Developmental biology:
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| Format: | Book |
| Language: | English |
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Sunderland, Mass.
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2006
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| Edition: | 8. ed. |
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| Online Access: | Inhaltsverzeichnis Klappentext |
| Item Description: | Titel der CD-ROM: Vade mecum 2, Vers. 2.2 / Mary S. Tyler ; Ronald N. Kozlowski |
| Physical Description: | XVIII, 817 S. Ill., graph. Darst. 1 CD-ROM (12 cm), 1 Beil. |
| ISBN: | 087893250X |
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| _version_ | 1804135282550767616 |
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| adam_text | Contents
part I Principles of
JL Development
Developmental Biology
CHAPTER
The Anatomical Tradition
The Questions of Developmental Biology
Approaches to Developmental Biology
The Anatomical Approach
Comparative embryology
Epigénesis
Naming the parts: The primary germ layers and early
organs
The four principles of Karl Ernst von Baer
Fate mapping the embryo
The Cellular Basis of Morphogenesis
Cell migration
Evolutionary Embryology
Embryonic homologies
Medical Embryology and Teratology
Genetic malformations and syndromes
Disruptions and teratogens
Mathematical Modeling of Development
The mathematics of organismal growth
The mathematics of patterning
Coda
CHAPTER
The Circle of Life: The Stages of Animal
Development
The frog life cycle
Multicellularity:The Evolution of Differentiation and
Morphogenesis
The volvocaceans
■ SID£LIGHTS£r
Differentiation and morphogenesis in Dictyostelium
■
Development in Flowering Plants
Developmental Patterns among the Metazoa
The Diploblasts, Protostomes, and Deuterostomes
■
Flatworms
viii
CONTENTS
CHAPTER
Environmental Developmental Biology
Environmental sex determination
Adaptation of embryos and larvae to their
environments
The Developmental Dynamics of Cell Specification
Autonomous specification
Syncytial specification
Conditional specification
Morphogen gradients revisited
■
Stem cells and commitment
Morphogenesis and Cell Adhesion
Differential cell affinity
The thermodynamic model of cell interactions
Cadherins and cell adhesion
Coda
CHAPTER
The Embryological Origins of the Gene Theory
Nucleus or cytoplasm: Which controls heredity?
The split between embryology and genetics
Early attempts at developmental genetics
Evidence for Genomic Equivalence
Amphibian cloning: The restriction of nuclear potency
Amphibian cloning: The totipotency of somatic cells
Cloning mammals
■
Differential Gene Expression
RNA Localization Techniques
Detecting specific mRNAs: RT-PCR
Microarrays
Macroarrays
Locating mRNAs in space and time: In situ
hybridization
Determining the Function of Genes during
Development
Transgenic cells and organisms
Determining the function of a message: Antisense RNA
Coda
CHAPTERS The Paradigm of Differential Gene Expression
Differential Gene Transcription
Anatomy of the gene: Active and repressed chromatin
Anatomy of the gene: Exons and introns
Anatomy of the gene: Promoters and enhancers
Transcription factors
■
Transcription factor cascades
■
Elements
Silencers
Methylation Pattern and the Control of
Transcription
DNA
■
Chromatin modification induced by
methylation
Insulators
Transcriptional regulation of an entire chromosome:
Dosage compensation
■
Chromosome Inactivation
Differential RNA Processing
Control of early development by nuclear RNA
selection
Creating families of proteins through differential nRNA
splicing
Splicing enhancers and recognition factors
■
Drosophila Sex Determination
Control of Gene Expression at the Level of
Translation
Differential mRNA longevity
Selective inhibition of mRNA translation: Stored oocyte
mRNAs
Control of RNA expression by cytoplasmic
localization
■
Regulation
Posttranslational regulation of gene expression
CONTENTS
IX
CHAPTER
Induction and Competence
Cascades of induction: Reciprocal and sequential
inductive events
Instructive and permissive interactions
Epithelial-mesenchymal interactions
Paracrine Factors: The Inducer Molecules
Signal Transduction Cascades: The Response to
Inducers
Fibroblast growth factors and the RTK pathway
The JAK-STAT pathway
The Hedgehog family
The Wnt family
The
■
Other paracrine factors
Cell Death Pathways
Juxtacrine Signaling
The Notch pathway: Juxtaposed ligands and receptors
■
Patterning
The extracellular matrix as a source of developmental
signals
Direct transmission of signals through gap junctions
Cross-Talk between Pathways
Maintenance of the Differentiated State
Coda
part
jLmá
CHAPTER
a New Organism
Structure of the Gametes
Sperm
The egg
Recognition of egg and sperm
External Fertilization in Sea Urchins
Sperm attraction: Action at a distance
The acrosome reaction
Species-specific recognition
Fusion of the egg and sperm cell membranes
The Prevention of Polyspermy
The fast block to polyspermy
The slow block to polyspermy
Calcium as the initiator of the cortical granule
reaction
Activation of Egg Metabolism in Sea Urchins
Early responses
Late responses: Resumption of protein and
synthesis
■
Metabolism
Fusion of genetic material
Mammalian Fertilization
Getting the gametes into the oviduct:
capacitation
In the vicinity of the oocyte: Hyperactivation,
thermotaxis,
Recognition at the
Gamete fusion and the prevention of polyspermy
Fusion of genetic material
Coda
■
Mammalian
CONTENTS
CHAPTER
EARLY DEVELOPMENTAL PROCESSES:
AN OVERVIEW
Cleavage
From fertilization to cleavage
The cytoskeletal mechanisms of mitosis
Patterns of embryonic cleavage
Gastrulation
Cell Specification and Axis Formation
EARLY DEVELOPMENT IN SEA URCHINS
Sea Urchin Cleavage
Blástula
Fate maps and the determination of sea urchin
blastomeres
Sea Urchin Gastrulation
Ingression of the primary mesenchyme
First stage of archenteron
Second and third stages of archenteron
THE EARLY DEVELOPMENT OF SNAILS
Cleavage in Snail Embryos
A fate map of Ilyanassa
The polar lobe: Cell determination and axis formation
■
Embryonic Cleavage
Gastrulation in Snails
EARLY DEVELOPMENT IN TUNICATES
Tunicate Cleavage
The tunicate fate map
Autonomous and conditional specification of tunicate
blastomeres
Specification of the embryonic axes
Gastrulation in Tunicates
THE NEMATODE CAENORHABDITIS ELEGANS
Why C.e/egans?
