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Nanodevices for the life sciences:

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Bibliographic Details
Format:	Book
Language:	English
Published:	Weinheim Wiley-VCH 2006
Edition:	1. ed.
Series:	Nanotechnologies for the life sciences 4
Subjects:	Biowissenschaften Biotechnology > methods Life sciences > Research Nanoscience Nanostructured materials Nanotechnology > methods Nanotechnologie
Online Access:	Inhaltstext Inhaltsverzeichnis
Physical Description:	XX, 469 S. Ill., Darst.
ISBN:	3527313842 9783527313846

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adam_text	CONTENTS PREFACE XIII LIST OF CONTRIBUTORS XVII THE PHYSICS AND MODELING OF BIOFUNCTIONALIZED NANOELECTROMECHANICAL SYSTEMS 1 MARK R. PAUL ANDJERRY E. SOLOMON 1.1 INTRODUCTION 1 1.2 THE STOCHASTIC DYNAMICS OF MICRO- AND NANOSCALE OSCILLATORS IN FLUID 4 1.2.1 FLUID DYNAMICS AT SMALL SCALES 4 1.2.2 AN EXACT APPROACH TO DETERMINE THE STOCHASTIC DYNAMICS OF ARRAYS OF CANTILEVERS OF ARBITRARY GEOMETRY IN FLUID 8 1.2.3 AN APPROXIMATE MODEL FOR LONG AND SLENDER CANTILEVERS IN FLUID 11 1.2.4 THE STOCHASTIC DYNAMICS OF A FLUID-COUPLED ARRAY OF (BIO)NEMS CANTILEVERS 16 1.3 THE PHYSICS DESCRIBING THE KINETICS OFTARGET ANALYTE CAPTURE ON THE OSCILLATOR 19 1.4 DETECTING NOISE IN NOISE: SIGNAL-PROCESSING CHALLENGES 24 1.5 CONCLUDING REMARKS 25 ACKNOWLEDGMENTS 26 REFERENCES 26 2 MATHEMATICAL AND COMPUTATIONAL MODELING: TOWARDS THE DEVELOPMENT AND APPLICATION OF NANODEVICES FOR DRUG DELIVERY 29 JOHN P. SINEK, HERMANN 8. FRIEBOES, 8ALAKRISHNAN SI~ARAMAN, SANDEEP SANGA, AND VITTORIO CRISTINI 2.1 INTRODUCTION 29 2.2 RES AVOIDANCE 30 2.2.1 A STATISTICAL MODEL OF NANOVECTOR SURFACE COVERAGE 31 2.2.2 MODELING THE FORCES MEDIATING PROTEIN APPROACH AND BINDING 35 2.3 TUMORAL VASCULATURE AND HEMODYNAMICS 35 NANOTECHNOLOGIES FOR THE LIFE SEIEN CES VOL. 4 NANODEVKESFOR THE LIFESEIENCES. EDITED BY CHALLA S. S. R. KUMAR COPYRIGHT 2006 WILEY-VCH VERLAG GMBH & CO. KGAA, WEINHEIM ISBN: 3-527-31384-2 V I CONTENTS 2.3.1 2.3.2 2.3.3 2.4 2.4.1 2.4.2 2.5 2.5.1 2.5.2 2.6 3 3.1 3.2 3.2.1 3.2.1.1 3.2.1.2 3.2.1.3 3.2.1.4 3.2.2 3.3 3.3.1 3.3.2 3.3.3 3.3.4 3.4 3.5 3.5.1 3.5.2 3.5.3 4 4.1 4.2 4.2.1 4.2.2 4.2.3 4.2.4 4.3 AN INVASION PERCOLATION MODEL OFVASCULOGENESIS AND HEMODYNAMICS 37 FLOW SIMULATIONS USING ANDERSON AND CHAPLAIN S MODEL 40 PARTIC1E DYNAMICS WITHIN THE TUMORAL VASCULATURE 45 RECEPTOR-LIGAND-MEDIATED BINDING 47 BELL SDETERMINISTIC MODEL 49 A STOCHASTIC MODEL 52 INTRATUMORAL AND CELLULAR DRUG KINETICS AND PHARMACODYNAMICS 54 A TWO-DIMENSIONAL MODEL OF CHEMOTHERAPY 55 REFINEMENTS OF THE MODEL 57 CONC1USION 61 REFERENCES 62 NANOLITHOGRAPHY: TOWARDS FABRICATION OF NANODEVICES FOR LIFE SCIENCES 67 JOHNPETER NDIANGU! NGLANJIRI, JIE-REN LI, ANDJAYNE CAROF CARNO INTRODUCTION: ENGINEERING SURFACES AT THE NANOSCALE 67 IMMOBILIZATION OF BIORNOLECULES FOR SURFACE ASSAYS 69 STRATEGIES FOR LINKING PROTEINS TO SURFACES 69 ELECTROSTATIC IMMOBILIZATION 70 COVALENT IMMOBILIZATION 70 MOLECULAR RECOGNITION AND SPECIFIC INTERACTIONS 71 NONSPECIFIC PHYSICAL ADSORPTION TO SURFACES 71 SAM CHEMISTRY 74 METHODS FOR NANOLITHOGRAPHY WITH