The adrenergic receptors: in the 21st century
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Totowa, NJ
Humana Press
2006
|
| Schriftenreihe: | The receptors
|
| Schlagworte: | |
| Online-Zugang: | Table of contents Klappentext Inhaltsverzeichnis |
| Beschreibung: | XI, 404 S. Ill., graph. Darst. |
| ISBN: | 1588294234 9781588294234 |
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| 245 | 1 | 0 | |a The adrenergic receptors |b in the 21st century |c ed. by Dianne M. Perez |
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| 300 | |a XI, 404 S. |b Ill., graph. Darst. | ||
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| 490 | 0 | |a The receptors | |
| 650 | 4 | |a Adrenaline |x Receptors | |
| 650 | 4 | |a Pharmacogenetics | |
| 650 | 4 | |a Receptors, Adrenergic |x physiology | |
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Datensatz im Suchindex
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| adam_text | The adrenergic receptors control many critical functions of the heart, kidney, brain, and all organs under
autonomie
signaling pathways. In The Adrenergic Receptors: In the 21st Century, senior scientists who have developed novel
molecular approaches describe the state-of-the-art understanding of the structure and function of the adrenergic
receptor subtypes, as well as the role played by these receptors in physiological and pathophysiological settings.
Topics range from structure-function studies and the imaging of adrenergic receptors to the use of genetically
altered mouse models and pharmacogenomics. Many of the methods described can be applied to characterize any
receptor of interest. Highlights include a survey of the knockout and overexpressed mouse models, a review of
the new ways that adrenergic receptors can signal, and the effects of polymorphisms on both clinical outcomes and
potential gene therapy applications. Additional chapters address modern techniques for assessing adrenergic
function, such as fluorescent labeling and microarrays, and offer an insightful historical survey of the extraordinary
progress made in our understanding of these receptors in the twentieth century.
Comprehensive and authoritative, The Adrenergic Receptors: In the 21st Century provides researchers
through its side-by-side comparison of all the adrenergic receptors (a,, a2, and
excellent survey of the field, including the rationale for how best to design better drugs for control of the heart, blood
pressure, and related pathophysiological systems.
Review of the roles played by adrenergic receptors
in physiology and pathophysiology can signal (novel signal paradigms)
Side-by-side comparison of all the adrenergic
receptors
Authoritative reviews by senior research scientists
in the adrenergic receptor field and pharmacogenomics
Novel paradigms and methods that may be applied
to any receptor of interest
Part I: Historical Perspectives. Adrenergic
Binding, Activation, and Agonist Trafficking. New Signal Transduction Paradigms. Regulation of the Cellular Localization and Trafficking
of the Adrenergic Receptors. Adrenergic Receptors in Clinical Medicine. Part
of Fluorescent Ligands and Receptors to Visualize Adrenergic Receptors. Localization of Adrenergic Receptor Subtypes and Transgenic
Expression of Fluorescent-Tagged Receptors. Part IV: Genetically Altered Mouse Models. The dj-Adrenergic Receptors: Lessons From
Knockouts. The c^-Adrenergic Receptors: Lessons From Knocfouts. The
Overexpressed Mouse Models. Adrenergic Receptor Signaling Components in Gene Therapy. Part V: Pbarmacogenomks. Genetic, Molec¬
ular, and Clinical Characterization of Adrenergic Receptor Polymorphisms. Microarray Analysis of Novel Adrenergic Receptor Functions.
Part VI: Summary «ad Future Endeavors. Summary and Future Endeavors.
Contents
Preface v
Contributors ix
Color Plates xi
Part I: Historical Perspectives
1 Adrenergic Receptors: Historical Perspectives
From the 20th Century
David B.Bylund 3
Part II: Structure-Function
2 Ligand Binding, Activation, and Agonist Trafficking
Angela M. Finch, Valerie Sarramegna,
and Robert M. Graham 25
3 New Signal Transduction Paradigms
Kenneth P. Minneman 87
4 Regulation of the Cellular Localization and Trafficking
of the Adrenergic Receptors
Michael T. Piascik, Mary Lolis Garcia-Cazarin,
and Steven R. Post 707
5 Adrenergic Receptors in Clinical Medicine
Martin C. Michel and Paul A. Insel 129
Part III: Imaging Adrenergic Receptors and Their Function
6 Use of Fluorescent Ligands and Receptors
to Visualize Adrenergic Receptors
John C. McGrath and Craig J. Daly 151
7 Localization of Adrenergic Receptor Subtypes and
Transgenic Expression of Fluorescent-Tagged Receptors
Dianne M. Perez 173
vii
viii Contents
Part IV: Genetically Altered Mouse Models
8 The (Xj-Adrenergic Receptors:
Lessons From Knockouts
Paul C.Simpson 207
9 The a2-Adrenergic Receptors:
Lessons From Knockouts
Christopher M. Tan and Lee E. Limbird 241
10 The |3-Adrenergic Receptors:
Lessons From Knockouts
YangXiang and Brian Kobilka 267
11 Lessons From Overexpressed Mouse Models
Cinzia Perrino, Liza Barki-Harrington,
and Howard A. Rockman 293
12 Adrenergic Receptor Signaling Components
in Gene Therapy
Andrea D. Eckhart and Walter J. Koch 321
Part V: Pharmacogenomics
13 Genetic, Molecular, and Clinical Characterization
of Adrenergic Receptor Polymorphisms
Stephen B.Liggett 339
14 Microarray Analysis of Novel Adrenergic
Receptor Functions
Boyd Rorabaugh, June Yun, and Dianne M. Perez 365
Part VI: Summary and Future Endeavors
15 Summary and Future Endeavors
Dianne M. Perez 395
Index 397
Color Plates
Color Plates follow p. 148.
