVIEW 107
LOGNORMAL TRANSFORMATION AND THE GEOMETRIE MEAN 108 OTHER TYPES OF
TRANSFORMATIONS 110 REFERENCES 112 SUGGESTED SUPPLEMENTAL READINGS 112
EXAMPLE PROBLEMS 112 ANSWERS TO PROBLEMS 113 7. CONFIDENCE INTERVALS AND
TOLERANCE LIMITS 117 SAMPLING DISTRIBUTION 117 STANDARD ERROROF THE MEAN
VERSUS THE STANDARD DEVIATION 119 CONFIDENCE INTERVALS 121 STATISTICAL
CONTROL CHARTS 125 PROCESS CAPABILITY INDICES 132 TOLERANCE LIMITS 140
REFERENCES 142 SUGGESTED SUPPLEMENTAL READINGS 143 EXAMPLE PROBLEMS 144
ANSWERS TO PROBLEMS 145 CONTENTS 8. HYPOTHESIS TESTING 151 HYPOTHESIS
TESTING 151 TYPES OF ERRORS , 154 TYPE I ERROR 155 TYPE II ERROR AND
POWER 159 EXPERIMENTAL ERRORS AND PROPAGATION OF ERRORS 166 REFERENCES
169 SUGGESTED SUPPLEMENTAL READINGS 170 EXAMPLE PROBLEMS 170 ANSWERS TO
PROBLEMS 171 9. T-TESTS 173 PARAMETRIC PROCEDURES 173 THE T-DISTRIBUTION
174 ONE-TAILED VS. TWO-TAILED TESTS 176 ONE-SAMPLE T-TESTS 177
TWO-SAMPLE T-TESTS 180 CORRECTED DEGREES OF FREEDOM FOR UNEQUAL
VARIANCES 184 ONE-SAMPLE T-TEST REVISITED FOR CRITICAL VALUE 186 MATCHED
PAIR T-TEST (DIFFERENCE T-TEST) 186 REFERENCES 190 SUGGESTED
SUPPLEMENTAL READINGS 191 EXAMPLE PROBLEMS 191 ANSWERS TO PROBLEMS 193
10. ONE-WAY ANALYSIS OF VARIANCE (ANOVA) 201 HYPOTHESIS TESTING WITH THE
ONE-WAY ANOVA 201 THE F-DISTRIBUTION 202 TEST STATISTIC 203 ANOVA
DEFMITIONAL FORMULA 205 ANOVA COMPUTATIONAL FORMULA 208 RANDOMIZED BLOCK
DESIGN 212 HOMOGENIETY OF VARIANCE 219 REFERENCES 221 SUGGESTED
SUPPLEMENTAL READINGS 222 EXAMPLE PROBLEMS 222 ANSWERS TO PROBLEMS 223
11. MULTIPLE COMPARISON TESTS 229 ERROR ASSOCIATED WITH MULTIPLE T-TESTS
229 OVERVIEW OF MULTIPLE COMPARISON TESTS 230 THE Q-STATISTIC 232
PLANNED MULTIPLE COMPARISONS 234 BONFERRONI ADJUSTMENT 234 SIDAEKTEST 236
CONTENTS DUNN S MULTIPLE COMPARISONS 237 DUNNETT S TEST 238 POST HOC
PROCEDURES 242 TUKEY HSD TEST 243 STUDENT NEWMAN-KEULS TEST 245 FISHER
LSD TEST 247 SCHEFFE PROCEDURE 249 SCHEFFE PROCEDURE FOR COMPLEX
COMPARISONS 253 UNBALANCED DESIGNS 255 LACKOF HOMOGENEITY 255 OTHER POST
HOC TESTS 256 REFERENCES 257 SUGGESTED SUPPLEMENTAL READINGS 257 EXAMPLE
PROBLEMS 257 ANSWERS TO PROBLEMS 259 12. FACTORIAL DESIGNS: AN
INTRODUCTION 267 FACTORIAL DESIGNS 267 TWO-WAY ANALYSIS OF VARIANCE 270
COMPUTATIONAL FORMULA WITH UNEQUAL CELL SIZE 281 POST HOC PROCEDURES 284
REPEATED MEASURES DESIGN 286 REPEATABILITY AND REPRODUCIBILITY 287 LATIN
SQUARE DESIGNS 291 OTHER DESIGNS 297 FIXED, RANDOM AND MIXED EFFECT
MODELS 298 BEYOND A TWO-WAY FACTORIAL DESIGN 299 REFERENCES 302
SUGGESTED SUPPLEMENTAL READINGS 302 EXAMPLE PROBLEMS 303 ANSWERS TO
PROBLEMS 304 13. CORRELATION 311 GRAPHIC REPRESENTATION OF TWO
CONTINUOUS VARIABLES 311 PEARSON PRODUCT-MOMENT CORRELATION COEFFICIENT
313 CORRELATION LINE 318 STATISTICAL SIGNIFICANCE OFA CORRELATION
COEFFICIENT 319 CORRELATION AND CAUSALITY 322 IN VIVO - IN VITRO
CORRELATION 324 OTHER TYPES OF BIVARIATE CORRELATIONS 325 PAIRWISE
CORRELATIONS INVOLVING MORE THAN TWO VARIABLES 326 MULTIPLE CORRELATIONS
