Biophysical aspects of transmembrane signaling: with 5 tables
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| Other Authors: | |
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| Format: | Book |
| Language: | English |
| Published: |
Berlin ; Heidelberg ; New York
Springer
2005
|
| Series: | Springer series in biophysics
Vol. 8 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XVIII, 321 S. Ill., graph. Darst. |
| ISBN: | 9783540250647 3540250646 |
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| adam_text | S Damjanovich (Ed )
Biophysical Aspects
ofTransmembrane
Signaling
With 41 Figures, 17 in Color and 5 Tables
4y Springer
VII
Contents
CHAPTER 1
The Impact of Environmental Signals on the Growth
and Survival of Human T Cells 1
FERNANDO A AROSA, ANA M FONSECA, SUSANA G SANTOS,
NUNO L ALVES
1 1 Introduction 1
1 2 Red Blood Cells: From Carriers of Respiratory Gases
to Modulators of T Cell Survival 1
121 RBC: Carriers of O2 and CO2 1
122 Novel Functions of RBC 2
123 Are Transmembrane Signals Involved in the Regulation
of T Cell Survival Induced by RBC? 4
124 Are RBC-Derived Vesicles Carriers of the RBC Bioactivity? 6
1 3 Epithelial Cells and IL-15: The Perfect Combination
for CD8+T Cell Differentiation 7
131 Interleukin-15: Major Features of a Multifunctional Cytokine 7
132 Physiological Expression of IL-15:
The Epithelial Cell Connection ^ 9
133 Epithelial Tissues as Sites for CD8-P• T Cell Positioning
and Survival 10
134 Epithelial Cells Deliver Activation and Survival Signals
Preferentially to CD8+T Cells - 11
1 4 MHC-Class I Molecules: Pleiotropic Transmembrane
Signaling Structures 12
141 The MHC Locus 12
142 Folding and Assembly of MHC-Class I Molecules 13
143 Cell-Surface MHC-Class I Molecules: trans Interactions
with the TCR and NK Receptors 13
144 Cell-Surface MHC-Class I Molecules: cis Interactions
with Growth Receptors 15
145 Cell-Surface MHC-Class I Molecules in T Cells:
Are Misfolding and cis Association Related Events? 16
146 MHC-Class I cis Associations and the Regulation
ofT Cell Growth and Survival 17
1 5 Concluding Remarks and Future Prospects 18
References 20
1VI III Contents
o
CHAPTER 2
Novel Single Cell Fluorescence Approaches
in the Investigation of Signaling at the Cellular Level 33
PETER NAGY, GYORGY VEREB, JANINE N POST, ELZA FRIEDLANDER,
JANOS SZOLLO SI
2 1 Introduction
2 2 Subcellular and Temporal Resolution vs Statistical Reliability 33
2 3 Labeling of Cells with Fluorescent Molecules 35
231 Monoclonal Antibodies and Their Derivatives 35
232 Visible Fluorescent Proteins 36
233 Novel Applications ofVFPs in Cell Biology 40
234 Labeling of Tetracysteine Motifs with Biarsenical Derivatives
of Fluorophores 42
235 Quantum Dots 43
236 Steric Effects of Fluorescent Labeling 45
2 4 Methods to Detect Fluorescence in Cell Biological Applications 46
241 Spatial Resolution of Fluorescence Microscopy 46
242 Confocal Microscopy 47
243 Multiphoton Microscopy 47
244 Focusing Microscopes Breaking the Abbe l imit 48
245 Scanning Near-Field Optical Microscopy (SNOM) 49
2 5 Fluorescence Resonance Energy Transfer (FRET) 49
251A Brief Introduction to FRET 49
252 Different Ways to Measure FRET 51
2521 Donor Quenching, Sensitized Emission of the Acceptor 51
2522 Acceptor Photobleaching, Photochromic FRET 52
2523 Donor Photobleaching 53
2524 FRET-Sensitized Photobleaching of the Acceptor 53
2525 Combined Donor and Acceptor Emission Measurements 54
2526 FRET Between Spectroscopically Identical Molecules 55