Color Plate 1. Confocal imaging of human aortic smooth muscle cells trans-
fected with an adenovirus (Fig. 1, Chapter 4; see full caption and
discussion on pp. 117-118).
Color Plate 2. Classical AR signaling (Fig. 1, Chapter 11; see full caption and
discussion on p. 294).
Color Plate 3. Major mechanisms involved in (3-AR desensitization and intern-
alization (Fig. 2, Chapter 11; see full caption on p. 296 and
discussion on p. 295).
Color Plate 4. Histopathological characteristics of left ventricular specimens
taken from mice overexpressing the human (31 -AR (Fig. 5, Chapter
11; see full caption on p. 307 and discussion on pp. 306-308).
Color Plate 5. Phylogenetics of P2-AR haplotypes (Fig. 2, Chapter 13; see full
caption on p. 342 and discussion on pp. 340-341).
xi
|
| adam_txt |
The adrenergic receptors control many critical functions of the heart, kidney, brain, and all organs under
autonomie
signaling pathways. In The Adrenergic Receptors: In the 21st Century, senior scientists who have developed novel
molecular approaches describe the state-of-the-art understanding of the structure and function of the adrenergic
receptor subtypes, as well as the role played by these receptors in physiological and pathophysiological settings.
Topics range from structure-function studies and the imaging of adrenergic receptors to the use of genetically
altered mouse models and pharmacogenomics. Many of the methods described can be applied to characterize any
receptor of interest. Highlights include a survey of the knockout and overexpressed mouse models, a review of
the new ways that adrenergic receptors can signal, and the effects of polymorphisms on both clinical outcomes and
potential gene therapy applications. Additional chapters address modern techniques for assessing adrenergic
function, such as fluorescent labeling and microarrays, and offer an insightful historical survey of the extraordinary
progress made in our understanding of these receptors in the twentieth century.
Comprehensive and authoritative, The Adrenergic Receptors: In the 21st Century provides researchers
through its side-by-side comparison of all the adrenergic receptors (a,, a2, and
excellent survey of the field, including the rationale for how best to design better drugs for control of the heart, blood
pressure, and related pathophysiological systems.
Review of the roles played by adrenergic receptors
in physiology and pathophysiology can signal (novel signal paradigms)
Side-by-side comparison of all the adrenergic
receptors
Authoritative reviews by senior research scientists
in the adrenergic receptor field and pharmacogenomics
Novel paradigms and methods that may be applied
to any receptor of interest
Part I: Historical Perspectives. Adrenergic
Binding, Activation, and Agonist Trafficking. New Signal Transduction Paradigms. Regulation of the Cellular Localization and Trafficking
of the Adrenergic Receptors. Adrenergic Receptors in Clinical Medicine. Part
of Fluorescent Ligands and Receptors to Visualize Adrenergic Receptors. Localization of Adrenergic Receptor Subtypes and Transgenic
Expression of Fluorescent-Tagged Receptors. Part IV: Genetically Altered Mouse Models. The dj-Adrenergic Receptors: Lessons From
Knockouts. The c^-Adrenergic Receptors: Lessons From Knocfouts. The
Overexpressed Mouse Models. Adrenergic Receptor Signaling Components in Gene Therapy. Part V: Pbarmacogenomks. Genetic, Molec¬
ular, and Clinical Characterization of Adrenergic Receptor Polymorphisms. Microarray Analysis of Novel Adrenergic Receptor Functions.
Part VI: Summary «ad Future Endeavors. Summary and Future Endeavors.
