Chondroitin sulfate: structure, role and pharmacological activity
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Amsterdam [u.a.]
Elsevier, AP
2006
|
| Series: | Advances in pharmacology
53 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XXVI, 568 S. Ill., graph. Darst. |
| ISBN: | 0120329557 9780120329557 |
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| 245 | 1 | 0 | |a Chondroitin sulfate |b structure, role and pharmacological activity |c ed. by Nicola Volpi |
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier, AP |c 2006 | |
| 300 | |a XXVI, 568 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Advances in pharmacology |v 53 | |
| 650 | 4 | |a Dermatane-sulfate | |
| 650 | 4 | |a Glycosaminoglycanes | |
| 650 | 4 | |a Médicaments - Recherche | |
| 650 | 4 | |a Protéoglycanes | |
| 650 | 4 | |a Chondroitin Sulfates | |
| 650 | 4 | |a Dermatan sulfate | |
| 650 | 4 | |a Glycosaminoglycans | |
| 650 | 4 | |a Pharmacy |x Research | |
| 650 | 4 | |a Proteoglycans | |
| 700 | 1 | |a Volpi, Nicola |e Sonstige |4 oth | |
| 830 | 0 | |a Advances in pharmacology |v 53 |w (DE-604)BV002534644 |9 53 | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-014942877 | ||
Record in the Search Index
| _version_ | 1804135575319478272 |
|---|---|
| adam_text | Contents
Abbreviations xv
Contributors xix
Preface xxv
PART I Structure
Isolation, Purification, and Analysis of Chondroitin
Sulfate Proteoglycans
Fumiko Matsui and Atsuhiko Oohira
I. Chapter Overview 3
II. Introduction 4
III. Preparation of Tissues for CSPGs Extraction 4
IV. Extraction of CSPGs 5
V. Isolation and Purification of CSPGs 8
VI. Structural Analyses of CSPGs 14
VII. Conclusions 18
References 19
vi Contents
Isolation and Purification of Chondroitin Sulfate
Luiz Claudio F. Silva
I. Chapter Overview 21
II. Introduction 22
III. General Characteristics of CS 22
IV. Sources and Structure of Commercial Forms of CS 23
V. General Preparative Procedures to Extract CS from Tissues 23
VI. Extraction from Tissues 25
VII. Recovery of CS from Proteinase Extracts 25
VIII. Fractionation Methods 27
IX. Conclusions 29
References 29
Structure of Chondroitin Sulfate
Fotini N. Lamari and Nikos K. Karamanos
I. Chapter Overview 33
II. Introduction 34
III. Linkage Region 38
IV. Repeating Disaccharide Region 39
V. Nonreducing Terminal 42
VI. Future Perspectives 43
References 43
Progress in the Structural Biology of Chondroitin Sulfate
Barbara Mulloy
I. Chapter Overview 49
II. Introduction 50
III. Experimental Structures of CS Chains 51
IV. Theoretical Studies 53
V. NMR Studies of CS and DS Polysaccharides 57
VI. Structures of CS Proteoglycans 58
VII. Chondroitin as a Covalent Cross Link Between Two or
More Proteins 60
VIII. Crystal Structures of Complexes Between Chondroitin Degrading
Enzymes and Oligosaccharides 61
IX. Specificity of Interactions Between Chondroitin Sequences
and Proteins 64
References 65
Contents vii
The Biosynthesis and Catabolism of Galactosaminoglycans
Vikas Prabhakar and Ram Sasisekharan
I. GalAG Biopolymers 69
II. GalAGs in the Extracellular Matrix 75
III. GalAG Protein Interactions 75
IV. GalAGs in Biomedicine 77
V. The Biosynthesis of GalAGs 81
VI. The Catabolism of GalAGs 88
VII. The Enzymatic Degradation of GalAGs 92
VIII. Perspectives 97
References 100
Biosynthesis of Chondroitin Sulfate: From the Early, Precursor
Discoveries to Nowadays, Genetics Approaches
