Isolation, characterization and biological activities of natural products from Croton Species (Euphorbiaceae):
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| Main Author: | |
|---|---|
| Format: | Book |
| Language: | German |
| Published: |
München
Verl. Dr. Hut
2006
|
| Edition: | 1. Aufl. |
| Series: | Pharmazeutische Chemie
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Zugl.: München, Universität, Diss., 2006 |
| Physical Description: | VII, 222 S. Ill., graph. Darst. 210 mm x 148 mm, 320 gr. |
| ISBN: | 9783899633962 3899633962 |
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| 245 | 1 | 0 | |a Isolation, characterization and biological activities of natural products from Croton Species (Euphorbiaceae) |c Karina Perrelli Randau |
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Record in the Search Index
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| adam_text | Table of Contents Page
Abstract v
Abbreviations vi
General Introduction 1
Research Aims and Objectives 2
1 CHAPTER 1 Natural Products in Drug Discovery 3
1.1 Natural products in drug discovery 3
1.2 Application of alkaloids in medicine 11
2 CHAPTER 2 Euphorbiaceae Family and Croton Genus 14
2.1 General introduction 14
2.2 Familiy Euphorbiaceae Juss. 15
2.3 Botanical description and systematic from Croton Genus 20
2.4 Phytochemical Investigations of Secondary Metabolites of 23
Croton Species
2.5 Selection and collection of Croton species 27
2.6 Ethnomedicinal Use 37
2.7 Previous investigations of Selected Species of Croton 37
2.7.1 Croton argyroglossum Baill. 37
2.7.2 Croton rhamnifolioides Pax Hoffm. 37
2.7.3 Croton rhamnifolius Humb, Bomp Kunth 38
2.7.4 Croton zehntneri Pax Hoffm. 39
3 CHAPTER 3 Isolation, Identification, Characterization and 40
Elucidation of Structures
3.1 Classification and Biosynthesis of Isoquinoline Alkaloids 40
3.1.1 The Aporphine Alkaloids 48
3.1.2 Quaternary Alkaloids 50
3.2 Phytochemical Investigation of Alkaloids from the Croton Genus 51
3.3 Extraction, Isolation and Structure Elucidation of Natural 56
Products from Croton Species
3.3.1 Extraction, Isolation and Structure Elucidation of Natural 57
Products from Croton argyroglossum Baill.
3.3.1.1 Orobanone 57
3.3.1.2 Pernambucone 59
3.3.1.3 N Methyl L tyrosine 66
3.3.1.4 Trigonelline 67
3.3.2 Extraction, Isolation and Structure Elucidation of Natural 69
Products from Croton rhamnifolioides Pax Hoffm.
3.3.2.1 1,2,3,4 tetrahydro 1 oxo p carboline 69
3.3.3 Extraction, Isolation and Structure Elucidation of Natural 71
Products from Croton zehntneri Pax Hoffm.
3.3.2.1 Crototropone 71
3.3.2.2 1,4 Dimethoxy 2 ((E) propenyl) benzene 77
3.3.4 Extraction, Isolation and Structure Elucidation of Isoquinolines 80
Alkaloids
3.3.4.1. Magnoflorine 90
3.3.4.2 Menisperine 94
3.3.4.3 Ramnifolioidine 98
3.3.4.4 Zehntnerine 104
3.3.4.5 Metorientaline 112
3.4 Identification and characterization of Compounds from Croton by 120
Gas Chromatography Mass Spectrometry
4 CHAPTER 4 Biological Activities 132
4.1 General introduction 132
4.1.2 Bioactivity of Croton Species Extracts and Isolated Compounds 132
4.1.3 Bioactivity of Isoquinoline Alkaloids 137
4.2 Assays 138
