A genetic switch: phage lambda revisited
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Cold Spring Harbor, NY
Cold Spring Harbor Laboratory Press
2004
|
| Edition: | 3. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XIV, 154 S. graph. Darst. |
| ISBN: | 0879697164 9780879697167 |
Staff View
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| 100 | 1 | |a Ptashne, Mark |d 1940- |e Verfasser |0 (DE-588)138150850 |4 aut | |
| 245 | 1 | 0 | |a A genetic switch |b phage lambda revisited |c Mark Ptashne |
| 250 | |a 3. ed. | ||
| 264 | 1 | |a Cold Spring Harbor, NY |b Cold Spring Harbor Laboratory Press |c 2004 | |
| 300 | |a XIV, 154 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Bactériophage lambda | |
| 650 | 4 | |a Génétique virale | |
| 650 | 4 | |a Régulation génétique | |
| 650 | 4 | |a Bacteriophage lambda | |
| 650 | 4 | |a Bacteriophage lambda |x genetics | |
| 650 | 4 | |a Gene Expression Regulation | |
| 650 | 4 | |a Genes, Viral | |
| 650 | 4 | |a Genetic regulation | |
| 650 | 4 | |a Lysogeny | |
| 650 | 4 | |a Repressor Proteins | |
| 650 | 4 | |a Viral genetics | |
| 650 | 0 | 7 | |a Genregulation |0 (DE-588)4122166-7 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Bakteriophage Lambda |0 (DE-588)4208901-3 |2 gnd |9 rswk-swf |
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Record in the Search Index
| _version_ | 1804135282357829632 |
|---|---|
| adam_text | IMAGE 1
CONTENTS
PREFACE TO THE THIRD EDITION, XI PREFACE TO THE FIRST EDITION, XIII
INTRODUCTION 1
CHAPTER ONE
THE MASTER ELEMENTS OF CONTROL I I
COMPONENTS OF THE SWITCH 14 DNA 14 RNA POLYMERASE 15 THE REPRESSOR 16
CRO 17
THE ACTION OF REPRESSOR AND CRO 18 NEGATIVE CONTROL 18 POSITIVE CONTROL
18
COOPERATIVITY OF REPRESSOR BINDING 20
INDUCTION -FLIPPING THE SWITCH 22
COOPERATIVITY-SWITCH STABILITY AND SENSITIVITY 26
THE EFFECT OF AUTOREGULATION 28
OTHER CASES 28
CHAPTER T WO
PROTEIN-DNA INTERACTIONS AND GENE CONTROL 31
THE OPERATOR 31
REPRESSOR 34
CRO 37
VII
IMAGE 2
VLLI CONTENTS
AMINO ACID-BASE PAIR INTERACTIONS 39
THE PROMOTER 43
GENE CONTROL 44
CHAPTER THREE
CONTROL CIRCUITS-SETTING THE SWITCH 47
A BRIEF OVERVIEW OF X GROWTH 48 THE GENETIC MAP 48 CIRCULARIZATION 49
GENE EXPRESSION 50
INTEGRATION 51
CONTROL OF TRANSCRIPTION 52 VERY EARLY 52 EARLY 52 LATE LYTIC 53
LATE LYSOGENIC 55
THE DECISION 56
CONTROL OF INTEGRATION AND EXCISION 57 CASE 1-ESTABLISHING LYSOGENY 58
CASE 2-LYTIC GROWTH 58 CASE 3-INDUCTION 58
OTHER PHAGES 60
THE SOS RESPONSE 60
X PATHWAYS AND CELL DEVELOPMENT 62 REGULATORY GENES 62 SWITCHES 63
PATTERNS OF GENE EXPRESSION 64
CHAPTER FOUR