2 6 Cell Biophysical Methods Reveal Molecular Interactions
in the ErbB Signaling Pathway 56
261 Small-Scale Associations: Homo- and Heterodimerization
in the ErbB Family 56
262 Large-Scale Associations of ErbB Proteins 57
263 Focal Stimulation of Cells with Magnetic Beads 58
264 Image Cytometry in Assessing the Activation State
of ErbB Receptor Tyrosine Kinases 60
265 Following the Internalization of Receptors Using
Fluorescence Approaches 61
References 62
Contents I IX
CHAPTER 3 °
Non-Random Patterns of Membrane Proteins
and Their Roles in Transmembrane Signaling 71
ANDREA BODNAR, GYORGY VAMOSI, KATALIN T6TH, ATTILA JENEI,
LASZL6 MATYUS, SANDOR DAMJANOVICH
3 1 Introduction 71
3 2 Fluorescence Resonance Energy Transfer (FRET) 74
321 Measurement of FRET by Flow Cytometry 74
3211 Sample Preparation 75
3212 Signals and Calculations 75
3 3 Mapping the Distribution of Cell-Surface Proteins 77
331 Self-Association of MHCI Molecules 77
332 Heteroassociation of MHC I Glycoproteins 79
333 Association Patterns of MHC I, MHC II and ICAM-1 Molecules 80
334 Supramolecular Complexes of IL-2/IL-15R
and MHC Glycoproteins on Human T Lymphoma Cells 81
3 4 Fluorescence Correlation Spectroscopy (FCS) 82
341 Instrumentation 87
342 Evaluation of FCS Experiments 88
343 The Co-mobility of IL-15Ra, IL-2Ra and MHC I
Was Studied in FT7 10 Cells 88
References 90
CHAPTER 4
Transmembrane Signals Mediated by IL-2
and IL-15 Control the Life and Death of Lymphocytes 97
THOMAS A WALDMANN, SIGRID DUBOIS, JURGEN MULLER,
CAROLYN GOLDMAN, SANDOR DAMJANOVICS
4 1 Introduction 97
4 2 The Classical View of the IL-2 and IL-15 Receptor
and Signaling Pathways That Underlie the Shared
Functions of These Two Cytokines 98
4 3 IL-15 Utilizes a Novel Receptor in Mast Cells 101
4 4 The Shared and Contrasting Functions of IL-2 and IL-15 101
4 5 Classical IL-2, IL-15 Signal Transduction Pathways
That Underlie the Shared Roles of IL-2 and IL-15 102
4 6 Suppressors of Cytokine Signaling 104
4 7 The Distinct Receptor Signaling Pathways That Underlie
the Contrasting Roles of IL-2 and IL-15 in the Life
and Death of Lymphocytes 104
4 8 The Distinct Roles of IL-2 and IL-15 in Signaling for AICD 107
481 AICD Signaling Downstream of Death Receptors 108
4 9 Distinct Signals for Proliferation Mediated by IL-2 and IL-15 109
491 ThePI-3 K Pathway 109
492 The FKBP12 6 Pathway 110
493 The MAPK Pathway : 110
J
1 Contents
4 10^ Immunotherapy Targeted to the IL-2/IL-2RIL-15/IL-15R System I l l
References 113
CHAPTER 5
Single-Molecule Imaging of Diffusion, Recruitment,
and Activation of Signaling Molecules in Living Cells 123
AKIHIRO KUSUMI, HIDEJI MURAKOSHI, KOTONO MURASE,
TAKAHIRO FUJIWARA
5 1 Introduction 123
5 2 The 30-Year-Old Enigma Concerning the Diffusion Rate
of Membrane Molecules in the Plasma Membrane 126
5 3 Corralling Effects of the Membrane Skeleton for Transmembrane
Proteins (the Membrane-Skeleton Fence Model) 127
5 4 Lipids Also Undergo Hop Diffusion in the Plasma Membrane 133
5 5 Oligomerization-Induced Trapping 138
56A Paradigm Shift of the Plasma Membrane Structure Concept
Is Necessary: From the Simple Two-Dimensional Continuum
Fluid Model to the Compartmentalized Fluid Model 140
5 7 FRET Strategy for Detecting the Activation
of Single Molecules of Ras 140
5 8 Visualizing the Activation of Single Molecules
of H-Ras in Living Cells 142
5 9 Ras Diffusion Slows Upon Activation 143
5 10 A Model for the Formation of the Active Ras
Signal Transduction Complex 146