PROTEINS 76 BIAS-INDUCED NANOLITHOGRAPHY OF SAMS 78 FORCE-INDUCED NANOLITHOGRAPHY OF SAMS 82 DPN OF SAMS AND PROTEINS 87 LATEX PARTICLE LITHOGRAPHY WITH PROTEINS 91 DETECTION OF PROTEIN BINDING AT THE NANOSCALE 94 PURURE DIRECTIONS 96 ADVANTAGES OF NANOSCALE DETECTION 96 DEVELOPMENT OF CANTILEVER ARRAYS 97 CONCLUDING REMARKS 101 REFERENCES 101 MICROCANTILEVER-BASED NANODEVICES IN THE LIFE SCIENCES 109 HORAEIE D. ESPINOSA, KELAN-HO KIM, AND NICOFAIE MOLDOVAN INTRODUCTION 109 MICROCANTILEVERS 111 MICROFABRICATION OF MINIATURIZED PROBES 112 CANTILEVER PROBES FOR NANOPATTERNING 116 ELASTOMERIC AFM PROBES 121 MONOLITHICALLY FABRICATED CONDUCTIVE DIAMOND PROBES 122 CANTILEVERS WITH INTEGRATED MIERE- AND NANOFIUIDICS 126 CONTENTS IVII 4.3.1 4.3.2 4.3.3 4.3.4 4.3.5 4.4 4.4.1 4.4.2 4.4.3 4.5 APERTURED PYRAMIDAL TIPS 126 OPEN-CHANNEL CANTILOVERED MICROSPOTTERS CLOSED-CHANNEL CANTILEVERED NANOPIPETTES MICROMACHINED HYPODERMIC NEEDLE ARRAYS NFPS 137 APPLICATIONS 141 PATTERNING OF DNA 141 PATTERNING OF PROTEINS 142 PATTERNING OF VIRUSES 143 CONCLUSIONS AND OUTLOOK 143 REFERENCES 144 128 133 136 5 5.1 5.2 5.3 5.3.1 5.3.2 5.4 5.4.1 5.4.2 5.5 5.5.1 5.5.2 5.5.2.1 5.5.2.2 5.5.2.3 5.5.2.4 5.5.2.5 5.6 5.7 NANOBIOELECTRONICS 150 ROSS RINALDI AND GIUSEPPE MARW;;C;O INTRODUCTION 150 BIO-SELF-ASSERNBLY AND MOTIVATION 150 FUNDAMENTALS OF THE BIO-BUILDING BLOCKS 153 DNA 153 PROTEINS 154 INTERCONNECTION, SELF-ASSEMBLY AND DEVICE IMPLEMENTATION 155 INTERCONNECTING MOLEEULES 157 DELIVERING MOLECULES 158 DEVICES BASED ON DNA AND DNA BASES 160 CHARGE TRANSFER IN DNA 161 DNA CONDUCTIVITY 164 NEAR-OHMIC BEHAVIOR (ACTIVATED HOPPING CONDUCTOR) 164 SEMICONDUCTING (BANDGAP) BEHAVIOR 168 INSULATING BEHAVIOR 169 DISCUSSION OF DNA CONDUCTIVITY 170 OTHER APPLICATIONS OF DNA IN MOLECULAR ELECTRONICS 173 DEVICES BASED ON PROTEINS 177 CONCLUSIONS 183 ACKNOWLEDGMENTS 183 REFERENCES 184 6 DNA NANODEVICES: PROTOTYPES AND APPLICATIONS 189 FRIEDRICH C. SIMMEL 6.1 INTRODUCTION 189 6.2 DNA AS A MATERIAL FOR NANOTECHNOLOGY 189 6.2.1 NANOSCALE SCIENCE 189 6.2.2 BIOPHYSICAL AND BIOCHEMICAL PROPERTIES OFNUCLEIC ACIDS 190 6.2.3 DNA NANOCONSTRUCTION 193 6.3 SIMPLE DNA DEVICES 193 6.3.1 CONFORMATIONAL CHANGES INDUCED BY SMALL MOLECULES AND IONS 193 6.3.2 HYBRIDIZATION-DRIVEN DEVICES 196 VIIII CONTENTS 6.4 6.4.1 6.4.2 6.4.3 6.4.4 6.5 6.5.1 6.5.2 6.6 TOWARDS FUNCTIONAL DEVICES 198 WALK AND ROLL 199 INTERACTION WITH PROTEINS 202 INFORMATION PROCESSING 206 SWITCHABLE NETWORKS AND HYBRID MATERIALS 207 AUTONOMOUS BEHAVIOR 209 DRIVING DEVICES WITH CHEMICAL REACTIONS 209 GENETIC CONTROL 210 CONELUSION 212 ACKNOWLEDGMENTS 213 REFERENCES 213 7 TOWARDS THE REALIZATION OF NANOBIOSENSORS BASED ON G-PROTEIN-COUPLED RECEPTORS 217 CECITTA PENNETTA, VLADIMIR AKIMOV, ETEONORA ALFINITO, UNO REGGIANI, TATIANA GOROJANKINA, [ASMINA MINIC, EDITH PAJOT-AUGY, MARIE-ANNICK PERSUV, ROLAND SA/ESSE, IGNACIO CASUSO, ABDELHAMID ERRACHID, GABRIE/ GOMILA, OSCAR RUIZ, JOSEP SAMITIER, YANXIA HOU, NICOLE JAFFREZIC, GIORGIO FERRARI, LAUM FUMAGAJII, AND MARCO SAMPIETRO 7.1 INTRODUCTION 217 7.2 PREPARATION AND IMMOBILIZATION OF GPCRS ON FUNCTIONALIZED SURFACES 220 7.3 SIGNAL TECHNIQUES 221 7.4 THEORETICAL APPROACH 