328 PARTIAL CORRELATIONS 329 NONLINEAR CORRELATIONS 331 ASSESSING
INDEPENDENCE AND RANDOMNESS 332 CONTENTS REFERENCES 335 SUGGESTED
SUPPLEMENTAL READINGS 335 EXAMPLE PROBLEMS 336 ANSWERS TO PROBLEMS 337
14. LINEAR REGRESSION 343 THE REGRESSION LINE 344 COEFFICIENT OF
DETERMINATION 349 ANOVA TABLE 353 CONFIDENCE INTERVALS AND HYPOTHESIS
TESTING FOR THE POPULATION SLOPE(/7) 357 CONFIDENCE INTERVALS FOR THE
REGRESSION LINE 362 INVERSE PREDICTION 364 MULTIPLE DATA AT VARIOUS
POINTS ON THE INDEPENDENT VARIABLE 366 ASSESSING PARALLELISM OF THE
SLOPES OF TWO SAMPLES 367 MULTIPLE LINEAR REGRESSION MODELS 370
REFERENCES 372 SUGGESTED SUPPLEMENTAL READINGS 372 EXAMPLE PROBLEMS 373
ANSWERS TO PROBLEMS 374 15. Z-TESTS OF PROPORTIONS 383 Z-TEST OF
PROPORTIONS - ONE-SAMPLE CASE 383 Z-TEST OF PROPORTIONS - TWO-SAMPLE
CASE 386 ESTIMATING POWER AND DESIRED SAMPLE SIZE FOR TWO-SAMPLE Z-TEST
OF PROPORTIONS 387 Z-TESTS FOR PROPORTIONS - YATES CORRECTION FOR
CONTINUITY 390 PROPORTION TESTING FOR MORE THAN TWO LEVELS OF A DISCRETE
INDEPENDENT VARIABLE 391 REFERENCES 392 SUGGESTED SUPPLEMENTAL READINGS
392 EXAMPLE PROBLEMS 392 ANSWERS TO PROBLEMS 393 16. CHI SQUARE TESTS
397 CHI SQUARE STATISTIC 397 CHI SQUARE FOR ONE DISCRETE INDEPENDENT
VARIABLE 398 CHI SQUARE GOODNESS-OF-FIT TEST 400 CHI SQUARE TEST OF
INDEPENDENCE 405 YATES CORRECTION FOR 2 X 2 CONTINGENCY TABLE 411
COMPARISON OF CHI SQUARE TO THE Z-TEST OF PROPORT IONS 414 FISHER S
EXACT TEST 414 MCNEMAR S TEST 416 COCHRAN S Q TEST 418 MANTEL-HAENSZEL
TEST 421 CONTENTS REFERENCES 423 SUGGESTED SUPPLEMENTAL READINGS 423
EXAMPLE PROBLEMS 424 ANSWERS TO PROBLEMS 426 17. MEASURES OF ASSOCIATION
433 INTRODUCTION 433 DICHOTOMOUS ASSOCIATIONS 437 NOMINAL ASSOCIATIONS
441 ORDINAL ASSOCIATIONS 446 NOMINAL-BY-INTERVAL ASSOCIATIONS 450
RELIABILITY MEASUREMENTS 453 SUMMARY 461 REFERENCES 461 SUGGESTED
SUPPLEMENTAL READINGS 461 EXAMPLE PROBLEMS 462 ANSWERS TO PROBLEM 464
18. ODDS RATIOS AND RELATIVE RISK RATIOS 469 PROBABILITY, ODDS, AND RISK
469 ODDS RATIO 470 RELATIVE RISK 474 GRAPHIC DISPLAY FOR ODDS RATIOS AND
RELATIVE RISK RATIOS 479 MANTEL-HAENSZEL ESTIMATE OF RELATIVE RISK 479
LOGISTIC REGRESSION 481 REFERENCES 488 SUGGESTED SUPPLEMENTAL READINGS
488 EXAMPLE PROBLEMS 489 ANSWERS TO PROBLEMS 490 19. EVIDENCE-BASED
PRACTICE: AN INTRODUCTION 495 SENSITIVITY AND SPECIFICITY 495 TWO-BY-TWO
CONTINGENCY TABLE 499 DEFINING EVIDENCE-BASED PRACTICE 500 FREQUENTIST
VERSUS BAYESIAN APPROACHES TO PROBABILITY 503 PREDICTIVE VALUES 504
LIKELIHOOD RATIOS 508 REFERENCES 515 SUGGESTED SUPPLEMENTAL READINGS 515
EXAMPLE PROBLEMS 516 ANSWERS TO PROBLEMS 516 20. SURVIVAL STATISTICS 521
CENSORED SURVIVAL DATA 522 LIFE TABLE ANALYSIS 523 CONTENTS SURVIVAL
CURVE 527 KAPLAN-MEIER PROCEDURE 531 VISUAL COMPARISON OF TWO SURVIVAL
CURVES 534 TESTS TO COMPARE TWO LEVELS OF AN INDEPENDENT VARIABLE 536
HAZARD RATIOS 542 MULTIPLE REGRESSION WITH SURVIVAL DATA: PROPORTIONAL
HAZARDS REGRESSION 546 OTHER MEASURES AND TESTS OF SURVIVAL 547
