Pulmonary arterial hypertension related to congenital heart disease:
Saved in:
| Other Authors: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
München ; Jena
Elsevier, Urban & Fischer
2006
|
| Edition: | 1. publ. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Literaturangaben |
| Physical Description: | XI, 228 S. Ill., graph. Darst. 25 cm |
| ISBN: | 9783437241109 3437241109 |
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MARC
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| 245 | 1 | 0 | |a Pulmonary arterial hypertension related to congenital heart disease |c chief ed. Maurice Beghetti. Co-ed. Robyn J. Barst ... |
| 250 | |a 1. publ. | ||
| 264 | 1 | |a München ; Jena |b Elsevier, Urban & Fischer |c 2006 | |
| 300 | |a XI, 228 S. |b Ill., graph. Darst. |c 25 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Literaturangaben | ||
| 650 | 4 | |a Heart Defects, Congenital |x complications | |
| 650 | 4 | |a Heart Defects, Congenital |x therapy | |
| 650 | 4 | |a Hypertension, Pulmonary |x epidemiology | |
| 650 | 4 | |a Hypertension, Pulmonary |x therapy | |
| 650 | 0 | 7 | |a Pulmonale Hypertonie |0 (DE-588)4176331-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Angeborene Krankheit |0 (DE-588)4331107-6 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Herzkrankheit |0 (DE-588)4024663-2 |2 gnd |9 rswk-swf |
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| 689 | 0 | 2 | |a Pulmonale Hypertonie |0 (DE-588)4176331-2 |D s |
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| 700 | 1 | |a Beghetti, Maurice |4 edt | |
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Record in the Search Index
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| adam_text | Contents
Part 1:
Classification, Epidemiology and Pathophysiology
Chapter 1
Current Understanding and Unanswered Questions 1
Introduction 1
Pulmonary arterial hypertension in CHD 3
Overview of congenital heart defects 4
Conclusions and unanswered questions 6
Chapter 2
Classification of Patients with Congenital Systemic-to-Pulmonary
Shunts Associated with Pulmonary Arterial Hypertension:
Current Status and Future Directions 11
Congenital heart disease classification attempts 11
Classification of congenital systemic-to-pulmonary shunts associated with
pulmonary arterial hypertension 12
The proposal for a revised classification 14
Future directions 16
Chapter 3
Pathophysiology of Pulmonary Arterial Hypertension Associated with
Congenital Heart Disease 19
Introduction 19
Definition and classification of pulmonary hypertension 21
Cellular alterations in pulmonary arterial hypertension 22
Molecular mechanisms in the development of PAH 25
Relevance of cellular and molecular alterations in shunt-induced PAH 36
Chapter 4
Role of Endothelin in Pulmonary Arterial Hypertension Associated with
Congenital Heart Disease 47
Introduction 47
Biosynthesis and regulation of ET 48
Biological effects of ET-1 50
Role of ET in PAH 52
Conclusions 58
Chapter 5
The Special Setting of Cavopulmonary Anastomosis 67
Summary 71
IX
Contents ____
Chapter 6
Pathophysiology of Postoperative Pulmonary Hypertension 75
Introduction 75
Preoperative factors that contribute to postoperative pulmonary hypertension 76
Endothelial cell dysfunction and its role in the pathophysiology of
pulmonary hypertension 78
Changes in postoperative physiology 83
Cardiopulmonary bypass 85
Hypoxia, carbon dioxide and pH and bronchoconstriction 86
Conclusion 86
Part 2: Clinical Management of Patients with PAH-CHD
Chapter 7
Pulmonary Arterial Hypertension Assessment in Pediatric Cardiology .... 93
Introduction 93
Identification of patients 94
Detection of PAH 94
Characterization of PAH and its etiology 99
Disease severity and prognosis 106
Conclusion 106
Chapter 8
Adult Patients with PAH and Congenital Heart Disease: Challenge in the
Management 113
Introduction 113
Patient presentation and outcome 114
General management 116
Complications 117
Treatment options 119
Conclusion 123
Chapter 9
The Management of Children with Congenital Heart Disease 129
Introduction 129
Preoperative pulmonary hypertension 129
Postoperative pulmonary hypertension 132
