Pharmacology and pathophysiology of the control of breathing:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Boca Raton, FL [u.a.]
Taylor & Francis
2005
|
| Schriftenreihe: | Lung biology in health and disease
202 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | 849 S. Ill., graph. Darst. 24 cm |
| ISBN: | 0824758900 9780824758905 |
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| 650 | 4 | |a Lungs |x Pathophysiology | |
| 650 | 4 | |a Pulmonary pharmacology | |
| 650 | 4 | |a Inhalation anesthesia | |
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Datensatz im Suchindex
| _version_ | 1804133578013933568 |
|---|---|
| adam_text | CONTENTS
I. NEUROPHARMACOLOGY AND PHYSIOLOGY 1
1. Peripheral Chemoreceptors: Sensors of Metabolic Status 3
Colin A. Nurse
I. Introduction 3
II. Cellular Organization and Innervation of the
Carotid Body 4
III. Carotid Body Chemoreceptors: O2 Sensitive
K+ Channels 6
IV. What is the O2 Sensor and How is it Linked to K+
Channel(s)? 8
V. Role of Fast Acting Neurotransmitters in
Chemosensory Processing 8
VI. Glucose Sensing in the Carotid Body 12
VII. Neuromodulation in the Carotid Body 12
VIII. Future Directions 15
Acknowledgments 15
References 16
2. Central Chemoreceptors 21
Luc J. Teppema and Albert Dahan
I. Introduction 21
Contents
II. Location of Central Chemoreceptors 24
III. Mechanism of Central Chemoreception 38
IV. Central Chemoreceptors and Breathing 47
References 55
3. Suprapontine Control of Breathing 71
Shakeeb H. Moosavi, David Paydarfar, and Steven A. Shea
I. Introduction 71
II. Definitions and Terminology 72
III. Volitional Control 72
IV. Involuntary Emotional Influences 75
V. Tonic Excitatory and Inhibitory Drives 84
VI. Interaction between Behavioral and
Automatic Control 86
VII. Learned Respiratory Behaviors 88
VIII. Summary 90
Acknowledgments 91
References 91
4. Measurement of Drug Effects on Ventilatory Control 103
Denham S. Ward
I. Introduction 103
II. Measurement Techniques 106
III. Quantification of Drug Pharmacodynamics 108
IV. Resting Measurements 109
V. Hypercapnic Ventilatory Response 110
VI. Hypoxic Ventilatory Response 117
VII. Changes in Airway Pressure 120
VIII. Other Stimuli 122
References 124
5. Response Surface Modeling of Drug Interactions:
Model Selection and Multimodel Inference Using
the Bootstrap 133
Erik Olofsen and Albert Dahan
I. Introduction 133
II. Pharmacodynamic Interaction Models 134
III. Model Selection and Multimodel Inference 137
IV. The Bootstrap 140
V. Applications 143
VI. Conclusions 151
References 152
Contents
6. Respiratory Neuroplasticity: Respiratory Gases,
Development, and Spinal Injury 155
David D. Fuller, Gordon S. Mitchell, and
Ryan W. Bavis
I. Introduction 155
II. Plasticity Induced by Respiratory Gases in
Adult Mammals 158
III. Developmental Plasticity and the Control of
Breathing 174
IV. Sex Hormones 187
V. Spinal Cord Injury (SCI) and Respiratory Plasticity 187
VI. Conclusion 198
Acknowledgments 199
References 199
7. Airway Reflexes in Humans 225
Takashi Nishino
I. Introduction 225
II. Central Nervous System 226
III. Afferent Innervation of the Upper Airway and
Receptors 226
IV. Reflex Responses from the Upper Airway 229
V. Afferent Innervation of the Lower Airway and
Receptors 234
VI. Integrative Aspects of the Airway Reflexes
Elicited from the Lower Airways 238
VII. Clinical Problems Associated with Airway Reflexes 244
VIII. Conclusions 250
Acknowledgments 251
References 251
8. Inheritance and Ventilatory Behavior in Animal Models 261
Kingman P. Strohl
I. Introduction 262
II. Evidence and Implications for Inheritance of
Ventilatory Traits in Humans 262
III. Targeting Ventilatory Traits in Small Animals 266