Mauro S. G. Pavao, Ana Cristina Vilela Silva, and Paulo A. S. Mourao
I. Chapter Overview 117
II. Introduction 118
III. Precursor Discoveries on the Biosynthesis of CS 119
IV. The Biosynthesis of the CS Starts with the Formation of the
Linkage Region 121
V. Post Translational Modifications of the Linkage Region Regulate the
Synthesis of the GAG chain 126
VI. Chain Initiation and Polymerization of CS/DS 127
VII. Sulfation of CS: General Properties of the Sulfotransferases 128
VIII. 6 O Sulfotransferase 129
IX. 4 O Sulfotransferase 131
X. 2 O Sulfotransferase 132
XI. Genetic Defects Affecting the Biosynthesis of CS 133
XII. Future Perspectives 134
References 134
Advances in the Analysis of Chondroitin/ Dermatan Sulfate
M. Stylianou, I. E. Triantaphyllidou, and D. H. Vynios
I. Chapter Overview 141
II. Introduction 142
III. Chromogenic Quantitative Methods 145
IV. Chromatographic Methods 148
V. Electromigration Methods 151
VI. Solid Phase Assays, ELISA and ELISA Based Procedures 158
VII. General Conclusions 159
References 161
viii Contents
Chondroitin Sulfate Lyases: Applications in
Analysis and Glycobiology
Emmanuel Petit, Cedric Delattre, Duke Papy Garcia, and Philippe Michaud
I. Chapter Overview 167
II. Introduction 168
III. Structures of Chondroitin Sulfates 170
IV. Degradation of Chondroitin Backbone by CS Lyases 170
V. Applications of Chondroitin Sulfates Lyases 177
VI. Conclusions 181
References 181
CS Lyases: Structure, Activity, and Applications in Analysis and
the Treatment of Diseases
Robert J. Linhardt, Fikri Y. Avci, Toshihiko Toida, Yeong Shik Kim, and Miroslaw Cygler
I. Chondroitin Sulfate Glycosaminoglycans 187
II. Enzymes Mediating GAG Synthesis 189
III. CS Degrading Enzymes 190
IV. Analytical Applications 203
V. Synthetic Applications 207
VI. Therapeutic Applications 207
VII. Conclusions 209
References 209
PART II Biological Role of Chondroitin Sulfate
Structure, Metabolism, and Tissue Roles of Chondroitin
Sulfate Proteoglycans
Christopher J. Handley, Tom Samiric, and Mirna Z. Ilic
I. Chapter Overview 219
II. Introduction 220
III. Major Structural Features of Proteoglycans 220
IV. Major Species of Chondroitin Sulfate Proteoglycans 222
V. Concluding Remarks 229
References 229
Contents ix
Emergence and Structural Characteristics of Chondroitin
Sulfates in the Animal Kingdom
Lucia O. Sampaio and Helena B. Nader
I. Chapter Overview 233
II. Introduction 234
III. Galactosaminoglycans in an Evolutionary Context 238
IV. Structural Characteristics of the Galactosaminoglycans 241
V. Concluding Remarks 245
References 245
Role of the Sulfation Pattern of Chondroitin
Sulfate in its Biological Activities and in the Binding
of Growth Factors
Chilkunda D. Nandini and Kazuyuki Sugahara
I. Chapter Overview 253
II. Introduction 254
III. Structures of Typical Disaccharide Units in CS chains 254
IV. Structural Variation in CS Chains 255
V. Epitope Structure Characterized by Monoclonal Antibodies Useful
for Immunohistochemistry 260
VI. Interactions of Heparin Binding Growth Factors with
CS Chains 261
VII. Influence of Structure on Biological Activities of CS 271
VIII. Perspectives 274
References 274
Chondroitin Sulfate as a Key Molecule in the Development of
Atherosclerosis and Cancer Progression
A. D. Theocharis, I. Tsolakis, G. N. Tzanakakis, and Nikos K. Karamanos
I. Chapter Overview 281
II. Types of CS Containing Proteoglycans 282