Cleavage and Axis Formation in
Rotational cleavage of the C. elegans egg
Anterior-posterior axis formation
Formation of the dorsal-ventral and right-left axes
Control of blastomere identity
Integration of autonomous and conditional specification:
Differentiation of the C. elegans pharynx
Gastrulation in C. elegans
Coda
CHAPTER
EARLY DROSOPHILA DEVELOPMENT
Fertilization
Cleavage
The mid-blastula transition
Gastrulation
GENES THAT PATTERN THE DfiOSOPHILA BODY PLAN
258
Primary Axis Formation during
Anterior-posterior polarity in the oocyte
Dorsal-ventral patterning in the oocyte
Generating Dorsal-Ventral Pattern in the Embryo
Dorsal, the ventral morphogen
Establishing a nuclear dorsal gradient
Effects of the dorsal protein gradient
Segmentation and the Anterior-Posterior Body Plan
Maternal gradients: Polarity regulation by oocyte
cytoplasm
The molecular model: Protein gradients in the early
embryo
The anterior organizing center: The Bicoid and
Hunchback gradients
The terminal gene group
Anterior-posterior axis specification: Summary
Segmentation Genes
■
The gap genes
The pair-rule genes
The segment polarity genes
The Homeotic Selector Genes
Patterns of homeotic gene expression
Initiating the patterns of homeotic gene expression
Maintaining the patterns of homeotic gene expression
Realisator
■
Axes and Organ Primordia: The Cartesian Coordinate
Model
Coda
CONTENTS
xi
CHAPTER
Early Amphibian Development
Fertilization and cortical rotation
Unequal radial holoblastic cleavage
The Mid-Blastula Transition: Preparing for
Gastrulation
Amphibian Gastrulation
The Xenopus fate map
Vegetal rotation and the
bottle cells
■
Mesoderma!
Epiboly of the prospective ectoderm
Progressive Determination of the Amphibian Axes
Hans Spemann and
Embryonic Induction
Mechanisms of Axis Determination in Amphibians
How does the organizer form?
Functions of the Organizer
Induction of neural ectoderm and dorsal
BMP inhibitors
The Regional Specificity of Induction
The determination of regional differences
■
The head
Trunk induction: Wnt signals and retinoic acid
Specifying the Left-Right Axis
Coda
■
Neurulation
CHAPTER
Fishy Birds, and Mammals
EARLY DEVELOPMENT IN FISH
Cleavage in Fish Eggs
Gastrulation in Fish Embryos
The formation of germ layers
Axis Formation in Fish Embryos
Dorsal-ventral axis formation: The embryonic shield and
Nieuwkoop center
The fish Nieuwkoop center
Anterior-posterior axis formation
Left-right axis formation
EARLY DEVELOPMENT IN BIRDS
Cleavage in Bird Eggs
Gastrulation of the Avian Embryo
The hypoblast
The primitive streak
Epiboly of the ectoderm
Axis Formation in the Chick Embryo
The role of gravity in forming the anterior-posterior
axis
The chick organizer
Left-Right Axis Formation
EARLY MAMMALIAN DEVELOPMENT
Cleavage in Mammals
The unique nature of mammalian cleavage
Compaction
Escape from the
Gastrulation in Mammals
Modifications for development within another
organism
Formation of extraembryonic membranes
■
Stem Cells
Mammalian Anterior-Posterior Axis Formation
Two signaling centers
Patterning the anterior-posterior axis: FGFs, retinoic acid,
and the Hox code hypothesis
Expression of Hox genes along the dorsal axis
Experimental analysis of the Hox code
The Dorsal-Ventral and Right-Left Axes in Mice
The dorsal-ventral axis
The left-right axis
Coda
XII
CONTENTS
PART y
Later Embryonic
Development
CHAPTER n The Emergence of the Ectoderm:
Central Nervous System and Epidermis
Establishing the Neural Cells
Formation of the Neural Tube
Primary neurulation
Secondary neurulation
Differentiation of the Neural Tube
The anterior-posterior axis
The dorsal-ventral axis
Tissue Architecture of the Central Nervous System
Spinal cord and medulla organization
Cerebellar organization
Cerebral organization
■
Human Brain
Adult neural stem cells
Differentiation of Neurons
Development of the Vertebrate
Eye
The dynamics of optic
development
Neural retina differentiation
Lens and cornea differentiation
The Epidermis and the Origin of Cutaneous
Structures
The origin of epidermal cells
Cutaneous appendages
The follicular stem cell
CHAPTER
THE NEURAL CREST
Specification of the Neural Crest Cells
Regionalization of the neural crest
Trunk Neural Crest
Migration pathways of trunk neural crest cells
The mechanisms of trunk neural crest migration
The Pluripotency of Neural Crest Cells
Cranial Neural Crest
■
Migration and Specification
Intramembranous ossification
Tooth formation
Cardiac Neural Crest
Cranial Placodes
NEURONAL
SPECIFICITY
The Generation of
Pattern Generation in the Nervous System
Cell adhesion and contact guidance by attractive and
permissive molecules
Guidance by specific growth cone repulsion
Guidance by diffusible molecules
Target selection
Forming the synapse: Activity-dependent development
Differential survival after
factors
Paths to glory: Migration of the retinal ganglion
The Development of Behaviors: Constancy and
Plasticity
CHAPTER
PARAXIAL MESODERM: THE SOMITES AND THEIR
DERIVATIVES
The Formation of Somites
The periodicity of somite formation
Where somites form: The Notch pathway
The separation of somites from the unsegmented
mesoderm
I SIDELIGHTS
in Somite Formation
CONTENTS
xiii
Epithelialization
Somite specification along the anterior-posterior axis
Derivatives of the somites
Determination of the sclerotome and dermatome
Determination of the myotome
Myogenesis: The Generation of Muscle
Specification and differentiation by myogenic bHLH
proteins
Muscle cell fusion
Osteogenesis: The Development of Bones
Endochondral ossification
Vertebrae formation
Tendon formation: The syndetome
INTERMEDIATE MESODERM: THE
SYSTEM
Specification of the Intermediate Mesoderm: Pax2/8
and
Progression of Kidney Types
Reciprocal Interactions of Developing Kidney
Tissues
The mechanisms of reciprocal induction
CHAPTER
LATERAL PLATE MESODERM
The Heart
Specification of heart tissue
Fusion of the heart rudiments and initial heartbeats
Looping and formation of heart chambers
■
Newborn Mammal
Formation of Blood Vessels
Constraints on the construction of blood vessels
Vasculogenesis: The initial formation of blood vessels
Angiogenesis: Sprouting of blood vessels and remodeling
of vascular beds
Arterial and venous differentiation
Organ-specific angiogenesis factors
The lymphatic vessels
The Development of Blood Cells
The stem cell concept
Sites of hematopoiesis
Committed stem cells and their fates
Hematopoietic inductive microenvironments
ENDODERM
The Pharynx
The Digestive Tube and Its Derivatives
Specification of the gut tissue
Liver, pancreas, and gallbladder
■
of Liver and Pancreas
The Respiratory Tube
The Extraembryonic Membranes
The amnion and chorion
The allantois and yolk sac
CHAPTER
Formation of the Limb Bud
Specification of the limb fields
Induction of the early limb bud: Wnt proteins and
fibroblast growth factors
Specification of forelimb or hindlimb: Tbx4 and Tbx5
508
Generating the Proximal-Distal Axis of the Limb
The apical
FGFs in the induction and maintenance of the AER
Specifying the limb mesoderm: Determining the
proximal-distal polarity of the limb
The Hox specification code for the limb
Specification of the Anterior-Posterior Limb Axis
The zone of polarizing activity
Specifying digit identity by Sonic hedgehog
■
Development and Formation of the ZPA
Generation of the Dorsal-Ventral Axis
Coordinating the Three Axes
Cell Death and the Formation of Digits and Joints
Sculpting the autopod
■
Evolution
Forming the joints
■
Epiphyseal Plates
Coda
XIV
CONTENTS
CHAPTER
Historical Views on Sex Determination
CHROMOSOMAL SEX DETERMINATION
The Mammalian Pattern: Primary and Secondary Sex
Determination
Primary Sex Determination
The developing gonads
Mechanisms of primary sex determination
The right time and the right place
Secondary Sex Determination in Mammals: Hormonal
Regulation of the Sexual Phenotype
Testosterone and dihydrotestosterone
Anti-Müllerian
Estrogen
Brain sex: Secondary sex determination through another
pathway?
