RNA interference technology: from basic science to drug development
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Cambridge [u.a.]
Cambridge Univ. Press
2005
|
| Edition: | 1. publ. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XXXIII, 510 S. Ill., graph. Darst. |
| ISBN: | 0521836778 |
Staff View
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Record in the Search Index
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| adam_text | Contents
Foreword by Andrew Fire page xi
Foreword by Marshall Nirenberg xiii
List of Contributors xv
Introduction 1
Krishnarao Appasani
Section one. Basic RNAi, siRNA, microRNAs and gene silencing
mechanisms
1 RNAi beginnings. Overview of the pathway in
C. elegans 17
Alia Grishok
2 Dicer in RNAi: Its roles in vivo and utility in vitro 29
Jason W. Myers and James E. Ferrell, Jr.
3 Genes required for RNA interference 55
Nathaniel R. Dudley, Ahmad Z. Amin, and Bob Goldstein
4 MicroRNAs: A small contribution from worms 69
Amy E. Pasquinelli
5 miRNAs in the brain and the application of RNAi
to neurons 84
Anna M. Krichevsky, Shih Chu Kao, Li Huei Tsai, and Kenneth S. Kosik
Section two. Design, synthesis of siRNAs
6 Design and synthesis of small interfering RNA (siRNA) 103
Queta Boese, William S. Marshall, and Anastasia Khvorova
7 Automated design and high throughput chemical synthesis
of siRNA 118
Yerramilli V. B. K. Subrahmanyam and Eric Lader
8 Rational design of siRNAs with the Sfold software 129
Ye Ding and Charles E. Lawrence
9 Enzymatic production of small interfering RNAs 139
Muhammad Sohail and Graeme Doran
iii Contents
Section three. Vector development and in vivo, in vitro and in ovo
delivery methods
10 Six methods of inducing RNAi in mammalian cells 147
Kathy Latham, Vince Pallotta, Lance Ford, Mike Byrom, Mehdi Banan,
Po Tsan Ku, and David Brown
11 Viral delivery of shRNA 161
Ying Mao, Chris Mello, Laurence Lamarcq, Brad Scherer, Thomas Quinn,
Patty Wong, and Andrew Farmer
12 siRNA delivery by lentiviral vectors: Design and applications 174
Oded Singer, Gustavo Tiscornia, and Inder Verma
13 Liposomal delivery of siRNAs in mice 186
Mouldy Sioud and Dag R. Scrensen
14 Chemical modifications to achieve increased stability and sensitive
detection of siRNA 194
Philipp Hadwiger and Hans Peter Vornlocher
15 RNA interference in postimplantation mouse embryos 207
Frank Buchholz, Federico Calegari, Ralf Kittler, and Wieland B. Huttner
16 In ovo RNAi opens new possibilities for functional genomics in
vertebrates 220
Dimitris Bourikas, Thomas Baeriswyl, Rejina Sadhu, and Esther T. Stoeckli
Section four. Gene silencing in model organisms
17 Practical applications of RNAi in C. elegans 235
Karen E. Stephens, Olivier Zugasti, Nigel J. O Neil, and Patricia E. Kuwabara
18 Inducible RNAi as a forward genetic tool in Trypanosoma brucei 247
Mark E. Drew, Shawn A. Motyka, James C. Morris, Zefeng Wang,
and Paul T. Englund
19 RNA mediated gene silencing in fission yeast 257
Greg M. Arndt
20 RNA silencing in filamentous fungi: Mucor cicdnelloides
as a model organism 270
Rosa M. Ruiz Vazque
21 RNAi and gene silencing phenomena mediated by viral suppressors
in plants 280
Ramachandran Vanitharani, Padmanabhan Chellappan, and
Claude M. Fauquet
Section five. Drug target validation
22 Delivering siRNA in vivo for functional genomics and novel
therapeutics 303
Patrick Y. Lu and Martin C. Woodle
23 The role of RNA interference in drug target validation: Application
to Hepatitis C 318
Antje Ostareck Lederer, Sandra Clauder Munster, Rolf Thermann, Maria
Polycarpou Schwarz, Marc Gentzel, Matthias Wilm, and Joe D. Lewis
24 RNAi in the drug discovery process 331
Steven A. Haney, Peter Lapan, Jeff Aalfs, Chris Childs, Paul Yaworsky, and
Chris Miller
Contents ix
25 RNA interference technology in the discovery and validation of
draggable targets 347
Neil J. Clarke, John E. Bisi, Caretha L. Creasy, Michael K. Dush, KrisJ.
