Molecular and immunological studies on filariasis: development of a specific and early diagnosis of onchocerciasis (river blindness) and the role of g-glutamyl [gamma-glutamyl] transpeptidase in the pathogenesis of tropical pulmonary eosinophilia syndrome (TPE)
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| Format: | Thesis Book |
| Language: | English |
| Published: |
2004
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Enth. 9 Sonderabdr. aus verschiedenen Zeitschr. |
| Physical Description: | 130 Bl. Ill., graph. Darst. 30 cm |
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| 245 | 1 | 0 | |a Molecular and immunological studies on filariasis |b development of a specific and early diagnosis of onchocerciasis (river blindness) and the role of g-glutamyl [gamma-glutamyl] transpeptidase in the pathogenesis of tropical pulmonary eosinophilia syndrome (TPE) |c vorgelegt von Edgar Lobos |
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Record in the Search Index
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| adam_text | 1. Titel
2. Bibliographic description 2
3. Introduction 4
General distribution of onchocerciasis and of lymphatic filariasis, prevalence and
socioeconomic aspects.
3.1. Onchocerciasis a major tropical disease and its control programmes. 8
3.2. Limitations of the parasitological diagnosis O. volvulus. 9
3.3. Limitations of the immunological diagnosis O. volvulus. 10
3.4. Analysis of the O. volvulus antigens recognized by infected patients from West and East
Africa: identification of non cross reacting antigens. 11
3.5. A novel molecular biological approach to the study of O. volvulus antigens. 23
3.6. Field work in an area hyperendemic for onchocerciasis on the bank of Niger River Basin, in
Mali West Africa. 23
3.7. Isolation of O. volvulus mRNA, in vitro translation of mRNA and immunoprecipitation of
in vitro translated proteins. 24
3.8. Construction of a O. volvulus cDNA library and immunoscreening. 24
3.9. Molecular and immunological characterization of O. volvulus OV 16 gene, a member of the
phosphatidylethanolamine binding (PBP) protein family. 25
3.10. Overexpression of OV 16 and analysis of the immune response in patients with
onchocerciasis, other filariasis and other helmintiasis. 37
3.11. Presence of anti OV 16 antibodies in children with pre patent onchocerciasis: first specific
diagnosis of pre patent onchocerciasis. 37
3.12. Development of a rapid field test for the diagnosis of onchocerciasis. 43
3.13. Cellular and molecular mechanisms of pathology of lymphatic filariasis: The syndrome of
tropical pulmonary eosinophilia (TPE). 48
3.14. Immunological and biochemical analysis of Bm2325, a major IgE inducing antigen from
Brugia malayi in patients with TPE. 49
3.15. In vitro B and T cell responses to Bm 2325 in peripheral blood mononuclear cells from
patients with TPE and other manifestations of lymphatic filariasis. 50
3.16. Molecular cloning of the gene encoding the microfilarial allergen Bm 2325, a homologue
of the enzyme y glutamyl transpeptidase (y GT). 57
3.17. High level expression of the B.malayi Y GT precursor polypeptide and of the L subunit
(5/m2325) for immunological analysis: allergenicity of the recombinant proteins 58
3.18. A Bm 2325 homologue is present in the major lymphatic filariae W. bancrofti. 72
3
3.19. Molecular cloning of y GT homologues from Brugia pahangi. 72
3.20. Sequence analysis of the cDNA and amino acid sequence of B. pahangi y GT. 73
3.21. Immunological basis of molecular mimicry. 81
3.22. Balb/c model of pulmonary inflammation using recombinant filarial y GT. 81
3.23. Airway inflammation in mice intranasally challenged withy GT. 82
3.24. Immunization of mice with B. malayi y GT produces cross reactive, autoimmune Abs to
endogenous murine y GT on airways epithelial cells. 83
3.25. Murine T cell responses to recombinant y GT after sensitization with Mf proteins. 95
3.26. Analysis of the IgG subclass responses to B. malayi y GT in a South Indian population
infected with W. bancrofti. 95
3.27. IgE specific to filarial y GT in patients with lymphatic filariasis defines this molecule as
one of the most potent allergens in nature. 96
3.28. Ratio analysis of B. malayi y GT specific IgE / IgG subclasses in patients with lymphatic
filariasis. 96
3.29. Identification of pathogenic epitopes on the B. malayi y GT. 105
3.30. Role of y GT in the glutathione metabolism. 106
3.31. Impact of humoral immune responses to filarial y GT in glutathione homeostasis. 107
3.32. Outlook 109
4. Acknowledgements 110
