Tutorials in mathematical biosciences: 2 Mathematical modeling of calcium dynamics and signal transduction
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| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Berlin [u.a.]
Springer
2005
|
| Series: | Lecture notes in mathematics
1867 : Mathematical biosciences subseries |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XII, 202 S. Ill., graph. Darst. |
| ISBN: | 3540254390 |
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MARC
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| 245 | 1 | 0 | |a Tutorials in mathematical biosciences |n 2 |p Mathematical modeling of calcium dynamics and signal transduction |c James Sneyd (ed.). With contributions by: R. Bertram ... |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 2005 | |
| 300 | |a XII, 202 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Lecture notes in mathematics |v 1867 : Mathematical biosciences subseries | |
| 490 | 0 | |a Lecture notes in mathematics |v ... | |
| 650 | 4 | |a matematični modeli - kalcijeva dinamika - molekularne osnove srčnega utripa - krčenje mišic - generiranje sile - prenos signalov - sinaptični modeli | |
| 650 | 4 | |a mathematical models - calcium dynamics - molecular basis for cardiac excitation - contraction coupling - contracting muscles - generation of force - signal transduction - synaptic models | |
| 650 | 7 | |a Biophysik |2 swd | |
| 650 | 7 | |a Cytologie |2 swd | |
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| 700 | 1 | |a Sneyd, James |e Sonstige |4 oth | |
| 700 | 1 | |a Bertram, R. |e Sonstige |4 oth | |
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Record in the Search Index
| _version_ | 1804133406612652032 |
|---|---|
| adam_text | Contents
Basic
Concepts
of Ca2+ Signaling in Cells and Tissues
M. J.
Sanderson
.................................................. 1
1
Introduction
............................................... 1
2
Са2 1
Stores and Pumps
..................................... 1
3
Ca2+ Release Channels
...................................... 3
4
Signaling by Ca2+ Transients
................................ 4
5
Cell Signaling by Ca2+ Oscillations
........................... 5
5.1 FM
Regulation of Cell Activity
.......................... 6
6
Spatial Aspects of Ca2+ Signaling
............................ 8
6.1
Elemental Ca2+ Signals
................................. 8
6.2 Microdomains
of Ca2 1 Signaling
......................... 8
6.3
Intracellular Ca2 1 Waves
............................... 9
6.4
Intercellular Ca2 1 Waves
................................ 10
6.5
Extracellular Ca2+ Waves
............................... 12
7
Summary
.................................................. 12
References
...................................................... 12
Modeling
ІРз
-Dependent
Calcium Dynamics
in Non-Excitable Cells
J. Sneyd
........................................................ 15
1
Introduction
............................................... 15
2
Calcium Oscillations and Waves
.............................. 18
3
Well-Mixed Cell Models: Calcium Oscillations
.................. 22
3.1
Influx
................................................ 23
3.2
Mitochondria
.......................................... 24
3.3
Calcium Buffers
....................................... 24
3.4
Calcium Pumps and Exchangers
......................... 24
3.4.1
Calcium ATPases
................................. 24
3.4.2
Calcium Exchangers
.............................. 28
3.5
IP3 Receptors
......................................... 28
3.5.1
An 8-State IP3 Receptor Model
.................... 29
VIII Contents
3.5.2
A Model with Saturating Binding Rates
............. 30
3.6
Putting the Pieces Together: a Model of Calcium Oscillations
35
3.7
IP3 Dynamics
......................................... 37
4
Calcium Waves
............................................. 40
4.1
Simulation of Spiral Waves in Xenopus
................... 42
4.2
Traveling Wave Equations and Bifurcation Analysis
........ 42
5
Calcium Buffering
.......................................... 46
5.1
Fast Buffers or Excess Buffers
........................... 46
6
Calcium Puffs and Stochastic Modeling
........................ 49
6.1
Stochastic IPR Models
................................. 49
6.2
Stochastic Models of Calcium Waves
..................... 52
7
Intercellular Calcium Waves
................................. 53
References
...................................................... 54
Integrated Calcium Management in Cardiac Myocytes
T.R. Shannon
................................................... 63
1
Introduction
............................................... 63
2
Geometry of the Cardiac Myocyte
............................ 63
3
Overview of Excitation-Contraction Coupling
.................. 66
4
Action Potentials
........................................... 67
4.1
The Resting Potential
.................................. 68
4.2
Construction of the AP Waveform
....................... 71
5
Ca Channels
............................................... 73
6
The SR Ca Release Channel
................................. 76
7
Ca-Induced Ca Release
...................................... 79
8
Na-Ca Exchange
........................................... 81
9
SL Ca Pump
............................................... 85
10
SR Ca Pump
.............................................. 85
11
The Balance of Fluxes
...................................... 88
12
Myocyte Contraction
........................................ 89
References
...................................................... 92
Mechanisms and Models of Cardiac Excitation-Contraction
Coupling
R.L. Winslow, R. Hinch, J.L. Greenstein
...........................
