Nanoparticle technology for drug delivery:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
New York [u.a.]
Taylor & Francis
2006
|
| Series: | Drugs and the pharmaceutical sciences
159 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Includes bibliographical references and index |
| Physical Description: | XIII, 403 S. Ill., graph. Darst. |
| ISBN: | 1574448579 |
Staff View
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| 650 | 4 | |a Drug Administration Routes | |
| 650 | 4 | |a Drug Delivery Systems | |
| 650 | 4 | |a Drug delivery systems | |
| 650 | 4 | |a Nanoparticles | |
| 650 | 4 | |a Nanostructures | |
| 650 | 4 | |a Nanotechnology - methods | |
| 650 | 4 | |a Nanoparticles | |
| 650 | 4 | |a Drug delivery systems | |
| 650 | 4 | |a Drug Delivery Systems | |
| 650 | 4 | |a Nanostructures | |
| 650 | 4 | |a Drug Administration Routes | |
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| adam_text | NANOPARTICLE TECHNOLOGY FOR DRUG DELIVERY EDITED BY RAM B. GUPTA AUBURN
UNIVERSITY AUBURN, ALABAMA UDAY B. KOMPELLA UNIVERSITY OF NEBRASKA
MEDICAL CENTER OMAHA, NEBRASKA TAYLOR &. FRANCIS TAYLOR & FRANCIS CROUP
CONTENTS PREFACE .... HI CONTRIBUTORS .... XI PART I: TECHNOLOGIES FOR
NANOPARTICLE MANUFACTURING 1. FUNDAMENTALS OF DRUG NANOPARTICLES RAM B.
GUPTA INTRODUCTION .... 1 N A N O P A R T I C L E SIZE .... 2 N A N O P
A R T I C L E SURFACE .... 3 N A N O P A R T I C L E S U S P E N S I O N
A N D SETTLING .... 4 M A G N E T I C A N D OPTICAL PROPERTIES .... 6 P
R O D U C T I O N OF NANOPARTICLES .... 6 BIOLOGICAL T R A N S P O R T
OF N A N O P A R T I C L E S .... 12 CONCLUSIONS .... 17 REFERENCES ....
18 V J CONTENTS 2. MANUFACTURING OF NANOPARTICLES BY MILLING AND
HOMOGENIZATION TECHNIQUES 21 RAINER H. MULLER, JAN MOSCHWITZER, AND
FARIS NADIEM BUSHRAB INTRODUCTION .... 21 PEARL/BALL-MILLING TECHNOLOGY
FOR THE PRODUCTION OF DRUG NANOCRYSTALS .... 25 DRUG NANOCRYSTALS
PRODUCED BY HIGH-PRESSURE HOMOGENIZATION .... 28 PRODUCTION OF DRUG
NANOCRYSTAL COMPOUNDS BY SPRAY-DRYING .... 33 PRODUCTION IN NONAQUEOUS
LIQUIDS .... 35 PRODUCTION IN HOT-MELTED MATRICES .... 37 PELLETIZATION
TECHNIQUES .... 41 DIRECT COMPRESS .... 45 REFERENCES .... 47 3.
SUPERCRITICAL FLUID TECHNOLOGY FOR PARTICLE ENGINEERING 53 RAM B. GUPTA
INTRODUCTION .... 53 SUPERCRITICAL CO 2 .... 54 SOLUBILITY IN
SUPERCRITICAL CO 2 .... 55 RAPID EXPANSION OF SUPERCRITICAL SOLUTION FOR
PARTICLE FORMATION .... 59 RESS WITH SOLID COSOLVENT FOR NANOPARTICLE
FORMATION .... 63 SUPERCRITICAL ANTISOLVENT PROCESS FOR PARTICLE
FORMATION .... 66 SAS WITH ENHANCED MASS (EM) TRANSFER (SAS-EM) PROCESS
FOR NANOPARTICLE FORMATION .... 69 FUNDAMENTALS GOVERNING PARTICLE
FORMATION WITH RESS AND SAS .... 70 OTHER APPLICATIONS OF SCFS FOR
PARTICLE ENGINEERING .... 74 SAFETY AND HEALTH ISSUES .... 78
CONCLUSIONS .... 78 REFERENCES .... 79 CONTENTS V A 4. POLYMER OR
PROTEIN STABILIZED NANOPARTICLES FROM EMULSIONS 85 RAM B. GUPTA
INTRODUCTION .... 85 EMULSIFICATION SOLVENT EVAPORATION PROCESS .... 86
EMULSIFICATION .... 87 NANOPARTICLE H A R D E N I N G .... 93 RESIDUAL
SOLVENT A N D EMULSIFIER .... 97 PROTEIN STABILIZED NANOPARTICLES ....