REFERENCES 547 SUGGESTED SUPPLEMENTAL READINGS 548 EXAMPLE PROBLEMS 548
ANSWERS TO PROBLEMS 550 21. NONPARAMETRIC TESTS 557 USE OF NONPARAMETRIC
TESTS 557 RANKING OF INFORMATION 559 MANN-WHITNEY U TEST 560 MEDIAEN TEST
563 WILCOXON MATCHED-PAIRS TEST 565 SIGNTEST 567 KRUSKAL-WALLIS TEST 569
POST HOC COMPARISONS USING KRUSKAL-WALLIS 572 FRIEDMAN TWO-WAY ANALYSIS
OF VARIANCE 573 SPEARMAN RANK-ORDER CORRELATION 575 THEIL S INCOMPLETE
METHOD 577 KOLMOGOROV-SMIRNOV GOODNESS-OF-FIT TEST 579 ANDERSON-DARLING
TEST 582 RUNS TESTS 583 RANGE TESTS 585 REFERENCES 588 SUGGESTED
SUPPLEMENTAL READINGS 588 EXAMPLE PROBLEMS 589 ANSWERS TO PROBLEMS 591
22. STATISTICAL TESTS FOR EQUIVALENCE 601 BIOEQUIVALENCE TESTING 601
EXPERIMENTAL DESIGNS FOR BIOEQUIVALENCE STUDIES 602 TWO-SAMPLE T-TEST
EXAMPLE 605 POWER IN BIOEQUIVALENCE TESTS 607 RULES FOR BIOEQUIVALENCE
609 CREATING CONFIDENCE INTERVALS 610 COMPARISON USING TWO ONE-SIDED
T-TESTS 613 CLINICAL EQUIVALENCE AND NONINFERIORITY 614 DISSOLUTION
TESTING 620 SUPAC-IR GUIDANCE 621 CONTENTS REFERENCES 624 SUGGESTED
SUPPLEMENTAL READINGS 626 EXAMPLE PROBLEMS 627 ANSWERS TO PROBLEMS 628
23. OUTLIER TESTS 633 REGULATOR/CONSIDERATIONS 633 OUTLIERS ON A SINGLE
CONTINUUM 634 PLOTTING AND THE NUMBER OF STANDARD DEVIATIONS FROM THE
CENTER 637 THE HUGE RULE 638 GRUBBS TEST FOR OUTLYING OBSERVATIONS
638 DIXON Q TEST 640 HAMPEL SRULE 641 MULTIPLE OUTLIERS 643 BIVARIATE
OUTLIERS IN CORRELATION AND REGRESSION ANALYSIS 644 REFERENCES 650
SUGGESTED SUPPLEMENTAL READINGS 650 EXAMPLE PROBLEMS 651 ANSWERS TO
PROBLEMS 651 24. STATISTICAL ERRORS IN THE LITERATURE 657 ERRORS AND THE
PEER REVIEW PROCESS 657 PROBLEMS WITH EXPERIMENTAL DESIGN 659 STANDARD
DEVIATIONS VERSUS STANDARD ERROR OF THE MEAN 660 PROBLEMS WITH
HYPOTHESIS TESTING 663 PROBLEMS WITH PARAMETRIC STATISTICS 664 ERRORS
WITH THE CHI SQUARE TEST OF INDEPENDENCE 666 SUMMARY 668 REFERENCES 669
SUGGESTED SUPPLEMENTAL READINGS 670 APPENDIX A: FLOW CHARTS FOR THE
SELECTION OF APPROPRIATE TESTS 671 APPENDIX B: STATISTICAL TABLES 677 BL
RANDOM NUMBERS TABLE 678 B2 NORMAL STANDARDIZED DISTRIBUTION 679 B3
K-VALUES FOR CALCULATING TOLERANCE LIMITS (TWO-TAILED) 680 B4 K-VALUES
FOR CALCULATING TOLERANCE LIMITS (ONE-TAILED) 681 B5 STUDENT
T-DISTRIBUTION (1 - A/2) 682 B6 COMPARISON OF ONE-TAILED VS. TWO-TAILED
T-DISTRIBUTIONS 683 B7 ANALYSIS OF VARIANCE F-DISTRIBUTION 684 B8 UPPER
PERCENTAGE POINTS OF THE F MAX STATISTIC 690 B9 UPPER PERCENTAGE POINTS
OF THE COCHRAN C TEST FOR HOMOGENEITY OF VARIANCE 691 CONTENTS BIO
PERCENTAGE POINTS OF THE STANDARDIZED RANGE (Q) 692 BL 1 PERCENTAGE
POINTS OF THE DUENN MULTIPLE COMPARISONS 693 B12 CRITICAL VALUES OF Q FOR
THE TWO-TAILED DUNNETT S TEST 694 B13 CRITICAL VALUES OF Q FOR THE
ONE-TAILED DUNNETT S TEST 695 B14 VALUES OF R AT DIFFERENT LEVELS OF
SIGNIFICANCE 696 B15 CHI SQUARE DISTRIBUTION 697 B16 CRITICAL VALUES FOR
KOLMOGOROV GOODNESS-OF-FIT TEST (A = 0.05) 698 B17 CRITICAL VALUES FOR
SMIRNOV TEST STATISTIC (A = 0.05) 699 B18 CRITICAL VALUES FOR THE RUNS