4.2.1 Agar Diffusion Assay 139
4.2.2 Kinesin Assay 141
4.2.3 Cytotoxicity Assay 143
4.2.4 Antimalarial Assay 147
5 CHAPTER 5 Conclusion and Future Directions 150
5.1 Conclusion 150
5.2. Future directions 154
6 CHAPTER 6 Experimental Section 155
6.1 General experimental procedures 155
6.1.1 Equipment 156
6.1.2 Chromatographic Separations and Identifications 156
6.1.3 Chemicals and solvents 159
6.1.4 Detection Methods and Spray Reagents for TLC 160
6.1.5 Collection of Plant Material 160
6.1.6 General Procedure for Extraction and Isolation of Alkaloids and 161
other Compounds from Croton
6.2 Isolation of compounds from Croton argyroglossum 163
6.3 Isolation of compounds from Croton rhamnifolioides 163
6.4 Isolation of compounds from Croton rhamnifolius 164
6.5 Isolation of compounds from Croton zehntneri 164
6.6 Isolation of quaternary alkaloids from Croton rhamnifolius, 164
Croton rhamnifolioides and Croton zehntneri
6.5 Data from isolated compounds 167
6.5.1 Orobanone 167
6.5.2 Pernambucone 169
6.5.3 N Methyl tyrosine 170
6.5.4 Trigonelline 171
6.5.5 1,2,3,4 tetrahydro 1 oxo p carboline 172
6.5.6 Crototropone 173
6.5.7 1,4 Dimethoxy 2 ((£) propenyl) benzene 174
6.5.8 Magnoflorine 175
6.5.9 Menisperine 177
6.5.10 Rhamnifolioidine 179
6.5.11 Zehntnerine 181
6.5.12 Metorientaline 183
6.6 Biological activities 185
6.6.1 Agar diffusion assay 185
6.6.2. Kinesin assay 186
6.6.3. Cytotoxicity assay 188
6.6.4 Antimalarial assay 191
7 Appendices 193
8 References 205
9 Curriculum vitae 222
|
| adam_txt |
Table of Contents Page
Abstract v
Abbreviations vi
General Introduction 1
Research Aims and Objectives 2
1 CHAPTER 1 Natural Products in Drug Discovery 3
1.1 Natural products in drug discovery 3
1.2 Application of alkaloids in medicine 11
2 CHAPTER 2 Euphorbiaceae Family and Croton Genus 14
2.1 General introduction 14
2.2 Familiy Euphorbiaceae Juss. 15
2.3 Botanical description and systematic from Croton Genus 20
2.4 Phytochemical Investigations of Secondary Metabolites of 23
Croton Species
2.5 Selection and collection of Croton species 27
2.6 Ethnomedicinal Use 37
2.7 Previous investigations of Selected Species of Croton 37
2.7.1 Croton argyroglossum Baill. 37
2.7.2 Croton rhamnifolioides Pax Hoffm. 37
2.7.3 Croton rhamnifolius Humb, Bomp Kunth 38
2.7.4 Croton zehntneri Pax Hoffm. 39
3 CHAPTER 3 Isolation, Identification, Characterization and 40
Elucidation of Structures
3.1 Classification and Biosynthesis of Isoquinoline Alkaloids 40
3.1.1 The Aporphine Alkaloids 48
3.1.2 Quaternary Alkaloids 50
3.2 Phytochemical Investigation of Alkaloids from the Croton Genus 51
3.3 Extraction, Isolation and Structure Elucidation of Natural 56
Products from Croton Species
3.3.1 Extraction, Isolation and Structure Elucidation of Natural 57
Products from Croton argyroglossum Baill.
3.3.1.1 Orobanone 57
3.3.1.2 Pernambucone 59
3.3.1.3 N Methyl L tyrosine 66
3.3.1.4 Trigonelline 67
3.3.2 Extraction, Isolation and Structure Elucidation of Natural 69
Products from Croton rhamnifolioides Pax Hoffm.
3.3.2.1 1,2,3,4 tetrahydro 1 oxo p carboline 69
3.3.3 Extraction, Isolation and Structure Elucidation of Natural 71
Products from Croton zehntneri Pax Hoffm.
