Click chemistry applied to the solid phase supported parallel synthesis of selective neuroreceptor ligands:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English German |
| Veröffentlicht: |
2005
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Erlangen-Nürnberg, Univ., Diss., 2005. - Enth. engl. und dt. Zsfassung |
| Beschreibung: | 144 S. |
Internformat
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Datensatz im Suchindex
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1. Introduction. p1
1.1 Solid Phase Organic Synthesis (SPOS) in drug discovery.
Preliminary considerations.
1.2 Click chemistry in drug discovery.
1.3 The biological target. Dopamine receptors.
1.4 Other related systems.
1.5 The D3 dopamine receptor and D3 receptor ligands.
1.6 The alpha-1 adrenergic receptor and its ligands.
2. Aims. p10
3. Click linker: Efficient and high yield synthesis of a new family p 12
of SPOS resins.
4. The FormylAryloxyMethylTriazole linker in drug discovery. p 16
4.1 Sequence optimization.
4.2 Validation methodology.
4.3 Production of the 3D library.
4.4 Biological screening of the 3D library.
4.5 Binding affinities (K,).
5. The HydroxyAryloxyMethylTriazole linker p 35
5.1 Recovery study.
5.2 Optimization in solid phase.
5.3 Linker selection.
5.4 Validation.
5.5 3D library production.
5.6 3D library screening.
5.7 Binding affinities (K,).
6 The FormylPyrrolylMethylTriazole linker p 50
6.1 Recovery study.
6.2 Model reactions.
6.3 Model library.
6.4 Design of the 3D library.
6.5 Production of the 3D library.
6.6 Screening of the 3D library.
6.7 Binding affinities (Ki).
7. Zusamenfassung p 65
8. Experimental part p 71
9. References p 132 |
| any_adam_object | 1 |
| author | Rodríguez Loaíza, Maria del Pilar 1973- |
| author_GND | (DE-588)130347264 |
| author_facet | Rodríguez Loaíza, Maria del Pilar 1973- |
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| author_sort | Rodríguez Loaíza, Maria del Pilar 1973- |
| author_variant | l m d p r lmdp lmdpr |
| building | Verbundindex |
| bvnumber | BV020039707 |
| classification_rvk | WD 5355 |
| ctrlnum | (OCoLC)255113106 (DE-599)BVBBV020039707 |
| discipline | Biologie Medizin |
| format | Thesis Book |
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| genre_facet | Hochschulschrift |
| id | DE-604.BV020039707 |
| illustrated | Not Illustrated |
| indexdate | 2025-02-11T15:00:39Z |
| institution | BVB |
| language | English German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-013360806 |
| oclc_num | 255113106 |
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| physical | 144 S. |
| publishDate | 2005 |
| publishDateSearch | 2005 |
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| spelling | Rodríguez Loaíza, Maria del Pilar 1973- Verfasser (DE-588)130347264 aut Click chemistry applied to the solid phase supported parallel synthesis of selective neuroreceptor ligands von Maria del Pilar Rodríguez Loaíza 2005 144 S. txt rdacontent n rdamedia nc rdacarrier Erlangen-Nürnberg, Univ., Diss., 2005. - Enth. engl. und dt. Zsfassung Erlangen-Nürnberg, Univ., Diss., 2005 Elimination (DE-588)4152012-9 gnd rswk-swf Festphasentechnik (DE-588)4154192-3 gnd rswk-swf Ligand (DE-588)4035711-9 gnd rswk-swf Terminations-Codon (DE-588)4400585-4 gnd rswk-swf Linker (DE-588)4510937-0 gnd rswk-swf Neurotransmitter-Rezeptor (DE-588)4171601-2 gnd rswk-swf Messenger-RNS (DE-588)4169499-5 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Messenger-RNS (DE-588)4169499-5 s Elimination (DE-588)4152012-9 s Terminations-Codon (DE-588)4400585-4 s DE-604 Neurotransmitter-Rezeptor (DE-588)4171601-2 s Ligand (DE-588)4035711-9 s Festphasentechnik (DE-588)4154192-3 s Linker (DE-588)4510937-0 s HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013360806&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Rodríguez Loaíza, Maria del Pilar 1973- Click chemistry applied to the solid phase supported parallel synthesis of selective neuroreceptor ligands Elimination (DE-588)4152012-9 gnd Festphasentechnik (DE-588)4154192-3 gnd Ligand (DE-588)4035711-9 gnd Terminations-Codon (DE-588)4400585-4 gnd Linker (DE-588)4510937-0 gnd Neurotransmitter-Rezeptor (DE-588)4171601-2 gnd Messenger-RNS (DE-588)4169499-5 gnd |
| subject_GND | (DE-588)4152012-9 (DE-588)4154192-3 (DE-588)4035711-9 (DE-588)4400585-4 (DE-588)4510937-0 (DE-588)4171601-2 (DE-588)4169499-5 (DE-588)4113937-9 |
| title | Click chemistry applied to the solid phase supported parallel synthesis of selective neuroreceptor ligands |
| title_auth | Click chemistry applied to the solid phase supported parallel synthesis of selective neuroreceptor ligands |
| title_exact_search | Click chemistry applied to the solid phase supported parallel synthesis of selective neuroreceptor ligands |
| title_full | Click chemistry applied to the solid phase supported parallel synthesis of selective neuroreceptor ligands von Maria del Pilar Rodríguez Loaíza |
| title_fullStr | Click chemistry applied to the solid phase supported parallel synthesis of selective neuroreceptor ligands von Maria del Pilar Rodríguez Loaíza |
| title_full_unstemmed | Click chemistry applied to the solid phase supported parallel synthesis of selective neuroreceptor ligands von Maria del Pilar Rodríguez Loaíza |
| title_short | Click chemistry applied to the solid phase supported parallel synthesis of selective neuroreceptor ligands |
| title_sort | click chemistry applied to the solid phase supported parallel synthesis of selective neuroreceptor ligands |
| topic | Elimination (DE-588)4152012-9 gnd Festphasentechnik (DE-588)4154192-3 gnd Ligand (DE-588)4035711-9 gnd Terminations-Codon (DE-588)4400585-4 gnd Linker (DE-588)4510937-0 gnd Neurotransmitter-Rezeptor (DE-588)4171601-2 gnd Messenger-RNS (DE-588)4169499-5 gnd |
| topic_facet | Elimination Festphasentechnik Ligand Terminations-Codon Linker Neurotransmitter-Rezeptor Messenger-RNS Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013360806&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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