Current surgical management of pulmonary metastases:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Philadelphia [u.a.]
Saunders
2006
|
| Schriftenreihe: | Thoracic surgery clinics
16,2 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | VII S., S. 116 - 202 Ill., graph. Darst. |
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Datensatz im Suchindex
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| adam_text | CURRENT SURGICAL MANAGEMENT OF PULMONARY
CONTENTS
Preface
Robert J. Downey
The Molecular Biology of Pulmonary Metastasis
Kartik Krishnan, Chand Khanna, and Lee J. Helman
The majority of deaths from cancer result not from growth of the original primary tumor,
but rather from the growth of metastatic disease. For cancer to spread from the primary
site, neoplastic cells must undertake a complex multi-step process. The molecular steps
involved in this process have been the subject of intense study for a number of years, and
they are now beginning to be elucidated. Moreover, inhibitors of the processes involved in
metastasis are in various stages of development, with the hope of molecularly targeting a
neoplastic cell s ability to disseminate. The lungs have long been known to be one of the
most common sites of metastasis. Initially presumed to be determined by blood flow and
oxygen tension, targeting of the lungs by metastatic cancer cells is now known to be a non-
random molecularly derived event. This review presents our current understanding of the
processes involved in the development of pulmonary metastasis from the genetic imprint
of the metastatic signature to the steps involved in the metastatic cascade.
Preoperative
Pulmonary Metastasectomy
Katherine S.
The workup of patients suspected of having pulmonary
fact that a high percentage of pulmonary
Helical CT scans and high-resolution CT scans currently miss many of the lesions eventu¬
ally detected at thoracotomy and many of the lesions detected are benign. The follow-up
of patients after pulmonary metastasectomy is a controversial topic because of the lack of
evidence-based practice guidelines. Though it is unlikely that current follow-up recom¬
mendations will ever be tested in randomized controlled trials, meta-analyses of existing
retrospective data could improve the quality of the existing literature.
Surgery for Colorectal and Sarcomatous Pulmonary
Management, and Future Directions
Robert J. Downey
This article provides a historical review of metastasectomy, reviews current surgical
management approaches, and proposes what direction future research must take to
VOLUME
determine whether there is a survival advantage associated with pulmonary metasta¬
sectomy and how best to integrate metastasectomy with medical therapies, primarily
induction, and adjuvant chemotherapy.
Lymphadenectomy in Metastasectomy
Alberto Dominguez-Ventura and Francis C. Nichols III
This article focuses on the incidence of lymph node involvement at the time of pul¬
monary metastasectomy, the impact on survival, and potential therapeutic implications.
There is current agreement that overall survival can be improved by surgical resection of
pulmonary
node
Combined Resection of Liver and Lung
Itzhak
This article evaluates the available evidence for the efficacy of combined liver and lung
metastasectomy. In addition, selection criteria identifying patients most likely to benefit
from this approach are discussed. Surgery offers the only possibility for prolonged survival
and is occasionally curative.
Minimally Invasive Techniques for Managing Pulmonary
Video-assisted Thoracic Surgery and Radiofrequency Ablation
Ara
Video-assisted thoracic surgery (VATS) and radiofrequency ablation
ingly being used in the treatment of primary and secondary pulmonary malignancies.
Although thoracotomy remains the standard of care for the treatment of the patient
with limited metastastic disease to the lung, VATS and
treatment of selected patients. The number and location of
influence the use of either VATS or
of literature and personal experience, make recommendations for the incorporation of
these modalities into the care of patients requiring pulmonary metastasectomy.
Pulmonary Metastasectomy in
Mark L. Kayton
This article describes the historical development of
but demonstrates that progress has been slow in understanding its proper applications.
Because many
patients of different histologies for the generation and analysis of case series. By exami¬
ning tumor types individually, however, it is seen that certain histologies (adrenocortical
carcinoma, alveolar soft part sarcoma, osteosarcoma) mandate surgical metastasectomy
for patient survival. Other
tion sensitive, and the application of metastasectomy is controversial. In the case of still
other types of tumor
metastasectomy is seldom performed except in highly unusual situations. Techniques for
minimally invasive biopsy and for muscle-sparing thoracotomy are described for
atrie
CONTENTS
Isolated Lung
Jeroen M.H.
Franz Schramel, and Paul E.Y. Van
Isolated lung
of high-dose chemotherapy to improve 5-year survival after pulmonary metastasectomy.
Extensive experimental work in animal models has demonstrated superior pharmaco-
kinetics and efficacy compared with systemic therapy. Phase I clinical trials of isolated
lung
and melphalan, whereas the combination of isolated lung
metastasectomy was feasible. The combination of isolated lung
lung
Index
CONTENTS
|
| adam_txt |
CURRENT SURGICAL MANAGEMENT OF PULMONARY
CONTENTS
Preface
Robert J. Downey
The Molecular Biology of Pulmonary Metastasis
Kartik Krishnan, Chand Khanna, and Lee J. Helman
The majority of deaths from cancer result not from growth of the original primary tumor,
but rather from the growth of metastatic disease. For cancer to spread from the primary
site, neoplastic cells must undertake a complex multi-step process. The molecular steps
involved in this process have been the subject of intense study for a number of years, and
they are now beginning to be elucidated. Moreover, inhibitors of the processes involved in
metastasis are in various stages of development, with the hope of molecularly targeting a
neoplastic cell's ability to disseminate. The lungs have long been known to be one of the
most common sites of metastasis. Initially presumed to be determined by blood flow and
oxygen tension, targeting of the lungs by metastatic cancer cells is now known to be a non-
random molecularly derived event. This review presents our current understanding of the
processes involved in the development of pulmonary metastasis from the genetic imprint
of the "metastatic signature" to the steps involved in the "metastatic cascade."
