Transdermal and topical drug delivery: from theory to clinical practice
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
London [u.a.]
Pharmaceutical Press
2003
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XII, 242 S. Ill., graph. Darst. |
| ISBN: | 0853694893 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV019657036 | ||
| 003 | DE-604 | ||
| 005 | 20160624 | ||
| 007 | t | ||
| 008 | 050113s2003 ad|| |||| 00||| eng d | ||
| 020 | |a 0853694893 |9 0-85369-489-3 | ||
| 035 | |a (OCoLC)53123369 | ||
| 035 | |a (DE-599)BVBBV019657036 | ||
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| 041 | 0 | |a eng | |
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| 100 | 1 | |a Williams, Adrian |d 1963- |e Verfasser |0 (DE-588)1045721859 |4 aut | |
| 245 | 1 | 0 | |a Transdermal and topical drug delivery |b from theory to clinical practice |c Adrian Williams |
| 264 | 1 | |a London [u.a.] |b Pharmaceutical Press |c 2003 | |
| 300 | |a XII, 242 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Médicaments - Administration - Dispositifs | |
| 650 | 4 | |a Médicaments - Administration par voie transdermique | |
| 650 | 4 | |a Administration, Cutaneous | |
| 650 | 4 | |a Administration, Topical | |
| 650 | 4 | |a Drug Delivery Systems |x methods | |
| 650 | 4 | |a Drug delivery systems | |
| 650 | 4 | |a Skin Absorption | |
| 650 | 4 | |a Transdermal medication | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012985542&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-012985542 | ||
Datensatz im Suchindex
| _version_ | 1804133034989977600 |
|---|---|
| adam_text | Contents
Preface xi
Acknowledgements xiii
About the author xiv
1 Structure and function of human skin 1
1.1 Introduction 1
1.2 Healthy skin structure and function 1
1.2.1 The subcutaneous fat layer 2
1.2.2 Thedermis 2
1.2.3 The epidermis 5
1.2.4 Epidermal enzyme systems 13
1.3 Physiological factors affecting transdermal and topical drug
delivery 14
1.3.1 Skin age 14
1.3.2 Body site 16
1.3.3 Race 17
1.3.4 Other factors 17
1.4 Pathological disorders 18
1.4.1 Eruptions 19
1.4.2 Infections 21
1.4.3 Ichthyoses 22
1.4.5 Tumours 23
1.5 References 23
2 Theoretical aspects of transdermal drug delivery 27
2.1 Terminology 27
2.2 The transdermal permeation process 28
2.3 Permeation pathways through the stratum corneum 30
2.3.1 Transappendageal transport 31
2.3.2 Transcellular route 32
2.3.3 Intercellular pathway 33
2.4 Influence of permeant physiaxhemical properties on route
of absorption 35
2.4.1 Partition coefficient 35
2.4.2 Molecular size 36
viii Contents
2.4.3 Solubility/melting point 37
2.4.4 lonisation 38
2.4.5 Other factors 39
2.5 Mathematics of skin permeation 40
2.5.1 Pseudo steady state permeation (infinite closing) 41
2.5.2 Transient permeation (finite dosing) 46
2.6 References 48
3 Experimental design 51
3.1 Introduction 51
3.2 In vivo or in vitro studies? 51
3.2.1 In vitro tissue; potential problems 53
3.3 Alternative membranes for in vitro studies 54
3.3.1 Animal membranes 54
3.3.2 Artificial membranes 56
3.4 Selection of membrane layers for in vitro studies 59
3.4.1 Preparation of skin membranes 60
3.5 Selection of diffusion cell for in vitro experiments 62
3.6 Formulation application considerations 64
3.6.1 Finite or infinite dose? 64
3.6.2 Vehicle effects 65
3.6.3 lonisation 68
3.6.4 Permeant detection 70
3.6.5 Donor solution concentration 73
3.7 Receptor solution for in vitro studies 73
3.8 Integrity checks 75
3.9 Temperature 76
3.10 Experimental duration 76
3.11 In vitro experimental replicates 77
3.12 Mass balance 77
3.13 Expression of results 77
3.14 Current regulatory guidelines 79
3.15 References 79
4 Chemical modulation of topical and transdermal
permeation 83
4.1 Introduction 83
4.2 Water 84
4.3 Chemical penetration enhancers 86
4.3.1 Sulfoxides and similar chemicals 87
4.3.2 Azone 89
4.3.3 Pyrrolidones 91
Contents ix
4.3.4 Fatty acids 92
4.3.5 Alcohols, fatty alcohols and glycols 94
4.3.6 Surfactants 96
4.3.7 Urea 98
4.3.8 Terpenes 98
4.3.9 Phospholipids 102
4.3.10 General comments on penetration enhancers 102
4.4 Chemical permeation retarders 104
4.4.1 Barrier creams 104
4.4.2 Permeation retarders 105
4.4.3 Cyclodextrins 106
4.5 Drug and formulation manipulation strategies 108
4.5.1 Prodrugs 108
4.5.2 Ion pairing 1 10
4.5.3 Eutectic systems/depression of permeant melting point 1 12
4.5.4 Supersaturation 114
4.6 References 116
5 Physical and technological modulation of topical and
transdermal drug delivery 1 23
5.1 Introduction 123
5.2 Vesicles 123
5.2.1 Liposomes 124
5.2.2 Non ionic surfactant vesicles (niosomes] 128
5.2.3 Highly deformable (or elastic) liposomes 1 30
5.2.4 Ethosomes 134
5.2.5 Othersomes 135
5.3 Needleless injection 136
5.3.1 Particles 137
5.3.2 Liquids 138
5.4 Physical avoidance of stratum corneum 1 39
5.4.1 Laser ablation 139
5.4.2 Other ablation methods 140
5.4.3 Microneedles 141
5.5 Ultrasound 142
5.6 Electrical methods 144
5.6.1 Iontophoresis 145
5.6.2 Electroporation 152
5.6.3 Other electrical enhancement strategies 154
5.7 Combined enhancement strategies 155
5.7.1 Iontophoresis with chemical penetration enhancers 156
