Poorly soluble drugs: formulation with nanocrystal and SolEmuls technology = Schwerlösliche Arzneistoffe : Formulierung mit NanoKristall- und SolEmuls-Technologie
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| Main Author: | |
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| Format: | Thesis Book |
| Language: | English German |
| Published: |
2004
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Berlin, Freie Univ., Diss., 2004. - Enth. engl. und dt. Zsfassung |
| Physical Description: | 212 S. Ill., graph. Darst. 21 cm |
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Record in the Search Index
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| adam_text | POORLY SOLUBLE DRUGS: FORMULATION WITH NANOCRYSTAL AND SOLEMULS
TECHNOLOGY SCHWERLOSLICHE ARZNEISTOFFE: FORMULIERUNG MIT NANOKRISTALL-
UND SOLEMULS-TECHNOLOGIE INAUGURAL-DISSERTATION ZUR ERLANGUNG DES
AKADEMISCHEN GRADES DES DOKTORS DER NATURWISSENSCHAFTEN (DR. RER. NAT.)
EINGEREICHT IM FACHBEREICH BIOLOGIE, CHEMIE UND PHARMAZIE DER FREIEN
UNIVERSITAT BERLIN VORGELEGT VON ASLIHAN AKKAR AUS ISTANBUL/TIIRKEI
OKTOBER, 2004 POORLY SOLUBLE DRUGS: FORMULATION WITH NANOCRYSTALS AND
SOLEMULS TECHNOLOGY 7 CONTENTS: 1 INTRODUCTION 11 1.1 PROBLEMS OF
POORLY SOLUBLE DRUGS 11 1.2 DEFINITIONS 12 1.2.1 SATURATION SOLUBILITY
AND SOLUBILITY 12 1.2.2 DISSOLUTION VELOCITY AND INTRINSIC DISSOLUTION
VELOCITY 13 2 NANOSUSPENSIONS 16 2.1 AN OVERVIEW OF NANONISATION
TECHNOLOGIES 16 2.1.1 PRECIPITATION TECHNIQUES 16 2.1.1.1 HYDROSOLS 17
2.1.1.2 - NANOMORPH* 17 2.1.2 DISINTEGRATION TECHNIQUES 18 2.1.2.1 PEARL
MILLING (NANOCRYSTALS*) 18 2.1.2.2 HOMOGENISATION IN WATER 19 2.1.3
HOMOGENISATION IN WATER-LIQUID MIXTURES AND NON-AQUEOUS MEDIA (NANOPURE*
TECHNOLOGY) 21 2.1.4 MICROPRECIPITATION TECHNOLOGY (NANOEDGE) 22 2.2
FORMULATION EXAMPLES FOR NANOSUSPENSIONS 25 2.2.1 ORAL APPLICATION 25
2.2.2 PARENTERAL APPLICATION 26 3 DRUG DELIVERY WITH OAV EMULSION
SYSTEMS 27 3.1 BASIC PRINCIPLES AND HISTORY OF SOLEMULS TECHNOLOGY 29 4
AIM OF THIS THESIS 31 5 MATERIALS AND METHODS 32 5.1 BASIC PRINCIPLES OF
HIGH PRESSURE HOMOGENISATION 32 5.1.1 PRODUCTION OF NANOSUSPENSIONS WITH
HIGH PRESSURE HOMOGENISATION 33 5.1.2 PRODUCTION OF DRUG LOADED
EMULSIONS WITH HIGH PRESSURE HOMOGENISATION 34 52 CHARACTERISATION OF
NANOSUSPENSIONS AND EMULSIONS 35 5.2.1 PHOTON CORRELATION SPECTROSCOPY
35 5.2.1.1 BASIC PRINCIPLES 35 5.2.1.2 MEASURING NANOSUSPENSIONS AND
EMULSIONS 37 5.2.2 LASER DIFFRACTOMETRY (LD) 37 5.2.2.1 BASIC PRINCIPLES
37 5.2.2.2 MEASURING NANOSUSPENSIONS AND EMULSIONS 39 5.2.3 LASER
DOPPLER ANEMOMETRY 39 5.2.4 ZETA POTENTIAL MEASUREMENTS 41 5.2.5
ASSESSMENT OF THE CRYSTAL NATURE OF THE NANOSUSPENSIONS 41 5.2.5.1
ROENTGEN DIFFRACTION 41 5.2.5.2 DIFFERENTIAL SCANNING CALORIMETRY (DSC)
43 5.2.6 SCANNING ELECTRON MICROSCOPY (SEM) 44 5.2.7 POLARIZED LIGHT
MICROSCOPY 46 5.3 MATERIALS 47 5.3.1 CARBAMAZEPINE 47 5.3.2 ITRACONAZOLE
49 POORLY SOLUBLE DRUGS: FORMULATION WITH NANOCRYSTALS AND SOLEMULS*
TECHNOLOGY 8~ 5.3.3 KETOCONAZOLE 51 5.3.4 LIPOFUNDIN MCT 20% 51 5.3.5