Contents
Preface v
Contributors ix
Color Plates xi
Part I: Historical Perspectives
1 Adrenergic Receptors: Historical Perspectives
From the 20th Century
David B.Bylund 3
Part II: Structure-Function
2 Ligand Binding, Activation, and Agonist Trafficking
Angela M. Finch, Valerie Sarramegna,
and Robert M. Graham 25
3 New Signal Transduction Paradigms
Kenneth P. Minneman 87
4 Regulation of the Cellular Localization and Trafficking
of the Adrenergic Receptors
Michael T. Piascik, Mary Lolis Garcia-Cazarin,
and Steven R. Post 707
5 Adrenergic Receptors in Clinical Medicine
Martin C. Michel and Paul A. Insel 129
Part III: Imaging Adrenergic Receptors and Their Function
6 Use of Fluorescent Ligands and Receptors
to Visualize Adrenergic Receptors
John C. McGrath and Craig J. Daly 151
7 Localization of Adrenergic Receptor Subtypes and
Transgenic Expression of Fluorescent-Tagged Receptors
Dianne M. Perez 173
vii
viii Contents
Part IV: Genetically Altered Mouse Models
8 The (Xj-Adrenergic Receptors:
Lessons From Knockouts
Paul C.Simpson 207
9 The a2-Adrenergic Receptors:
Lessons From Knockouts
Christopher M. Tan and Lee E. Limbird 241
10 The |3-Adrenergic Receptors:
Lessons From Knockouts
YangXiang and Brian Kobilka 267
11 Lessons From Overexpressed Mouse Models
Cinzia Perrino, Liza Barki-Harrington,
and Howard A. Rockman 293
12 Adrenergic Receptor Signaling Components
in Gene Therapy
Andrea D. Eckhart and Walter J. Koch 321
Part V: Pharmacogenomics
13 Genetic, Molecular, and Clinical Characterization
of Adrenergic Receptor Polymorphisms
Stephen B.Liggett 339
14 Microarray Analysis of Novel Adrenergic
Receptor Functions
Boyd Rorabaugh, June Yun, and Dianne M. Perez 365
Part VI: Summary and Future Endeavors
15 Summary and Future Endeavors
Dianne M. Perez 395
Index 397
Color Plates
Color Plates follow p. 148.
Color Plate 1. Confocal imaging of human aortic smooth muscle cells trans-
fected with an adenovirus (Fig. 1, Chapter 4; see full caption and
discussion on pp. 117-118).
Color Plate 2. Classical AR signaling (Fig. 1, Chapter 11; see full caption and
discussion on p. 294).
Color Plate 3. Major mechanisms involved in (3-AR desensitization and intern-
alization (Fig. 2, Chapter 11; see full caption on p. 296 and
discussion on p. 295).
Color Plate 4. Histopathological characteristics of left ventricular specimens
taken from mice overexpressing the human (31 -AR (Fig. 5, Chapter
11; see full caption on p. 307 and discussion on pp. 306-308).
Color Plate 5. Phylogenetics of P2-AR haplotypes (Fig. 2, Chapter 13; see full
caption on p. 342 and discussion on pp. 340-341).
xi |
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| index_date | 2024-07-02T15:08:54Z |
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| series2 | The receptors |
| spelling | The adrenergic receptors in the 21st century ed. by Dianne M. Perez Totowa, NJ Humana Press 2006 XI, 404 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier The receptors Adrenaline Receptors Pharmacogenetics Receptors, Adrenergic physiology Pharmakogenetik (DE-588)4271255-5 gnd rswk-swf Adrenerger Rezeptor (DE-588)4000526-4 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Adrenerger Rezeptor (DE-588)4000526-4 s Pharmakogenetik (DE-588)4271255-5 s b DE-604 Perez, Dianne M. Sonstige oth http://www.loc.gov/catdir/toc/ecip0510/2005008529.html Table of contents Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014885751&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Klappentext HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014885751&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | The adrenergic receptors in the 21st century Adrenaline Receptors Pharmacogenetics Receptors, Adrenergic physiology Pharmakogenetik (DE-588)4271255-5 gnd Adrenerger Rezeptor (DE-588)4000526-4 gnd |
| subject_GND | (DE-588)4271255-5 (DE-588)4000526-4 (DE-588)4143413-4 |
| title | The adrenergic receptors in the 21st century |
| title_auth | The adrenergic receptors in the 21st century |
| title_exact_search | The adrenergic receptors in the 21st century |
| title_exact_search_txtP | The adrenergic receptors in the 21st century |
| title_full | The adrenergic receptors in the 21st century ed. by Dianne M. Perez |
| title_fullStr | The adrenergic receptors in the 21st century ed. by Dianne M. Perez |
| title_full_unstemmed | The adrenergic receptors in the 21st century ed. by Dianne M. Perez |
| title_short | The adrenergic receptors |
| title_sort | the adrenergic receptors in the 21st century |
| title_sub | in the 21st century |
| topic | Adrenaline Receptors Pharmacogenetics Receptors, Adrenergic physiology Pharmakogenetik (DE-588)4271255-5 gnd Adrenerger Rezeptor (DE-588)4000526-4 gnd |
| topic_facet | Adrenaline Receptors Pharmacogenetics Receptors, Adrenergic physiology Pharmakogenetik Adrenerger Rezeptor Aufsatzsammlung |
| url | http://www.loc.gov/catdir/toc/ecip0510/2005008529.html http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014885751&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014885751&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
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