1,2,3-Trichloropropane:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Geneva
World Health Organization
2003
|
| Series: | Concise international chemical assessment document
56 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | IV, 41 S. |
| ISBN: | 9241530561 |
Staff View
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Record in the Search Index
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| adam_text | TABLE OF CONTENTS
FOREWORD 1
1. EXECUTIVE SUMMARY 4
2. IDENTITY AND PHYSICAL/CHEMICAL PROPERTIES 6
3. ANALYTICAL METHODS 7
4. SOURCES OF HUMAN AND ENVIRONMENTAL EXPOSURE 7
5. ENVIRONMENTAL TRANSPORT, DISTRIBUTION, AND TRANSFORMATION 8
5.1 Environmental transport and distribution 8
5.2 Abiotic transformation 8
5.3 Biotransformation and biodegradation 8
6. ENVIRONMENTAL LEVELS AND HUMAN EXPOSURE 9
6.1 Environmental levels 9
6.1.1 Atmosphere 9
6.1.2 Hydrosphere 9
6.2 Human exposure 9
6.2.1 General population exposure 9
6.2.2 Occupational exposure 10
6.2.3 Levels in humans 10
7. COMPARATIVE KINETICS AND METABOLISM IN LABORATORY ANIMALS AND
HUMANS 10
7.1 Absorption, distribution, and excretion 10
7.2 Biotransformation 10
7.3 Covalent binding 11
8. EFFECTS ON LABORATORY MAMMALS AND IN VITRO TEST SYSTEMS 11
8.1 Single exposure 11
8.2 Irritation and sensitization 13
8.3 Short and medium term exposure 13
8.3.1 Inhalation 13
8.3.2 Oral exposure 14
8.4 Long term exposure and carcinogenicity 15
8.5 Genotoxicity and related end points 17
8.5.1 In vitro studies 17
8.5.2 In vivo studies 19
8.6 Reproductive toxicity 20
8.6.1 Effects on fertility 20
8.6.2 Developmental toxicity 21
8.7 Other toxicity/mode of action 21
9. EFFECTS ON HUMANS 22
iii
Concise International Chemical Assessment Document 56
10. EFFECTS ON OTHER ORGANISMS IN THE LABORATORY AND FIELD 22
10.1 Aquatic environment 22
10.2 Terrestrial environment 22
11. EFFECTS EVALUATION 23
11.1 Evaluation of health effects 23
11.1.1 Hazard identification and dose response assessment 23
11.1.2 Criteria for setting tolerable intakes and tolerable concentrations for
1,2,3 trichloropropane 24
11.1.3 Sample risk characterization 24
11.1.3.1 Estimated population exposure 24
11.1.3.2 Health risks induced by the exposure 25
11.1.4 Uncertainties in the hazard characterization 25
11.2 Evaluation of environmental effects 26
11.2.1 Aquatic environment 26
11.2.2 Terrestrial environment 26
11.2.3 Uncertainties in the evaluation of environmental effects 26
12. PREVIOUS EVALUATIONS BY INTERNATIONAL BODIES 26
REFERENCES 27
APPENDIX 1 — SOURCE DOCUMENTS 31
APPENDIX 2 — CICAD PEER REVIEW 31
APPENDIX 3 — CICAD FINAL REVIEW BOARD 32
APPENDIX 4 — ABBREVIATIONS AND ACRONYMS 33
INTERNATIONAL CHEMICAL SAFETY CARD 34
RESUME D ORIENTATION 36
RESUMEN DE ORIENTACION 39
iv
|
| adam_txt |
TABLE OF CONTENTS
FOREWORD 1
1. EXECUTIVE SUMMARY 4
2. IDENTITY AND PHYSICAL/CHEMICAL PROPERTIES 6
3. ANALYTICAL METHODS 7
4. SOURCES OF HUMAN AND ENVIRONMENTAL EXPOSURE 7
5. ENVIRONMENTAL TRANSPORT, DISTRIBUTION, AND TRANSFORMATION 8
5.1 Environmental transport and distribution 8
5.2 Abiotic transformation 8
5.3 Biotransformation and biodegradation 8
6. ENVIRONMENTAL LEVELS AND HUMAN EXPOSURE 9
6.1 Environmental levels 9
6.1.1 Atmosphere 9
6.1.2 Hydrosphere 9
6.2 Human exposure 9
6.2.1 General population exposure 9
6.2.2 Occupational exposure 10
6.2.3 Levels in humans 10
7. COMPARATIVE KINETICS AND METABOLISM IN LABORATORY ANIMALS AND
HUMANS 10
7.1 Absorption, distribution, and excretion 10
7.2 Biotransformation 10
7.3 Covalent binding 11
8. EFFECTS ON LABORATORY MAMMALS AND IN VITRO TEST SYSTEMS 11
8.1 Single exposure 11
8.2 Irritation and sensitization 13
