The regulatory genome: gene regulatory networks in development and evolution
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier, Academic Press
2006
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XI, 289 S. Ill., graph. Darst. |
| ISBN: | 0120885638 9780120885633 |
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| 100 | 1 | |a Davidson, Eric H. |d 1937- |e Verfasser |0 (DE-588)1019158565 |4 aut | |
| 245 | 1 | 0 | |a The regulatory genome |b gene regulatory networks in development and evolution |c Eric H. Davidson |
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier, Academic Press |c 2006 | |
| 300 | |a XI, 289 S. |b Ill., graph. Darst. | ||
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| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Genregulation - Entwicklungsgenetik | |
| 650 | 4 | |a Genetic regulation | |
| 650 | 4 | |a Developmental genetics | |
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Datensatz im Suchindex
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|---|---|
| adam_text | CONTENTS
Preface fx
Chapter 1
The Regulatory Genome for Animal Development 1
The Framework 1
The Regulatory Apparatus Encoded in the DNA 3
Genomes, Genes, and Genomic Space 3
Overview of Regulatory Architecture 8
Gene Regulatory Networks 11
The Regulatory Demands of Development 16
Readout and Generation of Regulatory Information in
Developmental Specification 16
Spatial Gene Expression 18
From Regional Specification to Terminal Differentiation 21
Evolution, Development, and the Regulatory Genome 27
Chapter 2
cis Regulatory Modules, and the Structure/Function
Basis of Regulatory Logic 31
General Operating Principles 31
Modularity, A General Property of Genomic
cis Regulatory Control Units 33
Inside the cis Regulatory Module: Logic Processing
and Input/Output Relations 47
as Regulatory Logic Processors: Examples 48
Target Site Occupancy and Transcriptional Output 57
Generalization: The Combinatorial as Regulatory
Logic Code 59
cis Regulatory Design 61
Integration of Spatial Inputs at the as Regulatory Level 61
Repression and the Diversity of as Regulatory Design 68
as Regulatory Design and the Creation of Spatial
Complexity in Development 73
v
Contents
Control by Sequence Specific Interactions Among
Distant c/s Regualtory Elements 78
Development and BTA Specificity 79
Control Functions of Sequence Specific, Intra and
Intergenic Genomic Looping 80
Chapter 3
Development as a Process of Regulatory
State Specification 87
Developmental Processes of the Pregastrular Embryo 87
Vectorial Embryogeniss 88
Maternal Anisotropy and External Cues for Axial Polarity 90
Spatial Regulatory Complexity and Interblastomere Signaling 94
Territories 100
Comparative View of Embryonic Processes, and the
Organization of the Underlying Gene Regulatory
Networks 102
Shallow Gene Regulatory Networks of Type 1 Embryos 103
More Complex Forms of Embryonic Process 109
Regulatory State and Network Circuitry in Building
Adult Body Parts 114
Steps in the Postembryonic Developmental Process 114
The Progenitor Field Concept 115
Subdivision of the Progenitor Field Regulatory State 121
Body Plan Development and the Organism 122
Chapter 4
Gene Regulatory Networks for Development: What
They Are, How They Work, and What They Mean 125
General Structural Properties of Developmental
Gene Regulatory Networks 126
Overall Network Structure 127
Gene Regulatory Networks from Different Perspectives:
Subcircuits to Process Diagrams 135
Qualitative Diversity of Network Components 136
Extensions 140
Gene Regulatory Networks for Embryonic Development 144
The Sea Urchin Endomesoderm Network 144
Regulatory Gene Network for Specification of Mesoderm
in the Xenopus Embryo 159
Gene Regulatory Network Controlling Dorsal Ventral
Territorial Specification in the Drosophila Embryo 166
Contents vjj
Networks that Control Construction of Components
of Adult Body Parts 175
Network Organization in the Specification of
Pancreatic P Cells 176
Cell Fate Exclusion by microRNAs in a Gene Regulatory
Controlling Terminal Differentiation in C. elegans Taste
Network Neurons 180
Concluding Remarks 184
Chapter 5
