Immunodominance: the choice of the immune system
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Weinheim
Wiley-VCH
2006
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XXV, 288 S. Ill., graph. Darst. |
| ISBN: | 3527312749 9783527312740 |
Staff View
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| 650 | 4 | |a Immune response |x Regulation | |
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Record in the Search Index
| _version_ | 1804133598231527424 |
|---|---|
| adam_text | Contents
Preface XIII
List of Contributors XV
Color Plates XIX
I Mechanics of Antigen Processing 1
1 Class I MHC Antigen Processing 3
PeterJ. Miller and EdwardJ. Collins
1.1 Introduction 3
1.2 Properties of MHC 3
1.2.1 Structure of MHC 3
1.2.2 Polymorphic Residues Generate Specificity Pockets 5
1.3 Properties of Peptides 6
1.3.1 Peptides That Bind Are Not Random Sequences 6
1.3.2 Peptide binding Motifs 6
1.3.3 Peptide Length Is Limited in Class I MHC Peptides 7
1.3.4 Binding Affinity 7
1.3.5 Molecular Recognition 9
1.3.6 Epitope Prediction 9
1.4 Cytosolic Processing 10
1.4.1 The Proteasome 10
1.4.2 The Immunoproteasome 12
1.4.3 Opening the Immunoproteasome 13
1.4.4 Peptide Trimming 14
1.4.5 Association of the Proteasome with the Endoplasmic Reticulum 15
1.5 Peptide Transport 15
1.5.1 Transport via TAP 16
1.5.2 TAP Selectivity 16
1.5.3 TAP independent Peptide Transport 17
Immunodominance: The Choice of the Immune System. Edited by Jeffrey A. Frelinger
Copyright © 2006 WILEY VCH Verlag GmbH Co. KGaA, Weinheim
ISBN: 3 527 31274 9
VI I Contents
1.5.3.1 Endogenous Peptides 17
1.5.3.2 Exogenous Peptides 18
1.6 Class I MHC Maturation and Peptide Loading 19
1.6.1 ER Chaperones: Calnexin, Calreticulin, ERp57, and Tapasin 19
1.6.1.1 Calnexin 19
1.6.1.2 Tapasin 19
1.6.1.3 ERp57 21
1.6.1.4 Calreticulin 21
1.6.2 Peptide Loading 21
1.7 Immunodominance and Class I MHC Peptide Processing 22
2 The Mechanics of Class II Processing: Establishment
of a Peptide Class II Hierarchy 31
James R. Drake and Andrea J. Sant
2.1 General Overview 31
2.1.1 Immunodominance and Crypticity 31
2.1.2 The Impact of T Cell Repertoire in the Experimental Analysis of
Immunodominance 33
2.1.3 Different Antigen presenting Cells Have Different Functions 34
2.1 A The Phases of Antigen Processing 35
2.2 Phase I: MHC Class II Biosynthesis and Delivery to Peptide loading
Compartments 36
2.2.1 Invariant Chain Isoforms 36
2.2.2 Effects of Cell Signaling on MHC Class II Transport 37
2.3 Phase II: Antigen Internalization and Processing 38
2.3.1 BCR mediated Antigen Internalization 39
2.3.2 Dendritic Cells and Macrophages 40
2.4 Phase III: Formation and Expression of Antigenic Peptide by
MHC Class II Molecules 41
2.4.1 Proteolytic Antigen Processing 41
2.4.2 Class II Peptide Loading 43
2.4.2.1 DM 44
2.4.2.2 DO 45
2.4.2.3 DO , DM , and BCR Mediated Antigen Processing 46
2.4.2.4 The Distribution of MHC Class II and Other Proteins Within MIIC 46
2.4.3 Cell surface Delivery of Peptide Class II Complexes 47
2.4.3.1 Exosomes 48
2.4.3.2 Signaling Properties of Peptide Class II Complexes 49
2.5 Conclusions 50
Acknowledgments 50
VIII I Contents
5.3 In Vitro T cell Development 100
5.4 Concluding Remarks 101
6 CD8 T cell Immunodominance, Repertoire, and Memory 109
Dalia E. Caddis, MichaelJ. Fuller, and Allan J. Zajac
6.1 Introduction 109
6.2 CD8 T Cell Responses and Memory 111