Eisenmenger syndrome 134
Transplantation 136
Conclusion 136
Chapter 10
Postoperative Treatment of Pulmonary Hypertension 143
Introduction 143
Early repair 145
Anatomic investigation 145
Use of right-to-left shunt in right heart failure 146
Sedation and anesthesia 146
X
Contents
Alkalosis 148
Supplemental oxygen 149
Normal lung volume 149
Optimal hematocrit 150
Inotropic support 150
Intravenous vasodilators 152
Inhaled NO 153
Comparative effects of vasodilators 162
Surgical intervention for advanced pulmonary vascular disease 164
Chapter 11
Treatment Options for Children with Pulmonary Arterial Hypertension... 177
Introduction 177
General measures 178
Oxygen therapy 179
Diuretics/digoxin 180
Anticoagulation 180
Calcium channel blockers 180
Epoprostenol and prostacyclin analogues 181
Endothelin receptor antagonists 185
Nitric oxide 187
Phosphodiesterase inhibitors 187
Atrial septostomy 188
Transplantation 188
Conclusions 189
Chapter 12
Endpoints for Assessing PAH in CHD Patients 197
Introduction 197
Determinants and correlates of disease severity and survival in PAH 198
Clinical endpoints applied for PAH 207
Are specific clinical endpoints for CHD-PAH necessary? 216
Conclusions 218
Index 225
XI
|
| adam_txt |
Contents
Part 1:
Classification, Epidemiology and Pathophysiology
Chapter 1
Current Understanding and Unanswered Questions 1
Introduction 1
Pulmonary arterial hypertension in CHD 3
Overview of congenital heart defects 4
Conclusions and unanswered questions 6
Chapter 2
Classification of Patients with Congenital Systemic-to-Pulmonary
Shunts Associated with Pulmonary Arterial Hypertension:
Current Status and Future Directions 11
Congenital heart disease classification attempts 11
Classification of congenital systemic-to-pulmonary shunts associated with
pulmonary arterial hypertension 12
The proposal for a revised classification 14
Future directions 16
Chapter 3
Pathophysiology of Pulmonary Arterial Hypertension Associated with
Congenital Heart Disease 19
Introduction 19
Definition and classification of pulmonary hypertension 21
Cellular alterations in pulmonary arterial hypertension 22
Molecular mechanisms in the development of PAH 25
Relevance of cellular and molecular alterations in shunt-induced PAH 36
Chapter 4
Role of Endothelin in Pulmonary Arterial Hypertension Associated with
Congenital Heart Disease 47
Introduction 47
Biosynthesis and regulation of ET 48
Biological effects of ET-1 50
Role of ET in PAH 52
Conclusions 58
Chapter 5
The Special Setting of Cavopulmonary Anastomosis 67
Summary 71
IX
Contents _
Chapter 6
Pathophysiology of Postoperative Pulmonary Hypertension 75
Introduction 75
Preoperative factors that contribute to postoperative pulmonary hypertension 76
Endothelial cell dysfunction and its role in the pathophysiology of
pulmonary hypertension 78
Changes in postoperative physiology 83
Cardiopulmonary bypass 85
Hypoxia, carbon dioxide and pH and bronchoconstriction 86
Conclusion 86
Part 2: Clinical Management of Patients with PAH-CHD
Chapter 7
Pulmonary Arterial Hypertension Assessment in Pediatric Cardiology . 93
Introduction 93
Identification of patients 94
Detection of PAH 94
Characterization of PAH and its etiology 99
Disease severity and prognosis 106
Conclusion 106
Chapter 8
Adult Patients with PAH and Congenital Heart Disease: Challenge in the
Management 113
Introduction 113
Patient presentation and outcome 114
General management 116
Complications 117
Treatment options 119
Conclusion 123
Chapter 9
The Management of Children with Congenital Heart Disease 129
Introduction 129
Preoperative pulmonary hypertension 129
Postoperative pulmonary hypertension 132
Eisenmenger syndrome 134
Transplantation 136
Conclusion 136
Chapter 10
Postoperative Treatment of Pulmonary Hypertension 143
Introduction 143
Early repair 145
Anatomic investigation 145
Use of right-to-left shunt in right heart failure 146
Sedation and anesthesia 146
X
Contents
Alkalosis 148
Supplemental oxygen 149
Normal lung volume 149
Optimal hematocrit 150
Inotropic support 150
Intravenous vasodilators 152
Inhaled NO 153
Comparative effects of vasodilators 162