5 11 Recruitment of GAP334, the Ras-Binding, Catalytic Domain
of pl20RasGAP, on the Qell Membrane 147
5 12 Conclusions Regarding the FRET Method for Monitoring
the Activation of Single Ras Molecules 148
References 148
CHAPTER 6
Chemokine Signaling: The Functional Importance
of Stabilizing Receptor Conformations 153
Jos£ MIGUEL RoDRfGUEZ-FRADE, ANTONIO SERRANO,
CARLOS MARTINEZ-A, MARIO MELLADO
6 1 Chemokines and Their Receptors 153
6 2 Signaling Through Chemokine Receptors 154
621 Background 154
622 The Use of Biophysical Techniques to Measure Chemokine
Receptor Oligomerization 155
623 Characterization of Chemokine Receptor
Homo- and Heterodimerization 157
624 Chemokines Trigger JAK/STAT Pathway Activation 161
625 Chemokine Signaling Involves G Protein Activation 162
Contents I XI
6 3 General Considerations on the Biophysical Aspects of Signaling 162
631 Receptor Expression 163
632 Receptor Localization 163
6 4 Concluding Remarks 164
References 165
CHAPTER 7
Signaling and Reverse Signaling in the Tumor Necrosis
Factor/TNF Receptor System 171
ERNO DUDA, TUNDE NAGY, DANIELA N MANNEL,
GUNTHER ElSSNER
7 1 The TNF/TNFR System 171
711 Evolution of the TNF/TNFR System 173
712 General Structure 176
7121 Receptors 176
7122 Ligands 177
7 2 TNFR1 and the Apoptotic Signal 177
7 3 TNF Receptors and the Survival Signal 180
731 TNF Receptor-Associated Factors (TRAF1-7) 181
732 Signaling Pathways Activated by TRAFs 181
733 The NF-kappaB Pathway 183
734 The Role of Membrane Microdomains (Rafts)
in the Formation of Signaling Complexes 185
735 Activation of JNK 186
7 4 Signaling of Other Family Members 187
741 4-1BB 187
742 BAFFR 188
743 BCMA 9 188
744 CD27 189
745 CD30 189
746 CD40 190
747 DR3/TRAMP and DcR3 191
748 DR4 and DR5 (TRAILR1 and R2) and Decoy Receptors
DcRl and DcR2 192
749 EDAR 192
7 4 10 Fas Signaling 193
7 4 11 GITR/AITR 193
7 4 12 HVEM 194
7 4 13 Lymphotoxin-P Receptor 194
7 4 14 RANK and Osteoprotegerin (OPG) 195
7 4 15 TACI 195
7 4 16 TNFR2 195
7 4 17 TWEAKR/Fnl4 196
7 5 Reverse Signaling 196
7 6 Therapy/Intervention 198
References 199
XIII Contents
CHAPTER 8
Regulation of Immunoreceptor Activities:
The Paradigm of the Type I Fee Receptor 211
JAKUB ABRAMSON, ISRAEL PECHT
8 1 Introduction 211
8 2 Type I Fee Receptor (FceRI)-Mediated Cell Responses 211
821 FceRI Structure, Expression and Function 211
822 FCERI Stimulus-Response Coupling Cascade on Mast Cells 213
8221 The Original Model 213
8222 The Function of Monomeric IgE (mlgE) 214
8223 Lipid Rafts and FceRI Activation 215
8224 Lyn Activation and its Significance 216
8225 Fyn-Gab-2-PI3 K-Mediated Signaling 217
8226 The Syk-LAT-SLP-76 Signaling Pathway 219
8227 The (Btk)-PLC-y-PKC Coupling Cascade 221
8228 The Role ofMAPKinases in FceRI-Induced Gene Transcription 222
8229 Overview of the Current Model of the FceRI
Stimulus-Response Coupling Network 227
8 3 Mechanisms Regulating Response to the FceRI Stimulus 229
831 Regulatory Cytosolic Molecules 229
8311 Phosphatases 229
8312 Protein Kinases 232
8313 Adaptor Proteins 233
8314 E3 Ubiquitin Ligases - Negative Regulation by Protein
Endocytosis and Degradation 234
832 Transmembrane Adaptors Modulating FceRI Signaling 236
8321 Adaptor Proteins 236
8322 Tetraspanins « 236
833 Modulation of the FceRI Signaling Cascade
by ITIM-Containing Receptors 237
8331 ITIM-Bearing Immunoglobulin-like Receptors 239
8332 ITIM-Bearing C-Type Lectins 245
8 4 Epilogue 246
References 247
CHAPTER 9
Histamine Receptors and Signaling 265