222 7.5 THE IMPEDANCE NETWORK MODEL 224 7.6 EQUILIBRIUM FLUCTUATIONS 231 7.7 CONELUSIONS 235 ACKNOWLEDGMENTS 236 REFERENCES 236 8 PROTEIN-BASED NANOTECHNOLOGY: KINESIN-MICROTUBULE-DRIVEN SYSTEMS FOR BIOANALYTICAL APPLICATIONS 241 WILLIAM O. HANCOCK 8.1 INTRODUCTION 241 8.2 KINESIN AND MICROTUBULE CELL BIOLOGYAND BIOPHYSICS 242 8.2.1 KINESIN MOTILITY ASSAYS 244 8.3 THEORETICAL TRANSPORT ISSUES FOR DEVICEINTEGRATION 245 8.3.1 DIFFUSION VERSUS TRANSPORT TIMES 247 8.4 INTERACTION OF MOTOR PROTEINS AND FILAMENTS WITH SYNTHETIC SURFACES 249 8.4.1 MOTOR ADSORPTION 249 8.4.2 MICROTUBULE IMMOBILIZATION 251 8.5 CONTROLLING THE DIRECTION AND DISTANCE OF MICROSCALETRANSPORT 252 8.5.1 DIRECTING KINESIN-DRIVEN MICROTUBULES 252 8.5.2 MOVEMENT IN ENELOSED MICROCHANNELS 255 8.5.3 8.6 8.6.1 8.7 8.7.1 8.7.2 8.7.3 8.8 9 9.1 9.2 9.2.1 9.2.2 9.2.3 9.3 9.4 9.5 9.5.1 9.5.2 9.6 9.6.1 9.6.2 9.6.3 9.6.4 9.6.5 9.7 10 10.1 10.2 10.2.1 10.2.2 10.3 10.3.1 10.3.2 10.3.2.1 10.3.2.2 CONTENTS IIX IMMOBILIZED MICROTUBULE ARRAYS 257 CARGO ATTACHMENT 259 MAXIMUM CARGO SIZE 261 SYSTEM DESIGN CONSIDERATION 262 PROTEIN STABILITY AND LIFETIME 262 SAMPIE INTRODUCTION AND DETECTION 264 ANALYTE DETECTION AND COLLECTION 265 CONCLUSION 265 ACKNOWLEDGMENTS 266 REFERENCES 266 SELF.ASSEMBLY AND BIO-DIRECTED APPROACHES FOR CARBON NANOTUBES: TOWARDS DEVICE FABRICATION 272 ARIANNA FI/ORAMO INTRODUCTION 272 CNTS: BASIC FEATURES, SYNTHESIS AND DEVICE APPLICATIONS 274 BASIC FEATURES 274 SYNTHESIS OF NANOTUBES 276 DEVICE APPLICATIONS 277 FABRICATION OF CNT TRANSISTORS AND SELF-ASSEMBLY APPROACHES 278 IN SITU CVD GROWTH 280 SELECTIVE DEPOSITION OF CNTS BY SAM-ASSISTED TECHNIQUES 281 METHODOLOGY AND KEY PARAMETERS 282 PERFORMANCE OF CNTFETS FABRICATED BY THE SAM METHOD 288 DNA-DIRECTED SELF-ASSEMBLY 291 THE ASSEMBLY OF THE SCAFFOLD 292 SELECTIVE ATTACHMENT OF THE DNA SCAFFOLD ON THE SURFACE MICROSCALE ELECTRODES 294 POSITIONING OF NANO-OBJECTS OR NANODEVICES ON THE SCAFFOLD 295 REALIZATION OF ELECTRICAL CONNECTIONS AND CIRCUITRY 298 FABRICATION OF DNA-DIRECTED CNT DEVICES 303 CONCLUSION 304 REFERENCES 305 NANODEVICES FOR BIOSENSING: DESIGN, FABRICATION AND APPLICATIONS 317 LAURA M. LECHUGA, KIRILL ZINOVIEV, I.AURA G. CARRASCOSA, AND MIGUEL MORENO INTRODUCTION 317 FROM BIOSENSOR TO NANOBIOSENSOR DEVICES 318 OVERVIEW 318 BIOLOGICAL FUNCTIONALIZATION OF NANOBIOSENSORS 320 NANOPHOTONIE BIOSENSORS 321 OVERVIEW 321 INTEGRATED MACH-ZEHNDER INTERFEROMETER (MZI) NANODEVICE 322 DESIGN AND FABRICATION 323 CHARACTERIZATION AND APPLICATIONS 325 X CONTENTS 10.3.3 10.4 10.4.1 10.4.2 10.4.3 10.4.4 10.4.4.1 10.4.4.2 10.4.4.2.1 10.4.4.2.2 10.4.5 10.5 INTEGRATION IN MICROSYSTEMS 329 NANOMECHANICAL BIOSENSORS 330 OVERVIEW 330 WORKING PRINCIPLE 330 DETECTION SYSTEMS 332 DESIGN OF A STANDARD MICROCANTILEVER SENSOR 333 FABRICATION OF A STANDARD MICROCANTILEVER SENSOR 334 OPTICAL WAVEGUIDE MICROCANTILEVER: DESIGN AND FABRICATION PRINCIPLE OF OPERATION AND THEORETICAL ANALYSIS 338 FABRICATION AND CHARACTERIZATION 339 BIOSENSING APPLICATIONS OF N ANOMECHANICAL SENSORS 342 CONCLUSIONS AND FUTURE GOALS 344 ACLMOWLEDGMENTS 344 REFERENCES 344 337 11 11.1 11.2 11.3 11.4 11.4.1 11.4.2 11.4.3 11.4.4 