TEST (A = 0.05) 700 B19 CRITICAL VALUES FOR T, RANGE TEST (A = 0.05) 701
B20 CRITICAL VALUES FOR THE F R TEST FOR DISPERSION 702 B21 VALUES FOR
USE IN GRUBBS TEST FOR OUTLIER (A) 703 B22 VALUES FOR USE IN DIXON TEST
FOR OUTLIER (A) 704 INDEX 705
|
| adam_txt |
BASIC STATISTICS AND PHARMACEUTICAL STATISTICAL APPLICATIONS SECOND
EDITION JAMES E. DE MUTH JJCHAPMAN & HALL/CRC ^ ^ 0 1 TAYLORS.FRANCIS
GROUP BOCA RATON LONDON NEW YORK CHAPMAN & HALL/CRC IS AN IMPRINT OF THE
TAYLOR & FRANCIS GROUP, AN INFORMA BUSINESS CONTENTS 1. INTRODUCTION 1
TYPES OF STATISTICS 1 PARAMETERS AND STATISTICS 2 SAMPLING AND
INDEPENDENT OBSERVATIONS 3 TYPES OF VARIABLES 4 INDEPENDENT AND
DEPENDENT VARIABLES 8 SELECTION OF THE APPROPRIATE STATISTICAL TEST 8
PROCEDURES FOR INFERENTIAL STATISTICAL TESTS 9 REFERENCES 11 SUGGESTED
SUPPLEMENTAL READINGS 11 EXAMPLE PROBLEMS 11 ANSWERS TO PROBLEMS 14 2.
PROBABILITY 17 CLASSIC PROBABILITY 17 PROBABILITY INVOLVING TWO
VARIABLES 20 CONDITIONAL PROBABILITY 22 PROBABILITY DISTRIBUTION 24
COUNTING TECHNIQUES 27 BINOMIAL DISTRIBUTION 30 POISSON DISTRIBUTION 34
REFERENCES 36 SUGGESTED SUPPLEMENTAL READINGS 36 EXAMPLE PROBLEMS 36
ANSWERS TO PROBLEMS 38 3. SAMPLING 41 RANDOM SAMPLING 42 OTHER
PROBABILITY SAMPLING PROCEDURES 44 PRECISION, ACCURACY, AND BIAS 45
RELIABILITY AND VALIDITY 46 SUGGESTED SUPPLEMENTAL READINGS 47 EXAMPLE
PROBLEMS 47 ANSWERS TO PROBLEMS 48 CONTENTS 4. PRESENTATION MODES 49
TABULATIONOFDATA 49 VISUAL DISPLAYS FOR DISCRETE VARIABLES 51 VISUAL
DISPLAYS FOR CONTINUOUS VARIABLES 53 VISUAL DISPLAYS FOR TWO OR MORE
CONTINUOUS VARIABLES 62 REFERENCES 62 SUGGESTED SUPPLEMENTAL READINGS 63
EXAMPLE PROBLEMS 64 ANSWERS TO PROBLEMS 65 5. MEASURES OF CENTRAL
TENDENCY 69 CENTERS OF A CONTINUOUS DISTRIBUTION 69 DISPERSION WITHIN A
CONTINUOUS DISTRIBUTION 73 POPULATION VERSUS SAMPLE MEASURES OF CENTRAL
TENDENCY 78 MEASUREMENTS RELATED TO THE SAMPLE STANDARD DEVIATION 79
TRIMMED MEAN 81 ALTERNATIVE COMPUTATIONAL METHODS FOR CALCULATING
CENTRAL TENDENCY. 83 REFERENCES 89 SUGGESTED SUPPLEMENTAL READINGS 89
EXAMPLE PROBLEMS 89 ANSWERS TO PROBLEMS 90 6. THE NORMAL DISTRIBUTION
AND DATA TRANSFORMATION 95 THE NORMAL DISTRIBUTION 95 DETERMINING IF THE
DISTRIBUTION IS NORMAL 103 DATA TRANSFORMATIONS: AN OVERVIEW 107
LOGNORMAL TRANSFORMATION AND THE GEOMETRIE MEAN 108 OTHER TYPES OF
TRANSFORMATIONS 110 REFERENCES 112 SUGGESTED SUPPLEMENTAL READINGS 112
EXAMPLE PROBLEMS 112 ANSWERS TO PROBLEMS 113 7. CONFIDENCE INTERVALS AND
TOLERANCE LIMITS 117 SAMPLING DISTRIBUTION 117 STANDARD ERROROF THE MEAN
VERSUS THE STANDARD DEVIATION 119 CONFIDENCE INTERVALS 121 STATISTICAL
CONTROL CHARTS 125 PROCESS CAPABILITY INDICES 132 TOLERANCE LIMITS 140
REFERENCES 142 SUGGESTED SUPPLEMENTAL READINGS 143 EXAMPLE PROBLEMS 144
ANSWERS TO PROBLEMS 145 CONTENTS 8. HYPOTHESIS TESTING 151 HYPOTHESIS
TESTING 151 TYPES OF ERRORS , 154 TYPE I ERROR 155 TYPE II ERROR AND
POWER 159 EXPERIMENTAL ERRORS AND PROPAGATION OF ERRORS 166 REFERENCES