■
Behaviors
Chromosomal Sex Determination in Drosophila
The gene cascade of Drosophila sex determination
The Sex-lethal gene as the pivot for sex determination
Doublesex:
Brain Sex in Drosophila: Secondary Sex Determination
through another Pathway
Dosage Compensation
ENVIRONMENTAL SEX DETERMINATION
Temperature-Dependent Sex Determination in
Reptiles
Aromatase and cell proliferation during sex
determination
Sex reversal, aromatase, and conservation biology
Location-Dependent Sex Determination
CHAPTER
and Aging
METAMORPHOSIS: THE HORMONAL REACTIVATION
OF DEVELOPMENT
Amphibian Metamorphosis
Morphological changes associated with
metamorphosis
Hormonal control of amphibian metamorphosis
Regionally specific developmental programs
■
Amphibian Metamorphosis
Metamorphosis in Insects
Imaginai
Determination of the wing
Hormonal control of insect metamorphosis
The molecular biology of 20-hydroxyecdysone activity
REGENERATION
Epimorphic Regeneration of Salamander Limbs
Formation of the apical ectodermal cap and regeneration
blastema
Proliferation of the blastema cells: The requirement for
nerves
Proliferation of the blastema cells: The requirement for
FgflO
A two-step model
■
Regeneration Blastema
Morphallactic Regeneration in Hydra
The head activation gradient
The head inhibition gradient
The hypostome as an organizer
The basal disc activation and inhibition gradients
Compensatory Regeneration in the Mammalian
Liver
AGING: THE BIOLOGY OF SENESCENCE
Maximum Life Span and Life Expectancy
Causes of aging
Genetically regulated aging: The insulin pathway
Promoting longevity
■
Rule
CHAPTER
Germ Plasm and the Determination of the Primordial
Germ Cells
Germ cell determination in nematodes
Germ cell determination in insects
Germ cell determination in frogs and fish
Germ cell determination in mammals
CONTENTS
XV
■
Embryonic Stem Cells
The inert genome hypothesis
Germ Cell Migration
Germ cell migration in Drosophila
Germ cell migration in vertebrates
Meiosis
■
Sperm or Egg?
Spermatogenesis in Mammals
Forming the haploid
Spermiogenesis: The differentiation of the sperm
Oogénesis
Oogenic meiosis
Maturation of the oocytes in frogs
Gene transcription in amphibian oocytes
Meroistic
Maturation of the mammalian oocyte
Coda
PART
4
Developmental Bi
pmental Biology
CHAPTER
Plant Development
Gamete Production in Angiosperms
Gametophytes
Pollination
Fertilization
Embryonic Development
Embryogenesis 634
Dormancy
Germination
Vegetative Growth
Meristems 641
Root development
Shoot development
Leaf development
The Vegetative-to-Reproductive Transition
Juvenility
Floral signals
Inflorescence development
Floral meristem identity
Senescence
CHAPTER 2 Medical Implications of Developmental Biology
GENETIC ERRORS OF HUMAN DEVELOPMENT
Identifying the Genes for Human Developmental
Anomalies
The Nature of Human Syndromes
Pleiotropy
Genetic heterogeneity
Phenotypic variability
Mechanisms of dominance
Gene Expression and Human Disease
Inborn errors of nuclear RNA processing
Inborn errors of translation
INFERTILITY
Diagnosing Infertility
In Vitro Fertilization
The IVF procedure
Success rates and complications of IVF
■
Preimplantation Genetics
TERATOGENESIS: ENVIRONMENTAL ASSAULTS ON
HUMAN DEVELOPMENT
Teratogenic Agents
Alcohol as a teratogen
Retinoic acid as a teratogen
Other teratogenic agents
Endocrine disrupters and human development
Testicular dysgenesis and declining sperm counts
XVI
CONTENTS
■
Politics
DEVELOPMENTAL BIOLOGY AND THE FUTURE OF
MEDICINE
Developmental Cancer Therapies
■
Onset Illnesses
Cancer as a disease of altered development
■
Angiogenesis inhibition
Gene Therapy
Germline Gene Therapy
Stem Cells and Therapeutic Cloning
Embryonic stem cells and therapeutic cloning
Multipotent
Pluripotent adult stem cells
Transgenic stem cells
Regeneration therapy
CHAPTER
Phenotypic Plasticity
The Environment as Part of Normal Development
Gravity and pressure
Developmental symbiosis
Larval settlement
Sex in its season
Diapause: Suspended development
Polyphenisms and Plasticity
Seasonal polyphenism in lepidopterans
Nutritional polyphenism
Diet and
Environment-dependent sexual phenotype
■
Behavior
Polyphenisms for alternative environmental
conditions
Predator-induced polyphenisms
Learning: The Environmentally Adaptive Nervous
System
The formation of new neurons
Experiential changes in mammalian visual pathways
Endocrine Disrupters
Environmental estrogens
Environmental thyroid hormone disrupters
Chains of causation
■
Developmental Biology Meets the Real World
CHAPTER
Unity of Type and Conditions of Existence
Charles Darwin s synthesis
Life s splendid drama
Preconditions for Macroevolution through
Developmental Change
Modularity: Divergence through dissociation
Molecular parsimony: Gene duplication and diversion
■
Ancestor
Homologous Pathways of Development
Mechanisms of Macroevolutionary Change
Heterotopy
Heterochrony
Heterometry
Heterotypy
Recruitment
■
Tandem Repeats
■
742
Developmental Constraints
Physical constraints
Morphogenetic constraints
Phyletic constraints
■
Developmental Constraints
A New Evolutionary Synthesis
ILLUSTRATION SOURCES
AUTHOR INDEX
SUBJECT INDEX
www.devbio.com
the companion website for
Developmental Biology
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devbio.com is an extensive Web companion to the textbook that is intended to supplement and enrich courses in
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1.1
1.2
1.3
1.4
1.5
and mice) get their stripes?