III. CSPGs in the Development of Atherosclerosis 283
IV. CSPGs in Cancer Development 288
V. Conclusions 292
References 293
X Contents
Chondroitin Sulfate Proteoglycans in Tumor Progression
Yanusz Wegrowski and Francois Xavier Maquart
I. Chapter Overview 297
II. Introduction 298
III. The Stromal Reaction 299
IV. Tumor Stroma CS/DSPGs 300
V. Tumor Cell Membrane PGs 304
VI. PGs of the Nervous System 306
VII. Functions of PGs in Tumor Progression 307
VIII. Concluding Remarks 309
References 310
Chondroitin Sulfate Proteoglycans in the Brain
Sachiko Aono and Atsuhiko Oohira
I. Chapter Overview 323
II. Introduction 324
III. Species and Structures of CSPGs Specific to the CNS 324
IV. CSPGs in the Neurogenetic Stage 327
V. CSPGs in the Developing Brain 328
VI. CSPGs in the Mature Brain 329
VII. CSPGs and CNS Injuries 331
References 331
Chondroitin/Dermatan Sulfates in the Central Nervous System:
Their Structures and Functions in Health and Disease
Uwe Rauch and Joachim Kappler
I. Chapter Overview 337
II. Introduction 338
III. Structures and Expression Patterns of CSPGs in the CNS 338
IV. Physiological Functions of CSPGs 345
V. CSPGs in CNS Diseases 347
VI. Conclusions 349
References 350
Contents xi
Chondroitin Sulfate Proteoglycan and its Degradation Products
in CNS Repair
Asya Rolls and Michal Schwartz
I. Chapter Overview 357
II. Introduction 358
III. CSPG in Wound Healing 359
IV. General Aspects of CNS Repair 360
V. CSPG in CNS Repair 362
VI. Degradation Products 365
VII. Pharmacological Implications 366
VIII. Conclusions 369
References 370
Role of Chondroitin 4 Sulfate in Pregnancy Associated Malaria
D. Channe Gowda
I. Chapter Overview 375
II. Glycosaminoglycans as Receptor for Microbial Adhesion and
Invasion of Host Cells and Tissues 376
III. Structural Features and Occurrence of Chondroitin Sulfates 377
IV. Malaria Infection and Parasite Interaction with the Host 378
V. Adherence of P. falciparum lniected Erythrocytes in the Placenta and
Pregnancy Associated Malaria 380
VI. C4S Mediates the Adherence of P. falciparum IRBCS in Human
Placenta 381
VII. Uniquely Low Sulfated Extracellular CSPG is the Major Receptor for
IRBC Adherence in Human Placenta 383
VIII. CSPG Receptor for IRBC Adhesion is Localized in the Intervillous
Space of the Placenta 385
IX. Structural Requirement for the IRBC Adherence to Human Placental
CSPG Receptor 386
X. Minimum C4S Structural Motif Involved in the IRBC Adherence to
Placental CSPG 387
XI. Distribution of Sulfated Disaccharide Residues in the CS Chains of
Placental CSPG 389
XII. Low Sulfated Placental CSPG is Expressed Throughout the Second
and Third Trimester 389
XIII. Presence of C4S IRBC Antiadhesion Antibodies in Pregnant Women
in Malaria Endemic Areas 390
XIV. P. falciparum Adhesive Protein that Mediates IRBC Adherence to the
Placental CSPG 392
XV. Conclusions 392
References 394
xii Contents
PART III Pharmacological Activities of
Chondroitin Sulfate
Immunological Activity of Chondroitin Sulfate
Toshihiko Toida, Shinobu Sakai, Hiroshi Akiyama, and Robert J. Linhardt
I. Chapter Overview 403
II. Introduction 404
III. Clinical Experience (David and Lynne, 2003) 405
IV. Metabolic Fate of Orally Administered Chondroitin Sulfates 406
V. A New Concept for Explaining the Effect of Chondroitin Sulfate in
Arthritis Treatment 408
References 412
Antioxidant Activity of Chondroitin Sulfate
G. M. Campo, A. Avenoso, S. Campo, A. M. Ferlazzo, and A. Calatroni