HOW DO WE KNOW-THE KEY EXPERIMENTS 67
THE REPRESSOR IDEA 67 CLEAR AND VIRULENT MUTANTS 67 OBSERVATIONS 67
EXPLANATION 68
IMMUNITY AND HETEROIMMUNITY 69 OBSERVATIONS 69 EXPLANATION 70
IMAGE 3
CONTENTS IX
ASYMMETRY IN BACTERIAL MATING 70 OBSERVATIONS 70 EXPLANATION 71
THE REPRESSOR PROBLEM IN THE EARLY 1960S 71
REPRESSOR ISOLATION AND DNA BINDING 72
MAKING MORE REPRESSOR 74
THE CLAIMS OF CHAPTERS ONE AND TWO 76
THE REPRESSOR IS COMPOSED OF TWO GLOBULAR DOMAINS HELD TOGETHER BY A
LINKER OF SOME 40 AMINO ACIDS 76
THE REPRESSOR DIMERIZES, LARGELY THROUGH INTERACTION BETWEEN ITS
CARBOXYL DOMAINS 76
A REPRESSOR DIMER BINDS, THROUGH ITS AMINO DOMAINS, TO A 1 7 BASE PAIR
OPERATOR SITE 78 A SINGLE OPERATOR SITE BINDS ONE DIMER OF REPRESSOR 78
DINNERS FORM BEFORE DNA BINDING 80
THE AMINO DOMAINS CONTACT DNA 82
THERE ARE THREE 17 BASE PAIR REPRESSOR BINDING SITES IN THE RIGHT
OPERATOR.
AT EACH SITE REPRESSOR AND CRO BIND ALONG THE SAME FACE OF THE HELIX 84
CHEMICAL PROBES 84 OPERATOR MUTATIONS 85 BINDING TO SUPERCOILED AND
LINEAR DNA 85
REPRESSOR BINDS TO THREE SITES IN O R WITH ALTERNATE PAIRWISE
COOPERATIVITY. THE COOPERATIVITY IS MEDIATED BY INTERACTIONS BETWEEN
CARBOXYL DOMAINS OF ADJACENT DIMERS 86
IN A LYSOGEN REPRESSOR IS TYPICALLY BOUND TO O R 1 AND O R 2. THE BOUND
REPRESSORS TURN OFF RIGHTWARD TRANSCRIPTION OF CRO AND STIMULATE
LEFTWARD TRANSCRIPTION OF CL. AT HIGHER CONCENTRATIONS, REPRESSOR BINDS
TO O R 3 TO TURN OFF TRANSCRIPTION OF CL 87
CRO BINDS FIRST TO O R 3, THEN TO O R 1 AND O R 2, THEREBY FIRST TURNING
OFF P RM , THEN P R 92 SOME BACKGROUND ABOUT CRO 92 CRO IN VIVO 93
CRO IN VITRO 94
RECA CLEAVES REPRESSOR TO TRIGGER INDUCTION 94
WHEN CRO IS BOUND AT O R 3 THE SWITCH IS THROWN 95
REPRESSOR AND CRO BIND TO THE OPERATOR AS SHOWN IN FIGURES 2.6, 2.8,
2.10, AND 2.11 95 CRYSTALLOGRAPHY 95 THE HELIX SWAP EXPERIMENT 96
IMAGE 4
CONTENTS
SPECIFIC AMINO ACID-BASE PAIR CONTACTS 98 THE ROLE OF THE ARM OFX
REPRESSOR 99 REPRESSOR ACTIVATES TRANSCRIPTION OF CL BY BINDING TO O R 2
AND CONTACTING POLYMERASE WITH ITS AMINO DOMAIN 99
POSITIVE CONTROL MUTANTS 99 POSITIVE CONTROL IN VITRO 102 CONCLUSION 103
CHAPTER FIVE
2004: NEW DEVELOPMENTS 109
1. LONG-RANGE COOPERATIVITY AND REPRESSION OF P RM 109 AN OCTAMER OF
REPRESSOR BINDS O R AND O L 110 AUTONEGATIVE REGULATION OF REPRESSOR
SYNTHESIS 112
HOW DO WE KNOW 113 LONG-RANGE INTERACTIONS AND REPRESSION OF P R 113
LONG-RANGE INTERACTIONS AND REPRESSION OF P RM 114 ACTIVATION AND
REPRESSION OF P RM 114
REPRESSOR STRUCTURE 1 1 5
2. POSITIVE CONTROL (ACTIVATION OF TRANSCRIPTION) 122 POLYMERASE AND
