Fundamentals of bioMEMS and medical microdevices:
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Bellingham, Wash.
SPIE--The International Society for Optical Engineering
2006
|
| Subjects: | |
| Online Access: | Table of contents Inhaltsverzeichnis |
| Item Description: | Includes bibliographical references and index |
| Physical Description: | XXVII, 610 S. Ill., graph. Darst. |
| ISBN: | 0819459771 |
Staff View
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| 264 | 1 | |a Bellingham, Wash. |b SPIE--The International Society for Optical Engineering |c 2006 | |
| 300 | |a XXVII, 610 S. |b Ill., graph. Darst. | ||
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Record in the Search Index
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| adam_text | Contents
Symbols and Units xi
Acronyms xvii
Preface xxv
1 Introduction to BioMEMS 1
1.1 What are BioMEMS? 1
1.2 The Driving Force Behind Biomedical Applications 4
1.3 Biocompatibility 7
1.4 Reliability Considerations 7
1.5 Regulatory Considerations 8
1.6 Other Organizations 12
1.7 Education 13
1.8 Review Questions 14
References 14
2 Silicon Microfabrication 19
2.1 Hard Fabrication Considerations 20
2.2 Lithography 26
2.3 Etching Methods 38
2.4 Thin Film Deposition Processes 45
2.5 Ion Implantation 53
2.6 Wet Bulk Surface Micromachining 54
2.7 Dry Bulk Surface Micromachining 63
2.8 HEXIL Process 65
2.9 Electroplating 65
2.10 Substrate Bonding 68
2.11 Review Questions 69
References 70
3 Soft Fabrication Techniques 75
3.1 Introduction 75
3.2 Biomaterials 76
3.3 Soft Lithography 78
3.4 Micromolding 79
3.5 Three Dimensional Photopolymerization 86
3.6 Smart Polymers and Hydrogels 89
vii
1
viii CONTENTS
3.7 Nanomedicine 94
3.8 Thick Film Technologies 97 i
3.9 Review Questions 98
References 98
4 Polymer Materials 107
4.1 Polymers 107
4.2 Physical Properties 111
4.3 Copolymers 116
4.4 Review Questions 118
References 118
5 Microfluidic Principles 119
5.1 Introduction 120
5.2 Transport Processes 126
5.3 Electrokinetic Phenomena 137
5.4 Microvalves 148
5.5 Micromixers 152
5.6 Micropumps 153
5.7 Review Questions 158
References 160
6 Sensor Principles and Microsensors 167
6.1 Introduction 168
6.2 Fabrication 172
6.3 Basic Sensors 173
6.4 Optical Fibers 187
6.5 Piezoelectricity and SAW Devices 192
6.6 Electrochemical Detection 197
6.7 Applications in Medicine 204
6.8 Review Questions 213
References 214
7 Microactuators and Drug Delivery 219
7.1 Introduction 219
7.2 Activation Methods 220
7.3 Microactuators for Microfluidics 230
7.4 Equivalent Circuit Representation 232
7.5 Drug Delivery 234
7.6 Review Questions 243
References 243
8 Clinical Laboratory Medicine 249
8.1 Introduction 250
8.2 Chemistry 255
8.3 Hematology 261
CONTENTS ix
8.4 Immunology 266
8.5 Microbiology 269
8.6 Urinalysis 270
8.7 Coagulation Assays 271
8.8 Arterial Blood Gases 272
8.9 Review Questions 274
References 275
9 Micro Total Analysis Systems (jxTAS) 283
9.1 Lab on a Chip 284
9.2 Capillary Electrophoresis Arrays (CEA) 287
9.3 Cell, Molecule, and Particle Handling 290
9.4 Surface Modification 295
9.5 Microspheres 306
9.6 Cell Based Bioassay Systems 309
9.7 Review Questions 309
References 310
10 Detection and Measurement Methods 315
10.1 Introduction 315
10.2 Detection Schemes 316
10.3 Measurement Systems 322
10.4 Review Questions 329
References 329
11 Genomics and DNA Microarrays 341
11.1 Introduction to Genomics 341
11.2 Polymerase Chain Reaction (PCR) 351
11.3 Gene Expression Profiling 353
11.4 DNA LOC Devices 355
11.5 DNA Microarrays 356
11.6 Pharmacogenomics 373
11.7 Review Questions 374
References 374
12 Proteomics and Protein Microarrays 377
12.1 Introduction to Proteomics 377
12.2 Mass Spectrometry (MS) 382
12.3 Protein LOC Devices 392
12.4 Protein Microarrays 393
12.5 Bioinformatics 406
12.6 Review Questions 407
References 408
13 Emerging BioMEMs Technology 413
13.1 Introduction 414
13.2 Minimally Invasive Surgery 414
x CONTENTS