169 SUGGESTED SUPPLEMENTAL READINGS 170 EXAMPLE PROBLEMS 170 ANSWERS TO
PROBLEMS 171 9. T-TESTS 173 PARAMETRIC PROCEDURES 173 THE T-DISTRIBUTION
174 ONE-TAILED VS. TWO-TAILED TESTS 176 ONE-SAMPLE T-TESTS 177
TWO-SAMPLE T-TESTS 180 CORRECTED DEGREES OF FREEDOM FOR UNEQUAL
VARIANCES 184 ONE-SAMPLE T-TEST REVISITED FOR CRITICAL VALUE 186 MATCHED
PAIR T-TEST (DIFFERENCE T-TEST) 186 REFERENCES 190 SUGGESTED
SUPPLEMENTAL READINGS 191 EXAMPLE PROBLEMS 191 ANSWERS TO PROBLEMS 193
10. ONE-WAY ANALYSIS OF VARIANCE (ANOVA) 201 HYPOTHESIS TESTING WITH THE
ONE-WAY ANOVA 201 THE F-DISTRIBUTION 202 TEST STATISTIC 203 ANOVA
DEFMITIONAL FORMULA 205 ANOVA COMPUTATIONAL FORMULA 208 RANDOMIZED BLOCK
DESIGN 212 HOMOGENIETY OF VARIANCE 219 REFERENCES 221 SUGGESTED
SUPPLEMENTAL READINGS 222 EXAMPLE PROBLEMS 222 ANSWERS TO PROBLEMS 223
11. MULTIPLE COMPARISON TESTS 229 ERROR ASSOCIATED WITH MULTIPLE T-TESTS
229 OVERVIEW OF MULTIPLE COMPARISON TESTS 230 THE Q-STATISTIC 232
PLANNED MULTIPLE COMPARISONS 234 BONFERRONI ADJUSTMENT 234 SIDAEKTEST 236
CONTENTS DUNN'S MULTIPLE COMPARISONS 237 DUNNETT'S TEST 238 POST HOC
PROCEDURES 242 TUKEY HSD TEST 243 STUDENT NEWMAN-KEULS TEST 245 FISHER
LSD TEST 247 SCHEFFE PROCEDURE 249 SCHEFFE PROCEDURE FOR COMPLEX
COMPARISONS 253 UNBALANCED DESIGNS 255 LACKOF HOMOGENEITY 255 OTHER POST
HOC TESTS 256 REFERENCES 257 SUGGESTED SUPPLEMENTAL READINGS 257 EXAMPLE
PROBLEMS 257 ANSWERS TO PROBLEMS 259 12. FACTORIAL DESIGNS: AN
INTRODUCTION 267 FACTORIAL DESIGNS 267 TWO-WAY ANALYSIS OF VARIANCE 270
COMPUTATIONAL FORMULA WITH UNEQUAL CELL SIZE 281 POST HOC PROCEDURES 284
REPEATED MEASURES DESIGN 286 REPEATABILITY AND REPRODUCIBILITY 287 LATIN
SQUARE DESIGNS 291 OTHER DESIGNS 297 FIXED, RANDOM AND MIXED EFFECT
MODELS 298 BEYOND A TWO-WAY FACTORIAL DESIGN 299 REFERENCES 302
SUGGESTED SUPPLEMENTAL READINGS 302 EXAMPLE PROBLEMS 303 ANSWERS TO
PROBLEMS 304 13. CORRELATION 311 GRAPHIC REPRESENTATION OF TWO
CONTINUOUS VARIABLES 311 PEARSON PRODUCT-MOMENT CORRELATION COEFFICIENT
313 CORRELATION LINE 318 STATISTICAL SIGNIFICANCE OFA CORRELATION
COEFFICIENT 319 CORRELATION AND CAUSALITY 322 IN VIVO - IN VITRO
CORRELATION 324 OTHER TYPES OF BIVARIATE CORRELATIONS 325 PAIRWISE
CORRELATIONS INVOLVING MORE THAN TWO VARIABLES 326 MULTIPLE CORRELATIONS
328 PARTIAL CORRELATIONS 329 NONLINEAR CORRELATIONS 331 ASSESSING
INDEPENDENCE AND RANDOMNESS 332 CONTENTS REFERENCES 335 SUGGESTED
SUPPLEMENTAL READINGS 335 EXAMPLE PROBLEMS 336 ANSWERS TO PROBLEMS 337
14. LINEAR REGRESSION 343 THE REGRESSION LINE 344 COEFFICIENT OF
DETERMINATION 349 ANOVA TABLE 353 CONFIDENCE INTERVALS AND HYPOTHESIS
TESTING FOR THE POPULATION SLOPE(/7) ' 357 CONFIDENCE INTERVALS FOR THE
REGRESSION LINE 362 INVERSE PREDICTION 364 MULTIPLE DATA AT VARIOUS
POINTS ON THE INDEPENDENT VARIABLE 366 ASSESSING PARALLELISM OF THE
SLOPES OF TWO SAMPLES 367 MULTIPLE LINEAR REGRESSION MODELS 370
REFERENCES 372 SUGGESTED SUPPLEMENTAL READINGS 372 EXAMPLE PROBLEMS 373
ANSWERS TO PROBLEMS 374 15. Z-TESTS OF PROPORTIONS 383 Z-TEST OF