Gene Regulatory Networks: The Roots of Causality
and Diversity in Animal Evolution 187
Evolutionary Implications of the Structure and
Function of Gene Regulatory Networks 188
The Parts of Gene Regulatory Networks, and
the Qualities of Evolutionary Change 188
Linnaean Framework for the Evolutionary Consequences
of Alterations in Gene Regulatory Networks 195
Bilaterian Kernels, Predicted and Real 196
Caveats and a Caution 197
Regional Specification in the Bilaterian Nervous System 200
The Bilaterian Gut 212
A Possible Pan Bilaterian Kernel Underlying Specification
of the Heart Progenitor Field 218
Distribution of Kernels 221
Subphyletic Evolution of Bilaterian Body Plans:
box Genes as Sources of Labile Network
Input/Output Switches 223
Diverse Functional Consequences of box Gene Expression 223
Multiple Examples: Regional Repression and Installation
of Patterning Output, and the Evolutionary
Diversification of Body Parts 224
box Gene Subnetworks and Spatial Evolution 233
Metazoan Origins and Gene Networks Before Kernels 235
Deconstructing Bilaterian Gene Regulatory Networks
in Time 235
Concluding Reflection: The Principle of Animal
Development and Evolution 239
References 241
Figure Citations 275
Index 279
|
| adam_txt |
CONTENTS
Preface fx
Chapter 1
The "Regulatory Genome" for Animal Development 1
The Framework 1
The Regulatory Apparatus Encoded in the DNA 3
Genomes, Genes, and Genomic "Space" 3
Overview of Regulatory Architecture 8
Gene Regulatory Networks 11
The Regulatory Demands of Development 16
Readout and Generation of Regulatory Information in
Developmental Specification 16
Spatial Gene Expression 18
From Regional Specification to Terminal Differentiation 21
Evolution, Development, and the Regulatory Genome 27
Chapter 2
cis Regulatory Modules, and the Structure/Function
Basis of Regulatory Logic 31
General Operating Principles 31
Modularity, A General Property of Genomic
cis Regulatory Control Units 33
Inside the cis Regulatory Module: Logic Processing
and Input/Output Relations 47
as Regulatory Logic Processors: Examples 48
Target Site Occupancy and Transcriptional Output 57
Generalization: The Combinatorial as Regulatory
Logic Code 59
cis Regulatory Design 61
Integration of Spatial Inputs at the as Regulatory Level 61
Repression and the Diversity of as Regulatory Design 68
as Regulatory Design and the Creation of Spatial
Complexity in Development 73
v
Contents
Control by Sequence Specific Interactions Among
Distant c/s Regualtory Elements 78
Development and BTA Specificity 79
Control Functions of Sequence Specific, Intra and
Intergenic Genomic Looping 80
Chapter 3
Development as a Process of Regulatory
State Specification 87
Developmental Processes of the Pregastrular Embryo 87
Vectorial Embryogeniss 88
Maternal Anisotropy and External Cues for Axial Polarity 90
Spatial Regulatory Complexity and Interblastomere Signaling 94
Territories 100
Comparative View of Embryonic Processes, and the
Organization of the Underlying Gene Regulatory
Networks 102
Shallow Gene Regulatory Networks of Type 1 Embryos 103
More Complex Forms of Embryonic Process 109
Regulatory State and Network Circuitry in Building
Adult Body Parts 114
Steps in the Postembryonic Developmental Process 114
The Progenitor Field Concept 115
Subdivision of the Progenitor Field Regulatory State 121
Body Plan Development and the Organism 122
Chapter 4
Gene Regulatory Networks for Development: What
They Are, How They Work, and What They Mean 125
General Structural Properties of Developmental
Gene Regulatory Networks 126
Overall Network Structure 127
Gene Regulatory Networks from Different Perspectives:
Subcircuits to Process Diagrams 135
Qualitative Diversity of Network Components 136
Extensions 140
Gene Regulatory Networks for Embryonic Development 144
The Sea Urchin Endomesoderm Network 144
Regulatory Gene Network for Specification of Mesoderm
in the Xenopus Embryo 159
Gene Regulatory Network Controlling Dorsal Ventral
Territorial Specification in the Drosophila Embryo 166
Contents vjj
Networks that Control Construction of Components
of Adult Body Parts 175
Network Organization in the Specification of
Pancreatic P Cells 176