11.4.5 11.4.6 11.4.7 11.4.8 12 12.1 12.2 12.2.1 12.2.1.1 12.2.1.2 12.2.1.3 12.3 12.3.1 12.3.2 12.3.2.1 FULLERENE-BASED DEVICES FOR BIOLOGICAL APPLICATIONS 348 GINKA H. SAROVA, TATIANA DA ROS, AND DIRK M. GULDI INTRODUCTION 348 SOLUBILITY 348 TOXICITY 350 DNA PHOTOCLEAVAGE 351 PHOTODYNAMIC THERAPY (PDT) 353 FULLERENE-MEDIATED ELECTRON TRANSFER ACROSS MEMBRANES 358 NEUROPROTECTIVE ACTIVITY VIA RADICAL SCAVENGING 362 ENZYME INHIBITION AND ANTIVIRAL ACTIVITY 367 ANTIBACTERIAL ACTIVITY 369 FULLERENES AS NANODEVICES IN MONOCLONAL IMMUNOLOGY 371 FULLERENES AS RADIOTRACERS 373 FULLERENES AS VECTORS 375 ACKNOWLEDGMENTS 376 REFERENCES 376 NANOTECHNOLOGY FOR BIOMEDICAL DEVICES 386 LARS MONTEJIUS INTRODUCTION 386 NANOTECHNOLOGIES 388 OVERVIEWOF NANOTECHNOLOGIES AND NANOTOOLS 388 NIL 393 OTHER LITHOGRAPHY TECHNIQUES 393 SCANNING PROBES 395 APPLICATIONS 397 INTRODUCTION 397 BIOMEDICAL APPLICATIONS BASED ON NANOSTRUCTURED PASSIVE SURFACES 397 SEPARATION, CONCENTRATION AND ENRICHING STRUCTURES 398 CONTENTS IXI 12.3.2.2 12.3.2.3 12.3.3 12.3.4 12.3.5 12.3.6 12.3.7 12.3.8 12.3.8.1 12.3.8.2 12.3.8.3 12.4 MOLECULAR MOTORS TRANSPORTED IN NANOMETER CHANNELS 400 TOPOGRAPHICAL STRUCTURES, CELLS AND GUIDANCE OF NEURONS 401 BIOMEDICAL APPLICATIONS UTILIZING ACTIVE NANOSTRUCTURED SURFACES PROTEIN CHIPS 409 PROTEIN INTERACTIONS 412 BIOMEDICAL APPLICATIONS USING NANOWIRES 415 BIOMEDICAL APPLICATIONS USING NANOPARTICLES 416 BIOMEDICAL APPLICATIONS USING SPM TECHNOLOGY 416 IMAGING OF BIOMOLECULES USING SPM 418 FORCE DETECTION OF SINGLE MOLECULAR EVENTS 418 CANTILEVER-BASED DETECTION OF MOLECULAR EVENTS 418 DISCUSSION AND OUTLOOK 423 ACKNOWLEDGMENTS 424 REFERENCES 425 405 13 13.1 13.2 13.3 13.3.1 13.3.2 13.3.3 13.4 13.5 13.6 13.7 13.8 13.9 NANODEVICES IN NATURE 436 ALEXANDER G. VOLKOV AND COURTNEY L. BROWN INTRODUCTION 436 MULTIELECTRON PROCESSES IN BIOELECTROCHEMICAL NANOREACTORS 437 CYTOCHROME OXIDASE: A NANODEVICE FOR RESPIRATION 438 NANODEVICE ARCHITECTONICS 441 ACTIVATION ENERGY AND MECHANISM OF OXYGEN REDUCTION 442 PROTON PUMP 443 PHOTOSYNTHETIC ELECTROCHEMICAL NANOREACTORS, NANORECTIFIERS, NANOSWITCHES AND BIOLOGICALLY CLOSED ELECTRICALLY CIRCUITS 443 PHOTOTROPIC NANODEVICES IN GREEN PLANTS: SENSING THE DIRECTION OF LIGHT 448 MEMBRANE TRANSPORT AND ION CHANNELS 451 MOLECULAR MOTORS 453 NANODEVICES FOR ELECTRORECEPTION AND ELECTRIC ORGAN DISCHARGES 455 NEURONS 456 REFERENCES 456 INDEX 460
adam_txt	CONTENTS PREFACE XIII LIST OF CONTRIBUTORS XVII THE PHYSICS AND MODELING OF BIOFUNCTIONALIZED NANOELECTROMECHANICAL SYSTEMS 1 MARK R. PAUL ANDJERRY E. SOLOMON 1.1 INTRODUCTION 1 1.2 THE STOCHASTIC DYNAMICS OF MICRO- AND NANOSCALE OSCILLATORS IN FLUID 4 1.2.1 FLUID DYNAMICS AT SMALL SCALES 4 1.2.2 AN EXACT APPROACH TO DETERMINE THE STOCHASTIC DYNAMICS OF ARRAYS OF CANTILEVERS OF ARBITRARY GEOMETRY IN FLUID 8 1.2.3 AN APPROXIMATE MODEL FOR LONG AND SLENDER CANTILEVERS IN FLUID 11 1.2.4 THE STOCHASTIC DYNAMICS OF A FLUID-COUPLED ARRAY OF (BIO)NEMS CANTILEVERS 16 1.3 THE PHYSICS DESCRIBING THE KINETICS OFTARGET ANALYTE CAPTURE ON THE OSCILLATOR 19 1.4 DETECTING NOISE IN NOISE: SIGNAL-PROCESSING CHALLENGES 24 1.5 CONCLUDING REMARKS 25 ACKNOWLEDGMENTS 