PROPORTIONS - ONE-SAMPLE CASE 383 Z-TEST OF PROPORTIONS - TWO-SAMPLE
CASE 386 ESTIMATING POWER AND DESIRED SAMPLE SIZE FOR TWO-SAMPLE Z-TEST
OF PROPORTIONS 387 Z-TESTS FOR PROPORTIONS - YATES' CORRECTION FOR
CONTINUITY 390 PROPORTION TESTING FOR MORE THAN TWO LEVELS OF A DISCRETE
INDEPENDENT VARIABLE 391 REFERENCES 392 SUGGESTED SUPPLEMENTAL READINGS
392 EXAMPLE PROBLEMS 392 ANSWERS TO PROBLEMS 393 16. CHI SQUARE TESTS
397 CHI SQUARE STATISTIC 397 CHI SQUARE FOR ONE DISCRETE INDEPENDENT
VARIABLE 398 CHI SQUARE GOODNESS-OF-FIT TEST 400 CHI SQUARE TEST OF
INDEPENDENCE 405 YATES' CORRECTION FOR 2 X 2 CONTINGENCY TABLE 411
COMPARISON OF CHI SQUARE TO THE Z-TEST OF PROPORT IONS 414 FISHER'S
EXACT TEST 414 MCNEMAR'S TEST 416 COCHRAN'S Q TEST 418 MANTEL-HAENSZEL
TEST 421 CONTENTS REFERENCES 423 SUGGESTED SUPPLEMENTAL READINGS 423
EXAMPLE PROBLEMS 424 ANSWERS TO PROBLEMS 426 17. MEASURES OF ASSOCIATION
433 INTRODUCTION 433 DICHOTOMOUS ASSOCIATIONS 437 NOMINAL ASSOCIATIONS
441 ORDINAL ASSOCIATIONS 446 NOMINAL-BY-INTERVAL ASSOCIATIONS 450
RELIABILITY MEASUREMENTS 453 SUMMARY 461 REFERENCES 461 SUGGESTED
SUPPLEMENTAL READINGS 461 EXAMPLE PROBLEMS 462 ANSWERS TO PROBLEM 464
18. ODDS RATIOS AND RELATIVE RISK RATIOS 469 PROBABILITY, ODDS, AND RISK
469 ODDS RATIO 470 RELATIVE RISK 474 GRAPHIC DISPLAY FOR ODDS RATIOS AND
RELATIVE RISK RATIOS 479 MANTEL-HAENSZEL ESTIMATE OF RELATIVE RISK 479
LOGISTIC REGRESSION 481 REFERENCES 488 SUGGESTED SUPPLEMENTAL READINGS
488 EXAMPLE PROBLEMS 489 ANSWERS TO PROBLEMS 490 19. EVIDENCE-BASED
PRACTICE: AN INTRODUCTION 495 SENSITIVITY AND SPECIFICITY 495 TWO-BY-TWO
CONTINGENCY TABLE 499 DEFINING EVIDENCE-BASED PRACTICE 500 FREQUENTIST
VERSUS BAYESIAN APPROACHES TO PROBABILITY 503 PREDICTIVE VALUES 504
LIKELIHOOD RATIOS 508 REFERENCES 515 SUGGESTED SUPPLEMENTAL READINGS 515
EXAMPLE PROBLEMS 516 ANSWERS TO PROBLEMS 516 20. SURVIVAL STATISTICS 521
CENSORED SURVIVAL DATA 522 LIFE TABLE ANALYSIS 523 CONTENTS SURVIVAL
CURVE 527 KAPLAN-MEIER PROCEDURE 531 VISUAL COMPARISON OF TWO SURVIVAL
CURVES 534 TESTS TO COMPARE TWO LEVELS OF AN INDEPENDENT VARIABLE 536
HAZARD RATIOS 542 MULTIPLE REGRESSION WITH SURVIVAL DATA: PROPORTIONAL
HAZARDS REGRESSION 546 OTHER MEASURES AND TESTS OF SURVIVAL 547
REFERENCES 547 SUGGESTED SUPPLEMENTAL READINGS 548 EXAMPLE PROBLEMS 548
ANSWERS TO PROBLEMS 550 21. NONPARAMETRIC TESTS 557 USE OF NONPARAMETRIC
TESTS 557 RANKING OF INFORMATION 559 MANN-WHITNEY U TEST 560 MEDIAEN TEST
563 WILCOXON MATCHED-PAIRS TEST 565 SIGNTEST 567 KRUSKAL-WALLIS TEST 569
POST HOC COMPARISONS USING KRUSKAL-WALLIS 572 FRIEDMAN TWO-WAY ANALYSIS
OF VARIANCE 573 SPEARMAN RANK-ORDER CORRELATION 575 THEIL'S INCOMPLETE
METHOD 577 KOLMOGOROV-SMIRNOV GOODNESS-OF-FIT TEST 579 ANDERSON-DARLING
TEST 582 RUNS TESTS 583 RANGE TESTS 585 REFERENCES 588 SUGGESTED
SUPPLEMENTAL READINGS 588 EXAMPLE PROBLEMS 589 ANSWERS TO PROBLEMS 591
22. STATISTICAL TESTS FOR EQUIVALENCE 601 BIOEQUIVALENCE TESTING 601
EXPERIMENTAL DESIGNS FOR BIOEQUIVALENCE STUDIES 602 TWO-SAMPLE T-TEST