6.3 Analyzing the Memory Repertoire 114
6.4 Immunodominance 116
6.4.1 Antigen related Factors 117
6.4.2 T Cell related Factors 119
6.5 Epitope dependent Skewing of the Repertoire During Primary, Memory,
and Recall Responses 120
6.6 Heterologous Infections and Immunodominance 125
6.7 Chronic Infections and T cell Heterogeneity 127
6.8 Repertoire Limitation and Immunodominance 131
6.9 Impact of Epitope Variation 133
6.10 Concluding Remarks 135
IV Effects of Pathogens on the Immune Response 147
7 Listeria monocytogenes Infection and the CD8+ T Cell Hierarchy 149
Brandon B. Porter and John T. Harty
7.1 Introduction 149
7.2 Innate Immune Response to LM 150
7.3 Adaptive Immune Response to LM and Ag Presentation 151
7.4 Secreted Versus Non secreted Ag 152
7.5 The Hierarchy oftheCD8+T cell Responses to LM Epitopes 253
7.6 IFN y and the CD8 T cell Hierarchy 156
7.7 Timing of Ag Presentation and the CD8+T cell response 158
7.8 Conclusions 160
Acknowledgments 162
8 Immunodominance in Tuberculosis 263
David M. Lewinsohn andJoAnne L. Flynn
8.1 Immune Responses to Mycobacterium tuberculosis 163
8.2 B Cells 264
8.3 CD4T Cells 264
8.4 CD8T Cells 265
8.5 Antigen Processing and Presentation of Mtb Antigens 266
8.6 How Does Infection with Mtb Differ from Other Acute or Chronic
Infections? 268
Contents I IX
8.7 Immunodominance in the CD4 T cell Response 369
8.7.1 Human 169
8.7.2 Mouse 170
8.8 Immunodominance in the CD8 T cell Response 171
8.8.1 Human 171
8.8.2 Mouse 174
8.9 Non classically Restricted T Cells in TB 176
8.10 Conclusions and Implications for Future Research 177
Acknowledgments 178
9 T Cell Specificity and Respiratory Virus Infections 189
Sherry R. Crowe and David L Woodland
9.1 Introduction 189
9.2 Primary Immune Responses to Respiratory Virus Infections 190
9.3 Specificity of the Primary Immune Response 191
9.4 T Cell Memory to Respiratory Virus Infections 195
9.5 The Specificity of Memory T Cells 197
9.6 Recall Responses to Secondary Infections 198
9.7 Immunodominance Patterns in Recall Responses 199
9.8 Modification of Immunodominance Hierarchies by Vaccination 201
9.9 Conclusions 202
Acknowledgments 203
10 Effects of Pathogens on the Immune Response: HIV 209
Masafumi Takiguchi
10.1 Introduction 209
10.2 Identification of HIV 1 CTL Epitopes 211
10.2.1 Identification of HIV 1 CTL Epitopes by a Strategy
Using Overlapping Peptides 212
10.2.2 Identification of HIV 1 CTL Epitopes by the Strategy of Reverse
Immunogenetics 215
10.3 Immunodominant HIV 1 Epitopes Presented by
HLA Alleles Associated With Slow Progression to AIDS and Their
Escape Mutants 226
10.3.1 HLA B*57 restricted Immunodominant Epitopes and
Their Escape Mutants 216
10.3.2 HLA B*27 restricted Immunodominant Epitopes 218
10.3.3 HLA B*51 restricted Immunodominant Epitopes 218
10.4 Immunodominant HIV 1 Epitopes Presented by
HLA Alleles Associated With Rapid Progression to AIDS 219
10.5 Immunodominant HIV 1 Epitopes Presented by Other HLA
Alleles 219
10.5.1 HLA A 02 restricted Immunodominant Epitopes 219
10.5.2 HLA B 08 restricted Immunodominant Epitopes 220
Contents I VII
3 The Phenomenon of Immunodomination: Speculations on the Nature
of Immunodominance 57
Alessandro Sette and Roshni Sundaram
3.1 Introduction 57
3.2 MHC Binding, Cellular Processing, and T Cell Repertoire are Major
Determinants of Immunodominance 58
