Dendrimers in medicine and biotechnology: new molecular tools
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| Main Authors: | , , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Cambridge
RSC Publ.
2006
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | IX, 179 S. Ill. |
| ISBN: | 0854048529 9780854048526 |
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MARC
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| 245 | 1 | 0 | |a Dendrimers in medicine and biotechnology |b new molecular tools |c U. Boas ; J. B. Christensen ; P. M. H. Heegaard |
| 264 | 1 | |a Cambridge |b RSC Publ. |c 2006 | |
| 300 | |a IX, 179 S. |b Ill. | ||
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| 650 | 4 | |a Biomimetik | |
| 650 | 4 | |a Biotechnology | |
| 650 | 4 | |a Dendrimers | |
| 650 | 4 | |a Molecular structure | |
| 650 | 4 | |a Molekülstruktur | |
| 650 | 4 | |a Sternpolymere | |
| 650 | 4 | |a Biotechnology | |
| 650 | 4 | |a Dendrimers, in medicine | |
| 650 | 4 | |a Molecular structure | |
| 700 | 1 | |a Christensen, Jørn B. |e Verfasser |0 (DE-588)1078002622 |4 aut | |
| 700 | 1 | |a Heegaard, P. M. H. |e Verfasser |4 aut | |
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Record in the Search Index
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| adam_text | Table of Contents
Chapter 1 Dendrimers: Design, Synthesis and Chemical
Properties 1
1.1 Introduction 1
1.2 Terms and Nomenclature in Dendrimer Chemistry 3
1.3 Dendrimer Design 7
1.4 Dendrimer Synthesis 8
1.5 Physicochemical Properties of Dendrimers 16
1.6 Summary 24
References 24
Chapter 2 Properties of Dendrimers in Biological Systems 28
2.1 Significance of Multivalent Binding in Biological
Interactions 28
2.1.1 Dendritic Effect 29
2.1.2 Carbohydrate Ligands 30
2.2 Biocompatibility of Dendrimers 32
2.3 In Vitro Cytotoxicity of Dendrimers 32
2.4 In Vivo Cytotoxicity of Dendrimers 43
2.5 Biopermeability of Dendrimers 46
2.6 Biodistribution of Dendrimers 55
2.7 Immunogenicity of Dendrimers 57
2.8 Summary 57
References 59
Chapter 3 Dendrimers as Drug Delivery Devices 62
3.1 Introduction 62
3.2 Dendrimer Hosts 63
3.2.1 Dendrimer Hosts: Non Specific
Interactions with the Dendrimer Core 64
3.2.2 Dendritic Boxes or Topological
Trapping of Guests 70
viii Contents
3.2.3 Dendrimer Hosts: Specific Interactions
with the Dendrimer Core 71
3.2.4 Dendrimer Hosts: Non Polar Interactions
with the Dendrimer Surface Group 72
3.2.5 Dendrimer Hosts: Polar Interactions
with the Dendrimer Surface Groups 73
3.3 Covalently Bound Drug Dendrimer
Conjugates 76
3.3.1 Self Immolative Systems 79
3.4 Dendrimers as Gene Transfer Reagents 81
3.5 Summary 85
References 85
Chapter 4 Dendrimer Drugs 90
4.1 Introduction 90
4.2 Antiviral Dendrimers 91
4.3 Antibacterial Dendrimers 97
4.4 Dendrimers in Antitumour Therapy 103
4.5 Dendrimers in Therapy of Other Diseases 106
4.6 Dendrimer Based Vaccines 107
4.7 Dendrimer Interactions with Proteins.
Solublilisation of Protein Aggregates 119
4.8 Summary 123
References 124
Chapter 5 Dendrimers in Diagnostics 130
5.1 Contrast Agents based on Dendrimers 130
5.1.1 Dendrimer based Contrast Agents for CT 131
5.1.2 Dendrimer based Contrast Agents
forMRI 132
5.1.3 Dendrimer based Contrast Agents
for Scintigraphy 133
5.2 Fluorescence Enhanced by Dendrimers 133
5.3 Dendrimers in Bioassays 135
5.3.1 Dendrimer Enhanced Signal
Generation 135
5.3.2 Dendrimers for Amplifying the Covalent
Binding Capacity of Solid Phases 139
5.3.3 Microarray Application of Dendrimers 141
5.3.4 Fluorophore Labelled Dendrimers for
Visualisation Purposes 145
Contents ix
5.3.5 Using Dendrimers to Increase DNA
Extraction Yields 147
5.3.6 Using Dendrimers for direct Detection
of Live Bacteria 148
5.4 Summary 149
References 149
Chapter 6 Dendrimers as Biomimics 152
6.1 Introduction 152
6.2 Dendrimers as Protein Mimics 153
6.3 Dendrimers as Artificial Enzymes 161
6.4 Dendrimers as Artificial Antigens, Cell
Surfaces and Antibodies 167
6.5 Summary 170
References 171
Subject Index 173
|
| adam_txt |
Table of Contents
Chapter 1 Dendrimers: Design, Synthesis and Chemical
Properties 1
1.1 Introduction 1
1.2 Terms and Nomenclature in Dendrimer Chemistry 3
1.3 Dendrimer Design 7
1.4 Dendrimer Synthesis 8
1.5 Physicochemical Properties of Dendrimers 16
1.6 Summary 24
References 24
Chapter 2 Properties of Dendrimers in Biological Systems 28
2.1 Significance of Multivalent Binding in Biological
Interactions 28
2.1.1 Dendritic Effect 29
2.1.2 Carbohydrate Ligands 30
2.2 Biocompatibility of Dendrimers 32
2.3 In Vitro Cytotoxicity of Dendrimers 32