VM2 The compound microscope
VM2 Histotechniques
2.1
2.2
2.3
VM2 The amphibian life cycle
VM2 Slime mold life cycle
VM2 The amniote egg
3.1
3.2
3.3
3.4
3.5
3.6
VM2
VM2
Establishing experimental
embryology
Receptor gradients
Rediscovery of the morphogenetic field
Demonstrating the thermodynamic model
Cadherins: Functional anatomy
Other cell adhesion molecules
Sea urchins and UV radiation
Sea urchin development
5.8
The embryological origin of the gene theory
Creating developmental genetics
Amphibian cloning: Potency and deformity
Metaplasia
4.5
equivalence
4.6 DNA
4.7
4.8
5.1
5.2
5.3
transcription complex assembly
5.4
5.5
5.6
5.7
5.9
Further mechanisms of transcriptional
regulation
Imprinting in humans and mice
5.10
dimunition
5.11
5.12
(continued on inside back cover)
(continued from inside front cover)
5.13
5.14
5.15
5.16
5.17
pression
6.1
Hen s teeth
6.2
FGF binding
6.3
FgfR mutations
6.4
The uses of apoptosis
6.5
Notch mutations
6.6
Photoreceptor induction:
Conserved pathways
6.7
Connexin mutations
VM2
Cyclopia induced in ze-
brafish
7.1
7.2
research
7.3
7.4
7.5
7.6
VM2 Gametogenesis
VM2
VM2 Sea urchin fertilization
8.1
8.2
8.3
8.4
8.5
8.6
VM2 Sea urchin development
9.1
9.2
9.3
9.4
9.5
9.6 Christiane Nüsslein-Volhard
approach to development
9.7
9.8
VM2 Drosophila development
10.1
10.2
10.3
10.4
10.5
10.6
10.7
VM2 Amphibian development
11.1
11.2
11.3
formation of the inner cell mass
11.4
11.5
11.6
11.7
VM2 Zebrafish development
VM2 Chick development
VM2 Retinoic acid as a teratogen
12.1
12.2
12.3
12.4
12.5
12.6 Neuronal
12.7
12.8
12.9
12.10
VM2 Chick neurulation
13.1
13.2
13.3
13.4
13.5
13.6
13.7
13.8
13.9
13.10
13.11
13.12
13.13
14.1
14.2
14.3
14.4
14.5
human bone growth
VM2 Mesoderm in the vertebrate embryo
15.1
15.2
VM2 Early heart development
16.1
development
16.2
16.3
17.1
research
17.2
17.3
17.4
17.5
17.6
17.7
Drosophila
17.8
17.9
18.1
18.2
18.3
18.4
18.5
18.6
18.7
VM2 Amphibian metamorphosis and frog calls
VM2 Chromosome squash
19.1
19.2
19.3
19.4
19.5
19.6
19.7
19.8
19.9
19.10
19.11
19.12
VM2 Germ cells in the Drosophila embryo
VM2
20.1
21.1
21.2
21.3
21.4 Thalidomide
21.5
21.6
22.1
22.2
22.3
22.4
22.5
22.6
22.7
22.8
22.9
23.1
23.2
23.3
23.4
23.5
23.6
23.7
23.8
23.9
23.10
developmental biology
23.11
23.12
|
| adam_txt |
Contents
part I Principles of
JL Development
Developmental Biology
CHAPTER
The Anatomical Tradition
The Questions of Developmental Biology
Approaches to Developmental Biology
The Anatomical Approach
Comparative embryology
Epigénesis
Naming the parts: The primary germ layers and early
organs
The four principles of Karl Ernst von Baer
Fate mapping the embryo
The Cellular Basis of Morphogenesis
Cell migration
Evolutionary Embryology
Embryonic homologies
Medical Embryology and Teratology
Genetic malformations and syndromes
Disruptions and teratogens
Mathematical Modeling of Development
The mathematics of organismal growth
The mathematics of patterning
Coda
CHAPTER
The Circle of Life: The Stages of Animal
Development
The frog life cycle
Multicellularity:The Evolution of Differentiation and
Morphogenesis
The volvocaceans
■ SID£LIGHTS£r
Differentiation and morphogenesis in Dictyostelium
■
Development in Flowering Plants
Developmental Patterns among the Metazoa
The Diploblasts, Protostomes, and Deuterostomes
■
Flatworms
viii
CONTENTS
CHAPTER
Environmental Developmental Biology
Environmental sex determination
Adaptation of embryos and larvae to their
environments
The Developmental Dynamics of Cell Specification
Autonomous specification
Syncytial specification
Conditional specification
Morphogen gradients revisited
■
Stem cells and commitment
Morphogenesis and Cell Adhesion
Differential cell affinity
The thermodynamic model of cell interactions
Cadherins and cell adhesion
Coda
CHAPTER
The Embryological Origins of the Gene Theory
Nucleus or cytoplasm: Which controls heredity?
