Statistics applied to clinical trials:
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Dordrecht
Springer
2006
|
| Edition: | 3. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis Klappentext |
| Item Description: | Ab 5. Aufl. u.d.T.: Cleophas, Ton J.: Statistics applied to clinical studies |
| Physical Description: | XIV, 366 S. graph. Darst. |
| ISBN: | 1402042299 9781402042294 9781402005701 |
Staff View
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| adam_text | TABLE OF CONTENTS
PREFACE xiii
FOREWORD xv
CHAPTER
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
CHAPTER
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
CHAPTER
1.
2.
3.
4.
5.
6.
7.
8.
CHAPTER
1.
2.
vi
3.
4.
5.
6.
7.
CHAPTER
1.
2.
3.
4.
5.
6.
7.
(the type III error)
8.
9.
CHAPTER
1.
2.
3.
4.
5.
6.
7.
CHAPTER
1.
2.
3.
4.
5.
CHAPTER
TRIALS
1.
2.
3.
4.
5.
6.
7.
8.
TABLE OF CONTENTS
CHAPTER
1.
2.
3.
4.
5.
and p
6.
7.
8.
9.
10.
11.
12.
13.
CHAPTER
COMPATIBLE WITH RANDOM SAMPLING
1.
2.
3.
4.
5.
CHAPTER
1.
2.
3.
4.
5.
6.
7.
(exploratory purpose)
8.
CHAPTER
REGRESSION: CONFOUNDING, INTERACTION, SYNERGISM
1.
2.
3.
4.
5.(11.)
6.
7.
8.
viii TABLE OF CONTENTS
9.
149
10.
149
11.
150
CHAPTER
1.
151
2.
152
3.
154
4.
160
5.
162
6.
162
CHAPTER
REGRESSION MODELING, MARKOW MODELS
1.
165
2.
165
3.
169
4.
171
5.
174
6.
175
7.
177
8.
177
CHAPTER
1.
2.
the underlying mechanism
3.
4.
as efficacy data
5.
6.
7.
CHAPTER
A CASE FOR LOGISTIC REGRESSION ANALYSIS
1.
2.
3.
4.
5.
TABLE OF CONTENTS lx
CHAPTER
1.
2.
3.
data example
4.
5.
6.
7.
CHAPTER
1.
2.
3.
4.
5.
6.
7.
8.
9.
CHAPTER
VARIABLES
1.
2.
3.
4.
5.
6.
7.
CHAPTER
1.
2.
3.
4.
5.
6.
7.
8.
CHAPTER
TREATMENTS WITH DIFFERENT CHEMICAL CLASS
1.
2.
x TABLE OF CONTENTS
3.
not have been used
4.
trials published
5.
6.
7.
CHAPTER
TRIALS
1.
2.
3.
4.
5.
6.
provides increased precision
7.
8.
9.
CHAPTER
1.
2.
3.
4.
5.
6.
CHAPTER
1.
2.
3.
4.
5.
null-hypothesis testing with chi-square distribution
6.
7.
8.
9.
10.
TABLE OF CONTENTS xi
CHAPTER
1.
2.
3.
4.
5.
6.
CHAPTER
IMPORTANT THAN AVERAGES
1.
2.
3.
4.
5.
6.
7.
8.
9.
CHAPTER
1.
2.
3.
4.
5.
6.
7.
8.
CHAPTER
1.
2.
3.
4.
5.
6.
7.
CHAPTER
1.
2.
3.
4.
5.
xii TABLE OF CONTENTS
6.
7.
CHAPTER
1.
2.
3.
4.
5.
6.
7.
8.
benefits of current research
9.
10.
11.
CHAPTER
GUIDELINES
1.
2.
3.
4.
5.
6.
7.
independence of science
8.
9.
APPENDIX
INDEX
Statistics Applied to Clinical Trials
Third Edition
TJ. Cleophas, A.H. Zwinderman and T.F. Cleophas
The previous two editions of this book, rather than having been comprehensive,
concentrated on the most relevant aspects of statistical analysis. Although well-
received by students, clinicians, and researchers, these editions did not answer
all of their questions. This updated and extended edition has been written to
serve as a more complete guide and reference-text to students, physicians, and
investigators, and, at the same time, preserves the comrnos sense approach to
statistical problem-solving of the previous editions.