3.3.2.1 Crototropone 71
3.3.2.2 1,4 Dimethoxy 2 ((E) propenyl) benzene 77
3.3.4 Extraction, Isolation and Structure Elucidation of Isoquinolines 80
Alkaloids
3.3.4.1. Magnoflorine 90
3.3.4.2 Menisperine 94
3.3.4.3 Ramnifolioidine 98
3.3.4.4 Zehntnerine 104
3.3.4.5 Metorientaline 112
3.4 Identification and characterization of Compounds from Croton by 120
Gas Chromatography Mass Spectrometry
4 CHAPTER 4 Biological Activities 132
4.1 General introduction 132
4.1.2 Bioactivity of Croton Species Extracts and Isolated Compounds 132
4.1.3 Bioactivity of Isoquinoline Alkaloids 137
4.2 Assays 138
4.2.1 Agar Diffusion Assay 139
4.2.2 Kinesin Assay 141
4.2.3 Cytotoxicity Assay 143
4.2.4 Antimalarial Assay 147
5 CHAPTER 5 Conclusion and Future Directions 150
5.1 Conclusion 150
5.2. Future directions 154
6 CHAPTER 6 Experimental Section 155
6.1 General experimental procedures 155
6.1.1 Equipment 156
6.1.2 Chromatographic Separations and Identifications 156
6.1.3 Chemicals and solvents 159
6.1.4 Detection Methods and Spray Reagents for TLC 160
6.1.5 Collection of Plant Material 160
6.1.6 General Procedure for Extraction and Isolation of Alkaloids and 161
other Compounds from Croton
6.2 Isolation of compounds from Croton argyroglossum 163
6.3 Isolation of compounds from Croton rhamnifolioides 163
6.4 Isolation of compounds from Croton rhamnifolius 164
6.5 Isolation of compounds from Croton zehntneri 164
6.6 Isolation of quaternary alkaloids from Croton rhamnifolius, 164
Croton rhamnifolioides and Croton zehntneri
6.5 Data from isolated compounds 167
6.5.1 Orobanone 167
6.5.2 Pernambucone 169
6.5.3 N Methyl tyrosine 170
6.5.4 Trigonelline 171
6.5.5 1,2,3,4 tetrahydro 1 oxo p carboline 172
6.5.6 Crototropone 173
6.5.7 1,4 Dimethoxy 2 ((£) propenyl) benzene 174
6.5.8 Magnoflorine 175
6.5.9 Menisperine 177
6.5.10 Rhamnifolioidine 179
6.5.11 Zehntnerine 181
6.5.12 Metorientaline 183
6.6 Biological activities 185
6.6.1 Agar diffusion assay 185
6.6.2. Kinesin assay 186
6.6.3. Cytotoxicity assay 188
6.6.4 Antimalarial assay 191
7 Appendices 193
8 References 205
9 Curriculum vitae 222 |
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| language | German |
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| physical | VII, 222 S. Ill., graph. Darst. 210 mm x 148 mm, 320 gr. |
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| publisher | Verl. Dr. Hut |
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| spelling | Perrelli Randau, Karina Verfasser aut Isolation, characterization and biological activities of natural products from Croton Species (Euphorbiaceae) Karina Perrelli Randau 1. Aufl. München Verl. Dr. Hut 2006 VII, 222 S. Ill., graph. Darst. 210 mm x 148 mm, 320 gr. txt rdacontent n rdamedia nc rdacarrier Pharmazeutische Chemie Zugl.: München, Universität, Diss., 2006 Alkaloide swd Biologische Aktivität swd Wolfsmilchgewächse swd (DE-588)4113937-9 Hochschulschrift gnd-content HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014962203&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Perrelli Randau, Karina Isolation, characterization and biological activities of natural products from Croton Species (Euphorbiaceae) Alkaloide swd Biologische Aktivität swd Wolfsmilchgewächse swd |
| subject_GND | (DE-588)4113937-9 |
| title | Isolation, characterization and biological activities of natural products from Croton Species (Euphorbiaceae) |
| title_auth | Isolation, characterization and biological activities of natural products from Croton Species (Euphorbiaceae) |
| title_exact_search | Isolation, characterization and biological activities of natural products from Croton Species (Euphorbiaceae) |
| title_exact_search_txtP | Isolation, characterization and biological activities of natural products from Croton Species (Euphorbiaceae) |
| title_full | Isolation, characterization and biological activities of natural products from Croton Species (Euphorbiaceae) Karina Perrelli Randau |
| title_fullStr | Isolation, characterization and biological activities of natural products from Croton Species (Euphorbiaceae) Karina Perrelli Randau |
| title_full_unstemmed | Isolation, characterization and biological activities of natural products from Croton Species (Euphorbiaceae) Karina Perrelli Randau |
| title_short | Isolation, characterization and biological activities of natural products from Croton Species (Euphorbiaceae) |
| title_sort | isolation characterization and biological activities of natural products from croton species euphorbiaceae |
| topic | Alkaloide swd Biologische Aktivität swd Wolfsmilchgewächse swd |
| topic_facet | Alkaloide Biologische Aktivität Wolfsmilchgewächse Hochschulschrift |
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