13.3 Point of Care Clinical Diagnosis 415
13.4 Cardiovascular 418
13.5 Diabetes 422
13.6 Endoscopy 424
13.7 Neurosciences 425
13.8 Oncology 431 ,
13.9 Ophthalmology 432
13.10 Dermabrasion 435
13.11 Tissue Engineering 436
13.12 Cell Based Biosensors 437
13.13 Homeland Security 438
13.14 Review Questions 441
References 442
14 Packaging, Power, Data, and RF Safety 449
14.1 Packaging 449
14.2 Electronic Assembly and Packaging 458
14.3 Power Systems 463
14.4 Data transmission 470
14.5 Radio Frequency (RF) Safety 472
14.6 Review Questions 477
References 478
15 Biocompatibility, FDA, and ISO 10993 483
15.1 Introduction 484
15.2 FDA Guidance 485
15.3 International Organization for Standardization 485
15.4 Cytotoxicity 493
15.5 Sensitization . 495
15.6 Irritation 498
15.7 Systemic Toxicity 499
15.8 Genotoxicity, Carcinogenicity and Reproduction 500
15.9 Implantation 501
15.10 Hemocompatibility 504
15.11 Degradation 506
15.12 Biocompatibility of Polymers 508
15.13 Biofouling 511
15.14 Biocompatibility of Other Materials 512
15.15 Review Questions 516
References 517
Appendix A: Common BioMEMS Polymers 527
Appendix B: Medical Imaging 545
Appendix C: FDA Blue Book Memorandum #G95 1 557
Glossary 561
Index 595
|
| adam_txt |
Contents
Symbols and Units xi
Acronyms xvii
Preface xxv
1 Introduction to BioMEMS 1
1.1 What are BioMEMS? 1
1.2 The Driving Force Behind Biomedical Applications 4
1.3 Biocompatibility 7
1.4 Reliability Considerations 7
1.5 Regulatory Considerations 8
1.6 Other Organizations 12
1.7 Education 13
1.8 Review Questions 14
References 14
2 Silicon Microfabrication 19
2.1 Hard Fabrication Considerations 20
2.2 Lithography 26
2.3 Etching Methods 38
2.4 Thin Film Deposition Processes 45
2.5 Ion Implantation 53
2.6 Wet Bulk Surface Micromachining 54
2.7 Dry Bulk Surface Micromachining 63
2.8 HEXIL Process 65
2.9 Electroplating 65
2.10 Substrate Bonding 68
2.11 Review Questions 69
References 70
3 "Soft" Fabrication Techniques 75
3.1 Introduction 75
3.2 Biomaterials 76
3.3 Soft Lithography 78
3.4 Micromolding 79
3.5 Three Dimensional Photopolymerization 86
3.6 Smart Polymers and Hydrogels 89
vii
1
viii CONTENTS
3.7 Nanomedicine 94
3.8 Thick Film Technologies 97 i
3.9 Review Questions 98
References 98
4 Polymer Materials 107
4.1 Polymers 107
4.2 Physical Properties 111
4.3 Copolymers 116
4.4 Review Questions 118
References 118
5 Microfluidic Principles 119
5.1 Introduction 120
5.2 Transport Processes 126
5.3 Electrokinetic Phenomena 137
5.4 Microvalves 148
5.5 Micromixers 152
5.6 Micropumps 153
5.7 Review Questions 158
References 160
6 Sensor Principles and Microsensors 167
6.1 Introduction 168
6.2 Fabrication 172
6.3 Basic Sensors 173
6.4 Optical Fibers 187
6.5 Piezoelectricity and SAW Devices 192
6.6 Electrochemical Detection 197
6.7 Applications in Medicine 204
6.8 Review Questions 213
References 214
7 Microactuators and Drug Delivery 219
7.1 Introduction 219
7.2 Activation Methods 220
7.3 Microactuators for Microfluidics 230
7.4 Equivalent Circuit Representation 232
7.5 Drug Delivery 234
7.6 Review Questions 243
References 243
8 Clinical Laboratory Medicine 249
8.1 Introduction 250
8.2 Chemistry 255
8.3 Hematology 261
CONTENTS ix
8.4 Immunology 266
8.5 Microbiology 269
8.6 Urinalysis 270
8.7 Coagulation Assays 271
8.8 Arterial Blood Gases 272
8.9 Review Questions 274
References 275
9 Micro Total Analysis Systems (jxTAS) 283
9.1 Lab on a Chip 284
9.2 Capillary Electrophoresis Arrays (CEA) 287
9.3 Cell, Molecule, and Particle Handling 290
9.4 Surface Modification 295
9.5 Microspheres 306
9.6 Cell Based Bioassay Systems 309
9.7 Review Questions 309
References 310
10 Detection and Measurement Methods 315
10.1 Introduction 315
10.2 Detection Schemes 316
10.3 Measurement Systems 322
10.4 Review Questions 329
References 329
11 Genomics and DNA Microarrays 341
11.1 Introduction to Genomics 341
11.2 Polymerase Chain Reaction (PCR) 351
11.3 Gene Expression Profiling 353