IV. Evidence for the Inheritance of Ventilatory
Traits in Rodents 271
V. Estimates of the Strength of Inheritance 274
VI. Studies of Gene Effects in Rodent Models 276
VII. A Physiogenetic Map of Ventilatory Behavior 279
Contents
VIII. Overview and Future Directions 282
Acknowledgments 283
References 283
II. PATHOPHYSIOLOGY 293
9. Congenital Central Hypoventilation Syndrome: Should
We Rename it Congenital Autonomopathy? 295
David Gozal
I. Introduction 295
II. Definition and Diagnosis 296
III. Pathophysiology 298
IV. Animal Models 300
V. Structural Central Nervous System
Abnormalities 300
VI. Physiologic Abnormalities of Ventilatory
Control 301
VII. Autonomic Nervous System Dysfunction 304
VIII. Summary and Conclusions 304
Acknowledgment 304
References 304
10. Upper Airway Obstruction in Sleep Apnea 313
Susheel P. Patil, Hartmut Schneider, Philip L. Smith,
and Alan R. Schwartz
I. Introduction 313
II. Epidemiologic and Clinical Risk Factors 314
III. Pathogenesis of Upper Airway Obstruction 317
IV. Therapeutic Implications 333
V. Summary and Conclusions 335
References 336
11. High Altitude 357
Frank L. Powell and Philip E. Bickler
I. Introduction 357
II. Ventilatory Response to High Altitude 358
III. Time Domains of the HVR 360
IV. Increases in the Hypercapnic Ventilatory
Response (HCVR) with Acclimatization 372
V. High Altitude Diseases and Ventilatory Control 372
References 376
Contents
12. Obesity and the Control of Breathing 383
Khalid F. Almoosa and Shahrokh Javaheri
I. Introduction 383
II. Overview of Obesity 384
III. Effects of Obesity on the Respiratory System 388
IV. Disorders of Ventilatory Control Associated
with Obesity 399
V. Effects of Treatment of Obesity and OSAH on
Ventilatory Control and PaCo2 408
VI. Conclusion 412
References 412
III. CLINICAL PHARMACOLOGY 423
13. Pain Management and Regional Anesthesia 425
Peter L. Bailey and Rajbala Thakur
I. Introduction 425
II. Postoperative Respiratory Dysfunction 426
III. Other Effects of Pain and Surgical Trauma 433
IV. Pain Control and Chronic Pain 438
V. Effects of Pain and Pain Management on
Respiratory Function 438
VI. Regional Analgesia 454
VII. Other Analgesic Agents 473
VIII. Pre Emptive Analgesia 483
IX. Perioperative Analgesia and Pulmonary Outcome 483
X. Cardiac Surgery 487
XI. Summary 489
References 490
14. Ventilatory Effects of Medications Used for Moderate
and Deep Sedation 513
Jeffrey B. Gross and Dante A. Cerza
I. Introduction 513
II. Sedatives 516
III. Opioids 540
IV. Drug Combinations 553
V. Strategies for Minimizing Respiratory
Risks of Sedation 557
VI. Conclusion 559
References 559
Contents
15. Central Effects of General Anesthesia 571
Eckehard A.E. Stuth, Edward J. Zuperku, and Astrid G. Stucke
I. Introduction 571
II. General Effects of Anesthetics on Respiration 572
III. Anesthetic Effects on Fast Synaptic Neurotransmission 583
IV. Overview of the Brainstem Respiratory Network 597
V. Paradigms of Anesthetic Effects on Respiratory
Neurotransmission 613
VI. Summary and Outlook 630
Acknowledgment 630
References 630
16. The Influence of Inhalational Anesthetics on Carotid
Body Mediated Ventilatory Responses 653
Albert Dahan, Raymonda Romberg, Elise Sarton, and
Luc J. Teppema
I. Introduction 653
II. Influence of Inhalational Anesthetics on the Ventilatory
Response to Hypoxia and Hypercapnia 655
III. Pain and Behavioral Responses 671
IV. Short Term Potentiation of Breathing (STP) 674
V. Conclusions 677
References 677
17. General Anesthesia and Respiratory Mechanics 687
David O. Warner
I. Introduction 687
II. Normal Function of the Respiratory Pump 688
III. Effects of Anesthesia on Chest Wall Mechanics 694
IV. Effects of Anesthesia on Upper Airway Mechanics 709