The split between embryology and genetics
Early attempts at developmental genetics
Evidence for Genomic Equivalence
Amphibian cloning: The restriction of nuclear potency
Amphibian cloning: The totipotency of somatic cells
Cloning mammals
■
Differential Gene Expression
RNA Localization Techniques
Detecting specific mRNAs: RT-PCR
Microarrays
Macroarrays
Locating mRNAs in space and time: In situ
hybridization
Determining the Function of Genes during
Development
Transgenic cells and organisms
Determining the function of a message: Antisense RNA
Coda
CHAPTERS The Paradigm of Differential Gene Expression
Differential Gene Transcription
Anatomy of the gene: Active and repressed chromatin
Anatomy of the gene: Exons and introns
Anatomy of the gene: Promoters and enhancers
Transcription factors
■
Transcription factor cascades
■
Elements
Silencers
Methylation Pattern and the Control of
Transcription
DNA
■
Chromatin modification induced by
methylation
Insulators
Transcriptional regulation of an entire chromosome:
Dosage compensation
■
Chromosome Inactivation
Differential RNA Processing
Control of early development by nuclear RNA
selection
Creating families of proteins through differential nRNA
splicing
Splicing enhancers and recognition factors
■
Drosophila Sex Determination
Control of Gene Expression at the Level of
Translation
Differential mRNA longevity
Selective inhibition of mRNA translation: Stored oocyte
mRNAs
Control of RNA expression by cytoplasmic
localization
■
Regulation
Posttranslational regulation of gene expression
CONTENTS
IX
CHAPTER
Induction and Competence
Cascades of induction: Reciprocal and sequential
inductive events
Instructive and permissive interactions
Epithelial-mesenchymal interactions
Paracrine Factors: The Inducer Molecules
Signal Transduction Cascades: The Response to
Inducers
Fibroblast growth factors and the RTK pathway
The JAK-STAT pathway
The Hedgehog family
The Wnt family
The
■
Other paracrine factors
Cell Death Pathways
Juxtacrine Signaling
The Notch pathway: Juxtaposed ligands and receptors
■
Patterning
The extracellular matrix as a source of developmental
signals
Direct transmission of signals through gap junctions
Cross-Talk between Pathways
Maintenance of the Differentiated State
Coda
part
jLmá
CHAPTER
a New Organism
Structure of the Gametes
Sperm
The egg
Recognition of egg and sperm
External Fertilization in Sea Urchins
Sperm attraction: Action at a distance
The acrosome reaction
Species-specific recognition
Fusion of the egg and sperm cell membranes
The Prevention of Polyspermy
The fast block to polyspermy
The slow block to polyspermy
Calcium as the initiator of the cortical granule
reaction
Activation of Egg Metabolism in Sea Urchins
Early responses
Late responses: Resumption of protein and
synthesis
■
Metabolism
Fusion of genetic material
Mammalian Fertilization
Getting the gametes into the oviduct:
capacitation
In the vicinity of the oocyte: Hyperactivation,
thermotaxis,
Recognition at the
Gamete fusion and the prevention of polyspermy
Fusion of genetic material
Coda
■
Mammalian
CONTENTS
CHAPTER
EARLY DEVELOPMENTAL PROCESSES:
AN OVERVIEW
Cleavage
From fertilization to cleavage
The cytoskeletal mechanisms of mitosis
Patterns of embryonic cleavage
Gastrulation
Cell Specification and Axis Formation
EARLY DEVELOPMENT IN SEA URCHINS
Sea Urchin Cleavage
Blástula
Fate maps and the determination of sea urchin
blastomeres
Sea Urchin Gastrulation
Ingression of the primary mesenchyme
First stage of archenteron
Second and third stages of archenteron
THE EARLY DEVELOPMENT OF SNAILS
Cleavage in Snail Embryos
A fate map of Ilyanassa
The polar lobe: Cell determination and axis formation
■
Embryonic Cleavage
Gastrulation in Snails
EARLY DEVELOPMENT IN TUNICATES
Tunicate Cleavage
The tunicate fate map
Autonomous and conditional specification of tunicate
blastomeres
Specification of the embryonic axes
Gastrulation in Tunicates
THE NEMATODE CAENORHABDITIS ELEGANS
Why C.e/egans?
Cleavage and Axis Formation in
Rotational cleavage of the C. elegans egg
Anterior-posterior axis formation
Formation of the dorsal-ventral and right-left axes
Control of blastomere identity
Integration of autonomous and conditional specification:
Differentiation of the C. elegans pharynx
Gastrulation in C. elegans
Coda
CHAPTER
EARLY DROSOPHILA DEVELOPMENT
Fertilization
Cleavage
The mid-blastula transition
Gastrulation
GENES THAT PATTERN THE DfiOSOPHILA BODY PLAN
258
Primary Axis Formation during
Anterior-posterior polarity in the oocyte
Dorsal-ventral patterning in the oocyte
Generating Dorsal-Ventral Pattern in the Embryo
Dorsal, the ventral morphogen
Establishing a nuclear dorsal gradient
Effects of the dorsal protein gradient
Segmentation and the Anterior-Posterior Body Plan
Maternal gradients: Polarity regulation by oocyte
cytoplasm
The molecular model: Protein gradients in the early
embryo
The anterior organizing center: The Bicoid and
Hunchback gradients
The terminal gene group
Anterior-posterior axis specification: Summary
Segmentation Genes
■
The gap genes
The pair-rule genes
The segment polarity genes
The Homeotic Selector Genes
Patterns of homeotic gene expression
Initiating the patterns of homeotic gene expression
Maintaining the patterns of homeotic gene expression
Realisator
■
Axes and Organ Primordia: The Cartesian Coordinate
Model
Coda
CONTENTS
xi
CHAPTER
Early Amphibian Development
Fertilization and cortical rotation
Unequal radial holoblastic cleavage
The Mid-Blastula Transition: Preparing for
Gastrulation
Amphibian Gastrulation
The Xenopus fate map
Vegetal rotation and the
bottle cells
■
Mesoderma!
Epiboly of the prospective ectoderm
Progressive Determination of the Amphibian Axes
Hans Spemann and
Embryonic Induction
Mechanisms of Axis Determination in Amphibians
How does the organizer form?
