Handbook of the biology of aging:
A handbook for biologists and other scientists involved with aging research, as well as gerontologists and practitioners dealing with an aging population. Provides a comprehensive overview of the concepts and theories of aging, covering systemic factors, cellular processes, and models of retarded ag...
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
San Diego, Calif.[u.a.]
Academic Press
2001
|
| Edition: | 5. ed. |
| Series: | The handbooks of aging
|
| Subjects: | |
| Online Access: | Publisher description Table of contents Inhaltsverzeichnis |
| Summary: | A handbook for biologists and other scientists involved with aging research, as well as gerontologists and practitioners dealing with an aging population. Provides a comprehensive overview of the concepts and theories of aging, covering systemic factors, cellular processes, and models of retarded aging. |
| Item Description: | Includes bibliographical references and index |
| Physical Description: | xxi, 534 p. ill. : 26 cm |
| ISBN: | 0124782604 |
Staff View
MARC
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Record in the Search Index
| _version_ | 1804133016165941248 |
|---|---|
| adam_text | Contents
Contributors xi
Foreword xv
Preface xvii
About the Editors xix
Part One
Introduction
1. Concepts and Theories of Aging
Steven N. Austad
I. Introduction 3
II. Measuring the Rate of Aging 4
HI. Theories of Aging 12
IV. Conclusions 18
References 18
Part Two
Cellular Processes Influencing Organismic Aging
Edited by Judith Campisi
2. Oxidative Processes in Aging
Tilman Grime and Kelvin J. A. Davies
I. The Oxygen Paradox 25
II. The Free Radical Theory of Aging 26
HI. Early Studies of Age Related Oxidative Stress 27
IV. Lipid Peroxidation and Cell Damage During Aging 27
V. The Role of DNA Damage—Is Mitochondrial DNA Damage a Pacemaker of the
Aging Process? 28
VI. Investigations of Age Related Changes in Antioxidant Defenses 19
v
vi Contents
VII. Accumulation of Oxidized Proteins during Aging 32
Vin. Adaptive Responses to Oxidative Stress and Regulation of Gene Expression 37
IX. Diminishing Oxidative Stress during Aging by Dietary Interventions 39
X. Future Developments 41
References 42
3. Protein Structure and Turnover
Aii Gafni
I. Introduction 59
II. Classification of Aging Related Protein Modifications 61
III. Age Related Changes in Protein Maturation and Turnover 73
IV. Concluding Remarks and Future Prospects 75
References 76
4. Instability of the Nuclear Genome and the Role of DNA Repair
Jan Vijg and Maitijn E. T. Dolle
I. Definitions and Historical Background 84
II. Evolutionary Logic of Genome Instability 86
III. Origin of Mutations: DNA Damage 86
IV. DNA Alterations with Age 87
V. In Vivo End Points of Nuclear Genome Instability 93
VI. Conclusions 104
References 105
5. Alterations of the Mitochondrial Genome
Jonathan Wanagat, Maiisol Lopez, and Judd M. Aiken
I. Introduction 114
II. Characteristics of the Mitochondrial Genome and Implications for Age Related
Alterations 115
HI. Age Related Biochemical Damage to the Mitochondrial DNA 116
IV. DNA Repair Mechanisms in the Mitochondrion 118
V. Age Associated Mutations of the Mitochondrial Genome 119
VI. Cellular and Tissue Impact of Age Associated Mitochondrial Genetic
Alterations 125
VII. Conclusion 131
References 131
6. Effect of Age on Gene Expression
Ewn Soo Han, Holly Van Remmen, Mark Steinhelpei, Mohammad A. Pahlavani,
J. Randy Strong, and Allan Richaidson
I. Introduction 140
n. Transcription 140
III. Translation 161
References 167
7. Mitogen Activated Protein Kinase Signaling Pathways and Aging
Yasen Liu and Nikki J. Holbiook
I. Introduction 179
n. MAPK Signaling Pathways 180
Contents yj|