EXAMPLE 605 POWER IN BIOEQUIVALENCE TESTS 607 RULES FOR BIOEQUIVALENCE
609 CREATING CONFIDENCE INTERVALS 610 COMPARISON USING TWO ONE-SIDED
T-TESTS 613 CLINICAL EQUIVALENCE AND NONINFERIORITY 614 DISSOLUTION
TESTING 620 SUPAC-IR GUIDANCE 621 CONTENTS REFERENCES 624 SUGGESTED
SUPPLEMENTAL READINGS 626 EXAMPLE PROBLEMS 627 ANSWERS TO PROBLEMS 628
23. OUTLIER TESTS 633 REGULATOR/CONSIDERATIONS 633 OUTLIERS ON A SINGLE
CONTINUUM 634 PLOTTING AND THE NUMBER OF STANDARD DEVIATIONS FROM THE
CENTER 637 THE "HUGE" RULE 638 GRUBBS' TEST FOR OUTLYING OBSERVATIONS
638 DIXON Q TEST 640 HAMPEL'SRULE 641 MULTIPLE OUTLIERS 643 BIVARIATE
OUTLIERS IN CORRELATION AND REGRESSION ANALYSIS 644 REFERENCES 650
SUGGESTED SUPPLEMENTAL READINGS 650 EXAMPLE PROBLEMS 651 ANSWERS TO
PROBLEMS 651 24. STATISTICAL ERRORS IN THE LITERATURE 657 ERRORS AND THE
PEER REVIEW PROCESS 657 PROBLEMS WITH EXPERIMENTAL DESIGN 659 STANDARD
DEVIATIONS VERSUS STANDARD ERROR OF THE MEAN 660 PROBLEMS WITH
HYPOTHESIS TESTING 663 PROBLEMS WITH PARAMETRIC STATISTICS 664 ERRORS
WITH THE CHI SQUARE TEST OF INDEPENDENCE 666 SUMMARY 668 REFERENCES 669
SUGGESTED SUPPLEMENTAL READINGS 670 APPENDIX A: FLOW CHARTS FOR THE
SELECTION OF APPROPRIATE TESTS 671 APPENDIX B: STATISTICAL TABLES 677 BL
RANDOM NUMBERS TABLE 678 B2 NORMAL STANDARDIZED DISTRIBUTION 679 B3
K-VALUES FOR CALCULATING TOLERANCE LIMITS (TWO-TAILED) 680 B4 K-VALUES
FOR CALCULATING TOLERANCE LIMITS (ONE-TAILED) 681 B5 STUDENT
T-DISTRIBUTION (1 - A/2) 682 B6 COMPARISON OF ONE-TAILED VS. TWO-TAILED
T-DISTRIBUTIONS 683 B7 ANALYSIS OF VARIANCE F-DISTRIBUTION 684 B8 UPPER
PERCENTAGE POINTS OF THE F MAX STATISTIC 690 B9 UPPER PERCENTAGE POINTS
OF THE COCHRAN C TEST FOR HOMOGENEITY OF VARIANCE 691 CONTENTS BIO
PERCENTAGE POINTS OF THE STANDARDIZED RANGE (Q) 692 BL 1 PERCENTAGE
POINTS OF THE DUENN MULTIPLE COMPARISONS 693 B12 CRITICAL VALUES OF Q FOR
THE TWO-TAILED DUNNETT'S TEST 694 B13 CRITICAL VALUES OF Q FOR THE
ONE-TAILED DUNNETT'S TEST 695 B14 VALUES OF R AT DIFFERENT LEVELS OF
SIGNIFICANCE 696 B15 CHI SQUARE DISTRIBUTION 697 B16 CRITICAL VALUES FOR
KOLMOGOROV GOODNESS-OF-FIT TEST (A = 0.05) 698 B17 CRITICAL VALUES FOR
SMIRNOV TEST STATISTIC (A = 0.05) 699 B18 CRITICAL VALUES FOR THE RUNS
TEST (A = 0.05) 700 B19 CRITICAL VALUES FOR T, RANGE TEST (A = 0.05) 701
B20 CRITICAL VALUES FOR THE F R TEST FOR DISPERSION 702 B21 VALUES FOR
USE IN GRUBBS TEST FOR OUTLIER (A) 703 B22 VALUES FOR USE IN DIXON TEST
FOR OUTLIER (A) 704 INDEX 705 |
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| author | De Muth, James E. |
| author_facet | De Muth, James E. |
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| dewey-full | 615/.190072/7 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
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| dewey-search | 615/.190072/7 |
| dewey-sort | 3615 6190072 17 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| discipline_str_mv | Medizin |
| edition | 2. ed. |
| format | Book |