97
1
Introduction
............................................... 97
2
The Molecular and Structural Basis
of Cardiac EC Coupling
.....................................
98
2.1
Structural Basis of EC Coupling
.........................
98
2.2
The Molecular Basis of Cardiac EC Coupling
..............
2.2.1
Properties of LCCs
...............................
2.2.2
Properties of RyRs
...............................
10°
2.2.3
Calcium-Induced Calcium-Release
..................
10
2.2.4
Ca2+ Re-Uptake and Extrusion
....................
103
3
Computational Models of Cardiac EC Coupling
................
10
Contents
IX
3.1
Common
Pool Models
of CICR
..........................104
3.1.1
Strengths of Common Pool Models
.................105
3.1.2
Weaknesses of Common Pool Models
................105
3.2
A Stochastic Local-Control Model of CICR
................107
3.3
Coupled LCC-RyR Gating Models of CICR
...............112
3.3.1
A Minimal Coupled LCC-RyR Gating Model
.......112
3.3.2
Generalized Coupled LCC-RyR Gating Models
.......118
4
Modeling Applications
......................................121
4.1
AP Duration Regulation in Heart Failure
.................121
4.2
A General Mechanism for Regulation of AP Duration
.......123
5
Discussion
.................................................125
5.1
Regulation of Cardiac EC Coupling by Signaling Pathways
. . 125
5.2
Dyadic Ca2+ Dynamics
.................................126
5.3
Localized Signaling within Molecular Complexes
...........126
References
......................................................127
Mathematical Analysis of the Generation
of Force and Motion in Contracting Muscle
E. Pate
.........................................................133
1
Introduction
...............................................133
2
A.F. Huxley s Cross-Bridge Model
............................135
3
Isometric Contraction
.......................................138
4
Isotonic Contraction
........................................141
5
Transient Simulations
.......................................146
6
Analysis of Systems of Small Numbers
of Cross-Bridges
............................................148
References
......................................................152
Signal Transduction in Vertebrate Olfactory Receptor Cells
J. Reisert
.......................................................155
1
The Odour-Induced Response
in Olfactory Receptor Cells
..................................155
2
Olfactory Signal Transduction
................................158
2.1
The Olfactory
G
Protein-Coupled Cascade
................158
2.2
The Olfactory Cyclic Nucleotide-Gated Channel:
A Source of Ca2+
......................................159
2.3
The Olfactory Ca2+-activated
СГ
Channel:
A Large Secondary Current
.............................160
2.4
Adaptation and Modulation of the Odour Response
........162
3
Mathematical Approaches in
Olfaction
........................164
References
......................................................165
X
Contents
Mathematical Models of Synaptic Transmission
and Short-Term Plasticity
R. Bertram
.....................................................173
1
Introduction
...............................................173
2
Neurotransmitter
Release is Evoked by Ca2+ Influx
.............174
3
Primed Vesicles are Located Close to Ca2+ Channels
............175
4
Reaction-Diffusion Equations
................................175
5
The Simon and
Llinás
Model
.................................176
6
Steady-State Approximations
for Ca2+
Microdomains .....................................177
7
Modeling the Postsynaptic Response
..........................180
8
A Simple Model
............................................182
9
Short-Term Plasticity
.......................................184
10
Mathematical Models for Facilitation
.........................185
11
Residual Free Ca2+ Models
..................................186
12
A Residual Bound Ca2+ Model for Facilitation
.................190
13
A Model for Facilitation Based on Buffer Saturation
............192
14
Synaptic Depression
........................................193
15
G
Protein Inhibition of Presynaptic Ca2+ Channels