3.3 Previous Systematic Analysis of Immunodominance by Our Group 59
3.4 Cellular and Molecular Events in Immunodomination 62
3.5 Speculations on the Mechanism of Immunodomination 63
3.5.1 Involvement of APCs 63
3.5.2 Possible Involvement of the Immune Synapse in
Immunodomination 65
3.5.3 The Potential Role of MTOC in Immunodomination 67
3.6 Significance of Studying Immunodominance for Vaccine
Development 67
3.7 Conclusions 68
II Proteosome Specificity and Immuno Proteosomes 73
4 Endogenous Antigen Processing 75
Jonathan W. YewdeU
4.1 Unbottling the Genie 75
4.2 DRiPs to the Rescue 76
4.3 The Ubiquitin Proteasome Pathway 77
4.4 Pressing TDH Questions 80
4.4.1 Answer to Question 1 80
4.4.2 The Real World 81
4.4.3 Answer to Question 2 82
4.5 What Does This Have to Do With Immunodominance? 84
III Effect of the T Cell Repertoire on Dominance 89
5 Regulation of Early T Cell Development in the Thymus 91
Thomas M. Schmitt and Juan Carlos Zuniga Pflucker
5.1 Introduction 91
5.2 T Cell Development in the Thymus 92
5.2.1 Early T Cell Progenitors 95
5.2.2 Thymocyte Migration 96
5.2.3 Factors Regulating T cell Development 97
5.2.4 Notch and T cell Development 98
X I Contents
10.6 Escape Mutations and Viral Fitness 220
10.7 Effect of Nef mediated HLA Class I Downregulation
on Recognition of HIV 1 infected CD4+ T Cells by
HIV 1 specific CD8+ T Cells 222
10.8 Skewed Maturation of HIV 1 specific CD8+ T Cells 224
11 The Effects of Pathogens on the Immune System:
Viral Hepatitis 233
Mala Maini and Antonio Bertoletti
11.1 Introduction 233
11.2 The Viruses and the Disease 233
11.2.1 Genomic Organization 233
11.2.2 Prevalence 233
11.2.3 Hepatic Disease and Chronicity After Infection 235
11.3 Importance of CD4 and CD8 T Cells in HBV and HCV Control 235
11A Limitations of Existing Data 236
11.4.1 Low Frequency of HBV and HCV specific T Cells 237
11.4.2 Pre selection of Epitopes 23 7
11.4.3 Stage of Infection 238
11.4.4 Variations in Viral Inoculum 238
11.5 Hierarchy of T cell Responses During HBV Infection: Helper CD4 T cell
Response 238
11.6 Hierarchy of T cell Responses During HBV Infection: Cytotoxic T cell
Response 240
11.7 Hierarchy of HCV Proteins 243
11.8 Hierarchy of H CV Epitopes 244
11.9 Immunodominance and Liver Pathology 248
11.10 Concluding Remarks 249
12 Immunodominance in the T Cell Response to Herpesviruses 255
Michael W. Munks and Ann B. Hill
12.1 Introduction 255
12.2 General Considerations 256
12.2.1 Herpesviruses: A Brief Virological Primer 256
12.2.2 A General Framework for Thinking About Immunodominance
in the T Cell Response to Herpesvirus Infections 258
12.3 Immunodominance in the CD8 T Cell Response to the
Three Classes of Herpesvirus 260
12.3.1 Alphaherpesviruses 260
12.3.1.1 Human Studies: Immunodominance of Structural
Virion Proteins that can be Presented in the Face of Immune
Evasion 260
12.3.1.2 Mouse Studies of HSV 263
12.3.1.3 The Remarkable Immunodominance of gB SSIEFARL in B6 Mice 262
Contents I XI
12.3.2 Betaherpesviruses 263
12.3.2.1 The Acute CD8 T Cell Response to MCMV 263
12.3.2.2 The Memory CD8 T Cell Response to MCMV Becomes More Focused
Over Time 264
12.3.2.3 The Impact of Interference With Antigen Presentation
by MCMV s Viprs on the CD8 T Cell Response 265
12.3.2.4 The Memory T Cell Response to HCMV 267
12.3.2.5 Increasing Size and Oligoclonaliry of the CD8 T cell Response