POLYSORBATE 80 (TWEEN 80) 52 5.3.6 POLYETHYLENE GLYCOLS (PEGS) 53 5.3.7
POLOXAMERL88 54 5.3.8 GLYCEROL (100%) 55 5.3.9 WATER 55 6
NANOSUSPENSIONS WITH CARBAMAZEPINE 56 7 NANOSUSPENSIONS WITH
ITRACONAZOLE 72 7.1 DETERMINATION OF THE SATURATION SOLUBILITY 78 7.2
CRYSTAL STRUCTURE 83 8 NANOSUSPENSIONS WITH KETOCONAZOLE 89 8.1
DETERMINATION OF THE SATURATION SOLUBILITY 93 8.2 CRYSTAL STRUCTURE 98 9
EFFECT OF PRODUCTION TEMPERATURE AND DISPERSION MEDIUM ON THE PARTICLE
SIZE, DISTRIBUTION AND MORPHOLOGY OF NANOSUSPENSIONS 105 9.1 EFFECT OF
PRODUCTION TEMPERATURE AND DISPERSION MEDIUM ON THE PARTICLE SIZE AND
DISTRIBUTION 105 9.2 EFFECT OF PRODUCTION TEMPERATURE AND DISPERSION
MEDIUM ON THE MORPHOLOGY OF THE NANOSUSPENSIONS 121 10 CARBAMAZEPINE
EMULSIONS PRODUCED WITH SOLEMULS TECHNOLOGY 127 10.1 AIM OF THE STUDY
127 10.2 PARTICLE SIZE CHARACTERISATION DATA 128 10.3 ASSAY OF FREE,
NON-INCORPORATED DRUG 134 10.4 LONG-TERM STABILITY OF CARBAMAZEPINE
EMULSIONS 136 10.5 CONCLUSIONS TO CARBAMAZEPINE LOADED EMULSIONS 142 11
ITRACONAZOLE EMULSIONS PRODUCED WITH SOLEMULS TECHNOLOGY 143 11.1 AIM OF
THE STUDY 143 11.2 PARTICLE SIZE CHARACTERISATION DATA 144 11.3 ASSAY OF
FREE, NON-INCORPORATED DRUG 149 11.4 LONG TERM STABILITY OF ITRACONAZOLE
EMULSIONS 151 11.5 CONCLUSION TO ITRACONAZOLE LOADED EMULSIONS 157 12
DRUG CONCENTRATION EFFECT OF THE DRUG LOADED EMULSIONS PRODUCED BY
SOLEMULS CONCEPT 158 12.1 CARBAMAZEPINE LOADED EMULSIONS 158 12.2
ITRACONAZOLE LOADED EMULSIONS 160 POORLY SOLUBLE DRUGS: FORMULATION WITH
NANOCRYSTALS AND SOLEMULS TECHNOLOGY 13 KETOCONAZOLE EMULSIONS PRODUCED
WITH SOLEMULS TECHNOLOGY 163 13.1 AIM OF THE STUDY 163 13.2
STABILISATION STUDY OF KETOCONAZOLE EMULSIONS 163 13.3 CONCLUSION TO
KETOCONAZOLE LOADED EMULSION 176 14 SUMMARY 177 15 ZUSAMMENFASSUNG 181
16 REFERENCES 186 17 ACKNOWLEDGMENTS 199 18 APPENDIX: TABLES TO THE
FIGURES 200 19 PUBLICATION LIST 207 20 CURRICULUM VTTAE 211
|
| any_adam_object | 1 |
| author | Akkar, Aslihan 1978- |
| author_GND | (DE-588)129763748 |
| author_facet | Akkar, Aslihan 1978- |
| author_role | aut |
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| building | Verbundindex |
| bvnumber | BV019839539 |
| ctrlnum | (OCoLC)76677236 (DE-599)BVBBV019839539 |
| dewey-full | 610 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 610 - Medicine and health |
| dewey-raw | 610 |
| dewey-search | 610 |
| dewey-sort | 3610 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Thesis Book |
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| indexdate | 2024-07-09T20:07:19Z |
| institution | BVB |
| language | English German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-013164465 |
| oclc_num | 76677236 |
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| owner | DE-29T DE-12 DE-83 DE-188 |
| owner_facet | DE-29T DE-12 DE-83 DE-188 |
| physical | 212 S. Ill., graph. Darst. 21 cm |
| publishDate | 2004 |
| publishDateSearch | 2004 |
| publishDateSort | 2004 |
| record_format | marc |
