Gene regulation: a eukaryotic perspective
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
New York, NY [u.a.]
Taylor & Francis
2005
|
| Edition: | 5. ed. |
| Series: | BIOS advanced text
|
| Subjects: | |
| Online Access: | Table of contents Inhaltsverzeichnis |
| Physical Description: | X, 374 S. Ill., graph. Darst. |
| ISBN: | 0415365104 |
Staff View
MARC
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| 100 | 1 | |a Latchman, David S. |d 1956- |e Verfasser |0 (DE-588)120416859 |4 aut | |
| 245 | 1 | 0 | |a Gene regulation |b a eukaryotic perspective |c David S. Latchman |
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| 264 | 1 | |a New York, NY [u.a.] |b Taylor & Francis |c 2005 | |
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| 650 | 7 | |a Expressão gênica |2 larpcal | |
| 650 | 7 | |a Regulação gênica |2 larpcal | |
| 650 | 7 | |a Transcrição gênica |2 larpcal | |
| 650 | 4 | |a Eukaryotic Cells | |
| 650 | 4 | |a Eukaryotic cells | |
| 650 | 4 | |a Gene Expression Regulation | |
| 650 | 4 | |a Gene expression | |
| 650 | 4 | |a Genetic regulation | |
| 650 | 4 | |a Genetic transcription | |
| 650 | 4 | |a Transcription, Genetic | |
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Record in the Search Index
| _version_ | 1804133583314485248 |
|---|---|
| adam_text | viii Contents
3.3 Post transcriptional events 54
Capping ss
Polyadenylation s/
RNA splicing 59
Coupling of transcription and RNA processing within the nucleus 64
RNA transport 66
Translation 70
3.4 Conclusions 74
References
79
4 Regulation at transcription
Summary Vt
4.1 Introduction ^
4.2 Evidence for transcriptional regulation 7^
Evidence from studies of nuclear RNA 79
Evidence from pulse labeling studies °4
Evidence from nuclear run on assays
Evidence from polytene chromosomes °^
4.3 Regulation at transcriptional elongation 91
Initiation of transcription }_
Transcriptional elongation
4.4 Conclusions ^
References
99
5 Post transcriptional regulation *
Summary JJ
5.1 Regulation after transcription?
5.2 Regulation of RNA splicing 10
RNA splicing }00
Alternative RNA splicing 1
Mechanism of alternative RNA splicing ®
Generality of alternative RNA splicing }
5.3 RNA editing n°
5.4 Regulation of RNA transport 1J^
Transport from nucleus to cytoplasm
Transport within the cytoplasm „
5.5 Regulation of RNA stability 1^
Cases of regulation by alterations in RNA stability }z.
Mechanisms of stability regulation Vl
Role of stability changes in regulation of gene expression ^~
5.6 Regulation of translation ^
Cases of translational control ~~
Mechanism of translational control :^q
Significance of translational control :^Q
5.7 Inhibition of gene expression by small RNAs 1f,
5.8 Conclusions U
References 142
6 Transcriptional control chromatin structure 7
Summary 14
6.1 Introduction ^
6.2 Commitment to the differentiated state and its stability 15
Contents ix
6.3 Chromatin structure 153
6.4 Changes in chromatin structure in active or potentially active genes 157
Active DNA is organized in a nudeosomal structure 157
Sensitivity of active chromatin to DNasel digestion 158
6.5 Alterations in DNA methylation in active or potentially active genes 162
Nature of DNA methylation 162
Evidence that DNA methylation plays a role in regulating 164
chromatin structure
Mechanism by which DNA methylation affects chromatin structure 166
6.6 Modification of histones in the chromatin of active or potentially 168
active genes
Acetylation 169
Ubiquitination and sumoylation 172
Phosphorylation 173
Methylation 175
6.7 Changes in chromatin structure in the regulatory regions of active 178
or potentially active genes
DNasel hypersensitive sites 178
Chromatin remodeling by proteins capable of displacing 184
nucleosomes or altering their structure
6.8 Other situations in which chromatin structure is regulated 189
X chromosome inactivation 190
Genomic imprinting 192
6.9 Conclusions 196
References 197
7 Transcriptional control DNA sequence elements 203
Summary 203
7.1 Introduction 203
Relationship of gene regulation in prokaryotes and eukaryotes 203
Coordinately regulated genes are not linked in eukaryotes 203
The Britten and Davidson model for the coordinate regulation 205
of unlinked genes
7.2 Short sequence elements located within or adjacent to the gene promoter 206
Short regulatory elements 206
The 70 kDa heat shock protein gene 207
Other response elements 211
DNA binding by short sequence elements 213
Mechanism of action of promoter regulatory elements 219
7.3 Enhancers 220
Regulatory sequences that act at a distance 220