26 REFERENCES 26 2 MATHEMATICAL AND COMPUTATIONAL MODELING: TOWARDS THE DEVELOPMENT AND APPLICATION OF NANODEVICES FOR DRUG DELIVERY 29 JOHN P. SINEK, HERMANN 8. FRIEBOES, 8ALAKRISHNAN SI~ARAMAN, SANDEEP SANGA, AND VITTORIO CRISTINI 2.1 INTRODUCTION 29 2.2 RES AVOIDANCE 30 2.2.1 A STATISTICAL MODEL OF NANOVECTOR SURFACE COVERAGE 31 2.2.2 MODELING THE FORCES MEDIATING PROTEIN APPROACH AND BINDING 35 2.3 TUMORAL VASCULATURE AND HEMODYNAMICS 35 NANOTECHNOLOGIES FOR THE LIFE SEIEN CES VOL. 4 NANODEVKESFOR THE LIFESEIENCES. EDITED BY CHALLA S. S. R. KUMAR COPYRIGHT 2006 WILEY-VCH VERLAG GMBH & CO. KGAA, WEINHEIM ISBN: 3-527-31384-2 V\ I CONTENTS 2.3.1 2.3.2 2.3.3 2.4 2.4.1 2.4.2 2.5 2.5.1 2.5.2 2.6 3 3.1 3.2 3.2.1 3.2.1.1 3.2.1.2 3.2.1.3 3.2.1.4 3.2.2 3.3 3.3.1 3.3.2 3.3.3 3.3.4 3.4 3.5 3.5.1 3.5.2 3.5.3 4 4.1 4.2 4.2.1 4.2.2 4.2.3 4.2.4 4.3 AN INVASION PERCOLATION MODEL OFVASCULOGENESIS AND HEMODYNAMICS 37 FLOW SIMULATIONS USING ANDERSON AND CHAPLAIN'S MODEL 40 PARTIC1E DYNAMICS WITHIN THE TUMORAL VASCULATURE 45 RECEPTOR-LIGAND-MEDIATED BINDING 47 BELL'SDETERMINISTIC MODEL 49 A STOCHASTIC MODEL 52 INTRATUMORAL AND CELLULAR DRUG KINETICS AND PHARMACODYNAMICS 54 A TWO-DIMENSIONAL MODEL OF CHEMOTHERAPY 55 REFINEMENTS OF THE MODEL 57 CONC1USION 61 REFERENCES 62 NANOLITHOGRAPHY: TOWARDS FABRICATION OF NANODEVICES FOR LIFE SCIENCES 67 JOHNPETER NDIANGU! NGLANJIRI, JIE-REN LI, ANDJAYNE CAROF CARNO INTRODUCTION: ENGINEERING SURFACES AT THE NANOSCALE 67 IMMOBILIZATION OF BIORNOLECULES FOR SURFACE ASSAYS 69 STRATEGIES FOR LINKING PROTEINS TO SURFACES 69 ELECTROSTATIC IMMOBILIZATION 70 COVALENT IMMOBILIZATION 70 MOLECULAR RECOGNITION AND SPECIFIC INTERACTIONS 71 NONSPECIFIC PHYSICAL ADSORPTION TO SURFACES 71 SAM CHEMISTRY 74 METHODS FOR NANOLITHOGRAPHY WITH PROTEINS 76 BIAS-INDUCED NANOLITHOGRAPHY OF SAMS 78 FORCE-INDUCED NANOLITHOGRAPHY OF SAMS 82 DPN OF SAMS AND PROTEINS 87 LATEX PARTICLE LITHOGRAPHY WITH PROTEINS 91 DETECTION OF PROTEIN BINDING AT THE NANOSCALE 94 PURURE DIRECTIONS 96 ADVANTAGES OF NANOSCALE DETECTION 96 DEVELOPMENT OF CANTILEVER ARRAYS 97 CONCLUDING REMARKS 101 REFERENCES 101 MICROCANTILEVER-BASED NANODEVICES IN THE LIFE SCIENCES 109 HORAEIE D. ESPINOSA, KELAN-HO KIM, AND NICOFAIE MOLDOVAN INTRODUCTION 109 MICROCANTILEVERS 111 MICROFABRICATION OF MINIATURIZED PROBES 112 CANTILEVER PROBES FOR NANOPATTERNING 116 ELASTOMERIC AFM PROBES 121 MONOLITHICALLY FABRICATED CONDUCTIVE DIAMOND PROBES 122 CANTILEVERS WITH INTEGRATED MIERE- AND NANOFIUIDICS 126 CONTENTS IVII 4.3.1 4.3.2 4.3.3 4.3.4 4.3.5 4.4 4.4.1 4.4.2 4.4.3 4.5 APERTURED PYRAMIDAL TIPS 126 OPEN-CHANNEL CANTILOVERED MICROSPOTTERS CLOSED-CHANNEL CANTILEVERED NANOPIPETTES MICROMACHINED HYPODERMIC NEEDLE ARRAYS NFPS 137 APPLICATIONS 141 PATTERNING OF DNA 141 PATTERNING OF PROTEINS 142 PATTERNING OF VIRUSES 143 CONCLUSIONS AND OUTLOOK 143 REFERENCES 144 128 133 136 5 5.1 5.2 5.3 5.3.1 5.3.2 5.4 5.4.1 5.4.2 5.5 5.5.1 5.5.2 5.5.2.1 5.5.2.2 5.5.2.3 5.5.2.4 5.5.2.5 5.6 5.7 NANOBIOELECTRONICS 150 ROSS RINALDI AND GIUSEPPE MARW;;C;O INTRODUCTION 150 BIO-SELF-ASSERNBLY AND MOTIVATION 150 FUNDAMENTALS OF THE BIO-BUILDING BLOCKS 153 DNA 153 PROTEINS 154 