5. References HI
Figures 117
Declaration of independent work 127
Curriculum vitae 128
4
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| ctrlnum | (OCoLC)255327962 (DE-599)BVBBV020038307 |
| discipline | Medizin |
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| indexdate | 2024-07-09T20:11:26Z |
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| language | English |
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| spelling | Lobos, Edgar 1956- Verfasser (DE-588)129927295 aut Molecular and immunological studies on filariasis development of a specific and early diagnosis of onchocerciasis (river blindness) and the role of g-glutamyl [gamma-glutamyl] transpeptidase in the pathogenesis of tropical pulmonary eosinophilia syndrome (TPE) vorgelegt von Edgar Lobos 2004 130 Bl. Ill., graph. Darst. 30 cm txt rdacontent n rdamedia nc rdacarrier Enth. 9 Sonderabdr. aus verschiedenen Zeitschr. Leipzig, Univ., Habil.-Schr., 2004 Diagnose (DE-588)4012040-5 gnd rswk-swf Onchozerkose (DE-588)4172585-2 gnd rswk-swf Filariose (DE-588)4154338-5 gnd rswk-swf Immunoscreening (DE-588)4419502-3 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Onchozerkose (DE-588)4172585-2 s Diagnose (DE-588)4012040-5 s Immunoscreening (DE-588)4419502-3 s DE-604 Filariose (DE-588)4154338-5 s b DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013359418&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Lobos, Edgar 1956- Molecular and immunological studies on filariasis development of a specific and early diagnosis of onchocerciasis (river blindness) and the role of g-glutamyl [gamma-glutamyl] transpeptidase in the pathogenesis of tropical pulmonary eosinophilia syndrome (TPE) Diagnose (DE-588)4012040-5 gnd Onchozerkose (DE-588)4172585-2 gnd Filariose (DE-588)4154338-5 gnd Immunoscreening (DE-588)4419502-3 gnd |
| subject_GND | (DE-588)4012040-5 (DE-588)4172585-2 (DE-588)4154338-5 (DE-588)4419502-3 (DE-588)4113937-9 |
| title | Molecular and immunological studies on filariasis development of a specific and early diagnosis of onchocerciasis (river blindness) and the role of g-glutamyl [gamma-glutamyl] transpeptidase in the pathogenesis of tropical pulmonary eosinophilia syndrome (TPE) |
| title_auth | Molecular and immunological studies on filariasis development of a specific and early diagnosis of onchocerciasis (river blindness) and the role of g-glutamyl [gamma-glutamyl] transpeptidase in the pathogenesis of tropical pulmonary eosinophilia syndrome (TPE) |
| title_exact_search | Molecular and immunological studies on filariasis development of a specific and early diagnosis of onchocerciasis (river blindness) and the role of g-glutamyl [gamma-glutamyl] transpeptidase in the pathogenesis of tropical pulmonary eosinophilia syndrome (TPE) |
| title_full | Molecular and immunological studies on filariasis development of a specific and early diagnosis of onchocerciasis (river blindness) and the role of g-glutamyl [gamma-glutamyl] transpeptidase in the pathogenesis of tropical pulmonary eosinophilia syndrome (TPE) vorgelegt von Edgar Lobos |
| title_fullStr | Molecular and immunological studies on filariasis development of a specific and early diagnosis of onchocerciasis (river blindness) and the role of g-glutamyl [gamma-glutamyl] transpeptidase in the pathogenesis of tropical pulmonary eosinophilia syndrome (TPE) vorgelegt von Edgar Lobos |
| title_full_unstemmed | Molecular and immunological studies on filariasis development of a specific and early diagnosis of onchocerciasis (river blindness) and the role of g-glutamyl [gamma-glutamyl] transpeptidase in the pathogenesis of tropical pulmonary eosinophilia syndrome (TPE) vorgelegt von Edgar Lobos |
| title_short | Molecular and immunological studies on filariasis |
| title_sort | molecular and immunological studies on filariasis development of a specific and early diagnosis of onchocerciasis river blindness and the role of g glutamyl gamma glutamyl transpeptidase in the pathogenesis of tropical pulmonary eosinophilia syndrome tpe |
| title_sub | development of a specific and early diagnosis of onchocerciasis (river blindness) and the role of g-glutamyl [gamma-glutamyl] transpeptidase in the pathogenesis of tropical pulmonary eosinophilia syndrome (TPE) |
| topic | Diagnose (DE-588)4012040-5 gnd Onchozerkose (DE-588)4172585-2 gnd Filariose (DE-588)4154338-5 gnd Immunoscreening (DE-588)4419502-3 gnd |
| topic_facet | Diagnose Onchozerkose Filariose Immunoscreening Hochschulschrift |
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