Preventing end stage renal disease in diabetic patients: genetic aspects and dual blockade of the renin-angiotensin system
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| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
København
Lægeforeningens Forl.
2004
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Zsfassung in dän. Sprache - Zugl.: København, Univ., Diss., 2005 |
| Physical Description: | 79 S. graph. Darst. |
| ISBN: | 8778911060 |
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Record in the Search Index
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| adam_text | CONTENTS
1. Introduction and aims 9
1.1. Diabetic nephropathy 9
1.2. Aims 10
2. Design and methods 11
2.1. Study populations 11
2.2. Designs 11
2.3. Methods and evaluation of decline in kidney function .. 12
3. Non-genetic risk factors for progression of
diabetic nephropathy 13
3.1. Blood pressure 13
3.2. Albuminuria 14
3.3. Summary 15
4. The renin-angiotensin system in diabetic nephropathy .... 15
4.1. Experimental evidence of renal RAS activation 15
4.2. Evidence of renal RAS activation from human studies . 17
4.3. Glucose, systemic haemodynamic and RAS 18
4.4. Summary 20
5. Genetic variation and progression of diabetic
nephropathy 20
5.1. Methodological aspects of genetic studies 21
5.2. Pharmacogenetics 23
5.3. Polymorphisms in the renin-angiotensin system 23
5.3.1. Angiotensin converting enzyme 23
5.3.2. Angiotensinogen 28
5.3.3. Angiotensin II type 1 receptor 29
5.3.4. Genetic interaction and pharmacogenomics .... 31
5.4. Genetic polymorphisms outside the
renin-angiotensin system 33
5.4.1. The human plasma-cell membrane antigen
(PC-1) 33
5.4.2. Other susceptibility genes 34
5.5. Gender 35
5.6. Conclusion and future strategy 36
6. Dual blockade of the renin-angiotensin system 37
6.1. Rationale 37
7
6.2. Animal models 38
6.3. Renal disease in humans 39
6.3.1. Dosing of ACE-I/ARB 42
6.3.2. Adverse and side effects 46
6.3.3. Underlying mechanisms in man 47
6.3.4. Individual responses 50
6.3.5. Conclusions 51
6.4. Other cardiovascular diseases in humans 51
6.5. Future strategy for optimal RAS blockade 52
7. Conclusions and clinical applications 55
8. Summary in Danish 56
9. References 59
8
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| indexdate | 2024-07-09T20:03:34Z |
| institution | BVB |
| isbn | 8778911060 |
| language | English |
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| physical | 79 S. graph. Darst. |
| publishDate | 2004 |
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| publisher | Lægeforeningens Forl. |
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| spelling | Jacobsen, Peter Karl Verfasser aut Preventing end stage renal disease in diabetic patients genetic aspects and dual blockade of the renin-angiotensin system Peter Karl Jacobsen København Lægeforeningens Forl. 2004 79 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Zsfassung in dän. Sprache - Zugl.: København, Univ., Diss., 2005 Nephropathia diabetica (DE-588)4136461-2 gnd rswk-swf Renin-Angiotensin-System (DE-588)4177770-0 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Nephropathia diabetica (DE-588)4136461-2 s Renin-Angiotensin-System (DE-588)4177770-0 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013004763&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Jacobsen, Peter Karl Preventing end stage renal disease in diabetic patients genetic aspects and dual blockade of the renin-angiotensin system Nephropathia diabetica (DE-588)4136461-2 gnd Renin-Angiotensin-System (DE-588)4177770-0 gnd |
| subject_GND | (DE-588)4136461-2 (DE-588)4177770-0 (DE-588)4113937-9 |
| title | Preventing end stage renal disease in diabetic patients genetic aspects and dual blockade of the renin-angiotensin system |
| title_auth | Preventing end stage renal disease in diabetic patients genetic aspects and dual blockade of the renin-angiotensin system |
| title_exact_search | Preventing end stage renal disease in diabetic patients genetic aspects and dual blockade of the renin-angiotensin system |
| title_full | Preventing end stage renal disease in diabetic patients genetic aspects and dual blockade of the renin-angiotensin system Peter Karl Jacobsen |
| title_fullStr | Preventing end stage renal disease in diabetic patients genetic aspects and dual blockade of the renin-angiotensin system Peter Karl Jacobsen |
| title_full_unstemmed | Preventing end stage renal disease in diabetic patients genetic aspects and dual blockade of the renin-angiotensin system Peter Karl Jacobsen |
| title_short | Preventing end stage renal disease in diabetic patients |
| title_sort | preventing end stage renal disease in diabetic patients genetic aspects and dual blockade of the renin angiotensin system |
| title_sub | genetic aspects and dual blockade of the renin-angiotensin system |
| topic | Nephropathia diabetica (DE-588)4136461-2 gnd Renin-Angiotensin-System (DE-588)4177770-0 gnd |
| topic_facet | Nephropathia diabetica Renin-Angiotensin-System Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013004763&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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