I. Chapter Overview 417
II. Background 418
III. The Ability of CS and HA to Chelate Metal Ions 419
IV. In Vitro Studies 420
V. In Vivo Studies 421
VI. Antioxidant Mechanism 424
VII. Pharmacological Strategies 425
VIII. Conclusions 428
References 428
Effects of Chondroitin Sulfate on the Cellular Metabolism
N. Brandl, J. Holzmann, R. Schabus, and M. Huettinger
I. Potential of the Versatile Molecule Chondroitin Sulfate to Interfere
with Cellular Reactions 433
II. Chondroitin Sulfate Functions in Nerve Tissue 435
III. Biological and Pharmacological Changes in Chondroitin Sulfate
Levels that Effect Metabolic Changes 437
IV. Effects of Soluble Chondroitin Sulfate on Chondrocytes 438
V. Concluding Statement 442
References 443
Contents xiH
In Vitro Effects of Chondroitin Sulfate
A. Fioravanti and G. Collodel
I. Chapter Overview 449
II. Introduction 450
III. In Vitro Models for the Study of Structure Modifying
Drugs for OA 451
IV. In Vitro Effects of CS 453
V. Conclusions 462
References 463
Effect of Chondroitin Sulfate as Nutraceutical in Dogs
with Arthropathies
Britta Dobenecker
I. Chapter Overview 467
II. Introduction 468
III. Results and Conclusions 469
References 473
Chondroitin Sulfate as a Structure Modifying Agent
Daniel Uebelhart, Ruud Knols, Eling D de Bruin, and Gust Verbruggen
I. Chapter Overview 475
II. Introduction 476
III. Methods 478
IV. Results 479
V. Discussion 483
VI. Conclusions 485
References 485
PART IV Clinical Efficacy and Trials
Chondroitin Sulfate in the Management of Erosive
Osteoarthritis of the Interphalangeal Finger Joints
Gust Verbruggen
I. Chapter Overview 491
II. Introduction: The Pathology of Erosive Osteoarthritis 492
XIV Contents
III. Chondroitin Sulfates and the Management of Erosive Osteoarthritis
of the Finger Joints 495
IV. Discussion 499
References 502
Chondroitin Sulfate in the Management of Hip and Knee
Osteoarthritis: An Overview
Geraldine Bana, Benedicte Jamard, Evelyne Verrouil, and Bernard Mazieres
I. Chapter Overview 507
II. Introduction 508
III. Methods 509
IV. Results 511
V. Discussion 518
References 519
Treatment of Knee Osteoarthritis with Oral
Chondroitin Sulfate
Daniel Uebelhart, Ruud Knols, Eling D de Bruin, and Gust Verbruggen
I. Chapter Overview 523
II. Introduction 524
III. Methods 527
IV. Results 529
V. Discussion 533
VI. Conclusions 537
References 537
Index 541
Contents of Previous Volumes 555
|
| adam_txt |
Contents
Abbreviations xv
Contributors xix
Preface xxv
PART I Structure
Isolation, Purification, and Analysis of Chondroitin
Sulfate Proteoglycans
Fumiko Matsui and Atsuhiko Oohira
I. Chapter Overview 3
II. Introduction 4
III. Preparation of Tissues for CSPGs Extraction 4
IV. Extraction of CSPGs 5
V. Isolation and Purification of CSPGs 8
VI. Structural Analyses of CSPGs 14
VII. Conclusions 18
References 19
vi Contents
Isolation and Purification of Chondroitin Sulfate
Luiz Claudio F. Silva
I. Chapter Overview 21
II. Introduction 22
III. General Characteristics of CS 22
IV. Sources and Structure of Commercial Forms of CS 23
V. General Preparative Procedures to Extract CS from Tissues 23
VI. Extraction from Tissues 25
VII. Recovery of CS from Proteinase Extracts 25
VIII. Fractionation Methods 27
IX. Conclusions 29
References 29
Structure of Chondroitin Sulfate
Fotini N. Lamari and Nikos K. Karamanos
I. Chapter Overview 33
II. Introduction 34
III. Linkage Region 38