PROMOTER 122 THE MECHANISM OF ACTIVATION 123 HOW DO WE KNOW 123
ACTIVATING REGION VARIANTS 123 A SUPPRESSOR OF A PC MUTANT 125
CRYSTALLOGRAPHY 125 ACTIVATOR BYPASS 125 CHANGING ACTIVATING REGIONS AND
TARGET CONTEXT 127
3. THE STRUCTURE OF THE REPRESSOR MONOMER AND THE MECHANISM OF REPRESSOR
CLEAVAGE 131 HOW DO WE KNOW 132 4. EVOLVING THE SWITCH 133
CHANGING THE AFFINITIES OF SITES IN O R FOR REPRESSOR 133 ELIMINATING
POSITIVE CONTROL 134 ELIMINATING COOPERATIVITY BETWEEN DNA-BINDING
DIMERS 134
5. CLL AND THE DECISION 136
INDEX 151
|
| adam_txt |
IMAGE 1
CONTENTS
PREFACE TO THE THIRD EDITION, XI PREFACE TO THE FIRST EDITION, XIII
INTRODUCTION 1
CHAPTER ONE
THE MASTER ELEMENTS OF CONTROL I I
COMPONENTS OF THE SWITCH 14 DNA 14 RNA POLYMERASE 15 THE REPRESSOR 16
CRO 17
THE ACTION OF REPRESSOR AND CRO 18 NEGATIVE CONTROL 18 POSITIVE CONTROL
18
COOPERATIVITY OF REPRESSOR BINDING 20
INDUCTION -FLIPPING THE SWITCH 22
COOPERATIVITY-SWITCH STABILITY AND SENSITIVITY 26
THE EFFECT OF AUTOREGULATION 28
OTHER CASES 28
CHAPTER T WO
PROTEIN-DNA INTERACTIONS AND GENE CONTROL 31
THE OPERATOR 31
REPRESSOR 34
CRO 37
VII
IMAGE 2
VLLI CONTENTS
AMINO ACID-BASE PAIR INTERACTIONS 39
THE PROMOTER 43
GENE CONTROL 44
CHAPTER THREE
CONTROL CIRCUITS-SETTING THE SWITCH 47
A BRIEF OVERVIEW OF X GROWTH 48 THE GENETIC MAP 48 CIRCULARIZATION 49
GENE EXPRESSION 50
INTEGRATION 51
CONTROL OF TRANSCRIPTION 52 VERY EARLY 52 EARLY 52 LATE LYTIC 53
LATE LYSOGENIC 55
THE DECISION 56
CONTROL OF INTEGRATION AND EXCISION 57 CASE 1-ESTABLISHING LYSOGENY 58
CASE 2-LYTIC GROWTH 58 CASE 3-INDUCTION 58
OTHER PHAGES 60
THE SOS RESPONSE 60
X PATHWAYS AND CELL DEVELOPMENT 62 REGULATORY GENES 62 SWITCHES 63
PATTERNS OF GENE EXPRESSION 64
CHAPTER FOUR
HOW DO WE KNOW-THE KEY EXPERIMENTS 67
THE REPRESSOR IDEA 67 CLEAR AND VIRULENT MUTANTS 67 OBSERVATIONS 67
EXPLANATION 68
IMMUNITY AND HETEROIMMUNITY 69 OBSERVATIONS 69 EXPLANATION 70
IMAGE 3
CONTENTS IX
ASYMMETRY IN BACTERIAL MATING 70 OBSERVATIONS 70 EXPLANATION 71
THE REPRESSOR PROBLEM IN THE EARLY 1960S 71
REPRESSOR ISOLATION AND DNA BINDING 72
MAKING MORE REPRESSOR 74
THE CLAIMS OF CHAPTERS ONE AND TWO 76
THE REPRESSOR IS COMPOSED OF TWO GLOBULAR DOMAINS HELD TOGETHER BY A
LINKER OF SOME 40 AMINO ACIDS 76
THE REPRESSOR DIMERIZES, LARGELY THROUGH INTERACTION BETWEEN ITS
CARBOXYL DOMAINS 76
A REPRESSOR DIMER BINDS, THROUGH ITS AMINO DOMAINS, TO A 1 7 BASE PAIR
OPERATOR SITE 78 A SINGLE OPERATOR SITE BINDS ONE DIMER OF REPRESSOR 78
DINNERS FORM BEFORE DNA BINDING 80
THE AMINO DOMAINS CONTACT DNA 82
THERE ARE THREE 17 BASE PAIR REPRESSOR BINDING SITES IN THE RIGHT
OPERATOR.