98 CONCLUSIONS .... 99 REFERENCES .... 101 PART II: NANOPARTICLE
CHARACTERIZATION AND PROPERTIES 5. PHYSICAL CHARACTERIZATION OF
NANOPARTICLES .. . 103 ROY J. HASKELL INTRODUCTION .... 103 MEASUREMENT
OF SIZE .... 105 AVAILABLE METHODS .... 109 IN VITRO RELEASE .... 119
EXAMPLE: PARTICLE SIZE .... 121 CONCLUSIONS .... 130 REFERENCES .... 132
6. NANOPARTICLE INTERFACE: AN IMPORTANT DETERMINANT IN
NANOPARTICLE-MEDIATED DRUG/GENE DELIVERY 139 SANJEEB K. SAHOO AND VINOD
LABHASCTICAR INTRODUCTION .... 139 INFLUENCE OF EMULSIFIER ON
PHARMACEUTICAL PROPERTIES OF NANOPARTICLES .... 140 IMPLICATION ON
CELLULAR UPTAKE/ TOXICITY GENE DELIVERY .... 148 BIODISTRIBUTION ....
153 CONCLUSIONS .... 154 REFERENCES .... 154 CONTENTS 7. TOXICOLOGICAL
CHARACTERIZATION OF ENGINEERED NANOPARTICLES PAUL J. A. BORM AND ROEL P.
F. SCHINS INTRODUCTION .... 161 INHALATION OF PARTICLES .... 164 EFFECTS
OF NANOPARTICLES .... 170 SCREENING ENGINEERED NP FOR TOXICOLOGICAL
HAZARDS .... 178 CONCLUSION .... 187 REFERENCES .... 188 PART III: DRUG
DELP7ERY APPLICATIONS OF NANOPARTICLES 8. INJECTABLE NANOPARTICLES FOR
EFFICIENT DRUG DELIVERY 199 BARRETT RABINOW AND MAHESH V. CHAUBAL
INTRODUCTION: MEDICAL NEEDS ADDRESSABLE BY NANOPARTICULATE DRUG DELIVERY
.... 199 TYPES OF CARRIERS .... 209 COATING FUNCTIONALITY .... 215
EXTERNAL ASSISTANCE IN TARGETING .... 215 DRUGS INCORPORATED .... 216
CLINICAL DEVELOPMENT .... 217 CONCLUSIONS .... 220 REFERENCES .... 221
9. POLYMERIC NANOPARTICLES FOR ORAL DRUG DELIVERY 231 VIVEKANAND
BHARDWAJ AND MAJETI NAGA VENKATA RAVI KUMAR INTRODUCTION .... 231
PHYSIOLOGY OF GIT WITH RELEVANCE TO PARTICULATE UPTAKE .... 232 PARTICLE
SIZE AND SURFACE CHARGE: CRITICAL FACTORS IN PARTICLE ABSORPTION ....
236 BIOADHESION .... 237 TRACER TECHNIQUES .... 241 CONTENTS JX IN VITRO
AND IN VIVO MODELS .... 243 NANOPARTICLE FORMULATION .... 244
APPLICATIONS .... 253 FUTURE DIRECTIONS .... 260 REFERENCES .... 262 10.
BRAIN DELIVERY BY NANOPARTICLES 273 SVETLANA GELPERINA INTRODUCTION ....
273 BIODISTRIBUTION STUDIES .... 276 PHARMACOLOGICAL ACTIVITY .... 289
MECHANISMS OF DRUG DELIVERY TO THE BRAIN BY MEANS OF POLYMERIC NP . . .
