Introduction to statistical methods in modern genetics:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Gordon & Breach Science Publ.
2000
|
| Schriftenreihe: | Asian mathematics series
v. 3 |
| Schlagworte: | |
| Online-Zugang: | Table of contents Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references (p. 233-244) and index |
| Beschreibung: | XI, 247 S. Ill., zahlr. graph. Darst. |
| ISBN: | 9056991345 |
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| 650 | 7 | |a Biometrie |2 swd | |
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Datensatz im Suchindex
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|---|---|
| adam_text | INTRODUCTION TO
STATISTICAL METHODS IN
MODERN GENETICS
Mark C K Yang
Department of Statistics
University of Florida, USA
GORDON AND BREACH SCIENCE PUBLISHERS
Australia • Canada • France • Germany • India
Japan • Luxembourg • Malaysia • The Netherlands
Russia • Singapore • Switzerland
Contents
Introduction to the Series vii
Preface ix
Notations xi
1 Background to Modern Statistical Genetics 1
1 1 Introduction: Where is the Gene? 1
1 2 Function of Genes in Reproduction 5
1 3 Some Facts in Molecular Genetics 14
1 4 Tools in Molecular Genetics 22
1 5 Genetic Engineering 30
Exercise 1 39
2 Linkage Analysis with Qualitative Trait 43
2 1 Basic Concepts in Pedigree Analysis 43
2 2 Linkage Analysis for Large Pedigrees 53
2 3 Incomplete Penetrance and Sibling Studies 65
2 4 Designs in Linkage Analysis 82
Exercise 2 92
3 Genetics of Quantitative Trait 97
3 1 Quantitative Trait Locus (QTL) Based on Sibpairs 97
3 2 Interval Mapping of Quantitative Trait Loci 107
3 3 Heritability Estimation 126
3 4 Breeding Value Evaluation Models 140
Exercise 3 154
4 Special Topics 157
4 1 Small Area Gene Mapping by Linkage Disequilibrium 157
4 2 Gene, Exon and Intron Identification 166
vi CONTENTS
4 3 Reconstruction of Evolutionary Path 172
4 4 Forensic Evidence Using Genetic Markers 182
Exercise 4 192
Appendix A Statistical Results Useful in Genetics 195
A I Multivariate Analysis and Regression 195
A 2 Likelihood Ratio Test and General Linear Models 199
A 3 Multinomial Distribution 204
A 4 Inference on Frequency Tables 206
A 5 Discriminant Analysis and Neural Network 208
Appendix B Selected Public Domain Computer Programs
for Genetic Data Analysis 213
BIA Teaching Linkage Analysis Program for Two Generation
Families 213
B2A Simulation Program to Compute ELOD and Var(LOD)
for Two Generation Families 217
B 3 Liped and Programs Described in Terwilliger and Ott s
Handbook 219
B 4 Simlink—Power Prediction for Given Pedigrees 220
B 5 SIB-PAIR: A Nonparametric Linkage Software 221
B 6 MAPMAKER/SIBS, MAPMAKER/QTL, Genehunter,
GAS (Genetic Analysis System) 222
B7A SAS Program to Compute Kinships Coefficients 223
B 8 Using SAS-IML to Solve Handerson s Equation 224
B 9 ETDT (Extended Transmission Disequilibrium Test) 225
B 10 GeneBank and Genetic Data Sources 225
Answers or Hints to Exercises 227
Bibliography 233
Index 245
|
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| indexdate | 2024-07-09T20:00:00Z |
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| isbn | 9056991345 |
| language | English |
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| spelling | Yang, Mark C. K. Verfasser aut Introduction to statistical methods in modern genetics Mark C. K. Yang Amsterdam [u.a.] Gordon & Breach Science Publ. 2000 XI, 247 S. Ill., zahlr. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Asian mathematics series v. 3 Includes bibliographical references (p. 233-244) and index Biomathematik swd Biometrie swd Genetik swd Methode swd Genetics Statistical methods http://www.loc.gov/catdir/toc/fy032/2002421665.html Table of contents HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012885725&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Yang, Mark C. K. Introduction to statistical methods in modern genetics Biomathematik swd Biometrie swd Genetik swd Methode swd Genetics Statistical methods |
| title | Introduction to statistical methods in modern genetics |
| title_auth | Introduction to statistical methods in modern genetics |
| title_exact_search | Introduction to statistical methods in modern genetics |
| title_full | Introduction to statistical methods in modern genetics Mark C. K. Yang |
| title_fullStr | Introduction to statistical methods in modern genetics Mark C. K. Yang |
| title_full_unstemmed | Introduction to statistical methods in modern genetics Mark C. K. Yang |
| title_short | Introduction to statistical methods in modern genetics |
| title_sort | introduction to statistical methods in modern genetics |
| topic | Biomathematik swd Biometrie swd Genetik swd Methode swd Genetics Statistical methods |
| topic_facet | Biomathematik Biometrie Genetik Methode Genetics Statistical methods |
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