IV. Repeating Disaccharide Region 39
V. Nonreducing Terminal 42
VI. Future Perspectives 43
References 43
Progress in the Structural Biology of Chondroitin Sulfate
Barbara Mulloy
I. Chapter Overview 49
II. Introduction 50
III. Experimental Structures of CS Chains 51
IV. Theoretical Studies 53
V. NMR Studies of CS and DS Polysaccharides 57
VI. Structures of CS Proteoglycans 58
VII. Chondroitin as a Covalent Cross Link Between Two or
More Proteins 60
VIII. Crystal Structures of Complexes Between Chondroitin Degrading
Enzymes and Oligosaccharides 61
IX. Specificity of Interactions Between Chondroitin Sequences
and Proteins 64
References 65
Contents vii
The Biosynthesis and Catabolism of Galactosaminoglycans
Vikas Prabhakar and Ram Sasisekharan
I. GalAG Biopolymers 69
II. GalAGs in the Extracellular Matrix 75
III. GalAG Protein Interactions 75
IV. GalAGs in Biomedicine 77
V. The Biosynthesis of GalAGs 81
VI. The Catabolism of GalAGs 88
VII. The Enzymatic Degradation of GalAGs 92
VIII. Perspectives 97
References 100
Biosynthesis of Chondroitin Sulfate: From the Early, Precursor
Discoveries to Nowadays, Genetics Approaches
Mauro S. G. Pavao, Ana Cristina Vilela Silva, and Paulo A. S. Mourao
I. Chapter Overview 117
II. Introduction 118
III. Precursor Discoveries on the Biosynthesis of CS 119
IV. The Biosynthesis of the CS Starts with the Formation of the
Linkage Region 121
V. Post Translational Modifications of the Linkage Region Regulate the
Synthesis of the GAG chain 126
VI. Chain Initiation and Polymerization of CS/DS 127
VII. Sulfation of CS: General Properties of the Sulfotransferases 128
VIII. 6 O Sulfotransferase 129
IX. 4 O Sulfotransferase 131
X. 2 O Sulfotransferase 132
XI. Genetic Defects Affecting the Biosynthesis of CS 133
XII. Future Perspectives 134
References 134
Advances in the Analysis of Chondroitin/ Dermatan Sulfate
M. Stylianou, I. E. Triantaphyllidou, and D. H. Vynios
I. Chapter Overview 141
II. Introduction 142
III. Chromogenic Quantitative Methods 145
IV. Chromatographic Methods 148
V. Electromigration Methods 151
VI. Solid Phase Assays, ELISA and ELISA Based Procedures 158
VII. General Conclusions 159
References 161
viii Contents
Chondroitin Sulfate Lyases: Applications in
Analysis and Glycobiology
Emmanuel Petit, Cedric Delattre, Duke Papy Garcia, and Philippe Michaud
I. Chapter Overview 167
II. Introduction 168
III. Structures of Chondroitin Sulfates 170
IV. Degradation of Chondroitin Backbone by CS Lyases 170
V. Applications of Chondroitin Sulfates Lyases 177
VI. Conclusions 181
References 181
CS Lyases: Structure, Activity, and Applications in Analysis and
the Treatment of Diseases
Robert J. Linhardt, Fikri Y. Avci, Toshihiko Toida, Yeong Shik Kim, and Miroslaw Cygler
I. Chondroitin Sulfate Glycosaminoglycans 187
II. Enzymes Mediating GAG Synthesis 189
III. CS Degrading Enzymes 190
IV. Analytical Applications 203
V. Synthetic Applications 207
VI. Therapeutic Applications 207
VII. Conclusions 209
References 209
PART II Biological Role of Chondroitin Sulfate
Structure, Metabolism, and Tissue Roles of Chondroitin
Sulfate Proteoglycans
Christopher J. Handley, Tom Samiric, and Mirna Z. Ilic
I. Chapter Overview 219
II. Introduction 220
III. Major Structural Features of Proteoglycans 220
IV. Major Species of Chondroitin Sulfate Proteoglycans 222
V. Concluding Remarks 229
References 229
Contents ix
Emergence and Structural Characteristics of Chondroitin