AT EACH SITE REPRESSOR AND CRO BIND ALONG THE SAME FACE OF THE HELIX 84
CHEMICAL PROBES 84 OPERATOR MUTATIONS 85 BINDING TO SUPERCOILED AND
LINEAR DNA 85
REPRESSOR BINDS TO THREE SITES IN O R WITH ALTERNATE PAIRWISE
COOPERATIVITY. THE COOPERATIVITY IS MEDIATED BY INTERACTIONS BETWEEN
CARBOXYL DOMAINS OF ADJACENT DIMERS 86
IN A LYSOGEN REPRESSOR IS TYPICALLY BOUND TO O R 1 AND O R 2. THE BOUND
REPRESSORS TURN OFF RIGHTWARD TRANSCRIPTION OF CRO AND STIMULATE
LEFTWARD TRANSCRIPTION OF CL. AT HIGHER CONCENTRATIONS, REPRESSOR BINDS
TO O R 3 TO TURN OFF TRANSCRIPTION OF CL 87
CRO BINDS FIRST TO O R 3, THEN TO O R 1 AND O R 2, THEREBY FIRST TURNING
OFF P RM , THEN P R 92 SOME BACKGROUND ABOUT CRO 92 CRO IN VIVO 93
CRO IN VITRO 94
RECA CLEAVES REPRESSOR TO TRIGGER INDUCTION 94
WHEN CRO IS BOUND AT O R 3 THE SWITCH IS THROWN 95
REPRESSOR AND CRO BIND TO THE OPERATOR AS SHOWN IN FIGURES 2.6, 2.8,
2.10, AND 2.11 95 CRYSTALLOGRAPHY 95 THE "HELIX SWAP" EXPERIMENT 96
IMAGE 4
CONTENTS
SPECIFIC AMINO ACID-BASE PAIR CONTACTS 98 THE ROLE OF THE ARM OFX
REPRESSOR 99 REPRESSOR ACTIVATES TRANSCRIPTION OF CL BY BINDING TO O R 2
AND CONTACTING POLYMERASE WITH ITS AMINO DOMAIN 99
POSITIVE CONTROL MUTANTS 99 POSITIVE CONTROL IN VITRO 102 CONCLUSION 103
CHAPTER FIVE
2004: NEW DEVELOPMENTS 109
1. LONG-RANGE COOPERATIVITY AND REPRESSION OF P RM 109 AN OCTAMER OF
REPRESSOR BINDS O R AND O L 110 AUTONEGATIVE REGULATION OF REPRESSOR
SYNTHESIS 112
HOW DO WE KNOW 113 LONG-RANGE INTERACTIONS AND REPRESSION OF P R 113
LONG-RANGE INTERACTIONS AND REPRESSION OF P RM 114 ACTIVATION AND
REPRESSION OF P RM 114
REPRESSOR STRUCTURE 1 1 5
2. POSITIVE CONTROL (ACTIVATION OF TRANSCRIPTION) 122 POLYMERASE AND
PROMOTER 122 THE MECHANISM OF ACTIVATION 123 HOW DO WE KNOW 123
ACTIVATING REGION VARIANTS 123 A SUPPRESSOR OF A PC MUTANT 125
CRYSTALLOGRAPHY 125 ACTIVATOR BYPASS 125 CHANGING ACTIVATING REGIONS AND
TARGET CONTEXT 127
3. THE STRUCTURE OF THE REPRESSOR MONOMER AND THE MECHANISM OF REPRESSOR
CLEAVAGE 131 HOW DO WE KNOW 132 4. EVOLVING THE SWITCH 133
CHANGING THE AFFINITIES OF SITES IN O R FOR REPRESSOR 133 ELIMINATING
POSITIVE CONTROL 134 ELIMINATING COOPERATIVITY BETWEEN DNA-BINDING
DIMERS 134
5. CLL AND THE DECISION 136
INDEX 151 |
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| id | DE-604.BV021534251 |
| illustrated | Illustrated |
| index_date | 2024-07-02T14:26:13Z |
| indexdate | 2024-07-09T20:38:02Z |
| institution | BVB |
| isbn | 0879697164 9780879697167 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-014750560 |
| oclc_num | 54035585 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-20 DE-11 |
| owner_facet | DE-355 DE-BY-UBR DE-20 DE-11 |