In
Medical Research Council in the British Medical Journal. Until then,
observations had been uncontrolled. Initially, trials frequently did not confirm
hypotheses to be tested. This phenomenon was attributed to little sensitivity due
to small samples, as well as inappropriate hypotheses based on biased prior
trials. Additional flaws were being recognized and, subsequently were better
accounted for: carryover effects due to insufficient washout from previous
treatments, time effects due to external factors and the natural history of the
condition under study, bias due to asymmetry between
of sensitivity due to a negative correlation between treatment responses etc.
Such flaws mainly of a technical nature have been largely implemented and
lead to trials after
past decade focused, in addition to technical aspects, on the need for
circumspection in planning and conducting of clinical trials. As a consequence,
prior to approval, clinical trial protocols are now routinely scrutinized by
different circumstantial organs, including ethic committees, institutional and
federal review boards, national and international scientific organizations, and
monitoring committees charged with conducting interim analyses. The present
book not only explains classical statistical analyses of clinical trials, but also
addresses relatively novel issues, including equivalence testing, interim
analyses, sequential analyses, meta-analyses, and provides a framework of the
best statistical methods currently available for such purpose. This book is not
only useful for investigators involved in the field of clinical trials, but also for
students and physicians who wish to better understand
the data of trials as published currently.
|
| adam_txt |
TABLE OF CONTENTS
PREFACE xiii
FOREWORD xv
CHAPTER
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
CHAPTER
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
CHAPTER
1.
2.
3.
4.
5.
6.
7.
8.
CHAPTER
1.
2.
vi
3.
4.
5.
6.
7.
CHAPTER
1.
2.
3.
4.
5.
6.
7.
(the type III error)
8.
9.
CHAPTER
1.
2.
3.
4.
5.
6.
7.
CHAPTER
1.
2.
3.
4.
5.
CHAPTER
TRIALS
1.
2.
3.
4.
5.
6.
7.
8.
TABLE OF CONTENTS
CHAPTER
1.
2.
3.
4.
5.
and p
6.
7.
8.
9.
10.
11.
12.
13.
CHAPTER
COMPATIBLE WITH RANDOM SAMPLING
1.
2.
3.
4.
5.
CHAPTER
1.
2.
3.
4.
5.
6.
7.
(exploratory purpose)
8.
CHAPTER
REGRESSION: CONFOUNDING, INTERACTION, SYNERGISM
1.
2.
3.
4.
5.(11.)
6.
7.
8.
viii TABLE OF CONTENTS
9.
149
10.
149
11.
150
CHAPTER
1.
151
2.
152
3.
154
4.
160
5.
162
6.
162
CHAPTER
REGRESSION MODELING, MARKOW MODELS
1.
165
2.
165
3.
169
4.
171
5.
174
6.
175
7.
177
8.
177
CHAPTER
1.
2.
the underlying mechanism
3.
4.
as efficacy data
5.
6.
7.
CHAPTER
A CASE FOR LOGISTIC REGRESSION ANALYSIS
1.
2.
3.
4.
5.
TABLE OF CONTENTS lx
CHAPTER
1.
2.
3.
data example
4.
5.
6.
7.
CHAPTER
1.
2.
3.
4.
5.
6.
7.
8.
9.
CHAPTER
VARIABLES
1.
2.
3.
4.
5.
6.
7.
CHAPTER
1.
2.
3.
4.
5.
6.
7.
8.
CHAPTER
TREATMENTS WITH DIFFERENT CHEMICAL CLASS
1.
2.
x TABLE OF CONTENTS
3.
not have been used
4.
trials published
5.
6.
7.
CHAPTER
TRIALS
1.
2.
3.
4.
5.
6.
provides increased precision
7.
8.
9.
CHAPTER
1.
2.
3.
4.
5.
6.
CHAPTER
1.
2.
3.
4.
5.
null-hypothesis testing with chi-square distribution
6.
7.
8.
9.
10.
TABLE OF CONTENTS xi
CHAPTER
1.
2.
3.
4.
5.
6.
CHAPTER
IMPORTANT THAN AVERAGES
1.
2.
3.
4.
5.
6.
7.
8.
9.
CHAPTER
1.
2.
3.
4.
5.
6.
7.
8.
CHAPTER
1.
2.
3.
4.
5.
6.
7.
CHAPTER
1.
2.
3.
4.
5.
xii TABLE OF CONTENTS
6.
7.
CHAPTER
1.
2.