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| id | DE-604.BV021824528 |
| illustrated | Illustrated |
| index_date | 2024-07-02T15:55:16Z |
| indexdate | 2024-07-09T20:45:29Z |
| institution | BVB |
| isbn | 0849337992 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-015036621 |
| oclc_num | 64771022 |
| open_access_boolean | |
| owner | DE-M347 DE-20 |
| owner_facet | DE-M347 DE-20 |
| physical | 714 S. Ill., graph. Darst. |
| publishDate | 2006 |
| publishDateSearch | 2006 |
| publishDateSort | 2006 |
| publisher | Chapman & Hall |
| record_format | marc |
| series | Biostatistics |
| series2 | Biostatistics |
| spelling | De Muth, James E. Verfasser aut Basic statistics and pharmaceutical statistical applications James E. De Muth 2. ed. Boca Raton [u.a.] Chapman & Hall 2006 714 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Biostatistics 16 Estatística aplicada larpcal Estatística larpcal Farmácia (métodos estatísticos) larpcal Pharmacie - Méthodes statistiques Statistiques Statistik Pharmacy Statistical methods Pharmacy methods Statistics Statistics Biostatistics 16 (DE-604)BV013101415 16 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015036621&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | De Muth, James E. Basic statistics and pharmaceutical statistical applications Biostatistics Estatística aplicada larpcal Estatística larpcal Farmácia (métodos estatísticos) larpcal Pharmacie - Méthodes statistiques Statistiques Statistik Pharmacy Statistical methods Pharmacy methods Statistics Statistics |
| title | Basic statistics and pharmaceutical statistical applications |
| title_auth | Basic statistics and pharmaceutical statistical applications |
| title_exact_search | Basic statistics and pharmaceutical statistical applications |
| title_exact_search_txtP | Basic statistics and pharmaceutical statistical applications |
| title_full | Basic statistics and pharmaceutical statistical applications James E. De Muth |
| title_fullStr | Basic statistics and pharmaceutical statistical applications James E. De Muth |
| title_full_unstemmed | Basic statistics and pharmaceutical statistical applications James E. De Muth |
| title_short | Basic statistics and pharmaceutical statistical applications |
| title_sort | basic statistics and pharmaceutical statistical applications |
| topic | Estatística aplicada larpcal Estatística larpcal Farmácia (métodos estatísticos) larpcal Pharmacie - Méthodes statistiques Statistiques Statistik Pharmacy Statistical methods Pharmacy methods Statistics Statistics |
| topic_facet | Estatística aplicada Estatística Farmácia (métodos estatísticos) Pharmacie - Méthodes statistiques Statistiques Statistik Pharmacy Statistical methods Pharmacy methods Statistics Statistics |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015036621&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV013101415 |
| work_keys_str_mv | AT demuthjamese basicstatisticsandpharmaceuticalstatisticalapplications |