Tissue specific activity of enhancers 221
Mechanism of action of enhancers 224
7.4 Negatively acting sequence elements 229
Silencers 229
Insulators 231
7.5 Locus control regions 232
The locus control region 232
Mechanism of action ofLCRs 234
7.6 Regulation of transcription by RNA polymerases I and III 236
7.7 Conclusions 239
References 240
x Contents
8 Transcriptional control transcription factors 243
Summary 243
8.1 Introduction 243
8.2 DNA binding by transcription factors 247
Introduction 247
The helix turn helix motif 247
The zinc finger motif 256
The leucine zipper, the helix loop helix motif and the basic 264
DNA binding domain
Other DNA binding domains 267
8.3 Regulation of transcription 268
Introduction 268
Activation domains 269
How is transcription activated? 272
Repression of transcription 282
8.4 What regulates the regulators? 286
Introduction 286
Regulated synthesis of transcription factors 287
Regulated activity of transcription factors 289
8.5 Conclusions 299
References 301
9 Gene regulation and human disease 307
Summary 307
9.1 Gene regulation and human disease 307
Transcriptional regulators 308
Chromatin remodeling factors 312
Post transcriptional events 314
9.2 Proto oncogenes 315
9.3 Elevated expression of oncogenes 319
9.4 Transcription factors as oncogenes 324
Fos, Jun and API 325
v erbA and the thyroid hormone receptor 327
Other transcription factor related oncogenes 331
9.5 Anti oncogenes 334
Nature of anti oncogenes 334
pS3 335
The retinoblastoma protein 339
Other anti oncogene transcription factors 342
9.6 Oncogenes/anti oncogenes: the relationship of cancer and 343
normal cellular function
9.7. Gene regulation and therapy of human diseases 345
9.8. Conclusions 351
References 352
10 Conclusions and future prospects 357
Index 363
|
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| isbn | 0415365104 |
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| spelling | Latchman, David S. 1956- Verfasser (DE-588)120416859 aut Gene regulation a eukaryotic perspective David S. Latchman 5. ed. New York, NY [u.a.] Taylor & Francis 2005 X, 374 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier BIOS advanced text Células eucarióticas larpcal Expressão gênica larpcal Regulação gênica larpcal Transcrição gênica larpcal Eukaryotic Cells Eukaryotic cells Gene Expression Regulation Gene expression Genetic regulation Genetic transcription Transcription, Genetic Eukaryoten (DE-588)4070991-7 gnd rswk-swf Genregulation (DE-588)4122166-7 gnd rswk-swf Eukaryoten (DE-588)4070991-7 s Genregulation (DE-588)4122166-7 s 1\p DE-604 http://www.loc.gov/catdir/toc/ecip0510/2005009966.html Table of contents HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013342575&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Latchman, David S. 1956- Gene regulation a eukaryotic perspective Células eucarióticas larpcal Expressão gênica larpcal Regulação gênica larpcal Transcrição gênica larpcal Eukaryotic Cells Eukaryotic cells Gene Expression Regulation Gene expression Genetic regulation Genetic transcription Transcription, Genetic Eukaryoten (DE-588)4070991-7 gnd Genregulation (DE-588)4122166-7 gnd |
| subject_GND | (DE-588)4070991-7 (DE-588)4122166-7 |
| title | Gene regulation a eukaryotic perspective |
| title_auth | Gene regulation a eukaryotic perspective |
| title_exact_search | Gene regulation a eukaryotic perspective |
| title_full | Gene regulation a eukaryotic perspective David S. Latchman |
| title_fullStr | Gene regulation a eukaryotic perspective David S. Latchman |
| title_full_unstemmed | Gene regulation a eukaryotic perspective David S. Latchman |
| title_short | Gene regulation |
| title_sort | gene regulation a eukaryotic perspective |
| title_sub | a eukaryotic perspective |
| topic | Células eucarióticas larpcal Expressão gênica larpcal Regulação gênica larpcal Transcrição gênica larpcal Eukaryotic Cells Eukaryotic cells Gene Expression Regulation Gene expression Genetic regulation Genetic transcription Transcription, Genetic Eukaryoten (DE-588)4070991-7 gnd Genregulation (DE-588)4122166-7 gnd |
| topic_facet | Células eucarióticas Expressão gênica Regulação gênica Transcrição gênica Eukaryotic Cells Eukaryotic cells Gene Expression Regulation Gene expression Genetic regulation Genetic transcription Transcription, Genetic Eukaryoten Genregulation |
| url | http://www.loc.gov/catdir/toc/ecip0510/2005009966.html http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013342575&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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