INTERCONNECTION, SELF-ASSEMBLY AND DEVICE IMPLEMENTATION 155 INTERCONNECTING MOLEEULES 157 DELIVERING MOLECULES 158 DEVICES BASED ON DNA AND DNA BASES 160 CHARGE TRANSFER IN DNA 161 DNA CONDUCTIVITY 164 NEAR-OHMIC BEHAVIOR (ACTIVATED HOPPING CONDUCTOR) 164 SEMICONDUCTING (BANDGAP) BEHAVIOR 168 INSULATING BEHAVIOR 169 DISCUSSION OF DNA CONDUCTIVITY 170 OTHER APPLICATIONS OF DNA IN MOLECULAR ELECTRONICS 173 DEVICES BASED ON PROTEINS 177 CONCLUSIONS 183 ACKNOWLEDGMENTS 183 REFERENCES 184 6 DNA NANODEVICES: PROTOTYPES AND APPLICATIONS 189 FRIEDRICH C. SIMMEL 6.1 INTRODUCTION 189 6.2 DNA AS A MATERIAL FOR NANOTECHNOLOGY 189 6.2.1 NANOSCALE SCIENCE 189 6.2.2 BIOPHYSICAL AND BIOCHEMICAL PROPERTIES OFNUCLEIC ACIDS 190 6.2.3 DNA NANOCONSTRUCTION 193 6.3 SIMPLE DNA DEVICES 193 6.3.1 CONFORMATIONAL CHANGES INDUCED BY SMALL MOLECULES AND IONS 193 6.3.2 HYBRIDIZATION-DRIVEN DEVICES 196 VIIII CONTENTS 6.4 6.4.1 6.4.2 6.4.3 6.4.4 6.5 6.5.1 6.5.2 6.6 TOWARDS FUNCTIONAL DEVICES 198 WALK AND ROLL 199 INTERACTION WITH PROTEINS 202 INFORMATION PROCESSING 206 SWITCHABLE NETWORKS AND HYBRID MATERIALS 207 AUTONOMOUS BEHAVIOR 209 DRIVING DEVICES WITH CHEMICAL REACTIONS 209 GENETIC CONTROL 210 CONELUSION 212 ACKNOWLEDGMENTS 213 REFERENCES 213 7 TOWARDS THE REALIZATION OF NANOBIOSENSORS BASED ON G-PROTEIN-COUPLED RECEPTORS 217 CECITTA PENNETTA, VLADIMIR AKIMOV, ETEONORA ALFINITO, UNO REGGIANI, TATIANA GOROJANKINA, [ASMINA MINIC, EDITH PAJOT-AUGY, MARIE-ANNICK PERSUV, ROLAND SA/ESSE, IGNACIO CASUSO, ABDELHAMID ERRACHID, GABRIE/ GOMILA, OSCAR RUIZ, JOSEP SAMITIER, YANXIA HOU, NICOLE JAFFREZIC, GIORGIO FERRARI, LAUM FUMAGAJII, AND MARCO SAMPIETRO 7.1 INTRODUCTION 217 7.2 PREPARATION AND IMMOBILIZATION OF GPCRS ON FUNCTIONALIZED SURFACES 220 7.3 SIGNAL TECHNIQUES 221 7.4 THEORETICAL APPROACH 222 7.5 THE IMPEDANCE NETWORK MODEL 224 7.6 EQUILIBRIUM FLUCTUATIONS 231 7.7 CONELUSIONS 235 ACKNOWLEDGMENTS 236 REFERENCES 236 8 PROTEIN-BASED NANOTECHNOLOGY: KINESIN-MICROTUBULE-DRIVEN SYSTEMS FOR BIOANALYTICAL APPLICATIONS 241 WILLIAM O. HANCOCK 8.1 INTRODUCTION 241 8.2 KINESIN AND MICROTUBULE CELL BIOLOGYAND BIOPHYSICS 242 8.2.1 KINESIN MOTILITY ASSAYS 244 8.3 THEORETICAL TRANSPORT ISSUES FOR DEVICEINTEGRATION 245 8.3.1 DIFFUSION VERSUS TRANSPORT TIMES 247 8.4 INTERACTION OF MOTOR PROTEINS AND FILAMENTS WITH SYNTHETIC SURFACES 249 8.4.1 MOTOR ADSORPTION 249 8.4.2 MICROTUBULE IMMOBILIZATION 251 8.5 CONTROLLING THE DIRECTION AND DISTANCE OF MICROSCALETRANSPORT 252 8.5.1 DIRECTING KINESIN-DRIVEN MICROTUBULES 252 8.5.2 MOVEMENT IN ENELOSED MICROCHANNELS 255 8.5.3 8.6 8.6.1 8.7 8.7.1 8.7.2 8.7.3 8.8 9 9.1 9.2 9.2.1 9.2.2 9.2.3 9.3 9.4 9.5 9.5.1 9.5.2 9.6 9.6.1 9.6.2 9.6.3 9.6.4 9.6.5 9.7 10 10.1 10.2 10.2.1 10.2.2 10.3 10.3.1 10.3.2 10.3.2.1 10.3.2.2 CONTENTS IIX IMMOBILIZED MICROTUBULE ARRAYS 257 CARGO ATTACHMENT 259 MAXIMUM CARGO SIZE 261 SYSTEM DESIGN CONSIDERATION 262 PROTEIN STABILITY AND LIFETIME 262 SAMPIE INTRODUCTION AND DETECTION 264 ANALYTE DETECTION AND COLLECTION 265 CONCLUSION 265 ACKNOWLEDGMENTS 266 REFERENCES 266 SELF.ASSEMBLY AND BIO-DIRECTED APPROACHES FOR CARBON NANOTUBES: TOWARDS DEVICE FABRICATION 272 ARIANNA FI/ORAMO INTRODUCTION 272 CNTS: BASIC