1,1-Dichloroethene (Vinylidene chloride):
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Geneva
World Health Organization
2003
|
| Schriftenreihe: | Concise international chemical assessment document
51 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | IV, 42 S. |
| ISBN: | 9241530510 |
Internformat
MARC
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Datensatz im Suchindex
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| adam_text | TABLE OF CONTENTS
FOREWORD 1
1. EXECUTIVE SUMMARY 4
2. IDENTITY AND PHYSICAL/CHEMICAL PROPERTIES 5
3. ANALYTICAL METHODS 5
4. SOURCES OF HUMAN AND ENVIRONMENTAL EXPOSURE 6
5. ENVIRONMENTAL TRANSPORT, DISTRIBUTION, AND TRANSFORMATION 6
5.1 Transformation and distribution 6
5.1.1 Air 6
5.1.2 Water 7
5.1.3 Soils and sediments 7
5.2 Biotransformation 7
5.3 Bioaccumulation 7
6. ENVIRONMENTAL LEVELS AND HUMAN EXPOSURE 8
6.1 Environmental levels 8
6.1.1 Air 8
6.1.2 Water 8
6.1.3 Sewage sludge 8
6.1.4 Soil 8
6.2 Human exposure 8
7. COMPARATIVE KINETICS AND METABOLISM IN LABORATORY ANIMALS AND
HUMANS 9
8. EFFECTS ON LABORATORY MAMMALS AND IN VITRO TEST SYSTEMS 11
8.1 Single exposure 11
8.2 Skin sensitization 11
8.3 Short term exposure 11
8.3.1 Oral 11
8.3.2 Inhalation 12
8.4 Medium term exposure 12
8.4.1 Oral 12
8.4.2 Inhalation 13
8.5 Long term exposure and carcinogenicity 14
8.5.1 Oral 14
8.5.2 Inhalation 14
8.5.3 Dermal 15
8.6 Genotoxicity and related end points 16
8.7 Reproductive toxicity 16
8.7.1 Effects on fertility 16
8.7.2 Developmental toxicity 16
8.7.2.1 Oral 16
8.7.2.2 Inhalation 18
iii
Concise International Chemical Assessment Document 51 8.8 Cardiac sensitization 19
8.9 Mode of action 20
9. EFFECTS ON HUMANS 20
10. EFFECTS ON OTHER ORGANISMS IN THE LABORATORY AND FIELD 20
10.1 Aquatic environment 20
10.2 Terrestrial environment 21
11. EFFECTS EVALUATION 22
11.1 Evaluation of health effects 22
11.1.1 Hazard identification and dose response assessment 22
11.1.2 Criteria for setting tolerable intakes and tolerable concentrations 23
11.1.3 Sample risk characterization 23
11.1.4 Uncertainties in the evaluation of health risks 23
11.2 Evaluation of environmental effects 24
11.2.1 Uncertainties in the evaluation of environmental effects 24
11. PREVIOUS EVALUATIONS BY INTERNATIONAL BODIES 24
REFERENCES 25
APPENDIX 1 — SOURCE DOCUMENTS 31
APPENDIX 2 — CICAD PEER REVIEW 32
APPENDIX 3 — CICAD FINAL REVIEW BOARD 33
APPENDIX 4 — BENCHMARK DOSE ANALYSIS 34
APPENDIX 5 — LIST OF ACRONYMS AND ABBREVIATIONS 36
INTERNATIONAL CHEMICAL SAFETY CARD 37
RESUME D ORIENTATION 39
RESUMEN DE ORIENTACI6N 41
iv
|
| adam_txt |
TABLE OF CONTENTS
FOREWORD 1
1. EXECUTIVE SUMMARY 4
2. IDENTITY AND PHYSICAL/CHEMICAL PROPERTIES 5
3. ANALYTICAL METHODS 5
4. SOURCES OF HUMAN AND ENVIRONMENTAL EXPOSURE 6
5. ENVIRONMENTAL TRANSPORT, DISTRIBUTION, AND TRANSFORMATION 6
5.1 Transformation and distribution 6
5.1.1 Air 6
5.1.2 Water 7
5.1.3 Soils and sediments 7
5.2 Biotransformation 7
5.3 Bioaccumulation 7
6. ENVIRONMENTAL LEVELS AND HUMAN EXPOSURE 8
6.1 Environmental levels 8
6.1.1 Air 8
6.1.2 Water 8
6.1.3 Sewage sludge 8
6.1.4 Soil 8
6.2 Human exposure 8
7. COMPARATIVE KINETICS AND METABOLISM IN LABORATORY ANIMALS AND
HUMANS 9
8. EFFECTS ON LABORATORY MAMMALS AND IN VITRO TEST SYSTEMS 11
8.1 Single exposure 11
8.2 Skin sensitization 11
8.3 Short term exposure 11
8.3.1 Oral 11
8.3.2 Inhalation 12