| spelling | Akkar, Aslihan 1978- Verfasser (DE-588)129763748 aut Poorly soluble drugs formulation with nanocrystal and SolEmuls technology = Schwerlösliche Arzneistoffe : Formulierung mit NanoKristall- und SolEmuls-Technologie von Aslihan Akkar Schwerlösliche Arzneistoffe : Formulierung mit NanoKristall- und SolEmuls-Technologie 2004 212 S. Ill., graph. Darst. 21 cm txt rdacontent n rdamedia nc rdacarrier Berlin, Freie Univ., Diss., 2004. - Enth. engl. und dt. Zsfassung Berlin, Freie Univ., Diss., 2004 Arzneimittel (DE-588)4003115-9 gnd rswk-swf Schwerlöslicher Stoff (DE-588)4352869-7 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Arzneimittel (DE-588)4003115-9 s Schwerlöslicher Stoff (DE-588)4352869-7 s DE-188 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013164465&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Akkar, Aslihan 1978- Poorly soluble drugs formulation with nanocrystal and SolEmuls technology = Schwerlösliche Arzneistoffe : Formulierung mit NanoKristall- und SolEmuls-Technologie Arzneimittel (DE-588)4003115-9 gnd Schwerlöslicher Stoff (DE-588)4352869-7 gnd |
| subject_GND | (DE-588)4003115-9 (DE-588)4352869-7 (DE-588)4113937-9 |
| title | Poorly soluble drugs formulation with nanocrystal and SolEmuls technology = Schwerlösliche Arzneistoffe : Formulierung mit NanoKristall- und SolEmuls-Technologie |
| title_alt | Schwerlösliche Arzneistoffe : Formulierung mit NanoKristall- und SolEmuls-Technologie |
| title_auth | Poorly soluble drugs formulation with nanocrystal and SolEmuls technology = Schwerlösliche Arzneistoffe : Formulierung mit NanoKristall- und SolEmuls-Technologie |
| title_exact_search | Poorly soluble drugs formulation with nanocrystal and SolEmuls technology = Schwerlösliche Arzneistoffe : Formulierung mit NanoKristall- und SolEmuls-Technologie |
| title_full | Poorly soluble drugs formulation with nanocrystal and SolEmuls technology = Schwerlösliche Arzneistoffe : Formulierung mit NanoKristall- und SolEmuls-Technologie von Aslihan Akkar |
| title_fullStr | Poorly soluble drugs formulation with nanocrystal and SolEmuls technology = Schwerlösliche Arzneistoffe : Formulierung mit NanoKristall- und SolEmuls-Technologie von Aslihan Akkar |
| title_full_unstemmed | Poorly soluble drugs formulation with nanocrystal and SolEmuls technology = Schwerlösliche Arzneistoffe : Formulierung mit NanoKristall- und SolEmuls-Technologie von Aslihan Akkar |
| title_short | Poorly soluble drugs |
| title_sort | poorly soluble drugs formulation with nanocrystal and solemuls technology schwerlosliche arzneistoffe formulierung mit nanokristall und solemuls technologie |
| title_sub | formulation with nanocrystal and SolEmuls technology = Schwerlösliche Arzneistoffe : Formulierung mit NanoKristall- und SolEmuls-Technologie |
| topic | Arzneimittel (DE-588)4003115-9 gnd Schwerlöslicher Stoff (DE-588)4352869-7 gnd |
| topic_facet | Arzneimittel Schwerlöslicher Stoff Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013164465&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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