V. Effects of Anesthesia on Lung Mechanics 714
VI. Summary 722
References 722
18. Recovery from Anesthesia 737
Shiroh Isono and Jacob Rosenberg
I. Introduction 737
II. Impairment and Recovery of Upper Airway
Function after Anesthesia 738
III. Impairment and Recovery of Chemical
Control of Breathing after Anesthesia 750
Contents
IV. Impairment and Recovery of Lung Function
after Surgery 752
V. Late Postoperative Nocturnal Hypoxemia 755
References 764
19. Neuromuscular Blocking Agents and Ventilation 779
Lars I. Eriksson
I. Regulation of Breathing 780
II. Respiratory Pump Function and the
Control of the Upper Airways 785
References 789
20. Cardiovascular Drugs and the Control of Breathing 793
Denham S. Ward and Suzanne Karan
I. Introduction 793
II. Catecholamine Agonists and Antagonists 794
III. Renin Angiotensin System 800
IV. Calcium Channel Blockers 801
V. Purinoceptor Agonists and Antagonists 802
VI. Other Agents 804
References 805
Author Index 815
Subject Index 823
|
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| spelling | Pharmacology and pathophysiology of the control of breathing ed. by Denham S. Ward ... Boca Raton, FL [u.a.] Taylor & Francis 2005 849 S. Ill., graph. Darst. 24 cm txt rdacontent n rdamedia nc rdacarrier Lung biology in health and disease 202 Includes bibliographical references and index Respiration Regulation Lungs Pathophysiology Pulmonary pharmacology Inhalation anesthesia Physiologie (DE-588)4045981-0 gnd rswk-swf Regulationsstörung (DE-588)4678063-4 gnd rswk-swf Atemregulation (DE-588)4219519-6 gnd rswk-swf Inhalationsnarkotikum (DE-588)4027001-4 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Atemregulation (DE-588)4219519-6 s Physiologie (DE-588)4045981-0 s DE-604 Inhalationsnarkotikum (DE-588)4027001-4 s Regulationsstörung (DE-588)4678063-4 s b DE-604 Ward, Denham S. Sonstige oth Lung biology in health and disease 202 (DE-604)BV000008326 202 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013339312&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Pharmacology and pathophysiology of the control of breathing Lung biology in health and disease Respiration Regulation Lungs Pathophysiology Pulmonary pharmacology Inhalation anesthesia Physiologie (DE-588)4045981-0 gnd Regulationsstörung (DE-588)4678063-4 gnd Atemregulation (DE-588)4219519-6 gnd Inhalationsnarkotikum (DE-588)4027001-4 gnd |
| subject_GND | (DE-588)4045981-0 (DE-588)4678063-4 (DE-588)4219519-6 (DE-588)4027001-4 (DE-588)4143413-4 |
| title | Pharmacology and pathophysiology of the control of breathing |
| title_auth | Pharmacology and pathophysiology of the control of breathing |
| title_exact_search | Pharmacology and pathophysiology of the control of breathing |
| title_full | Pharmacology and pathophysiology of the control of breathing ed. by Denham S. Ward ... |
| title_fullStr | Pharmacology and pathophysiology of the control of breathing ed. by Denham S. Ward ... |
| title_full_unstemmed | Pharmacology and pathophysiology of the control of breathing ed. by Denham S. Ward ... |
| title_short | Pharmacology and pathophysiology of the control of breathing |
| title_sort | pharmacology and pathophysiology of the control of breathing |
| topic | Respiration Regulation Lungs Pathophysiology Pulmonary pharmacology Inhalation anesthesia Physiologie (DE-588)4045981-0 gnd Regulationsstörung (DE-588)4678063-4 gnd Atemregulation (DE-588)4219519-6 gnd Inhalationsnarkotikum (DE-588)4027001-4 gnd |
| topic_facet | Respiration Regulation Lungs Pathophysiology Pulmonary pharmacology Inhalation anesthesia Physiologie Regulationsstörung Atemregulation Inhalationsnarkotikum Aufsatzsammlung |
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