. 296 CONCLUSIONS .... 309 REFERENCES .... 311 11. NANOPARTICLES FOR
OCULAR DRUG DELIVERY 319 ANIRUDDHA C. AMRITE AND UDAY B. KOMPELLA
INTRODUCTION .... 319 DISPOSITION OF NANOPARTICLES IN THE EYE .... 322
OCULAR DRUG DELIVERY ENHANCEMENT USING NANOPARTICLES .... 336 SAFETY AND
TOLERABILITY OF PARTICULATE SYSTEMS .... 347 CONCLUSIONS .... 352
REFERENCES .... 353 12. DNA NANOPARTICLE GENE DELIVERY SYSTEMS . . . 361
MOSES O. OYEWUMI AND KEVIN G. RICE GENE DELIVERY VECTORS .... 361
POLYMERS USED TO PREPARE DNA NANOPARTICLES .... 363 PHYSICAL PROPERTIES
OF DNA NANOPARTICLES .... 365 BIODISTRIBUTION AND TRAFFICKING OF DNA
NANOPARTICLES .... 371 CONCLUSIONS .... 372 REFERENCES .... 373 X
CONTENTS PART TV: CLINICAL, ETHICAL, AND REGULATORY ISSUES 13.
NANOTECHNOLOGY AND NANOPARTICLES: CLINICAL, ETHICAL, AND REGULATORY
ISSUES 381 MAKENA HAMMOND AND UDAY B. KOMPELLA INTRODUCTION .... 381
CLINICAL ASPECTS .... 382 ENVIRONMENTAL, SOCIAL, AND ETHICAL ISSUES ....
385 REGULATORY CHALLENGES .... 388 CONCLUSIONS .... 392 REFERENCES ....
393 INDEX .... 397
|
| adam_txt |
NANOPARTICLE TECHNOLOGY FOR DRUG DELIVERY EDITED BY RAM B. GUPTA AUBURN
UNIVERSITY AUBURN, ALABAMA UDAY B. KOMPELLA UNIVERSITY OF NEBRASKA
MEDICAL CENTER OMAHA, NEBRASKA TAYLOR &. FRANCIS TAYLOR & FRANCIS CROUP
CONTENTS PREFACE . HI CONTRIBUTORS . XI PART I: TECHNOLOGIES FOR
NANOPARTICLE MANUFACTURING 1. FUNDAMENTALS OF DRUG NANOPARTICLES RAM B.
GUPTA INTRODUCTION . 1 N A N O P A R T I C L E SIZE . 2 N A N O P
A R T I C L E SURFACE . 3 N A N O P A R T I C L E S U S P E N S I O N
A N D SETTLING . 4 M A G N E T I C A N D OPTICAL PROPERTIES . 6 P
R O D U C T I O N OF NANOPARTICLES . 6 BIOLOGICAL T R A N S P O R T
OF N A N O P A R T I C L E S . 12 CONCLUSIONS . 17 REFERENCES .
18 V J CONTENTS 2. MANUFACTURING OF NANOPARTICLES BY MILLING AND
HOMOGENIZATION TECHNIQUES 21 RAINER H. MULLER, JAN MOSCHWITZER, AND
FARIS NADIEM BUSHRAB INTRODUCTION . 21 PEARL/BALL-MILLING TECHNOLOGY
FOR THE PRODUCTION OF DRUG NANOCRYSTALS . 25 DRUG NANOCRYSTALS
PRODUCED BY HIGH-PRESSURE HOMOGENIZATION . 28 PRODUCTION OF DRUG
NANOCRYSTAL COMPOUNDS BY SPRAY-DRYING . 33 PRODUCTION IN NONAQUEOUS
LIQUIDS . 35 PRODUCTION IN HOT-MELTED MATRICES . 37 PELLETIZATION
TECHNIQUES . 41 DIRECT COMPRESS . 45 REFERENCES . 47 3.