to HCMV With Age 268
12.3.2.6 What Accounts for Memory Inflation and TCR V/? Focusing? 268
12.3.3 HCMV and Immunosenescence 271
12.3.4 T Cell Cross reactivity Between Betaherpesviruses 272
12.3.5 Gammaherpresviruses 272
12.3.6 Epstein Barr Virus 273
12.3.6.1 Interference with the MHC Class I Pathway by EBV 273
12.3.6.2 Overview of the Response to Lytic and Latent Proteins 274
12.3.6.3 Immunodominance Hierarchy for the Acute Response
to Lytic Cycle Proteins 274
12.3.6.4 Kinetics of the Response to Lytic Proteins 276
12.3.6.5 Immunodominance Hierarchy of the Response to Latent Proteins 276
12.3.6.6 Kinetics of the Response to Latent Proteins 277
12.3.6.7 Immunodominance of the LC13 TCR in Responding to HLA B8/
FLRGRAYGL: An Extreme Example of TCR Immunodominance 278
12.4 Concluding Remarks 279
Index 285
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| indexdate | 2024-07-09T20:11:15Z |
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| spelling | Immunodominance the choice of the immune system ed. by Jeffrey A. Frelinger Weinheim Wiley-VCH 2006 XXV, 288 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Immunreaktion - Regulation - Aufsatzsammlung Antibody Formation physiology Antigen Presentation physiology Antigens Immune System physiology Immune response Regulation Immunoglobulins Immunreaktion (DE-588)4133841-8 gnd rswk-swf Regulation (DE-588)4049075-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Immunreaktion (DE-588)4133841-8 s Regulation (DE-588)4049075-0 s DE-604 Frelinger, Jeffrey A. Sonstige (DE-588)130668435 oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013352242&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Immunodominance the choice of the immune system Immunreaktion - Regulation - Aufsatzsammlung Antibody Formation physiology Antigen Presentation physiology Antigens Immune System physiology Immune response Regulation Immunoglobulins Immunreaktion (DE-588)4133841-8 gnd Regulation (DE-588)4049075-0 gnd |
| subject_GND | (DE-588)4133841-8 (DE-588)4049075-0 (DE-588)4143413-4 |
| title | Immunodominance the choice of the immune system |
| title_auth | Immunodominance the choice of the immune system |
| title_exact_search | Immunodominance the choice of the immune system |
| title_full | Immunodominance the choice of the immune system ed. by Jeffrey A. Frelinger |
| title_fullStr | Immunodominance the choice of the immune system ed. by Jeffrey A. Frelinger |
| title_full_unstemmed | Immunodominance the choice of the immune system ed. by Jeffrey A. Frelinger |
| title_short | Immunodominance |
| title_sort | immunodominance the choice of the immune system |
| title_sub | the choice of the immune system |
| topic | Immunreaktion - Regulation - Aufsatzsammlung Antibody Formation physiology Antigen Presentation physiology Antigens Immune System physiology Immune response Regulation Immunoglobulins Immunreaktion (DE-588)4133841-8 gnd Regulation (DE-588)4049075-0 gnd |
| topic_facet | Immunreaktion - Regulation - Aufsatzsammlung Antibody Formation physiology Antigen Presentation physiology Antigens Immune System physiology Immune response Regulation Immunoglobulins Immunreaktion Regulation Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013352242&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT frelingerjeffreya immunodominancethechoiceoftheimmunesystem |