8.4 Medium term exposure 12
8.4.1 Oral 12
8.4.2 Inhalation 13
8.5 Long term exposure and carcinogenicity 14
8.5.1 Oral 14
8.5.2 Inhalation 14
8.5.3 Dermal 15
8.6 Genotoxicity and related end points 16
8.7 Reproductive toxicity 16
8.7.1 Effects on fertility 16
8.7.2 Developmental toxicity 16
8.7.2.1 Oral 16
8.7.2.2 Inhalation 18
iii
Concise International Chemical Assessment Document 51 8.8 Cardiac sensitization 19
8.9 Mode of action 20
9. EFFECTS ON HUMANS 20
10. EFFECTS ON OTHER ORGANISMS IN THE LABORATORY AND FIELD 20
10.1 Aquatic environment 20
10.2 Terrestrial environment 21
11. EFFECTS EVALUATION 22
11.1 Evaluation of health effects 22
11.1.1 Hazard identification and dose response assessment 22
11.1.2 Criteria for setting tolerable intakes and tolerable concentrations 23
11.1.3 Sample risk characterization 23
11.1.4 Uncertainties in the evaluation of health risks 23
11.2 Evaluation of environmental effects 24
11.2.1 Uncertainties in the evaluation of environmental effects 24
11. PREVIOUS EVALUATIONS BY INTERNATIONAL BODIES 24
REFERENCES 25
APPENDIX 1 — SOURCE DOCUMENTS 31
APPENDIX 2 — CICAD PEER REVIEW 32
APPENDIX 3 — CICAD FINAL REVIEW BOARD 33
APPENDIX 4 — BENCHMARK DOSE ANALYSIS 34
APPENDIX 5 — LIST OF ACRONYMS AND ABBREVIATIONS 36
INTERNATIONAL CHEMICAL SAFETY CARD 37
RESUME D'ORIENTATION 39
RESUMEN DE ORIENTACI6N 41
iv |
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| index_date | 2024-07-02T14:46:37Z |
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| isbn | 9241530510 |
| language | English |
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| series | Concise international chemical assessment document |
| series2 | Concise international chemical assessment document |
| spelling | 1,1-Dichloroethene (Vinylidene chloride) 1. draft prepared by Bob Benson ... Geneva World Health Organization 2003 IV, 42 S. txt rdacontent n rdamedia nc rdacarrier Concise international chemical assessment document 51 CHEMICALS unbist RISK ASSESSMENT unbist TOXIC SUBSTANCES unbist Benson, Bob Sonstige oth Concise international chemical assessment document 51 (DE-604)BV021595306 51 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014812939&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | 1,1-Dichloroethene (Vinylidene chloride) Concise international chemical assessment document CHEMICALS unbist RISK ASSESSMENT unbist TOXIC SUBSTANCES unbist |
| title | 1,1-Dichloroethene (Vinylidene chloride) |
| title_auth | 1,1-Dichloroethene (Vinylidene chloride) |
| title_exact_search | 1,1-Dichloroethene (Vinylidene chloride) |
| title_exact_search_txtP | 1,1-Dichloroethene (Vinylidene chloride) |
| title_full | 1,1-Dichloroethene (Vinylidene chloride) 1. draft prepared by Bob Benson ... |
| title_fullStr | 1,1-Dichloroethene (Vinylidene chloride) 1. draft prepared by Bob Benson ... |
| title_full_unstemmed | 1,1-Dichloroethene (Vinylidene chloride) 1. draft prepared by Bob Benson ... |
| title_short | 1,1-Dichloroethene (Vinylidene chloride) |
| title_sort | 1 1 dichloroethene vinylidene chloride |
| topic | CHEMICALS unbist RISK ASSESSMENT unbist TOXIC SUBSTANCES unbist |
| topic_facet | CHEMICALS RISK ASSESSMENT TOXIC SUBSTANCES |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014812939&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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