3.
4.
5.
6.
7.
8.
benefits of current research
9.
10.
11.
CHAPTER
GUIDELINES
1.
2.
3.
4.
5.
6.
7.
independence of science
8.
9.
APPENDIX
INDEX
Statistics Applied to Clinical Trials
Third Edition
TJ. Cleophas, A.H. Zwinderman and T.F. Cleophas
The previous two editions of this book, rather than having been comprehensive,
concentrated on the most relevant aspects of statistical analysis. Although well-
received by students, clinicians, and researchers, these editions did not answer
all of their questions. This updated and extended edition has been written to
serve as a more complete guide and reference-text to students, physicians, and
investigators, and, at the same time, preserves the comrnos sense approach to
statistical problem-solving of the previous editions.
In
Medical Research Council in the British Medical Journal. Until then,
observations had been uncontrolled. Initially, trials frequently did not confirm
hypotheses to be tested. This phenomenon was attributed to little sensitivity due
to small samples, as well as inappropriate hypotheses based on biased prior
trials. Additional flaws were being recognized and, subsequently were better
accounted for: carryover effects due to insufficient washout from previous
treatments, time effects due to external factors and the natural history of the
condition under study, bias due to asymmetry between
of sensitivity due to a negative correlation between treatment responses etc.
Such flaws mainly of a technical nature have been largely implemented and
lead to trials after
past decade focused, in addition to technical aspects, on the need for
circumspection in planning and conducting of clinical trials. As a consequence,
prior to approval, clinical trial protocols are now routinely scrutinized by
different circumstantial organs, including ethic committees, institutional and
federal review boards, national and international scientific organizations, and
monitoring committees charged with conducting interim analyses. The present
book not only explains classical statistical analyses of clinical trials, but also
addresses relatively novel issues, including equivalence testing, interim
analyses, sequential analyses, meta-analyses, and provides a framework of the
best statistical methods currently available for such purpose. This book is not
only useful for investigators involved in the field of clinical trials, but also for
students and physicians who wish to better understand
the data of trials as published currently. |
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| illustrated | Illustrated |
| index_date | 2024-07-02T14:31:01Z |
| indexdate | 2024-07-09T20:38:23Z |
| institution | BVB |
| isbn | 1402042299 9781402042294 9781402005701 |
| language | English |
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| publisher | Springer |
| record_format | marc |
| spelling | Cleophas, Ton J. 1947- Verfasser (DE-588)1069424161 aut Statistics applied to clinical trials 3. ed. Dordrecht Springer 2006 XIV, 366 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Ab 5. Aufl. u.d.T.: Cleophas, Ton J.: Statistics applied to clinical studies Clinical Trials as Topic methods Clinical trials Statistical methods Data Interpretation, Statistical Drugs Testing Statistical methods Medizinische Statistik (DE-588)4127563-9 gnd rswk-swf Medizinische Statistik (DE-588)4127563-9 s DE-604 Zwinderman, Aeilko H. 1960- Verfasser (DE-588)108382225X aut Cleophas, Toine F. Verfasser aut Digitalisierung UBRegensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014765387&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014765387&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Cleophas, Ton J. 1947- Zwinderman, Aeilko H. 1960- Cleophas, Toine F. Statistics applied to clinical trials Clinical Trials as Topic methods Clinical trials Statistical methods Data Interpretation, Statistical Drugs Testing Statistical methods Medizinische Statistik (DE-588)4127563-9 gnd |
| subject_GND | (DE-588)4127563-9 |
| title | Statistics applied to clinical trials |
| title_auth | Statistics applied to clinical trials |
| title_exact_search | Statistics applied to clinical trials |
| title_exact_search_txtP | Statistics applied to clinical trials |
| title_full | Statistics applied to clinical trials |
| title_fullStr | Statistics applied to clinical trials |
| title_full_unstemmed | Statistics applied to clinical trials |
| title_short | Statistics applied to clinical trials |
| title_sort | statistics applied to clinical trials |
| topic | Clinical Trials as Topic methods Clinical trials Statistical methods Data Interpretation, Statistical Drugs Testing Statistical methods Medizinische Statistik (DE-588)4127563-9 gnd |
| topic_facet | Clinical Trials as Topic methods Clinical trials Statistical methods Data Interpretation, Statistical Drugs Testing Statistical methods Medizinische Statistik |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014765387&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014765387&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
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