FEATURES, SYNTHESIS AND DEVICE APPLICATIONS 274 BASIC FEATURES 274 SYNTHESIS OF NANOTUBES 276 DEVICE APPLICATIONS 277 FABRICATION OF CNT TRANSISTORS AND SELF-ASSEMBLY APPROACHES 278 IN SITU CVD GROWTH 280 SELECTIVE DEPOSITION OF CNTS BY SAM-ASSISTED TECHNIQUES 281 METHODOLOGY AND KEY PARAMETERS 282 PERFORMANCE OF CNTFETS FABRICATED BY THE SAM METHOD 288 DNA-DIRECTED SELF-ASSEMBLY 291 THE ASSEMBLY OF THE SCAFFOLD 292 SELECTIVE ATTACHMENT OF THE DNA SCAFFOLD ON THE SURFACE MICROSCALE ELECTRODES 294 POSITIONING OF NANO-OBJECTS OR NANODEVICES ON THE SCAFFOLD 295 REALIZATION OF ELECTRICAL CONNECTIONS AND CIRCUITRY 298 FABRICATION OF DNA-DIRECTED CNT DEVICES 303 CONCLUSION 304 REFERENCES 305 NANODEVICES FOR BIOSENSING: DESIGN, FABRICATION AND APPLICATIONS 317 LAURA M. LECHUGA, KIRILL ZINOVIEV, I.AURA G. CARRASCOSA, AND MIGUEL MORENO INTRODUCTION 317 FROM BIOSENSOR TO NANOBIOSENSOR DEVICES 318 OVERVIEW 318 BIOLOGICAL FUNCTIONALIZATION OF NANOBIOSENSORS 320 NANOPHOTONIE BIOSENSORS 321 OVERVIEW 321 INTEGRATED MACH-ZEHNDER INTERFEROMETER (MZI) NANODEVICE 322 DESIGN AND FABRICATION 323 CHARACTERIZATION AND APPLICATIONS 325 X\ CONTENTS 10.3.3 10.4 10.4.1 10.4.2 10.4.3 10.4.4 10.4.4.1 10.4.4.2 10.4.4.2.1 10.4.4.2.2 10.4.5 10.5 INTEGRATION IN MICROSYSTEMS 329 NANOMECHANICAL BIOSENSORS 330 OVERVIEW 330 WORKING PRINCIPLE 330 DETECTION SYSTEMS 332 DESIGN OF A STANDARD MICROCANTILEVER SENSOR 333 FABRICATION OF A STANDARD MICROCANTILEVER SENSOR 334 OPTICAL WAVEGUIDE MICROCANTILEVER: DESIGN AND FABRICATION PRINCIPLE OF OPERATION AND THEORETICAL ANALYSIS 338 FABRICATION AND CHARACTERIZATION 339 BIOSENSING APPLICATIONS OF N ANOMECHANICAL SENSORS 342 CONCLUSIONS AND FUTURE GOALS 344 ACLMOWLEDGMENTS 344 REFERENCES 344 337 11 11.1 11.2 11.3 11.4 11.4.1 11.4.2 11.4.3 11.4.4 11.4.5 11.4.6 11.4.7 11.4.8 12 12.1 12.2 12.2.1 12.2.1.1 12.2.1.2 12.2.1.3 12.3 12.3.1 12.3.2 12.3.2.1 FULLERENE-BASED DEVICES FOR BIOLOGICAL APPLICATIONS 348 GINKA H. SAROVA, TATIANA DA ROS, AND DIRK M. GULDI INTRODUCTION 348 SOLUBILITY 348 TOXICITY 350 DNA PHOTOCLEAVAGE 351 PHOTODYNAMIC THERAPY (PDT) 353 FULLERENE-MEDIATED ELECTRON TRANSFER ACROSS MEMBRANES 358 NEUROPROTECTIVE ACTIVITY VIA RADICAL SCAVENGING 362 ENZYME INHIBITION AND ANTIVIRAL ACTIVITY 367 ANTIBACTERIAL ACTIVITY 369 FULLERENES AS NANODEVICES IN MONOCLONAL IMMUNOLOGY 371 FULLERENES AS RADIOTRACERS 373 FULLERENES AS VECTORS 375 ACKNOWLEDGMENTS 376 REFERENCES 376 NANOTECHNOLOGY FOR BIOMEDICAL DEVICES 386 LARS MONTEJIUS INTRODUCTION 386 NANOTECHNOLOGIES 388 OVERVIEWOF NANOTECHNOLOGIES AND NANOTOOLS 388 NIL 393 OTHER LITHOGRAPHY TECHNIQUES 393 SCANNING PROBES 395 APPLICATIONS 397 INTRODUCTION 397 BIOMEDICAL APPLICATIONS BASED ON NANOSTRUCTURED PASSIVE SURFACES 397 SEPARATION, CONCENTRATION AND ENRICHING STRUCTURES 398 CONTENTS IXI 12.3.2.2 12.3.2.3 12.3.3 12.3.4 12.3.5 12.3.6 12.3.7 12.3.8 12.3.8.1 12.3.8.2 12.3.8.3 12.4 MOLECULAR MOTORS TRANSPORTED IN NANOMETER CHANNELS 400 TOPOGRAPHICAL STRUCTURES, CELLS AND GUIDANCE OF NEURONS 401 BIOMEDICAL APPLICATIONS UTILIZING ACTIVE NANOSTRUCTURED SURFACES PROTEIN CHIPS 409 PROTEIN INTERACTIONS 412 BIOMEDICAL APPLICATIONS USING NANOWIRES 415 BIOMEDICAL APPLICATIONS