Surgical intervention for advanced pulmonary vascular disease 164
Chapter 11
Treatment Options for Children with Pulmonary Arterial Hypertension. 177
Introduction 177
General measures 178
Oxygen therapy 179
Diuretics/digoxin 180
Anticoagulation 180
Calcium channel blockers 180
Epoprostenol and prostacyclin analogues 181
Endothelin receptor antagonists 185
Nitric oxide 187
Phosphodiesterase inhibitors 187
Atrial septostomy 188
Transplantation 188
Conclusions 189
Chapter 12
Endpoints for Assessing PAH in CHD Patients 197
Introduction 197
Determinants and correlates of disease severity and survival in PAH 198
Clinical endpoints applied for PAH 207
Are specific clinical endpoints for CHD-PAH necessary? 216
Conclusions 218
Index 225
XI |
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| id | DE-604.BV021676841 |
| illustrated | Illustrated |
| index_date | 2024-07-02T15:10:16Z |
| indexdate | 2024-07-09T20:41:25Z |
| institution | BVB |
| isbn | 9783437241109 3437241109 |
| language | English |
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| physical | XI, 228 S. Ill., graph. Darst. 25 cm |
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| spelling | Pulmonary arterial hypertension related to congenital heart disease chief ed. Maurice Beghetti. Co-ed. Robyn J. Barst ... 1. publ. München ; Jena Elsevier, Urban & Fischer 2006 XI, 228 S. Ill., graph. Darst. 25 cm txt rdacontent n rdamedia nc rdacarrier Literaturangaben Heart Defects, Congenital complications Heart Defects, Congenital therapy Hypertension, Pulmonary epidemiology Hypertension, Pulmonary therapy Pulmonale Hypertonie (DE-588)4176331-2 gnd rswk-swf Angeborene Krankheit (DE-588)4331107-6 gnd rswk-swf Herzkrankheit (DE-588)4024663-2 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 2004 Luzern gnd-content Herzkrankheit (DE-588)4024663-2 s Angeborene Krankheit (DE-588)4331107-6 s Pulmonale Hypertonie (DE-588)4176331-2 s DE-604 Beghetti, Maurice edt HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014891113&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Pulmonary arterial hypertension related to congenital heart disease Heart Defects, Congenital complications Heart Defects, Congenital therapy Hypertension, Pulmonary epidemiology Hypertension, Pulmonary therapy Pulmonale Hypertonie (DE-588)4176331-2 gnd Angeborene Krankheit (DE-588)4331107-6 gnd Herzkrankheit (DE-588)4024663-2 gnd |
| subject_GND | (DE-588)4176331-2 (DE-588)4331107-6 (DE-588)4024663-2 (DE-588)1071861417 |
| title | Pulmonary arterial hypertension related to congenital heart disease |
| title_auth | Pulmonary arterial hypertension related to congenital heart disease |
| title_exact_search | Pulmonary arterial hypertension related to congenital heart disease |
| title_exact_search_txtP | Pulmonary arterial hypertension related to congenital heart disease |
| title_full | Pulmonary arterial hypertension related to congenital heart disease chief ed. Maurice Beghetti. Co-ed. Robyn J. Barst ... |
| title_fullStr | Pulmonary arterial hypertension related to congenital heart disease chief ed. Maurice Beghetti. Co-ed. Robyn J. Barst ... |
| title_full_unstemmed | Pulmonary arterial hypertension related to congenital heart disease chief ed. Maurice Beghetti. Co-ed. Robyn J. Barst ... |
| title_short | Pulmonary arterial hypertension related to congenital heart disease |
| title_sort | pulmonary arterial hypertension related to congenital heart disease |
| topic | Heart Defects, Congenital complications Heart Defects, Congenital therapy Hypertension, Pulmonary epidemiology Hypertension, Pulmonary therapy Pulmonale Hypertonie (DE-588)4176331-2 gnd Angeborene Krankheit (DE-588)4331107-6 gnd Herzkrankheit (DE-588)4024663-2 gnd |
| topic_facet | Heart Defects, Congenital complications Heart Defects, Congenital therapy Hypertension, Pulmonary epidemiology Hypertension, Pulmonary therapy Pulmonale Hypertonie Angeborene Krankheit Herzkrankheit Konferenzschrift 2004 Luzern |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014891113&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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