Principles of bioseparations engineering:
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Singapore [u.a.]
World Scientific
2006
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XIV, 265 S. Ill., graph. Darst. |
| ISBN: | 9812568921 |
Staff View
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| 650 | 4 | |a Biomolécules - Séparation | |
| 650 | 4 | |a Génie biochimique | |
| 650 | 4 | |a Séparation (Technologie) | |
| 650 | 4 | |a Biochemical engineering | |
| 650 | 4 | |a Biomolecules |x Separation | |
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Record in the Search Index
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| adam_text | Contents
Preface ix
1. Overview of bioseparations engineering 1
1.1. Introduction 1
1.2. What is separated in bioseparation? 2
1.3. Economic importance of bioseparation 3
1.4. Nature of bioseparation 4
1.5. Basis of separation in bioseparation processes 5
1.6. Physical forms separated in bioseparation 6
1.7. Bioseparation techniques 8
1.8. The RIPP scheme 9
1.9. Example of bioseparation 10
1.10. Current trends in the bioseparation 10
2. Properties of biological material 13
2.1. Introduction 13
2.2. Size 13
2.3. Molecular weight 17
2.4. Diffusivity 19
2.5. Sedimentation coefficient 20
2.6. Osmotic pressure 21
2.7. Electrostatic charge 22
2.8. Solubility 23
2.9. Partition coefficient 24
2.10. Light absorption 24
2.11. Fluorescence 25
xi
xii Principles of Bioseparations Engineering
3. Mass transfer 29
3.1. Introduction 29
3.2. Molecular diffusion in liquid medium 30
3.3. Measurement of diffusivity 32
3.4. Estimation of diffusivity 33
3.5. Diffusion of solutes in dense solid 35
3.6. Diffusion of solutes in porous solid 35
3.7. Convective mass transfer 37
3.8. Experimental determination of mass transfer coefficient 40
3.9. Estimation of mass transfer coefficient 41
3.10. Inter phase mass transfer 42
3.11. Unsteady state mass transfer 42
3.12. Equilibrium and rate processes 45
4. Cell disruption 49
4.1. Introduction 49
4.2. Cells 49
4.3. Cell disruption using bead mill 53
4.4. Cell disruption using rotor stator mill 56
4.5. Cell disruption using French press 56
4.6. Cell disruption using ultrasonic vibrations 58
4.7. Cell disruption using detergents 61
4.8. Cell disruption using enzymes 61
4.9. Cell disruption using organic solvents 62
4.10. Cell disruption by osmotic shock 62
5. Precipitation 65
5.1. Introduction 65
5.2. Factors utilized for precipitation 66
5.3. Precipitation using organic solvents 69
5.4. Precipitation using anti chaotropic salts 72
5.5. Mechanism of precipitate formation 74
6. Centrifugation 79
6.1. Introduction 79
6.2. Laboratory centrifuge 80
6.3. Preparative centrifuge 83
Contents xiii
6.4. Ultracentrifugation 87
7. Extraction 89
7.1. Introduction 89
7.2. Solvent systems 89
7.3. Theory of extraction 90
7.4. Aqueous two phase extraction 93
7.5. Batch extraction 95
7.6. Single stage continuous extraction using immiscible solvents 95
7.7. Batch extraction using partially miscible solvents 102
7.8. Cross current continuous extraction using immiscible
solvents 103
7.9. Staged counter current extraction 104
7.10. Differential extraction 109
7.11. Supercritical fluid extraction 113
8. Adsorption 121
8.1. Introduction 121
8.2. Adsorbents 122
8.3. Separation mechanisms 123
8.4. Adsorption isotherms 132
8.5. Diffusional limitations in adsorption processes 135
8.6. Batch adsorption 136
8.7. Packed bed adsorption 140
8.8. Other types of adsorption devices 147
9. Chromatography 151
9.1. Introduction 151
9.2. Chromatography system 152
9.3. Theory of chromatography 15 8
9.4. Shape and yield of a chromatographic peak 167
9.5. Binary chromatography 173
9.6. Hydrodynamic chromatography 176
10. Filtration 181
10.1. Introduction 181
10.2. Theory of filtration 181
xiv Principles of Bioseparations Engineering
10.3. Filter medium 183
10.4. Driving force 183
10.5. Constant pressure cake filtration 184
10.6. Constant rate cake filtration 190
10.7. Improvement of filtration efficiency 191
10.8. Mode of operation 192
10.9. Filtration equipment 194
11. Membrane based bioseparation 199
11.1. Introduction 199
11.2. Classification of membrane processes 205
11.3. Membrane equipment 206
11.4. Ultrafiltration 211
11.5.Microfiltration 232
11.6. Dialysis 235
11.7. Liquid membrane processes 240
11.8. Membrane chromatography 242
12. Miscellaneous bioseparation processes 251
12.1. Introduction 251
12.2. Electrophoresis 251
12.3. Affinity ultrafiltration 255
12.4. Field flow fractionation 255
Index 257
|
| adam_txt |
Contents
Preface ix
1. Overview of bioseparations engineering 1
1.1. Introduction 1
1.2. What is separated in bioseparation? 2
1.3. Economic importance of bioseparation 3
1.4. Nature of bioseparation 4
1.5. Basis of separation in bioseparation processes 5
1.6. Physical forms separated in bioseparation 6
1.7. Bioseparation techniques 8
1.8. The RIPP scheme 9
1.9. Example of bioseparation 10
1.10. Current trends in the bioseparation 10
2. Properties of biological material 13
2.1. Introduction 13
2.2. Size 13
2.3. Molecular weight 17
2.4. Diffusivity 19
2.5. Sedimentation coefficient 20
2.6. Osmotic pressure 21