Fisher, John M. Johnson III, Christopher J. A. Ring, and Mark R. Edbrooke
Section six. Therapeutic and drug development
26 RNAi mediated silencing of viral gene expression and replication 363
Derek M. Dykxhoom
27 RNAi in drug development: Practical considerations 384
Dmitry Samarsky, Margaret Taylor, Mark A. Kay, and Anton P. McCaffrey
28 RNA interference studies in liver failure 396
Lars Zender, Michael P. Manns, and Stefan Kubicka
29 RNAi applications in living animal systems 406
Lisa Scherer and John J. Rossi
Section seven. High throughput genome wide RNAi analysis
30 High throughput RNAi by soaking in Caenorhabtis elegans 419
Asako Sugimoto
31 Tools for integrative genomics: Genome wide RNAi and expression
profiling in Drosophila 433
Michael Boutros and Marc Hild
32 Microarray analysis and RNA silencing to determine genes
functionally important in mesothelioma 447
Maria E. Ramos Nino and Brooke T. Mossman
33 High throughput RNA interference 470
Howard Y. Chang, Nancy N. Wang, and Jen Tsan Chi
34 Generation of highly specific vector based shRNAi libraries
directed against the entire human genome 480
Makoto Miyagishi, Sahohime Matsumoto, Takashi Futami, Hideo Akashi,
Krishnarao Appasani, Yasuomi Takagi, Shizuyo Sutou, Takashi Kadowaki,
Ryozo Nagai, and Kazunari Taira
Index 497
|
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| discipline | Biologie |
| edition | 1. publ. |
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| language | English |
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| spelling | RNA interference technology from basic science to drug development ed. by Krishnarao Appasani 1. publ. Cambridge [u.a.] Cambridge Univ. Press 2005 XXXIII, 510 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Inactivation génique Petits ARN interférents Rna de transferência larpcal Rna larpcal Ácidos nucléicos larpcal Gene silencing Small interfering RNA Geninaktivierung (DE-588)4820638-6 gnd rswk-swf RNS-Interferenz (DE-588)4802706-6 gnd rswk-swf RNS-Interferenz (DE-588)4802706-6 s Geninaktivierung (DE-588)4820638-6 s DE-604 Appasani, Krishnarao 1959- Sonstige (DE-588)135659663 oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013336972&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | RNA interference technology from basic science to drug development Inactivation génique Petits ARN interférents Rna de transferência larpcal Rna larpcal Ácidos nucléicos larpcal Gene silencing Small interfering RNA Geninaktivierung (DE-588)4820638-6 gnd RNS-Interferenz (DE-588)4802706-6 gnd |
| subject_GND | (DE-588)4820638-6 (DE-588)4802706-6 |
| title | RNA interference technology from basic science to drug development |
| title_auth | RNA interference technology from basic science to drug development |
| title_exact_search | RNA interference technology from basic science to drug development |
| title_full | RNA interference technology from basic science to drug development ed. by Krishnarao Appasani |
| title_fullStr | RNA interference technology from basic science to drug development ed. by Krishnarao Appasani |
| title_full_unstemmed | RNA interference technology from basic science to drug development ed. by Krishnarao Appasani |
| title_short | RNA interference technology |
| title_sort | rna interference technology from basic science to drug development |
| title_sub | from basic science to drug development |
| topic | Inactivation génique Petits ARN interférents Rna de transferência larpcal Rna larpcal Ácidos nucléicos larpcal Gene silencing Small interfering RNA Geninaktivierung (DE-588)4820638-6 gnd RNS-Interferenz (DE-588)4802706-6 gnd |
| topic_facet | Inactivation génique Petits ARN interférents Rna de transferência Rna Ácidos nucléicos Gene silencing Small interfering RNA Geninaktivierung RNS-Interferenz |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013336972&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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