Sulfates in the Animal Kingdom
Lucia O. Sampaio and Helena B. Nader
I. Chapter Overview 233
II. Introduction 234
III. Galactosaminoglycans in an Evolutionary Context 238
IV. Structural Characteristics of the Galactosaminoglycans 241
V. Concluding Remarks 245
References 245
Role of the Sulfation Pattern of Chondroitin
Sulfate in its Biological Activities and in the Binding
of Growth Factors
Chilkunda D. Nandini and Kazuyuki Sugahara
I. Chapter Overview 253
II. Introduction 254
III. Structures of Typical Disaccharide Units in CS chains 254
IV. Structural Variation in CS Chains 255
V. Epitope Structure Characterized by Monoclonal Antibodies Useful
for Immunohistochemistry 260
VI. Interactions of Heparin Binding Growth Factors with
CS Chains 261
VII. Influence of Structure on Biological Activities of CS 271
VIII. Perspectives 274
References 274
Chondroitin Sulfate as a Key Molecule in the Development of
Atherosclerosis and Cancer Progression
A. D. Theocharis, I. Tsolakis, G. N. Tzanakakis, and Nikos K. Karamanos
I. Chapter Overview 281
II. Types of CS Containing Proteoglycans 282
III. CSPGs in the Development of Atherosclerosis 283
IV. CSPGs in Cancer Development 288
V. Conclusions 292
References 293
X Contents
Chondroitin Sulfate Proteoglycans in Tumor Progression
Yanusz Wegrowski and Francois Xavier Maquart
I. Chapter Overview 297
II. Introduction 298
III. The Stromal Reaction 299
IV. Tumor Stroma CS/DSPGs 300
V. Tumor Cell Membrane PGs 304
VI. PGs of the Nervous System 306
VII. Functions of PGs in Tumor Progression 307
VIII. Concluding Remarks 309
References 310
Chondroitin Sulfate Proteoglycans in the Brain
Sachiko Aono and Atsuhiko Oohira
I. Chapter Overview 323
II. Introduction 324
III. Species and Structures of CSPGs Specific to the CNS 324
IV. CSPGs in the Neurogenetic Stage 327
V. CSPGs in the Developing Brain 328
VI. CSPGs in the Mature Brain 329
VII. CSPGs and CNS Injuries 331
References 331
Chondroitin/Dermatan Sulfates in the Central Nervous System:
Their Structures and Functions in Health and Disease
Uwe Rauch and Joachim Kappler
I. Chapter Overview 337
II. Introduction 338
III. Structures and Expression Patterns of CSPGs in the CNS 338
IV. Physiological Functions of CSPGs 345
V. CSPGs in CNS Diseases 347
VI. Conclusions 349
References 350
Contents xi
Chondroitin Sulfate Proteoglycan and its Degradation Products
in CNS Repair
Asya Rolls and Michal Schwartz
I. Chapter Overview 357
II. Introduction 358
III. CSPG in Wound Healing 359
IV. General Aspects of CNS Repair 360
V. CSPG in CNS Repair 362
VI. Degradation Products 365
VII. Pharmacological Implications 366
VIII. Conclusions 369
References 370
Role of Chondroitin 4 Sulfate in Pregnancy Associated Malaria
D. Channe Gowda
I. Chapter Overview 375
II. Glycosaminoglycans as Receptor for Microbial Adhesion and
Invasion of Host Cells and Tissues 376
III. Structural Features and Occurrence of Chondroitin Sulfates 377
IV. Malaria Infection and Parasite Interaction with the Host 378
V. Adherence of P. falciparum lniected Erythrocytes in the Placenta and
Pregnancy Associated Malaria 380
VI. C4S Mediates the Adherence of P. falciparum IRBCS in Human
Placenta 381
VII. Uniquely Low Sulfated Extracellular CSPG is the Major Receptor for
IRBC Adherence in Human Placenta 383
VIII. CSPG Receptor for IRBC Adhesion is Localized in the Intervillous
Space of the Placenta 385