2.7. Electrostatic charge 22
2.8. Solubility 23
2.9. Partition coefficient 24
2.10. Light absorption 24
2.11. Fluorescence 25
xi
xii Principles of Bioseparations Engineering
3. Mass transfer 29
3.1. Introduction 29
3.2. Molecular diffusion in liquid medium 30
3.3. Measurement of diffusivity 32
3.4. Estimation of diffusivity 33
3.5. Diffusion of solutes in dense solid 35
3.6. Diffusion of solutes in porous solid 35
3.7. Convective mass transfer 37
3.8. Experimental determination of mass transfer coefficient 40
3.9. Estimation of mass transfer coefficient 41
3.10. Inter phase mass transfer 42
3.11. Unsteady state mass transfer 42
3.12. Equilibrium and rate processes 45
4. Cell disruption 49
4.1. Introduction 49
4.2. Cells 49
4.3. Cell disruption using bead mill 53
4.4. Cell disruption using rotor stator mill 56
4.5. Cell disruption using French press 56
4.6. Cell disruption using ultrasonic vibrations 58
4.7. Cell disruption using detergents 61
4.8. Cell disruption using enzymes 61
4.9. Cell disruption using organic solvents 62
4.10. Cell disruption by osmotic shock 62
5. Precipitation 65
5.1. Introduction 65
5.2. Factors utilized for precipitation 66
5.3. Precipitation using organic solvents 69
5.4. Precipitation using anti chaotropic salts 72
5.5. Mechanism of precipitate formation 74
6. Centrifugation 79
6.1. Introduction 79
6.2. Laboratory centrifuge 80
6.3. Preparative centrifuge 83
Contents xiii
6.4. Ultracentrifugation 87
7. Extraction 89
7.1. Introduction 89
7.2. Solvent systems 89
7.3. Theory of extraction 90
7.4. Aqueous two phase extraction 93
7.5. Batch extraction 95
7.6. Single stage continuous extraction using immiscible solvents 95
7.7. Batch extraction using partially miscible solvents 102
7.8. Cross current continuous extraction using immiscible
solvents 103
7.9. Staged counter current extraction 104
7.10. Differential extraction 109
7.11. Supercritical fluid extraction 113
8. Adsorption 121
8.1. Introduction 121
8.2. Adsorbents 122
8.3. Separation mechanisms 123
8.4. Adsorption isotherms 132
8.5. Diffusional limitations in adsorption processes 135
8.6. Batch adsorption 136
8.7. Packed bed adsorption 140
8.8. Other types of adsorption devices 147
9. Chromatography 151
9.1. Introduction 151
9.2. Chromatography system 152
9.3. Theory of chromatography 15 8
9.4. Shape and yield of a chromatographic peak 167
9.5. Binary chromatography 173
9.6. Hydrodynamic chromatography 176
10. Filtration 181
10.1. Introduction 181
10.2. Theory of filtration 181
xiv Principles of Bioseparations Engineering
10.3. Filter medium 183
10.4. Driving force 183
10.5. Constant pressure cake filtration 184
10.6. Constant rate cake filtration 190
10.7. Improvement of filtration efficiency 191
10.8. Mode of operation 192
10.9. Filtration equipment 194
11. Membrane based bioseparation 199
11.1. Introduction 199
11.2. Classification of membrane processes 205
11.3. Membrane equipment 206
11.4. Ultrafiltration 211
11.5.Microfiltration 232
11.6. Dialysis 235
11.7. Liquid membrane processes 240
11.8. Membrane chromatography 242
12. Miscellaneous bioseparation processes 251
12.1. Introduction 251
12.2. Electrophoresis 251
12.3. Affinity ultrafiltration 255
12.4. Field flow fractionation 255
Index 257 |
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| language | English |
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| spelling | Ghosh, Raja Verfasser aut Principles of bioseparations engineering Raja Ghosh Singapore [u.a.] World Scientific 2006 XIV, 265 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Biomolécules - Séparation Génie biochimique Séparation (Technologie) Biochemical engineering Biomolecules Separation Separation (Technology) Biotechnologie (DE-588)4069491-4 gnd rswk-swf Trennverfahren (DE-588)4078395-9 gnd rswk-swf Biotechnologie (DE-588)4069491-4 s Trennverfahren (DE-588)4078395-9 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015006622&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Ghosh, Raja Principles of bioseparations engineering Biomolécules - Séparation Génie biochimique Séparation (Technologie) Biochemical engineering Biomolecules Separation Separation (Technology) Biotechnologie (DE-588)4069491-4 gnd Trennverfahren (DE-588)4078395-9 gnd |
| subject_GND | (DE-588)4069491-4 (DE-588)4078395-9 |
| title | Principles of bioseparations engineering |
| title_auth | Principles of bioseparations engineering |
| title_exact_search | Principles of bioseparations engineering |
| title_exact_search_txtP | Principles of bioseparations engineering |
| title_full | Principles of bioseparations engineering Raja Ghosh |
| title_fullStr | Principles of bioseparations engineering Raja Ghosh |
| title_full_unstemmed | Principles of bioseparations engineering Raja Ghosh |
| title_short | Principles of bioseparations engineering |
| title_sort | principles of bioseparations engineering |
| topic | Biomolécules - Séparation Génie biochimique Séparation (Technologie) Biochemical engineering Biomolecules Separation Separation (Technology) Biotechnologie (DE-588)4069491-4 gnd Trennverfahren (DE-588)4078395-9 gnd |
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