11.4 DNA LOC Devices 355
11.5 DNA Microarrays 356
11.6 Pharmacogenomics 373
11.7 Review Questions 374
References 374
12 Proteomics and Protein Microarrays 377
12.1 Introduction to Proteomics 377
12.2 Mass Spectrometry (MS) 382
12.3 Protein LOC Devices 392
12.4 Protein Microarrays 393
12.5 Bioinformatics 406
12.6 Review Questions 407
References 408
13 Emerging BioMEMs Technology 413
13.1 Introduction 414
13.2 Minimally Invasive Surgery 414
x CONTENTS
13.3 Point of Care Clinical Diagnosis 415
13.4 Cardiovascular 418
13.5 Diabetes 422
13.6 Endoscopy 424
13.7 Neurosciences 425
13.8 Oncology 431 ,
13.9 Ophthalmology 432
13.10 Dermabrasion 435
13.11 Tissue Engineering 436
13.12 Cell Based Biosensors 437
13.13 Homeland Security 438
13.14 Review Questions 441
References 442
14 Packaging, Power, Data, and RF Safety 449
14.1 Packaging 449
14.2 Electronic Assembly and Packaging 458
14.3 Power Systems 463
14.4 Data transmission 470
14.5 Radio Frequency (RF) Safety 472
14.6 Review Questions 477
References 478
15 Biocompatibility, FDA, and ISO 10993 483
15.1 Introduction 484
15.2 FDA Guidance 485
15.3 International Organization for Standardization 485
15.4 Cytotoxicity 493
15.5 Sensitization . 495
15.6 Irritation 498
15.7 Systemic Toxicity 499
15.8 Genotoxicity, Carcinogenicity and Reproduction 500
15.9 Implantation 501
15.10 Hemocompatibility 504
15.11 Degradation 506
15.12 Biocompatibility of Polymers 508
15.13 Biofouling 511
15.14 Biocompatibility of Other Materials 512
15.15 Review Questions 516
References 517
Appendix A: Common BioMEMS Polymers 527
Appendix B: Medical Imaging 545
Appendix C: FDA Blue Book Memorandum #G95 1 557
Glossary 561
Index 595 |
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| spelling | Saliterman, Steven S. Verfasser aut Fundamentals of bioMEMS and medical microdevices Steven Saliterman Bellingham, Wash. SPIE--The International Society for Optical Engineering 2006 XXVII, 610 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Biotechnologie Micromachines Nanotechnologie Nanotechnology Biotechnology Microelectromechanical systems Biotechnologie (DE-588)4069491-4 gnd rswk-swf Nanotechnologie (DE-588)4327470-5 gnd rswk-swf MEMS (DE-588)4824724-8 gnd rswk-swf Nanotechnologie (DE-588)4327470-5 s MEMS (DE-588)4824724-8 s Biotechnologie (DE-588)4069491-4 s DE-604 http://www.loc.gov/catdir/toc/ecip0513/2005015759.html Table of contents HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014774289&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Saliterman, Steven S. Fundamentals of bioMEMS and medical microdevices Biotechnologie Micromachines Nanotechnologie Nanotechnology Biotechnology Microelectromechanical systems Biotechnologie (DE-588)4069491-4 gnd Nanotechnologie (DE-588)4327470-5 gnd MEMS (DE-588)4824724-8 gnd |
| subject_GND | (DE-588)4069491-4 (DE-588)4327470-5 (DE-588)4824724-8 |
| title | Fundamentals of bioMEMS and medical microdevices |
| title_auth | Fundamentals of bioMEMS and medical microdevices |
| title_exact_search | Fundamentals of bioMEMS and medical microdevices |
| title_exact_search_txtP | Fundamentals of bioMEMS and medical microdevices |
| title_full | Fundamentals of bioMEMS and medical microdevices Steven Saliterman |
| title_fullStr | Fundamentals of bioMEMS and medical microdevices Steven Saliterman |
| title_full_unstemmed | Fundamentals of bioMEMS and medical microdevices Steven Saliterman |
| title_short | Fundamentals of bioMEMS and medical microdevices |
| title_sort | fundamentals of biomems and medical microdevices |
| topic | Biotechnologie Micromachines Nanotechnologie Nanotechnology Biotechnology Microelectromechanical systems Biotechnologie (DE-588)4069491-4 gnd Nanotechnologie (DE-588)4327470-5 gnd MEMS (DE-588)4824724-8 gnd |
| topic_facet | Biotechnologie Micromachines Nanotechnologie Nanotechnology Biotechnology Microelectromechanical systems MEMS |
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