| physical | XIV, 154 S. graph. Darst. |
| publishDate | 2004 |
| publishDateSearch | 2004 |
| publishDateSort | 2004 |
| publisher | Cold Spring Harbor Laboratory Press |
| record_format | marc |
| spelling | Ptashne, Mark 1940- Verfasser (DE-588)138150850 aut A genetic switch phage lambda revisited Mark Ptashne 3. ed. Cold Spring Harbor, NY Cold Spring Harbor Laboratory Press 2004 XIV, 154 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Bactériophage lambda Génétique virale Régulation génétique Bacteriophage lambda Bacteriophage lambda genetics Gene Expression Regulation Genes, Viral Genetic regulation Lysogeny Repressor Proteins Viral genetics Genregulation (DE-588)4122166-7 gnd rswk-swf Bakteriophage Lambda (DE-588)4208901-3 gnd rswk-swf Bakteriophage Lambda (DE-588)4208901-3 s Genregulation (DE-588)4122166-7 s DE-604 SWB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014750560&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Ptashne, Mark 1940- A genetic switch phage lambda revisited Bactériophage lambda Génétique virale Régulation génétique Bacteriophage lambda Bacteriophage lambda genetics Gene Expression Regulation Genes, Viral Genetic regulation Lysogeny Repressor Proteins Viral genetics Genregulation (DE-588)4122166-7 gnd Bakteriophage Lambda (DE-588)4208901-3 gnd |
| subject_GND | (DE-588)4122166-7 (DE-588)4208901-3 |
| title | A genetic switch phage lambda revisited |
| title_auth | A genetic switch phage lambda revisited |
| title_exact_search | A genetic switch phage lambda revisited |
| title_exact_search_txtP | A genetic switch phage lambda revisited |
| title_full | A genetic switch phage lambda revisited Mark Ptashne |
| title_fullStr | A genetic switch phage lambda revisited Mark Ptashne |
| title_full_unstemmed | A genetic switch phage lambda revisited Mark Ptashne |
| title_short | A genetic switch |
| title_sort | a genetic switch phage lambda revisited |
| title_sub | phage lambda revisited |
| topic | Bactériophage lambda Génétique virale Régulation génétique Bacteriophage lambda Bacteriophage lambda genetics Gene Expression Regulation Genes, Viral Genetic regulation Lysogeny Repressor Proteins Viral genetics Genregulation (DE-588)4122166-7 gnd Bakteriophage Lambda (DE-588)4208901-3 gnd |
| topic_facet | Bactériophage lambda Génétique virale Régulation génétique Bacteriophage lambda Bacteriophage lambda genetics Gene Expression Regulation Genes, Viral Genetic regulation Lysogeny Repressor Proteins Viral genetics Genregulation Bakteriophage Lambda |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014750560&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT ptashnemark ageneticswitchphagelambdarevisited |