.............195
16
Conclusion
.................................................197
References
......................................................198
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| id | DE-604.BV019878410 |
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| indexdate | 2024-07-09T20:08:13Z |
| institution | BVB |
| isbn | 3540254390 |
| language | English |
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| physical | XII, 202 S. Ill., graph. Darst. |
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| series | Lecture notes in mathematics |
| series2 | Lecture notes in mathematics |
| spelling | Tutorials in mathematical biosciences 2 Mathematical modeling of calcium dynamics and signal transduction James Sneyd (ed.). With contributions by: R. Bertram ... Berlin [u.a.] Springer 2005 XII, 202 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Lecture notes in mathematics 1867 : Mathematical biosciences subseries Lecture notes in mathematics ... matematični modeli - kalcijeva dinamika - molekularne osnove srčnega utripa - krčenje mišic - generiranje sile - prenos signalov - sinaptični modeli mathematical models - calcium dynamics - molecular basis for cardiac excitation - contraction coupling - contracting muscles - generation of force - signal transduction - synaptic models Biophysik swd Cytologie swd Physiologie swd (DE-588)1071861417 Konferenzschrift gnd-content Borisyuk, Alla Sonstige oth Sneyd, James Sonstige oth Bertram, R. Sonstige oth (DE-604)BV019769353 2 Lecture notes in mathematics 1867 : Mathematical biosciences subseries (DE-604)BV000676446 1867 Digitalisierung TU Muenchen application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013202609&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Tutorials in mathematical biosciences Lecture notes in mathematics matematični modeli - kalcijeva dinamika - molekularne osnove srčnega utripa - krčenje mišic - generiranje sile - prenos signalov - sinaptični modeli mathematical models - calcium dynamics - molecular basis for cardiac excitation - contraction coupling - contracting muscles - generation of force - signal transduction - synaptic models Biophysik swd Cytologie swd Physiologie swd |
| subject_GND | (DE-588)1071861417 |
| title | Tutorials in mathematical biosciences |
| title_auth | Tutorials in mathematical biosciences |
| title_exact_search | Tutorials in mathematical biosciences |
| title_full | Tutorials in mathematical biosciences 2 Mathematical modeling of calcium dynamics and signal transduction James Sneyd (ed.). With contributions by: R. Bertram ... |
| title_fullStr | Tutorials in mathematical biosciences 2 Mathematical modeling of calcium dynamics and signal transduction James Sneyd (ed.). With contributions by: R. Bertram ... |
| title_full_unstemmed | Tutorials in mathematical biosciences 2 Mathematical modeling of calcium dynamics and signal transduction James Sneyd (ed.). With contributions by: R. Bertram ... |
| title_short | Tutorials in mathematical biosciences |
| title_sort | tutorials in mathematical biosciences mathematical modeling of calcium dynamics and signal transduction |
| topic | matematični modeli - kalcijeva dinamika - molekularne osnove srčnega utripa - krčenje mišic - generiranje sile - prenos signalov - sinaptični modeli mathematical models - calcium dynamics - molecular basis for cardiac excitation - contraction coupling - contracting muscles - generation of force - signal transduction - synaptic models Biophysik swd Cytologie swd Physiologie swd |
| topic_facet | matematični modeli - kalcijeva dinamika - molekularne osnove srčnega utripa - krčenje mišic - generiranje sile - prenos signalov - sinaptični modeli mathematical models - calcium dynamics - molecular basis for cardiac excitation - contraction coupling - contracting muscles - generation of force - signal transduction - synaptic models Biophysik Cytologie Physiologie Konferenzschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013202609&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV019769353 (DE-604)BV000676446 |
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