8.3 Short and medium term exposure 13
8.3.1 Inhalation 13
8.3.2 Oral exposure 14
8.4 Long term exposure and carcinogenicity 15
8.5 Genotoxicity and related end points 17
8.5.1 In vitro studies 17
8.5.2 In vivo studies 19
8.6 Reproductive toxicity 20
8.6.1 Effects on fertility 20
8.6.2 Developmental toxicity 21
8.7 Other toxicity/mode of action 21
9. EFFECTS ON HUMANS 22
iii
Concise International Chemical Assessment Document 56
10. EFFECTS ON OTHER ORGANISMS IN THE LABORATORY AND FIELD 22
10.1 Aquatic environment 22
10.2 Terrestrial environment 22
11. EFFECTS EVALUATION 23
11.1 Evaluation of health effects 23
11.1.1 Hazard identification and dose response assessment 23
11.1.2 Criteria for setting tolerable intakes and tolerable concentrations for
1,2,3 trichloropropane 24
11.1.3 Sample risk characterization 24
11.1.3.1 Estimated population exposure 24
11.1.3.2 Health risks induced by the exposure 25
11.1.4 Uncertainties in the hazard characterization 25
11.2 Evaluation of environmental effects 26
11.2.1 Aquatic environment 26
11.2.2 Terrestrial environment 26
11.2.3 Uncertainties in the evaluation of environmental effects 26
12. PREVIOUS EVALUATIONS BY INTERNATIONAL BODIES 26
REFERENCES 27
APPENDIX 1 — SOURCE DOCUMENTS 31
APPENDIX 2 — CICAD PEER REVIEW 31
APPENDIX 3 — CICAD FINAL REVIEW BOARD 32
APPENDIX 4 — ABBREVIATIONS AND ACRONYMS 33
INTERNATIONAL CHEMICAL SAFETY CARD 34
RESUME D'ORIENTATION 36
RESUMEN DE ORIENTACION 39
iv |
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| isbn | 9241530561 |
| language | English |
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| physical | IV, 41 S. |
| publishDate | 2003 |
| publishDateSearch | 2003 |
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| publisher | World Health Organization |
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| series | Concise international chemical assessment document |
| series2 | Concise international chemical assessment document |
| spelling | 1,2,3-Trichloropropane 1. draft prepared by J. Kielhorn ... Geneva World Health Organization 2003 IV, 41 S. txt rdacontent n rdamedia nc rdacarrier Concise international chemical assessment document 56 ENVIRONMENTALLY HAZARDOUS ACTIVITIES unbist HEALTH HAZARDS unbist PROPANE unbist TOXIC SUBSTANCES unbist Kielhorn, Judith 1975- Sonstige (DE-588)129173541 oth Concise international chemical assessment document 56 (DE-604)BV021595306 56 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014812895&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | 1,2,3-Trichloropropane Concise international chemical assessment document ENVIRONMENTALLY HAZARDOUS ACTIVITIES unbist HEALTH HAZARDS unbist PROPANE unbist TOXIC SUBSTANCES unbist |
| title | 1,2,3-Trichloropropane |
| title_auth | 1,2,3-Trichloropropane |
| title_exact_search | 1,2,3-Trichloropropane |
| title_exact_search_txtP | 1,2,3-Trichloropropane |
| title_full | 1,2,3-Trichloropropane 1. draft prepared by J. Kielhorn ... |
| title_fullStr | 1,2,3-Trichloropropane 1. draft prepared by J. Kielhorn ... |
| title_full_unstemmed | 1,2,3-Trichloropropane 1. draft prepared by J. Kielhorn ... |
| title_short | 1,2,3-Trichloropropane |
| title_sort | 1 2 3 trichloropropane |
| topic | ENVIRONMENTALLY HAZARDOUS ACTIVITIES unbist HEALTH HAZARDS unbist PROPANE unbist TOXIC SUBSTANCES unbist |
| topic_facet | ENVIRONMENTALLY HAZARDOUS ACTIVITIES HEALTH HAZARDS PROPANE TOXIC SUBSTANCES |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014812895&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV021595306 |
| work_keys_str_mv | AT kielhornjudith 123trichloropropane |