Antimalarial chemotherapy: mechanisms of action, resistance, and new directions in drug discovery
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Totowa, NJ
Humana Press
2001
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XI, 396 S. Ill., graph. Darst. |
| ISBN: | 0896036707 |
Staff View
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| 245 | 1 | 0 | |a Antimalarial chemotherapy |b mechanisms of action, resistance, and new directions in drug discovery |c ed. by Philip J. Rosenthal |
| 264 | 1 | |a Totowa, NJ |b Humana Press |c 2001 | |
| 300 | |a XI, 396 S. |b Ill., graph. Darst. | ||
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| 650 | 4 | |a Antimalarials | |
| 650 | 4 | |a Antimalarials |x pharmacology | |
| 650 | 4 | |a Drug Resistance | |
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Record in the Search Index
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| adam_text | Contents
Preface v
List of Contributors ix
I Introduction
1 The Need for New Approaches to Antimalarial Chemotherapy
Philip J. Rosenthal and Louis H. Miller 3
2 The History of Antimalarial Drugs
Steven R. Meshnick and Mary J. Dobson 15
3 Transport and Trafficking in Plasmodium Infected Red Cells
Kasturi Haldar and Thomas Akompong 27
4 The Plasmodium Food Vacuole
Ritu Banerjee and Daniel E. Goldberg 43
5 Clinical and Public Health Implications of Antimalarial
Drug Resistance
Piero L. Olliaro and Peter B. Bloland 65
II Established Antimalarial Drugs and Compounds Under Clinical
Development
6 Chloroquine and Other Quinoline Antimalarials
Leann Tilley, Paul Loria, and Mick Foley 87
7 8 Aminoquinolines
RalfP. Brueckner, Colin Ohrt, J. Kevin Baird,
and Wilbur K. Milhous 123
8 Mechanisms of Quinoline Resistance
Grant Dorsey, David A. Fidock, Thomas E. Wellems,
and Philip J. Rosenthal 153
9 Folate Antagonists and Mechanisms of Resistance
Christopher V. Plowe 173
10 Artemisinin and Its Derivatives
Steven R. Meshnick 191
vii
viii Contents
11 Atovaquone Proguanil Combination
Akhil B. Vaidya 203
12 The Antimalarial Drug Portfolio and Research Pipeline
Piero L. Olliaro and Wilbur K. Milhous 219
III New Compounds, New Approaches, and New Targets
13 Novel Quinoline Antimalarials
Paul A. Stocks, Kaylene J. Raynes, and Stephen A. Ward 235
14 New Antimalarial Trioxanes and Endoperoxides
Gary H. Posner, Mikhail Krasavin, Michael McCutchen,
Poonsakdi Ploypradith, John P. Maxwell, Jeffrey S. Elias,
and Michael H. Parker 255
15 Antibiotics and the Plasmodial Plastid Organelle
Barbara Clough andR.J.M. (Iain) Wilson 265
16 Fresh Paradigms for Curative Antimetabolites
Pradipsinh K. Rathod 287
17 Iron Chelators
Mark Loyevsky and Victor R. Gordeuk 307
18 Protease Inhibitors
Philip J. Rosenthal 325
19 Inhibitors of Phospholipid Metabolism
Henri Joseph Vial and Michele Calas 347
20 Development of New Malaria Chemotherapy by Utilization
of Parasite Induced Transport
Annette M. Gero and Alexander L. Wets 367
Index 385
|
| adam_txt |
Contents
Preface v
List of Contributors ix
I Introduction
1 The Need for New Approaches to Antimalarial Chemotherapy
Philip J. Rosenthal and Louis H. Miller 3
2 The History of Antimalarial Drugs
Steven R. Meshnick and Mary J. Dobson 15
3 Transport and Trafficking in Plasmodium Infected Red Cells
Kasturi Haldar and Thomas Akompong 27
4 The Plasmodium Food Vacuole
Ritu Banerjee and Daniel E. Goldberg 43
5 Clinical and Public Health Implications of Antimalarial
Drug Resistance
Piero L. Olliaro and Peter B. Bloland 65
II Established Antimalarial Drugs and Compounds Under Clinical
Development
6 Chloroquine and Other Quinoline Antimalarials
Leann Tilley, Paul Loria, and Mick Foley 87