2.4 In Vivo Cytotoxicity of Dendrimers 43
2.5 Biopermeability of Dendrimers 46
2.6 Biodistribution of Dendrimers 55
2.7 Immunogenicity of Dendrimers 57
2.8 Summary 57
References 59
Chapter 3 Dendrimers as Drug Delivery Devices 62
3.1 Introduction 62
3.2 Dendrimer Hosts 63
3.2.1 Dendrimer Hosts: Non Specific
Interactions with the Dendrimer Core 64
3.2.2 Dendritic Boxes or Topological
Trapping of Guests 70
viii Contents
3.2.3 Dendrimer Hosts: Specific Interactions
with the Dendrimer Core 71
3.2.4 Dendrimer Hosts: Non Polar Interactions
with the Dendrimer Surface Group 72
3.2.5 Dendrimer Hosts: Polar Interactions
with the Dendrimer Surface Groups 73
3.3 Covalently Bound Drug Dendrimer
Conjugates 76
3.3.1 Self Immolative Systems 79
3.4 Dendrimers as Gene Transfer Reagents 81
3.5 Summary 85
References 85
Chapter 4 Dendrimer Drugs 90
4.1 Introduction 90
4.2 Antiviral Dendrimers 91
4.3 Antibacterial Dendrimers 97
4.4 Dendrimers in Antitumour Therapy 103
4.5 Dendrimers in Therapy of Other Diseases 106
4.6 Dendrimer Based Vaccines 107
4.7 Dendrimer Interactions with Proteins.
Solublilisation of Protein Aggregates 119
4.8 Summary 123
References 124
Chapter 5 Dendrimers in Diagnostics 130
5.1 Contrast Agents based on Dendrimers 130
5.1.1 Dendrimer based Contrast Agents for CT 131
5.1.2 Dendrimer based Contrast Agents
forMRI 132
5.1.3 Dendrimer based Contrast Agents
for Scintigraphy 133
5.2 Fluorescence Enhanced by Dendrimers 133
5.3 Dendrimers in Bioassays 135
5.3.1 Dendrimer Enhanced Signal
Generation 135
5.3.2 Dendrimers for Amplifying the Covalent
Binding Capacity of Solid Phases 139
5.3.3 Microarray Application of Dendrimers 141
5.3.4 Fluorophore Labelled Dendrimers for
Visualisation Purposes 145
Contents ix
5.3.5 Using Dendrimers to Increase DNA
Extraction Yields 147
5.3.6 Using Dendrimers for direct Detection
of Live Bacteria 148
5.4 Summary 149
References 149
Chapter 6 Dendrimers as Biomimics 152
6.1 Introduction 152
6.2 Dendrimers as Protein Mimics 153
6.3 Dendrimers as Artificial Enzymes 161
6.4 Dendrimers as Artificial Antigens, Cell
Surfaces and Antibodies 167
6.5 Summary 170
References 171
Subject Index 173 |
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| index_date | 2024-07-02T15:14:01Z |
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| isbn | 0854048529 9780854048526 |
| language | English |
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| physical | IX, 179 S. Ill. |
| publishDate | 2006 |
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| spelling | Boas, Ulrik Verfasser (DE-588)1078002843 aut Dendrimers in medicine and biotechnology new molecular tools U. Boas ; J. B. Christensen ; P. M. H. Heegaard Cambridge RSC Publ. 2006 IX, 179 S. Ill. txt rdacontent n rdamedia nc rdacarrier Biomimetik Biotechnology Dendrimers Molecular structure Molekülstruktur Sternpolymere Dendrimers, in medicine Christensen, Jørn B. Verfasser (DE-588)1078002622 aut Heegaard, P. M. H. Verfasser aut HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014903929&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Boas, Ulrik Christensen, Jørn B. Heegaard, P. M. H. Dendrimers in medicine and biotechnology new molecular tools Biomimetik Biotechnology Dendrimers Molecular structure Molekülstruktur Sternpolymere Dendrimers, in medicine |
| title | Dendrimers in medicine and biotechnology new molecular tools |
| title_auth | Dendrimers in medicine and biotechnology new molecular tools |
| title_exact_search | Dendrimers in medicine and biotechnology new molecular tools |
| title_exact_search_txtP | Dendrimers in medicine and biotechnology new molecular tools |
| title_full | Dendrimers in medicine and biotechnology new molecular tools U. Boas ; J. B. Christensen ; P. M. H. Heegaard |
| title_fullStr | Dendrimers in medicine and biotechnology new molecular tools U. Boas ; J. B. Christensen ; P. M. H. Heegaard |
| title_full_unstemmed | Dendrimers in medicine and biotechnology new molecular tools U. Boas ; J. B. Christensen ; P. M. H. Heegaard |
| title_short | Dendrimers in medicine and biotechnology |
| title_sort | dendrimers in medicine and biotechnology new molecular tools |
| title_sub | new molecular tools |
| topic | Biomimetik Biotechnology Dendrimers Molecular structure Molekülstruktur Sternpolymere Dendrimers, in medicine |
| topic_facet | Biomimetik Biotechnology Dendrimers Molecular structure Molekülstruktur Sternpolymere Dendrimers, in medicine |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014903929&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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