Cell Fate Exclusion by microRNAs in a Gene Regulatory
Controlling Terminal Differentiation in C. elegans Taste
Network Neurons 180
Concluding Remarks 184
Chapter 5
Gene Regulatory Networks: The Roots of Causality
and Diversity in Animal Evolution 187
Evolutionary Implications of the Structure and
Function of Gene Regulatory Networks 188
The Parts of Gene Regulatory Networks, and
the Qualities of Evolutionary Change 188
Linnaean Framework for the Evolutionary Consequences
of Alterations in Gene Regulatory Networks 195
Bilaterian Kernels, Predicted and Real 196
Caveats and a Caution 197
Regional Specification in the Bilaterian Nervous System 200
The Bilaterian Gut 212
A Possible Pan Bilaterian Kernel Underlying Specification
of the Heart Progenitor Field 218
Distribution of Kernels 221
Subphyletic Evolution of Bilaterian Body Plans:
box Genes as Sources of Labile Network
Input/Output Switches 223
Diverse Functional Consequences of box Gene Expression 223
Multiple Examples: Regional Repression and Installation
of Patterning Output, and the Evolutionary
Diversification of Body Parts 224
box Gene Subnetworks and Spatial Evolution 233
Metazoan Origins and Gene Networks Before Kernels 235
"Deconstructing" Bilaterian Gene Regulatory Networks
in Time 235
Concluding Reflection: The Principle of Animal
Development and Evolution 239
References 241
Figure Citations 275
Index 279 |
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| index_date | 2024-07-02T13:43:11Z |
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| institution | BVB |
| isbn | 0120885638 9780120885633 |
| language | English |
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| spelling | Davidson, Eric H. 1937- Verfasser (DE-588)1019158565 aut The regulatory genome gene regulatory networks in development and evolution Eric H. Davidson Amsterdam [u.a.] Elsevier, Academic Press 2006 XI, 289 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Genregulation - Entwicklungsgenetik Genetic regulation Developmental genetics Genregulation (DE-588)4122166-7 gnd rswk-swf Tiere (DE-588)4060087-7 gnd rswk-swf Entwicklungsbiologie (DE-588)4152440-8 gnd rswk-swf Tiere (DE-588)4060087-7 s Entwicklungsbiologie (DE-588)4152440-8 s Genregulation (DE-588)4122166-7 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014587163&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Davidson, Eric H. 1937- The regulatory genome gene regulatory networks in development and evolution Genregulation - Entwicklungsgenetik Genetic regulation Developmental genetics Genregulation (DE-588)4122166-7 gnd Tiere (DE-588)4060087-7 gnd Entwicklungsbiologie (DE-588)4152440-8 gnd |
| subject_GND | (DE-588)4122166-7 (DE-588)4060087-7 (DE-588)4152440-8 |
| title | The regulatory genome gene regulatory networks in development and evolution |
| title_auth | The regulatory genome gene regulatory networks in development and evolution |
| title_exact_search | The regulatory genome gene regulatory networks in development and evolution |
| title_exact_search_txtP | The regulatory genome gene regulatory networks in development and evolution |
| title_full | The regulatory genome gene regulatory networks in development and evolution Eric H. Davidson |
| title_fullStr | The regulatory genome gene regulatory networks in development and evolution Eric H. Davidson |
| title_full_unstemmed | The regulatory genome gene regulatory networks in development and evolution Eric H. Davidson |
| title_short | The regulatory genome |
| title_sort | the regulatory genome gene regulatory networks in development and evolution |
| title_sub | gene regulatory networks in development and evolution |
| topic | Genregulation - Entwicklungsgenetik Genetic regulation Developmental genetics Genregulation (DE-588)4122166-7 gnd Tiere (DE-588)4060087-7 gnd Entwicklungsbiologie (DE-588)4152440-8 gnd |
| topic_facet | Genregulation - Entwicklungsgenetik Genetic regulation Developmental genetics Genregulation Tiere Entwicklungsbiologie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014587163&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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