5.7.2 Iontophoresis with physical avoidance of the barrier 157
x Contents
5.7.3 Electroporation with chemical penetration enhancers 158
5.7.4 Electroporation with iontophoresis 158
5.7.5 Other combinations 159
5.8 References 159
6 Topical and transdermal formulations 169
6.1 Introduction 169
6.2 Formulation options 169
6.2.1 Liquid formulations 171
6.2.2 Semi solid formulations 172
6.2.3 Solid formulations 178
6.3 Transdermal patches 178
6.3.1 Types of transdermal patches 1 80
6.3.2 Transdermal patch components 183
6.4 Some general formulation rules 187
6.4.1 Select a good drug candidate 1 87
6.4.2 Estimate drug flux 188
6.4.3 Use thermodynamics 190
6.4.4 Be realistic 191
6.4.5 Alcohol helps 192
6.4.6 How to keep the drug localised? 193
6.5 References 194
7 Clinical principles 195
7.1 Introduction 195
7.2 What quantities are necessary? 195
7.3 Which formulation type to select? 196
7.4 Formulation is more important than concentration 197
7.5 What can be delivered to and through the skin? 198
7.6 Occlusion or not? 203
7.7 Dilution of preparations 203
7.8 Ensuring formulation equivalence 204
7.9 Drug delivery through a repairing barrier 213
7.10 Case studies 215
7.1 0.1 Case 1: Permethrin treatment of scabies 215
7.10.2 Case 2: PUVA therapy 216
7.10.3 Case 3: Salicylic acid 217
7.10.4 Case 4: Errors with patches 219
7.11 References 220
Glossary 223
Index 229
|
| any_adam_object | 1 |
| author | Williams, Adrian 1963- |
| author_GND | (DE-588)1045721859 |
| author_facet | Williams, Adrian 1963- |
| author_role | aut |
| author_sort | Williams, Adrian 1963- |
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| building | Verbundindex |
| bvnumber | BV019657036 |
| callnumber-first | R - Medicine |
| callnumber-label | RM151 |
| callnumber-raw | RM151 |
| callnumber-search | RM151 |
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| callnumber-subject | RM - Therapeutics and Pharmacology |
| classification_rvk | VX 7560 |
| ctrlnum | (OCoLC)53123369 (DE-599)BVBBV019657036 |
| dewey-full | 615.6 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.6 |
| dewey-search | 615.6 |
| dewey-sort | 3615.6 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Medizin |
| format | Book |
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| id | DE-604.BV019657036 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T20:02:18Z |
| institution | BVB |
| isbn | 0853694893 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-012985542 |
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| physical | XII, 242 S. Ill., graph. Darst. |
| publishDate | 2003 |
| publishDateSearch | 2003 |
| publishDateSort | 2003 |
| publisher | Pharmaceutical Press |
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| spelling | Williams, Adrian 1963- Verfasser (DE-588)1045721859 aut Transdermal and topical drug delivery from theory to clinical practice Adrian Williams London [u.a.] Pharmaceutical Press 2003 XII, 242 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Médicaments - Administration - Dispositifs Médicaments - Administration par voie transdermique Administration, Cutaneous Administration, Topical Drug Delivery Systems methods Drug delivery systems Skin Absorption Transdermal medication HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012985542&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Williams, Adrian 1963- Transdermal and topical drug delivery from theory to clinical practice Médicaments - Administration - Dispositifs Médicaments - Administration par voie transdermique Administration, Cutaneous Administration, Topical Drug Delivery Systems methods Drug delivery systems Skin Absorption Transdermal medication |
| title | Transdermal and topical drug delivery from theory to clinical practice |
| title_auth | Transdermal and topical drug delivery from theory to clinical practice |
| title_exact_search | Transdermal and topical drug delivery from theory to clinical practice |
| title_full | Transdermal and topical drug delivery from theory to clinical practice Adrian Williams |
| title_fullStr | Transdermal and topical drug delivery from theory to clinical practice Adrian Williams |
| title_full_unstemmed | Transdermal and topical drug delivery from theory to clinical practice Adrian Williams |
| title_short | Transdermal and topical drug delivery |
| title_sort | transdermal and topical drug delivery from theory to clinical practice |
| title_sub | from theory to clinical practice |
| topic | Médicaments - Administration - Dispositifs Médicaments - Administration par voie transdermique Administration, Cutaneous Administration, Topical Drug Delivery Systems methods Drug delivery systems Skin Absorption Transdermal medication |
| topic_facet | Médicaments - Administration - Dispositifs Médicaments - Administration par voie transdermique Administration, Cutaneous Administration, Topical Drug Delivery Systems methods Drug delivery systems Skin Absorption Transdermal medication |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012985542&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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