HARGITA HEGYESI, ZSUZSA DARVAS, ROBIN L THURMOND,
ANDRASFALUS
9 1 Introduction 265 •
9 2 H, Receptor 266
921 The H, Receptor Signaling Pathway 266
922 Some Effects of Histamine Through H, Receptor 269
9 3 H2 Receptor 270
931 The H2 Receptor Signaling Pathway 271
932 Some Effects of Histamine Through H2 Receptor 272
Contents I XIII
933 H, and H2 Receptors on Human Neoplasias ° 273
9 4 H3 Receptor 274
941 The H3 Receptor Signaling Pathway 275
942 Some Effects of Histamine Through H3 Receptors 276
943 Uses of H3 Receptor Antagonists 277
9 5 H4 Receptor 278
951 The H4 Receptor Signaling Pathway 279
952 Some Effects of Histamine Through H4 Receptors 280
953 Uses of H4 Receptor Antagonists 281
References 282
CHAPTER 10
Signal Transduction by Ion Channels in Lymphocytes 293
ZOLTAN VARGA, REZSO GASPAR
10 1 Introduction 293
10 2 The Role of Ion Channels in T Cell Activation 293
10 2 1 Ca2+ Release-Activated Ca2+ (CRAC) Channels 296
10 2 2 Voltage-Gated and Ca2+-Activated K+Channels 297
10 2 3 Ion Channels, Membrane Potential
and Lymphocyte Activation 299
10 2 4 Distribution of Kvl 3 Channels in the Lymphocyte
Membrane 300
10 3 The Role of Ion Channels in Volume Regulation
by Lymphocytes 302
10 4 The Role of Ion Channels in the Apoptosis of Lymphocytes 305
References 307
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| indexdate | 2024-07-09T20:10:41Z |
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| isbn | 9783540250647 3540250646 |
| language | English |
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| physical | XVIII, 321 S. Ill., graph. Darst. |
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| series2 | Springer series in biophysics |
| spelling | Biophysical aspects of transmembrane signaling with 5 tables S. Damjanovich (ed.) Berlin ; Heidelberg ; New York Springer 2005 XVIII, 321 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Springer series in biophysics Vol. 8 Signaltransduktion (DE-588)4318717-1 gnd rswk-swf Biomembran (DE-588)4006884-5 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Biomembran (DE-588)4006884-5 s Signaltransduktion (DE-588)4318717-1 s DE-604 Damjanovich, Sándor edt Springer series in biophysics Vol. 8 (DE-604)BV000666176 8 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013329138&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Biophysical aspects of transmembrane signaling with 5 tables Springer series in biophysics Signaltransduktion (DE-588)4318717-1 gnd Biomembran (DE-588)4006884-5 gnd |
| subject_GND | (DE-588)4318717-1 (DE-588)4006884-5 (DE-588)4143413-4 |
| title | Biophysical aspects of transmembrane signaling with 5 tables |
| title_auth | Biophysical aspects of transmembrane signaling with 5 tables |
| title_exact_search | Biophysical aspects of transmembrane signaling with 5 tables |
| title_full | Biophysical aspects of transmembrane signaling with 5 tables S. Damjanovich (ed.) |
| title_fullStr | Biophysical aspects of transmembrane signaling with 5 tables S. Damjanovich (ed.) |
| title_full_unstemmed | Biophysical aspects of transmembrane signaling with 5 tables S. Damjanovich (ed.) |
| title_short | Biophysical aspects of transmembrane signaling |
| title_sort | biophysical aspects of transmembrane signaling with 5 tables |
| title_sub | with 5 tables |
| topic | Signaltransduktion (DE-588)4318717-1 gnd Biomembran (DE-588)4006884-5 gnd |
| topic_facet | Signaltransduktion Biomembran Aufsatzsammlung |
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