Functions of the Organizer
Induction of neural ectoderm and dorsal
BMP inhibitors
The Regional Specificity of Induction
The determination of regional differences
■
The head
Trunk induction: Wnt signals and retinoic acid
Specifying the Left-Right Axis
Coda
■
Neurulation
CHAPTER
Fishy Birds, and Mammals
EARLY DEVELOPMENT IN FISH
Cleavage in Fish Eggs
Gastrulation in Fish Embryos
The formation of germ layers
Axis Formation in Fish Embryos
Dorsal-ventral axis formation: The embryonic shield and
Nieuwkoop center
The fish Nieuwkoop center
Anterior-posterior axis formation
Left-right axis formation
EARLY DEVELOPMENT IN BIRDS
Cleavage in Bird Eggs
Gastrulation of the Avian Embryo
The hypoblast
The primitive streak
Epiboly of the ectoderm
Axis Formation in the Chick Embryo
The role of gravity in forming the anterior-posterior
axis
The chick "organizer"
Left-Right Axis Formation
EARLY MAMMALIAN DEVELOPMENT
Cleavage in Mammals
The unique nature of mammalian cleavage
Compaction
Escape from the
Gastrulation in Mammals
Modifications for development within another
organism
Formation of extraembryonic membranes
■
Stem Cells
Mammalian Anterior-Posterior Axis Formation
Two signaling centers
Patterning the anterior-posterior axis: FGFs, retinoic acid,
and the Hox code hypothesis
Expression of Hox genes along the dorsal axis
Experimental analysis of the Hox code
The Dorsal-Ventral and Right-Left Axes in Mice
The dorsal-ventral axis
The left-right axis
Coda
XII
CONTENTS
PART y
Later Embryonic
Development
CHAPTER n The Emergence of the Ectoderm:
Central Nervous System and Epidermis
Establishing the Neural Cells
Formation of the Neural Tube
Primary neurulation
Secondary neurulation
Differentiation of the Neural Tube
The anterior-posterior axis
The dorsal-ventral axis
Tissue Architecture of the Central Nervous System
Spinal cord and medulla organization
Cerebellar organization
Cerebral organization
■
Human Brain
Adult neural stem cells
Differentiation of Neurons
Development of the Vertebrate
Eye
The dynamics of optic
development
Neural retina differentiation
Lens and cornea differentiation
The Epidermis and the Origin of Cutaneous
Structures
The origin of epidermal cells
Cutaneous appendages
The follicular stem cell
CHAPTER
THE NEURAL CREST
Specification of the Neural Crest Cells
Regionalization of the neural crest
Trunk Neural Crest
Migration pathways of trunk neural crest cells
The mechanisms of trunk neural crest migration
The Pluripotency of Neural Crest Cells
Cranial Neural Crest
■
Migration and Specification
Intramembranous ossification
Tooth formation
Cardiac Neural Crest
Cranial Placodes
NEURONAL
SPECIFICITY
The Generation of
Pattern Generation in the Nervous System
Cell adhesion and contact guidance by attractive and
permissive molecules
Guidance by specific growth cone repulsion
Guidance by diffusible molecules
Target selection
Forming the synapse: Activity-dependent development
Differential survival after
factors
Paths to glory: Migration of the retinal ganglion
The Development of Behaviors: Constancy and
Plasticity
CHAPTER
PARAXIAL MESODERM: THE SOMITES AND THEIR
DERIVATIVES
The Formation of Somites
The periodicity of somite formation
Where somites form: The Notch pathway
The separation of somites from the unsegmented
mesoderm
I SIDELIGHTS
in Somite Formation
CONTENTS
xiii
Epithelialization
Somite specification along the anterior-posterior axis
Derivatives of the somites
Determination of the sclerotome and dermatome
Determination of the myotome
Myogenesis: The Generation of Muscle
Specification and differentiation by myogenic bHLH
proteins
Muscle cell fusion
Osteogenesis: The Development of Bones
Endochondral ossification
Vertebrae formation
Tendon formation: The syndetome
INTERMEDIATE MESODERM: THE
SYSTEM
Specification of the Intermediate Mesoderm: Pax2/8
and
Progression of Kidney Types
Reciprocal Interactions of Developing Kidney
Tissues
The mechanisms of reciprocal induction
CHAPTER
LATERAL PLATE MESODERM
The Heart
Specification of heart tissue
Fusion of the heart rudiments and initial heartbeats
Looping and formation of heart chambers
■
Newborn Mammal
Formation of Blood Vessels
Constraints on the construction of blood vessels
Vasculogenesis: The initial formation of blood vessels
Angiogenesis: Sprouting of blood vessels and remodeling
of vascular beds
Arterial and venous differentiation
Organ-specific angiogenesis factors
The lymphatic vessels
The Development of Blood Cells
The stem cell concept
Sites of hematopoiesis
Committed stem cells and their fates
Hematopoietic inductive microenvironments
ENDODERM
The Pharynx
The Digestive Tube and Its Derivatives
Specification of the gut tissue
Liver, pancreas, and gallbladder
■
of Liver and Pancreas
The Respiratory Tube
The Extraembryonic Membranes
The amnion and chorion
The allantois and yolk sac
CHAPTER
Formation of the Limb Bud
Specification of the limb fields
Induction of the early limb bud: Wnt proteins and
fibroblast growth factors
Specification of forelimb or hindlimb: Tbx4 and Tbx5
508
Generating the Proximal-Distal Axis of the Limb
The apical
FGFs in the induction and maintenance of the AER
Specifying the limb mesoderm: Determining the
proximal-distal polarity of the limb
The Hox specification code for the limb
Specification of the Anterior-Posterior Limb Axis
The zone of polarizing activity
Specifying digit identity by Sonic hedgehog
■
Development and Formation of the ZPA
Generation of the Dorsal-Ventral Axis
Coordinating the Three Axes
Cell Death and the Formation of Digits and Joints
Sculpting the autopod
■
Evolution
Forming the joints
■
Epiphyseal Plates
Coda
XIV
CONTENTS
CHAPTER
Historical Views on Sex Determination
CHROMOSOMAL SEX DETERMINATION
The Mammalian Pattern: Primary and Secondary Sex
Determination
Primary Sex Determination
The developing gonads
Mechanisms of primary sex determination
The right time and the right place
Secondary Sex Determination in Mammals: Hormonal
Regulation of the Sexual Phenotype
Testosterone and dihydrotestosterone
Anti-Müllerian
Estrogen
Brain sex: Secondary sex determination through another
pathway?
■
Behaviors
Chromosomal Sex Determination in Drosophila
The gene cascade of Drosophila sex determination
The Sex-lethal gene as the pivot for sex determination
Doublesex:
Brain Sex in Drosophila: Secondary Sex Determination
through another Pathway
Dosage Compensation
ENVIRONMENTAL SEX DETERMINATION
Temperature-Dependent Sex Determination in
Reptiles
Aromatase and cell proliferation during sex
determination
Sex reversal, aromatase, and conservation biology
Location-Dependent Sex Determination
CHAPTER
and Aging
METAMORPHOSIS: THE HORMONAL REACTIVATION
OF DEVELOPMENT
Amphibian Metamorphosis
Morphological changes associated with
metamorphosis
Hormonal control of amphibian metamorphosis
Regionally specific developmental programs
■
Amphibian Metamorphosis
Metamorphosis in Insects
Imaginai
Determination of the wing
Hormonal control of insect metamorphosis
The molecular biology of 20-hydroxyecdysone activity
REGENERATION
Epimorphic Regeneration of Salamander Limbs
Formation of the apical ectodermal cap and regeneration
blastema
Proliferation of the blastema cells: The requirement for
nerves
Proliferation of the blastema cells: The requirement for
FgflO
A two-step model
■
Regeneration Blastema
Morphallactic Regeneration in Hydra
The head activation gradient
The head inhibition gradient
The hypostome as an "organizer"
The basal disc activation and inhibition gradients
Compensatory Regeneration in the Mammalian
Liver
AGING: THE BIOLOGY OF SENESCENCE
Maximum Life Span and Life Expectancy
Causes of aging
Genetically regulated aging: The insulin pathway
Promoting longevity
■
Rule
CHAPTER
Germ Plasm and the Determination of the Primordial
Germ Cells
Germ cell determination in nematodes
Germ cell determination in insects
Germ cell determination in frogs and fish
Germ cell determination in mammals
CONTENTS
XV
■
Embryonic Stem Cells
The inert genome hypothesis
Germ Cell Migration
Germ cell migration in Drosophila
Germ cell migration in vertebrates
Meiosis
■
Sperm or Egg?
