Aromatase inhibitors:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Basel [u.a.]
Birkhäuser
2006
|
| Schriftenreihe: | Milestones in drug therapy
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | Literaturangaben |
| Beschreibung: | IX, 182 S. Ill., graph. Darst. |
| ISBN: | 9783764371999 3764371994 |
Internformat
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Datensatz im Suchindex
| _version_ | 1804135343315746816 |
|---|---|
| adam_text | Contents
List of contributors
Preface
William R. Miller
Background and development of aromatase inhibitors
Angela Brodie
Aromatase inhibitors and models for breast cancer
Jürgen Geisler
Clinical pharmacology of aromatase inhibitors
Robert J. Paridaens
Clinical studies with exemestane
J. Michael Dixon
Clinical studies with letrozole
Anthony Howell and Alan Wakeling
Clinical studies with anastrozole
Aman
The third-generation aromatase inhibitors. a clinical overview
Evan R. Simpson, Margaret E. Jones and Colin D. Clyne
Lessons from the ArKO mouse
Barrington J.A. Furr
Possible additional therapeutic uses of aromatase inhibitors
Index
Many breast tumours are dependent upon oestrogen for their
development and continued growth. Over the last
therapy has progressed from the irreversible destruction of endocrine
glands to the use of drugs that reversibly suppress oestrogen
synthesis or action. The inhibition of oestrogen synthesis is most
readily achieved by inhibiting the final step in the pathway of
oestrogen biosynthesis, the reaction which transforms androgens
into oestrogens by creating an aromatic ring in the steroid molecule
(hence the enzyme s trivial name, aromatase).
Whereas the first aromatase inhibitors to be used therapeutically
could be shown to produce drug-induced inhibition of the enzyme
and therapeutic benefits in patients with breast cancer, they were not
particularly potent and lacked specificity. However, second-generation
drugs were developed subsequently and most recently third-
generation inhibitors have evolved, which possess remarkable
specificity and potency. Initial results from clinical trials suggest that
these agents will become the cornerstones of future endocrine
therapy.
|
| adam_txt |
Contents
List of contributors
Preface
William R. Miller
Background and development of aromatase inhibitors
Angela Brodie
Aromatase inhibitors and models for breast cancer
Jürgen Geisler
Clinical pharmacology of aromatase inhibitors
Robert J. Paridaens
Clinical studies with exemestane
J. Michael Dixon
Clinical studies with letrozole
Anthony Howell and Alan Wakeling
Clinical studies with anastrozole
Aman
The third-generation aromatase inhibitors." a clinical overview
Evan R. Simpson, Margaret E. Jones and Colin D. Clyne
Lessons from the ArKO mouse
Barrington J.A. Furr
Possible additional therapeutic uses of aromatase inhibitors
Index
Many breast tumours are dependent upon oestrogen for their
development and continued growth. Over the last
therapy has progressed from the irreversible destruction of endocrine
glands to the use of drugs that reversibly suppress oestrogen
synthesis or action. The inhibition of oestrogen synthesis is most
readily achieved by inhibiting the final step in the pathway of
oestrogen biosynthesis, the reaction which transforms androgens
into oestrogens by creating an aromatic ring in the steroid molecule
(hence the enzyme's trivial name, aromatase).
Whereas the first aromatase inhibitors to be used therapeutically
could be shown to produce drug-induced inhibition of the enzyme
and therapeutic benefits in patients with breast cancer, they were not
particularly potent and lacked specificity. However, second-generation
drugs were developed subsequently and most recently third-
generation inhibitors have evolved, which possess remarkable
specificity and potency. Initial results from clinical trials suggest that
these agents will become the cornerstones of future endocrine
therapy. |
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| id | DE-604.BV021574890 |
| illustrated | Illustrated |
| index_date | 2024-07-02T14:39:41Z |
| indexdate | 2024-07-09T20:39:00Z |
| institution | BVB |
| isbn | 9783764371999 3764371994 |
| language | English |
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| physical | IX, 182 S. Ill., graph. Darst. |
| publishDate | 2006 |
| publishDateSearch | 2006 |
| publishDateSort | 2006 |
| publisher | Birkhäuser |
| record_format | marc |
| series2 | Milestones in drug therapy |
| spelling | Aromatase inhibitors ed. by B. J. A. Furr Basel [u.a.] Birkhäuser 2006 IX, 182 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Milestones in drug therapy Literaturangaben Aromatase Inhibitors therapeutic use Aromatase Inhibitors Therapeutic use Breast Neoplasms drug therapy Breast Cancer Chemotherapy Aromatasehemmer (DE-588)4192306-6 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Aromatasehemmer (DE-588)4192306-6 s DE-604 Furr, Barrington J. A. Sonstige (DE-588)133674959 oth Digitalisierung UBRegensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014790649&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014790649&sequence=000002&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Aromatase inhibitors Aromatase Inhibitors therapeutic use Aromatase Inhibitors Therapeutic use Breast Neoplasms drug therapy Breast Cancer Chemotherapy Aromatasehemmer (DE-588)4192306-6 gnd |
| subject_GND | (DE-588)4192306-6 (DE-588)4143413-4 |
| title | Aromatase inhibitors |
| title_auth | Aromatase inhibitors |
| title_exact_search | Aromatase inhibitors |
| title_exact_search_txtP | Aromatase inhibitors |
| title_full | Aromatase inhibitors ed. by B. J. A. Furr |
| title_fullStr | Aromatase inhibitors ed. by B. J. A. Furr |
| title_full_unstemmed | Aromatase inhibitors ed. by B. J. A. Furr |
| title_short | Aromatase inhibitors |
| title_sort | aromatase inhibitors |
| topic | Aromatase Inhibitors therapeutic use Aromatase Inhibitors Therapeutic use Breast Neoplasms drug therapy Breast Cancer Chemotherapy Aromatasehemmer (DE-588)4192306-6 gnd |
| topic_facet | Aromatase Inhibitors therapeutic use Aromatase Inhibitors Therapeutic use Breast Neoplasms drug therapy Breast Cancer Chemotherapy Aromatasehemmer Aufsatzsammlung |
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