SUPERCRITICAL FLUID TECHNOLOGY FOR PARTICLE ENGINEERING 53 RAM B. GUPTA
INTRODUCTION . 53 SUPERCRITICAL CO 2 . 54 SOLUBILITY IN
SUPERCRITICAL CO 2 . 55 RAPID EXPANSION OF SUPERCRITICAL SOLUTION FOR
PARTICLE FORMATION . 59 RESS WITH SOLID COSOLVENT FOR NANOPARTICLE
FORMATION . 63 SUPERCRITICAL ANTISOLVENT PROCESS FOR PARTICLE
FORMATION . 66 SAS WITH ENHANCED MASS (EM) TRANSFER (SAS-EM) PROCESS
FOR NANOPARTICLE FORMATION . 69 FUNDAMENTALS GOVERNING PARTICLE
FORMATION WITH RESS AND SAS . 70 OTHER APPLICATIONS OF SCFS FOR
PARTICLE ENGINEERING . 74 SAFETY AND HEALTH ISSUES . 78
CONCLUSIONS . 78 REFERENCES . 79 CONTENTS V A 4. POLYMER OR
PROTEIN STABILIZED NANOPARTICLES FROM EMULSIONS 85 RAM B. GUPTA
INTRODUCTION . 85 EMULSIFICATION SOLVENT EVAPORATION PROCESS . 86
EMULSIFICATION . 87 NANOPARTICLE H A R D E N I N G . 93 RESIDUAL
SOLVENT A N D EMULSIFIER . 97 PROTEIN STABILIZED NANOPARTICLES .
98 CONCLUSIONS . 99 REFERENCES . 101 PART II: NANOPARTICLE
CHARACTERIZATION AND PROPERTIES 5. PHYSICAL CHARACTERIZATION OF
NANOPARTICLES . . 103 ROY J. HASKELL INTRODUCTION . 103 MEASUREMENT
OF SIZE . 105 AVAILABLE METHODS . 109 IN VITRO RELEASE . 119
EXAMPLE: PARTICLE SIZE . 121 CONCLUSIONS . 130 REFERENCES . 132
6. NANOPARTICLE INTERFACE: AN IMPORTANT DETERMINANT IN
NANOPARTICLE-MEDIATED DRUG/GENE DELIVERY 139 SANJEEB K. SAHOO AND VINOD
LABHASCTICAR INTRODUCTION . 139 INFLUENCE OF EMULSIFIER ON
PHARMACEUTICAL PROPERTIES OF NANOPARTICLES . 140 IMPLICATION ON
CELLULAR UPTAKE/'TOXICITY GENE DELIVERY . 148 BIODISTRIBUTION .
153 CONCLUSIONS . 154 REFERENCES . 154 CONTENTS 7. TOXICOLOGICAL
CHARACTERIZATION OF ENGINEERED NANOPARTICLES PAUL J. A. BORM AND ROEL P.
F. SCHINS INTRODUCTION . 161 INHALATION OF PARTICLES . 164 EFFECTS
OF NANOPARTICLES . 170 SCREENING ENGINEERED NP FOR TOXICOLOGICAL
HAZARDS . 178 CONCLUSION . 187 REFERENCES . 188 PART III: DRUG
DELP7ERY APPLICATIONS OF NANOPARTICLES 8. INJECTABLE NANOPARTICLES FOR
EFFICIENT DRUG DELIVERY 199 BARRETT RABINOW AND MAHESH V. CHAUBAL
INTRODUCTION: MEDICAL NEEDS ADDRESSABLE BY NANOPARTICULATE DRUG DELIVERY
. 199 TYPES OF CARRIERS . 209 COATING FUNCTIONALITY . 215
EXTERNAL ASSISTANCE IN TARGETING . 215 DRUGS INCORPORATED . 216
CLINICAL DEVELOPMENT . 217 CONCLUSIONS . 220 REFERENCES . 221
9. POLYMERIC NANOPARTICLES FOR ORAL DRUG DELIVERY 231 VIVEKANAND
BHARDWAJ AND MAJETI NAGA VENKATA RAVI KUMAR INTRODUCTION . 231
PHYSIOLOGY OF GIT WITH RELEVANCE TO PARTICULATE UPTAKE . 232 PARTICLE
SIZE AND SURFACE CHARGE: CRITICAL FACTORS IN PARTICLE ABSORPTION .
236 BIOADHESION . 237 TRACER TECHNIQUES . 241 CONTENTS JX IN VITRO
AND IN VIVO MODELS . 243 NANOPARTICLE FORMULATION . 244
APPLICATIONS . 253 FUTURE DIRECTIONS . 260 REFERENCES . 262 10.
BRAIN DELIVERY BY NANOPARTICLES 273 SVETLANA GELPERINA INTRODUCTION .
273 BIODISTRIBUTION STUDIES . 276 PHARMACOLOGICAL ACTIVITY . 289
MECHANISMS OF DRUG DELIVERY TO THE BRAIN BY MEANS OF POLYMERIC NP . . .