III. Summary, Conclusions, and Future Directions 194
References 195
8. Cell Proliferation in Mammalian Aging
Petei J. Hoinsby
I. The Maintenance of Organ Size: Atrophy and Hypertrophy in Aging 207
II. Principles of Growth Control 209
III. Replicative Senescence and Immortalization 210
IV. Methods for Studying Cell Proliferation in Aging 216
V. Telomere Shortening and Replicative Senescence In Vivo 216
VI. Diminution of Reserve Capacity 220
VII. Possible Occurrence of Cells with Characteristics of Replicative Senescence in
Tissues 221
Vni. Stem Cells 221
IX. Age Related Changes in Cell Proliferation 222
X. Changes in Tissue Structure Resulting from Changes in Proliferation 233
XI. Neoplastic Changes as a Function of Age 233
XII. Conclusions and Summary 234
References 235
9. Apoptosis and Aging
Eugenia Wang, Chantal Autexiei, and Edwin Chen
I. Introduction 246
II. General Molecular Mechanism of Apoptosis 247
HI. Apoptotic Susceptibility in Aging 250
IV. Apoptotic Resistance in Aging 252
V. Telomerase, Telomeres, and Apoptosis 254
VI. Potential Use of Telomerase Inhibition and Induction of Apoptosis as an Effective
Anticancer Therapy 258
VII. Concluding Remarks 259
References 260
Section Three
Systemic Factors Influencing Organismic Aging
Edited by Chades V. Mobbs
10. Effects of Aging on the Sympathoadrenal System
James B. Young
I. Introduction 269
II. Overview of the Sympathoadrenal System 269
III. Effect of Age on the Sympathetic Innervation of Peripheral Tissues 273
IV. Effect of Age on the Activity of the Peripheral Sympathetic Nervous System 276
V. Potential Mechanisms Underlying the Effect of Age on SNS Activity 282
VI. Effect of Age on Cardiovascular Regulation 283
VII. Effect of Age on Regulation of Sudomotor Function 284
Vni. Summary and Conclusions 285
References 286
viii Contents
11. Endocrine and Neuroendocrine Regulatory Functions
Andizej Baitke and Mark Lane
I. Introduction 297
II. Growth Hormone and the Somatotropic Axis 300
HI. Hormonal Control of Carbohydrate Metabolism 304
IV. Neuroendocrine Changes Related to Regulation of Food Intake and Body
Composition 308
V. Hypothalamic Pituitary Adrenal Axis 311
References 313
12. Immune System Activity
Rita B. Effios
I. Introduction 324
II. Immune Function and Life Span 325
m. T Cells 325
IV. B Cells 329
V. Natural Killer (NK) Cells 330
VI. Macrophages 330
VII. Telomerase Involvement in the Immune System 331
Vin. Thymic Involution Revisited 333
IX. Influence of Hematopoiesis 333
X. Effects of Antigen Presentation/Accessory Cell Function 335
XI. Physiological Effects of Aging That May Impact Immune Function 335
XII. Immune System Involvement in Diseases of Aging 337
Xm. Concluding Remarks 339
Part Four
Models of Retarded Aging
Edited by Geozge M. Mania
13. The Genetics of Aging in Drosophila
Stephen C. Steams and Linda Partridge
I. Introduction 353
II. Evidence on Antagonistic Pleiotropy 355
III. Evidence on Mutation Accumulation 357
TV Mortality Plateaus: The Heterogeneity Hypothesis 358
V. Evidence for Candidate Genes 359
VI. Transgenic Experiments 361
VII. Microarrays 363
References 364
14. Genetics of Increased Longevity and Retarded Aging in Mice
Richard A. Millei
I. Aging and Longevity 369
n. Mutations at Single Genes 371
IE. Mice Selectively Bred for Variation in Early Life Growth Rate 377
V. Analyses of Recombinant Inbred Mouse Lines 378
V. Selection—Natural and Artificial 381
Contents ix
VI. Analysis and Interpretation of Longevity Gene Experiments 384
VII. Summary and Prospectus 391
References 392
15. Dietary Restriction: An Experimental Approach to the Study of the Biology of
Aging
Edward J. Masoio
I. Introduction 396
II. Rodent Models 396
El. Nonhuman Primate Models 407