USING NANOPARTICLES 416 BIOMEDICAL APPLICATIONS USING SPM TECHNOLOGY 416 IMAGING OF BIOMOLECULES USING SPM 418 FORCE DETECTION OF SINGLE MOLECULAR EVENTS 418 CANTILEVER-BASED DETECTION OF MOLECULAR EVENTS 418 DISCUSSION AND OUTLOOK 423 ACKNOWLEDGMENTS 424 REFERENCES 425 405 13 13.1 13.2 13.3 13.3.1 13.3.2 13.3.3 13.4 13.5 13.6 13.7 13.8 13.9 NANODEVICES IN NATURE 436 ALEXANDER G. VOLKOV AND COURTNEY L. BROWN INTRODUCTION 436 MULTIELECTRON PROCESSES IN BIOELECTROCHEMICAL NANOREACTORS 437 CYTOCHROME OXIDASE: A NANODEVICE FOR RESPIRATION 438 NANODEVICE ARCHITECTONICS 441 ACTIVATION ENERGY AND MECHANISM OF OXYGEN REDUCTION 442 PROTON PUMP 443 PHOTOSYNTHETIC ELECTROCHEMICAL NANOREACTORS, NANORECTIFIERS, NANOSWITCHES AND BIOLOGICALLY CLOSED ELECTRICALLY CIRCUITS 443 PHOTOTROPIC NANODEVICES IN GREEN PLANTS: SENSING THE DIRECTION OF LIGHT 448 MEMBRANE TRANSPORT AND ION CHANNELS 451 MOLECULAR MOTORS 453 NANODEVICES FOR ELECTRORECEPTION AND ELECTRIC ORGAN DISCHARGES 455 NEURONS 456 REFERENCES 456 INDEX 460
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spelling	Nanodevices for the life sciences ed. by Challa S. S. R. Kumar 1. ed. Weinheim Wiley-VCH 2006 XX, 469 S. Ill., Darst. txt rdacontent n rdamedia nc rdacarrier Nanotechnologies for the life sciences 4 Biowissenschaften Biotechnology methods Life sciences Research Nanoscience Nanostructured materials Nanotechnology methods Biowissenschaften (DE-588)4129772-6 gnd rswk-swf Nanotechnologie (DE-588)4327470-5 gnd rswk-swf Nanotechnologie (DE-588)4327470-5 s Biowissenschaften (DE-588)4129772-6 s DE-604 Kumar, Challa S. S. R. Sonstige (DE-588)129740470 oth Nanotechnologies for the life sciences 4 (DE-604)BV020030849 4 text/html http://deposit.dnb.de/cgi-bin/dokserv?id=2774921&prov=M&dok_var=1&dok_ext=htm Inhaltstext OEBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014906829&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Nanodevices for the life sciences Nanotechnologies for the life sciences Biowissenschaften Biotechnology methods Life sciences Research Nanoscience Nanostructured materials Nanotechnology methods Biowissenschaften (DE-588)4129772-6 gnd Nanotechnologie (DE-588)4327470-5 gnd
subject_GND	(DE-588)4129772-6 (DE-588)4327470-5
title	Nanodevices for the life sciences
title_auth	Nanodevices for the life sciences
title_exact_search	Nanodevices for the life sciences
title_exact_search_txtP	Nanodevices for the life sciences
title_full	Nanodevices for the life sciences ed. by Challa S. S. R. Kumar
title_fullStr	Nanodevices for the life sciences ed. by Challa S. S. R. Kumar
title_full_unstemmed	Nanodevices for the life sciences ed. by Challa S. S. R. Kumar
title_short	Nanodevices for the life sciences
title_sort	nanodevices for the life sciences
topic	Biowissenschaften Biotechnology methods Life sciences Research Nanoscience Nanostructured materials Nanotechnology methods Biowissenschaften (DE-588)4129772-6 gnd Nanotechnologie (DE-588)4327470-5 gnd
topic_facet	Biowissenschaften Biotechnology methods Life sciences Research Nanoscience Nanostructured materials Nanotechnology methods Nanotechnologie
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