Spermatogenesis in Mammals
Forming the haploid
Spermiogenesis: The differentiation of the sperm
Oogénesis
Oogenic meiosis
Maturation of the oocytes in frogs
Gene transcription in amphibian oocytes
Meroistic
Maturation of the mammalian oocyte
Coda
PART
4
Developmental Bi
pmental Biology
CHAPTER
Plant Development
Gamete Production in Angiosperms
Gametophytes
Pollination
Fertilization
Embryonic Development
Embryogenesis 634
Dormancy
Germination
Vegetative Growth
Meristems 641
Root development
Shoot development
Leaf development
The Vegetative-to-Reproductive Transition
Juvenility
Floral signals
Inflorescence development
Floral meristem identity
Senescence
CHAPTER 2\ Medical Implications of Developmental Biology
GENETIC ERRORS OF HUMAN DEVELOPMENT
Identifying the Genes for Human Developmental
Anomalies
The Nature of Human Syndromes
Pleiotropy
Genetic heterogeneity
Phenotypic variability
Mechanisms of dominance
Gene Expression and Human Disease
Inborn errors of nuclear RNA processing
Inborn errors of translation
INFERTILITY
Diagnosing Infertility
In Vitro Fertilization
The IVF procedure
Success rates and complications of IVF
■
Preimplantation Genetics
TERATOGENESIS: ENVIRONMENTAL ASSAULTS ON
HUMAN DEVELOPMENT
Teratogenic Agents
Alcohol as a teratogen
Retinoic acid as a teratogen
Other teratogenic agents
Endocrine disrupters and human development
Testicular dysgenesis and declining sperm counts
XVI
CONTENTS
■
Politics
DEVELOPMENTAL BIOLOGY AND THE FUTURE OF
MEDICINE
Developmental Cancer Therapies
■
Onset Illnesses
Cancer as a disease of altered development
■
Angiogenesis inhibition
Gene Therapy
Germline Gene Therapy
Stem Cells and Therapeutic Cloning
Embryonic stem cells and therapeutic cloning
Multipotent
Pluripotent adult stem cells
Transgenic stem cells
Regeneration therapy
CHAPTER
Phenotypic Plasticity
The Environment as Part of Normal Development
Gravity and pressure
Developmental symbiosis
Larval settlement
Sex in its season
Diapause: Suspended development
Polyphenisms and Plasticity
Seasonal polyphenism in lepidopterans
Nutritional polyphenism
Diet and
Environment-dependent sexual phenotype
■
Behavior
Polyphenisms for alternative environmental
conditions
Predator-induced polyphenisms
Learning: The Environmentally Adaptive Nervous
System
The formation of new neurons
Experiential changes in mammalian visual pathways
Endocrine Disrupters
Environmental estrogens
Environmental thyroid hormone disrupters
Chains of causation
■
Developmental Biology Meets the Real World
CHAPTER
"Unity of Type" and "Conditions of Existence"
Charles Darwin's synthesis
"Life's splendid drama"
Preconditions for Macroevolution through
Developmental Change
Modularity: Divergence through dissociation
Molecular parsimony: Gene duplication and diversion
■
Ancestor
Homologous Pathways of Development
Mechanisms of Macroevolutionary Change
Heterotopy
Heterochrony
Heterometry
Heterotypy
Recruitment
■
Tandem Repeats
■
742
Developmental Constraints
Physical constraints
Morphogenetic constraints
Phyletic constraints
■
Developmental Constraints
A New Evolutionary Synthesis
ILLUSTRATION SOURCES
AUTHOR INDEX
SUBJECT INDEX
www.devbio.com
the companion website for
Developmental Biology
Eighth Edition
devbio.com is an extensive Web companion to the textbook that is intended to supplement and enrich courses in
developmental biology. It provides additional information for advanced students as well as historical, philosophical,
and ethical perspectives on issues in developmental biology. Included are articles, movies, interviews, opinions
(labeled as such). Web links, updates, and more. (Even a developmental biology humor page!)
devbio.COm is comprised of Web topics organized by textbook chapter, and these topics are referenced through¬
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ber of the topic.
The following is a comprehensive list of the numbered Web topics referenced in each chapter of the book. Also in¬
cluded are references to the
1.1
1.2
1.3
1.4
1.5
and mice) get their stripes?
VM2 The compound microscope
VM2 Histotechniques
2.1
2.2
2.3
VM2 The amphibian life cycle
VM2 Slime mold life cycle
VM2 The amniote egg
3.1
3.2
3.3
3.4
3.5
3.6
VM2
VM2
Establishing experimental
embryology
Receptor gradients
"Rediscovery" of the morphogenetic field
Demonstrating the thermodynamic model
Cadherins: Functional anatomy
Other cell adhesion molecules
Sea urchins and UV radiation
Sea urchin development
5.8
The embryological origin of the gene theory
Creating developmental genetics
Amphibian cloning: Potency and deformity
Metaplasia
4.5
equivalence
4.6 DNA
4.7
4.8
5.1
5.2
5.3
transcription complex assembly
5.4
5.5
5.6
5.7
5.9
Further mechanisms of transcriptional
regulation
Imprinting in humans and mice
5.10
dimunition
5.11
5.12
(continued on inside back cover)
(continued from inside front cover)
5.13
5.14
5.15
5.16
5.17
pression
6.1
Hen's teeth
6.2
FGF binding
6.3
FgfR mutations
6.4
The uses of apoptosis
6.5
Notch mutations
6.6
Photoreceptor induction:
Conserved pathways
6.7
Connexin mutations
VM2
Cyclopia induced in ze-
brafish
7.1
7.2
research
7.3
7.4
7.5
7.6
VM2 Gametogenesis
VM2
VM2 Sea urchin fertilization
8.1
8.2
8.3
8.4
8.5
8.6
VM2 Sea urchin development
9.1
9.2
9.3
9.4
9.5
9.6 Christiane Nüsslein-Volhard
approach to development
9.7
9.8
VM2 Drosophila development
10.1
10.2
10.3
10.4
10.5
10.6
10.7
VM2 Amphibian development
11.1
11.2
11.3
formation of the inner cell mass
11.4
11.5
11.6
11.7
VM2 Zebrafish development
VM2 Chick development
VM2 Retinoic acid as a teratogen
12.1
12.2
12.3
12.4
12.5
12.6 Neuronal