Preoperative
Pulmonary Metastasectomy
Katherine S.
The workup of patients suspected of having pulmonary
fact that a high percentage of pulmonary
Helical CT scans and high-resolution CT scans currently miss many of the lesions eventu¬
ally detected at thoracotomy and many of the lesions detected are benign. The follow-up
of patients after pulmonary metastasectomy is a controversial topic because of the lack of
evidence-based practice guidelines. Though it is unlikely that current follow-up recom¬
mendations will ever be tested in randomized controlled trials, meta-analyses of existing
retrospective data could improve the quality of the existing literature.
Surgery for Colorectal and Sarcomatous Pulmonary
Management, and Future Directions
Robert J. Downey
This article provides a historical review of metastasectomy, reviews current surgical
management approaches, and proposes what direction future research must take to
VOLUME
determine whether there is a survival advantage associated with pulmonary metasta¬
sectomy and how best to integrate metastasectomy with medical therapies, primarily
induction, and adjuvant chemotherapy.
Lymphadenectomy in Metastasectomy
Alberto Dominguez-Ventura and Francis C. Nichols III
This article focuses on the incidence of lymph node involvement at the time of pul¬
monary metastasectomy, the impact on survival, and potential therapeutic implications.
There is current agreement that overall survival can be improved by surgical resection of
pulmonary
node
Combined Resection of Liver and Lung
Itzhak
This article evaluates the available evidence for the efficacy of combined liver and lung
metastasectomy. In addition, selection criteria identifying patients most likely to benefit
from this approach are discussed. Surgery offers the only possibility for prolonged survival
and is occasionally curative.
Minimally Invasive Techniques for Managing Pulmonary
Video-assisted Thoracic Surgery and Radiofrequency Ablation
Ara
Video-assisted thoracic surgery (VATS) and radiofrequency ablation
ingly being used in the treatment of primary and secondary pulmonary malignancies.
Although thoracotomy remains the standard of care for the treatment of the patient
with limited metastastic disease to the lung, VATS and
treatment of selected patients. The number and location of
influence the use of either VATS or
of literature and personal experience, make recommendations for the incorporation of
these modalities into the care of patients requiring pulmonary metastasectomy.
Pulmonary Metastasectomy in
Mark L. Kayton
This article describes the historical development of
but demonstrates that progress has been slow in understanding its proper applications.
Because many
patients of different histologies for the generation and analysis of case series. By exami¬
ning tumor types individually, however, it is seen that certain histologies (adrenocortical
carcinoma, alveolar soft part sarcoma, osteosarcoma) mandate surgical metastasectomy
for patient survival. Other
tion sensitive, and the application of metastasectomy is controversial. In the case of still
other types of tumor
metastasectomy is seldom performed except in highly unusual situations. Techniques for
minimally invasive biopsy and for muscle-sparing thoracotomy are described for
atrie
CONTENTS
Isolated Lung
Jeroen M.H.
Franz Schramel, and Paul E.Y. Van
Isolated lung
of high-dose chemotherapy to improve 5-year survival after pulmonary metastasectomy.
Extensive experimental work in animal models has demonstrated superior pharmaco-
kinetics and efficacy compared with systemic therapy. Phase I clinical trials of isolated
lung
and melphalan, whereas the combination of isolated lung
metastasectomy was feasible. The combination of isolated lung
lung
Index
CONTENTS |
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| spelling | Current surgical management of pulmonary metastases guest ed. Robert J. Downey Philadelphia [u.a.] Saunders 2006 VII S., S. 116 - 202 Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Thoracic surgery clinics 16,2 Lungs Cancer Lungenmetastase (DE-588)4168321-3 gnd rswk-swf Chirurgie (DE-588)4009987-8 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Lungenmetastase (DE-588)4168321-3 s Chirurgie (DE-588)4009987-8 s b DE-604 Downey, Robert J. Sonstige oth Thoracic surgery clinics 16,2 (DE-604)BV019335438 16,2 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014871285&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
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| subject_GND | (DE-588)4168321-3 (DE-588)4009987-8 (DE-588)4143413-4 |
| title | Current surgical management of pulmonary metastases |
| title_auth | Current surgical management of pulmonary metastases |
| title_exact_search | Current surgical management of pulmonary metastases |
| title_exact_search_txtP | Current surgical management of pulmonary metastases |
| title_full | Current surgical management of pulmonary metastases guest ed. Robert J. Downey |
| title_fullStr | Current surgical management of pulmonary metastases guest ed. Robert J. Downey |
| title_full_unstemmed | Current surgical management of pulmonary metastases guest ed. Robert J. Downey |
| title_short | Current surgical management of pulmonary metastases |
| title_sort | current surgical management of pulmonary metastases |
| topic | Lungs Cancer Lungenmetastase (DE-588)4168321-3 gnd Chirurgie (DE-588)4009987-8 gnd |
| topic_facet | Lungs Cancer Lungenmetastase Chirurgie Aufsatzsammlung |
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