IV. Insights from Dietary Restriction Studies 410
V. Future Research Directions 410
References 411
Part Five
Epilogue
Edited by Steven N. Austad and Edward J. Masoro
16. Environment Gene and Gene Gene Interactions
Gerald E. McClearn, George P. Vogler, and Scott M. Hofer
I. Introduction 423
n. A Systems Perspective on Interactions 424
HI. Interactions Among Genes 427
IV. Gene Environment Interactions 430
V. Interactions and Aging 434
VI. Quantitative Approaches to Evaluating Gene Gene and Gene Environment
Interactions: New Opportunities 436
VII. Summary and Conclusions 438
References 439
17. Aging, Health, Longevity, and the Promise of Biomedical Research: The
Perspective of a Gerontologist and Geriatrician
William R. Hazzard
I. Aging, Health, Longevity, and the Promise of Biomedical Research: The Perspective
of a Gerontologist and Geriatrician 445
II. Preventive Gerontology: A Lifelong Strategy To Minimize Secondary Aging and
Make Successful and Usual Aging Synonymous 446
References 456
Author Index 457
Subject Index 515
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| spelling | Handbook of the biology of aging ed. Edward J. Masoro ... Biology of aging 5. ed. San Diego, Calif.[u.a.] Academic Press 2001 xxi, 534 p. ill. : 26 cm txt rdacontent n rdamedia nc rdacarrier The handbooks of aging Includes bibliographical references and index A handbook for biologists and other scientists involved with aging research, as well as gerontologists and practitioners dealing with an aging population. Provides a comprehensive overview of the concepts and theories of aging, covering systemic factors, cellular processes, and models of retarded aging. Aging Physiological aspects Handbooks, manuals, etc Aging physiology Entwicklungsbiologie (DE-588)4152440-8 gnd rswk-swf Altersphysiologie (DE-588)4142054-8 gnd rswk-swf Genetik (DE-588)4071711-2 gnd rswk-swf Altern (DE-588)4068596-2 gnd rswk-swf 1\p (DE-588)4143413-4 Aufsatzsammlung gnd-content Altern (DE-588)4068596-2 s Altersphysiologie (DE-588)4142054-8 s Entwicklungsbiologie (DE-588)4152440-8 s Genetik (DE-588)4071711-2 s 2\p DE-604 Masoro, Edward J. 1924- Sonstige (DE-588)123075297 oth http://www.loc.gov/catdir/description/els031/00110673.html Publisher description http://www.loc.gov/catdir/toc/els031/00110673.html Table of contents HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012972275&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Handbook of the biology of aging Aging Physiological aspects Handbooks, manuals, etc Aging physiology Entwicklungsbiologie (DE-588)4152440-8 gnd Altersphysiologie (DE-588)4142054-8 gnd Genetik (DE-588)4071711-2 gnd Altern (DE-588)4068596-2 gnd |
| subject_GND | (DE-588)4152440-8 (DE-588)4142054-8 (DE-588)4071711-2 (DE-588)4068596-2 (DE-588)4143413-4 |
| title | Handbook of the biology of aging |
| title_alt | Biology of aging |
| title_auth | Handbook of the biology of aging |
| title_exact_search | Handbook of the biology of aging |
| title_full | Handbook of the biology of aging ed. Edward J. Masoro ... |
| title_fullStr | Handbook of the biology of aging ed. Edward J. Masoro ... |
| title_full_unstemmed | Handbook of the biology of aging ed. Edward J. Masoro ... |
| title_short | Handbook of the biology of aging |
| title_sort | handbook of the biology of aging |
| topic | Aging Physiological aspects Handbooks, manuals, etc Aging physiology Entwicklungsbiologie (DE-588)4152440-8 gnd Altersphysiologie (DE-588)4142054-8 gnd Genetik (DE-588)4071711-2 gnd Altern (DE-588)4068596-2 gnd |
| topic_facet | Aging Physiological aspects Handbooks, manuals, etc Aging physiology Entwicklungsbiologie Altersphysiologie Genetik Altern Aufsatzsammlung |
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