12.7
12.8
12.9
12.10
VM2 Chick neurulation
13.1
13.2
13.3
13.4
13.5
13.6
13.7
13.8
13.9
13.10
13.11
13.12
13.13
14.1
14.2
14.3
14.4
14.5
human bone growth
VM2 Mesoderm in the vertebrate embryo
15.1
15.2
VM2 Early heart development
16.1
development
16.2
16.3
17.1
research
17.2
17.3
17.4
17.5
17.6
17.7
Drosophila
17.8
17.9
18.1
18.2
18.3
18.4
18.5
18.6
18.7
VM2 Amphibian metamorphosis and frog calls
VM2 Chromosome squash
19.1
19.2
19.3
19.4
19.5
19.6
19.7
19.8
19.9
19.10
19.11
19.12
VM2 Germ cells in the Drosophila embryo
VM2
20.1
21.1
21.2
21.3
21.4 Thalidomide
21.5
21.6
22.1
22.2
22.3
22.4
22.5
22.6
22.7
22.8
22.9
23.1
23.2
23.3
23.4
23.5
23.6
23.7
23.8
23.9
23.10
developmental biology
23.11
23.12 |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| author | Gilbert, Scott F. 1949- |
| author_GND | (DE-588)133098559 |
| author_facet | Gilbert, Scott F. 1949- |
| author_role | aut |
| author_sort | Gilbert, Scott F. 1949- |
| author_variant | s f g sf sfg |
| building | Verbundindex |
| bvnumber | BV021534388 |
| callnumber-first | Q - Science |
| callnumber-label | QL955 |
| callnumber-raw | QL955 |
| callnumber-search | QL955 |
| callnumber-sort | QL 3955 |
| callnumber-subject | QL - Zoology |
| classification_rvk | WX 6000 |
| classification_tum | BIO 753f BIO 186f BIO 756f BIO 750f |
| ctrlnum | (OCoLC)63703058 (DE-599)BVBBV021534388 |
| dewey-full | 571.8 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 571 - Physiology & related subjects |
| dewey-raw | 571.8 |
| dewey-search | 571.8 |
| dewey-sort | 3571.8 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| discipline_str_mv | Biologie |
| edition | 8. ed. |
| format | Book |
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| genre | 1\p (DE-588)4123623-3 Lehrbuch gnd-content |
| genre_facet | Lehrbuch |
| id | DE-604.BV021534388 |
| illustrated | Illustrated |
| index_date | 2024-07-02T14:26:15Z |
| indexdate | 2024-07-09T20:38:02Z |
| institution | BVB |
| isbn | 087893250X |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-014750695 |
| oclc_num | 63703058 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-M49 DE-BY-TUM DE-29T DE-20 DE-19 DE-BY-UBM |
| owner_facet | DE-355 DE-BY-UBR DE-M49 DE-BY-TUM DE-29T DE-20 DE-19 DE-BY-UBM |
| physical | XVIII, 817 S. Ill., graph. Darst. 1 CD-ROM (12 cm), 1 Beil. |
| publishDate | 2006 |
| publishDateSearch | 2006 |
| publishDateSort | 2006 |
| publisher | Sinauer |
| record_format | marc |
| spelling | Gilbert, Scott F. 1949- Verfasser (DE-588)133098559 aut Developmental biology Scott F. Gilbert Vade mecum 2 8. ed. Sunderland, Mass. Sinauer 2006 XVIII, 817 S. Ill., graph. Darst. 1 CD-ROM (12 cm), 1 Beil. txt rdacontent n rdamedia nc rdacarrier Titel der CD-ROM: Vade mecum 2, Vers. 2.2 / Mary S. Tyler ; Ronald N. Kozlowski Biologie du développement Embryologie Developmental Biology Developmental biology Embryology Ontogenie (DE-588)4043565-9 gnd rswk-swf Morphogenese (DE-588)4132460-2 gnd rswk-swf Embryologie (DE-588)4014562-1 gnd rswk-swf Entwicklungsphysiologie (DE-588)4152449-4 gnd rswk-swf Embryonalentwicklung (DE-588)4070792-1 gnd rswk-swf Entwicklungsbiologie (DE-588)4152440-8 gnd rswk-swf 1\p (DE-588)4123623-3 Lehrbuch gnd-content Entwicklungsbiologie (DE-588)4152440-8 s Morphogenese (DE-588)4132460-2 s Entwicklungsphysiologie (DE-588)4152449-4 s Embryologie (DE-588)4014562-1 s Ontogenie (DE-588)4043565-9 s 2\p DE-604 Embryonalentwicklung (DE-588)4070792-1 s 3\p DE-604 Tyler, Mary S. Sonstige oth Kozlowski, Ronald N. Sonstige oth Digitalisierung UBRegensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014750695&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014750695&sequence=000002&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 3\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Gilbert, Scott F. 1949- Developmental biology Biologie du développement Embryologie Developmental Biology Developmental biology Embryology Ontogenie (DE-588)4043565-9 gnd Morphogenese (DE-588)4132460-2 gnd Embryologie (DE-588)4014562-1 gnd Entwicklungsphysiologie (DE-588)4152449-4 gnd Embryonalentwicklung (DE-588)4070792-1 gnd Entwicklungsbiologie (DE-588)4152440-8 gnd |
| subject_GND | (DE-588)4043565-9 (DE-588)4132460-2 (DE-588)4014562-1 (DE-588)4152449-4 (DE-588)4070792-1 (DE-588)4152440-8 (DE-588)4123623-3 |
| title | Developmental biology |
| title_alt | Vade mecum 2 |
| title_auth | Developmental biology |
| title_exact_search | Developmental biology |
| title_exact_search_txtP | Developmental biology |
| title_full | Developmental biology Scott F. Gilbert |
| title_fullStr | Developmental biology Scott F. Gilbert |
| title_full_unstemmed | Developmental biology Scott F. Gilbert |
| title_short | Developmental biology |
| title_sort | developmental biology |
| topic | Biologie du développement Embryologie Developmental Biology Developmental biology Embryology Ontogenie (DE-588)4043565-9 gnd Morphogenese (DE-588)4132460-2 gnd Embryologie (DE-588)4014562-1 gnd Entwicklungsphysiologie (DE-588)4152449-4 gnd Embryonalentwicklung (DE-588)4070792-1 gnd Entwicklungsbiologie (DE-588)4152440-8 gnd |
| topic_facet | Biologie du développement Embryologie Developmental Biology Developmental biology Embryology Ontogenie Morphogenese Entwicklungsphysiologie Embryonalentwicklung Entwicklungsbiologie Lehrbuch |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014750695&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014750695&sequence=000002&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
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