7 8 Aminoquinolines
RalfP. Brueckner, Colin Ohrt, J. Kevin Baird,
and Wilbur K. Milhous 123
8 Mechanisms of Quinoline Resistance
Grant Dorsey, David A. Fidock, Thomas E. Wellems,
and Philip J. Rosenthal 153
9 Folate Antagonists and Mechanisms of Resistance
Christopher V. Plowe 173
10 Artemisinin and Its Derivatives
Steven R. Meshnick 191
vii
viii Contents
11 Atovaquone Proguanil Combination
Akhil B. Vaidya 203
12 The Antimalarial Drug Portfolio and Research Pipeline
Piero L. Olliaro and Wilbur K. Milhous 219
III New Compounds, New Approaches, and New Targets
13 Novel Quinoline Antimalarials
Paul A. Stocks, Kaylene J. Raynes, and Stephen A. Ward 235
14 New Antimalarial Trioxanes and Endoperoxides
Gary H. Posner, Mikhail Krasavin, Michael McCutchen,
Poonsakdi Ploypradith, John P. Maxwell, Jeffrey S. Elias,
and Michael H. Parker 255
15 Antibiotics and the Plasmodial Plastid Organelle
Barbara Clough andR.J.M. (Iain) Wilson 265
16 Fresh Paradigms for Curative Antimetabolites
Pradipsinh K. Rathod 287
17 Iron Chelators
Mark Loyevsky and Victor R. Gordeuk 307
18 Protease Inhibitors
Philip J. Rosenthal 325
19 Inhibitors of Phospholipid Metabolism
Henri Joseph Vial and Michele Calas 347
20 Development of New Malaria Chemotherapy by Utilization
of Parasite Induced Transport
Annette M. Gero and Alexander L. Wets 367
Index 385 |
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| spelling | Antimalarial chemotherapy mechanisms of action, resistance, and new directions in drug discovery ed. by Philip J. Rosenthal Totowa, NJ Humana Press 2001 XI, 396 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Antimalarials Antimalarials pharmacology Drug Resistance Malaria drug therapy Antimalariamittel (DE-588)4142684-8 gnd rswk-swf Antimalariamittel (DE-588)4142684-8 s DE-604 Rosenthal, Philip J. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014652880&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Antimalarial chemotherapy mechanisms of action, resistance, and new directions in drug discovery Antimalarials Antimalarials pharmacology Drug Resistance Malaria drug therapy Antimalariamittel (DE-588)4142684-8 gnd |
| subject_GND | (DE-588)4142684-8 |
| title | Antimalarial chemotherapy mechanisms of action, resistance, and new directions in drug discovery |
| title_auth | Antimalarial chemotherapy mechanisms of action, resistance, and new directions in drug discovery |
| title_exact_search | Antimalarial chemotherapy mechanisms of action, resistance, and new directions in drug discovery |
| title_exact_search_txtP | Antimalarial chemotherapy mechanisms of action, resistance, and new directions in drug discovery |
| title_full | Antimalarial chemotherapy mechanisms of action, resistance, and new directions in drug discovery ed. by Philip J. Rosenthal |
| title_fullStr | Antimalarial chemotherapy mechanisms of action, resistance, and new directions in drug discovery ed. by Philip J. Rosenthal |
| title_full_unstemmed | Antimalarial chemotherapy mechanisms of action, resistance, and new directions in drug discovery ed. by Philip J. Rosenthal |
| title_short | Antimalarial chemotherapy |
| title_sort | antimalarial chemotherapy mechanisms of action resistance and new directions in drug discovery |
| title_sub | mechanisms of action, resistance, and new directions in drug discovery |
| topic | Antimalarials Antimalarials pharmacology Drug Resistance Malaria drug therapy Antimalariamittel (DE-588)4142684-8 gnd |
| topic_facet | Antimalarials Antimalarials pharmacology Drug Resistance Malaria drug therapy Antimalariamittel |
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