. 296 CONCLUSIONS . 309 REFERENCES . 311 11. NANOPARTICLES FOR
OCULAR DRUG DELIVERY 319 ANIRUDDHA C. AMRITE AND UDAY B. KOMPELLA
INTRODUCTION . 319 DISPOSITION OF NANOPARTICLES IN THE EYE . 322
OCULAR DRUG DELIVERY ENHANCEMENT USING NANOPARTICLES . 336 SAFETY AND
TOLERABILITY OF PARTICULATE SYSTEMS . 347 CONCLUSIONS . 352
REFERENCES . 353 12. DNA NANOPARTICLE GENE DELIVERY SYSTEMS . . . 361
MOSES O. OYEWUMI AND KEVIN G. RICE GENE DELIVERY VECTORS . 361
POLYMERS USED TO PREPARE DNA NANOPARTICLES . 363 PHYSICAL PROPERTIES
OF DNA NANOPARTICLES . 365 BIODISTRIBUTION AND TRAFFICKING OF DNA
NANOPARTICLES . 371 CONCLUSIONS . 372 REFERENCES . 373 X
CONTENTS PART TV: CLINICAL, ETHICAL, AND REGULATORY ISSUES 13.
NANOTECHNOLOGY AND NANOPARTICLES: CLINICAL, ETHICAL, AND REGULATORY
ISSUES 381 MAKENA HAMMOND AND UDAY B. KOMPELLA INTRODUCTION . 381
CLINICAL ASPECTS . 382 ENVIRONMENTAL, SOCIAL, AND ETHICAL ISSUES .
385 REGULATORY CHALLENGES . 388 CONCLUSIONS . 392 REFERENCES .
393 INDEX . 397 |
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| series | Drugs and the pharmaceutical sciences |
| series2 | Drugs and the pharmaceutical sciences |
| spelling | Nanoparticle technology for drug delivery ed. by Ram B. Gupta ... New York [u.a.] Taylor & Francis 2006 XIII, 403 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Drugs and the pharmaceutical sciences 159 Includes bibliographical references and index Drug Administration Routes Drug Delivery Systems Drug delivery systems Nanoparticles Nanostructures Nanotechnology - methods Nanotechnology methods Wirkstofffreisetzung (DE-588)4190018-2 gnd rswk-swf Nanopartikel (DE-588)4333369-2 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Wirkstofffreisetzung (DE-588)4190018-2 s Nanopartikel (DE-588)4333369-2 s b DE-604 Gupta, Ram B. Sonstige oth Drugs and the pharmaceutical sciences 159 (DE-604)BV000002008 159 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014762709&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Nanoparticle technology for drug delivery Drugs and the pharmaceutical sciences Drug Administration Routes Drug Delivery Systems Drug delivery systems Nanoparticles Nanostructures Nanotechnology - methods Nanotechnology methods Wirkstofffreisetzung (DE-588)4190018-2 gnd Nanopartikel (DE-588)4333369-2 gnd |
| subject_GND | (DE-588)4190018-2 (DE-588)4333369-2 (DE-588)4143413-4 |
| title | Nanoparticle technology for drug delivery |
| title_auth | Nanoparticle technology for drug delivery |
| title_exact_search | Nanoparticle technology for drug delivery |
| title_exact_search_txtP | Nanoparticle technology for drug delivery |
| title_full | Nanoparticle technology for drug delivery ed. by Ram B. Gupta ... |
| title_fullStr | Nanoparticle technology for drug delivery ed. by Ram B. Gupta ... |
| title_full_unstemmed | Nanoparticle technology for drug delivery ed. by Ram B. Gupta ... |
| title_short | Nanoparticle technology for drug delivery |
| title_sort | nanoparticle technology for drug delivery |
| topic | Drug Administration Routes Drug Delivery Systems Drug delivery systems Nanoparticles Nanostructures Nanotechnology - methods Nanotechnology methods Wirkstofffreisetzung (DE-588)4190018-2 gnd Nanopartikel (DE-588)4333369-2 gnd |
| topic_facet | Drug Administration Routes Drug Delivery Systems Drug delivery systems Nanoparticles Nanostructures Nanotechnology - methods Nanotechnology methods Wirkstofffreisetzung Nanopartikel Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014762709&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000002008 |
| work_keys_str_mv | AT guptaramb nanoparticletechnologyfordrugdelivery |