IX. Structural Requirement for the IRBC Adherence to Human Placental
CSPG Receptor 386
X. Minimum C4S Structural Motif Involved in the IRBC Adherence to
Placental CSPG 387
XI. Distribution of Sulfated Disaccharide Residues in the CS Chains of
Placental CSPG 389
XII. Low Sulfated Placental CSPG is Expressed Throughout the Second
and Third Trimester 389
XIII. Presence of C4S IRBC Antiadhesion Antibodies in Pregnant Women
in Malaria Endemic Areas 390
XIV. P. falciparum Adhesive Protein that Mediates IRBC Adherence to the
Placental CSPG 392
XV. Conclusions 392
References 394
xii Contents
PART III Pharmacological Activities of
Chondroitin Sulfate
Immunological Activity of Chondroitin Sulfate
Toshihiko Toida, Shinobu Sakai, Hiroshi Akiyama, and Robert J. Linhardt
I. Chapter Overview 403
II. Introduction 404
III. Clinical Experience (David and Lynne, 2003) 405
IV. Metabolic Fate of Orally Administered Chondroitin Sulfates 406
V. A New Concept for Explaining the Effect of Chondroitin Sulfate in
Arthritis Treatment 408
References 412
Antioxidant Activity of Chondroitin Sulfate
G. M. Campo, A. Avenoso, S. Campo, A. M. Ferlazzo, and A. Calatroni
I. Chapter Overview 417
II. Background 418
III. The Ability of CS and HA to Chelate Metal Ions 419
IV. In Vitro Studies 420
V. In Vivo Studies 421
VI. Antioxidant Mechanism 424
VII. Pharmacological Strategies 425
VIII. Conclusions 428
References 428
Effects of Chondroitin Sulfate on the Cellular Metabolism
N. Brandl, J. Holzmann, R. Schabus, and M. Huettinger
I. Potential of the Versatile Molecule Chondroitin Sulfate to Interfere
with Cellular Reactions 433
II. Chondroitin Sulfate Functions in Nerve Tissue 435
III. Biological and Pharmacological Changes in Chondroitin Sulfate
Levels that Effect Metabolic Changes 437
IV. Effects of Soluble Chondroitin Sulfate on Chondrocytes 438
V. Concluding Statement 442
References 443
Contents xiH
In Vitro Effects of Chondroitin Sulfate
A. Fioravanti and G. Collodel
I. Chapter Overview 449
II. Introduction 450
III. In Vitro Models for the Study of Structure Modifying
Drugs for OA 451
IV. In Vitro Effects of CS 453
V. Conclusions 462
References 463
Effect of Chondroitin Sulfate as Nutraceutical in Dogs
with Arthropathies
Britta Dobenecker
I. Chapter Overview 467
II. Introduction 468
III. Results and Conclusions 469
References 473
Chondroitin Sulfate as a Structure Modifying Agent
Daniel Uebelhart, Ruud Knols, Eling D de Bruin, and Gust Verbruggen
I. Chapter Overview 475
II. Introduction 476
III. Methods 478
IV. Results 479
V. Discussion 483
VI. Conclusions 485
References 485
PART IV Clinical Efficacy and Trials
Chondroitin Sulfate in the Management of Erosive
Osteoarthritis of the Interphalangeal Finger Joints
Gust Verbruggen
I. Chapter Overview 491
II. Introduction: The Pathology of Erosive Osteoarthritis 492
XIV Contents
III. Chondroitin Sulfates and the Management of Erosive Osteoarthritis
of the Finger Joints 495
IV. Discussion 499
References 502
Chondroitin Sulfate in the Management of Hip and Knee
Osteoarthritis: An Overview
Geraldine Bana, Benedicte Jamard, Evelyne Verrouil, and Bernard Mazieres
I. Chapter Overview 507
II. Introduction 508
III. Methods 509
IV. Results 511
V. Discussion 518
References 519
Treatment of Knee Osteoarthritis with Oral
Chondroitin Sulfate
Daniel Uebelhart, Ruud Knols, Eling D de Bruin, and Gust Verbruggen
I. Chapter Overview 523
II. Introduction 524
III. Methods 527
IV. Results 529
V. Discussion 533
VI. Conclusions 537
References 537
Index 541
Contents of Previous Volumes 555 |
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| dewey-full | 515.1 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 515 - Analysis |
| dewey-raw | 515.1 |
| dewey-search | 515.1 |
| dewey-sort | 3515.1 |
| dewey-tens | 510 - Mathematics |
| discipline | Mathematik |
| discipline_str_mv | Mathematik |
| format | Book |
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| id | DE-604.BV021729347 |
| illustrated | Illustrated |
| index_date | 2024-07-02T15:25:50Z |
| indexdate | 2024-07-09T20:42:41Z |
| institution | BVB |
| isbn | 0120329557 9780120329557 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-014942877 |
| oclc_num | 70886366 |
| open_access_boolean | |
| owner | DE-19 DE-BY-UBM |
| owner_facet | DE-19 DE-BY-UBM |
| physical | XXVI, 568 S. Ill., graph. Darst. |
| publishDate | 2006 |
| publishDateSearch | 2006 |
| publishDateSort | 2006 |
| publisher | Elsevier, AP |
| record_format | marc |
| series | Advances in pharmacology |
| series2 | Advances in pharmacology |
| spelling | Chondroitin sulfate structure, role and pharmacological activity ed. by Nicola Volpi Amsterdam [u.a.] Elsevier, AP 2006 XXVI, 568 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in pharmacology 53 Dermatane-sulfate Glycosaminoglycanes Médicaments - Recherche Protéoglycanes Chondroitin Sulfates Dermatan sulfate Glycosaminoglycans Pharmacy Research Proteoglycans Volpi, Nicola Sonstige oth Advances in pharmacology 53 (DE-604)BV002534644 53 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014942877&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Chondroitin sulfate structure, role and pharmacological activity Advances in pharmacology Dermatane-sulfate Glycosaminoglycanes Médicaments - Recherche Protéoglycanes Chondroitin Sulfates Dermatan sulfate Glycosaminoglycans Pharmacy Research Proteoglycans |
| title | Chondroitin sulfate structure, role and pharmacological activity |
| title_auth | Chondroitin sulfate structure, role and pharmacological activity |
| title_exact_search | Chondroitin sulfate structure, role and pharmacological activity |
| title_exact_search_txtP | Chondroitin sulfate structure, role and pharmacological activity |
| title_full | Chondroitin sulfate structure, role and pharmacological activity ed. by Nicola Volpi |
| title_fullStr | Chondroitin sulfate structure, role and pharmacological activity ed. by Nicola Volpi |
| title_full_unstemmed | Chondroitin sulfate structure, role and pharmacological activity ed. by Nicola Volpi |
| title_short | Chondroitin sulfate |
| title_sort | chondroitin sulfate structure role and pharmacological activity |
| title_sub | structure, role and pharmacological activity |
| topic | Dermatane-sulfate Glycosaminoglycanes Médicaments - Recherche Protéoglycanes Chondroitin Sulfates Dermatan sulfate Glycosaminoglycans Pharmacy Research Proteoglycans |
| topic_facet | Dermatane-sulfate Glycosaminoglycanes Médicaments - Recherche Protéoglycanes Chondroitin Sulfates Dermatan sulfate Glycosaminoglycans Pharmacy Research Proteoglycans |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014942877&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002534644 |
| work_keys_str_mv | AT volpinicola chondroitinsulfatestructureroleandpharmacologicalactivity |