Regulatory mechanisms of intracellular membrane transport:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Berlin [u.a.]
Springer
2004
|
| Series: | Topics in Current Genetics
10 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | X, 214 S. Ill., graph. Darst. 235 mm x 155 mm |
| ISBN: | 3540223029 |
Staff View
MARC
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| 245 | 1 | 0 | |a Regulatory mechanisms of intracellular membrane transport |c Sirkka Keränen ; Jussi Jäntti (eds.) |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 2004 | |
| 300 | |a X, 214 S. |b Ill., graph. Darst. |c 235 mm x 155 mm | ||
| 336 | |b txt |2 rdacontent | ||
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| 490 | 1 | |a Topics in Current Genetics |v 10 | |
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| 650 | 7 | |a Genetica |2 gtt | |
| 650 | 7 | |a Membranen |2 gtt | |
| 650 | 7 | |a Transporteiwitten |2 gtt | |
| 650 | 4 | |a Biological transport | |
| 650 | 4 | |a Cell membranes | |
| 650 | 4 | |a Cellular control mechanisms | |
| 650 | 4 | |a Eukaryotic Cells |x metabolism | |
| 650 | 4 | |a Intracellular Membranes |x physiology | |
| 650 | 4 | |a Protein Transport |x physiology | |
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Record in the Search Index
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| adam_text | Table of contents
Introduction: Regulatory processes, an emerging feature in intracellular
membrane traffic 1
Sirkka Keranen and Jussi Jantti 1
Vesicle budding 3
Vesicle targeting regulation by Rab GTPases 4
Tethering complexes 4
SM proteins 5
Regulation of SNARE assembly by protein phosphorylation 6
Phosphoinositides in membrane traffic 6
Regulation ofdenovo membrane formation 6
References 7
Molecular mechanisms in clathrin mediated membrane budding 9
Brigitte Ritter and Peter S. McPherson 9
Abstract 9
1 Cellular sites of clathrin mediated membrane budding 9
2 Formation of endocytic CCVs 10
3 Machinery for CCV formation at the cell surface 14
3.1 Role of clathrin 14
3.2 Role of AP 2 15
3.3 Role of endocytic accessory proteins 18
3.4 Interactions of endocytic accessory proteins with AP 2 23
4 Clathrin trafficking at the TGN 26
4.1 AP 1 and GGA adaptor complexes 26
4.2 Structural analysis of the year and GAE domain 28
4.3 Enthoprotin (Clint/epsinR): identification of a novel y ear/GAE
domain binding consensus motif 29
5 Concluding remarks 30
Acknowledgments 31
References 31
Regulating membrane curvature 39
Joost C. M. Holthuis 39
Abstract 39
1 Introduction 39
2 Topological considerations 40
3 Extrinsic forces affecting membrane curvature 42
3.1 Cytoskeleton 42
3.2 Adhesion to curved particles 44
3.3 Coat assembly 44
4 Intrinsic forces affecting membrane curvature 46
4.1 Transbilayer area asymmetry 46
4.2 Transbilayer curvature asymmetry 52
4.3 Lipid domain induced curvature 56
5 Concluding remarks 57
Acknowledgements 57
References 58
Functions of Rab GTPases in organelle biogenesis 65
Christopher G. Burd and Ruth N. Collins 65
Abstract 65
1 General considerations 65
2 The GTPase cycle 66
2.1 Structural features of Rab 68
2.2 Prenylation and localization of Rab GTPases 70
3 Regulation of inter organelle trafficking and organelle transport 71
3.1 Cargo sorting and vesicle budding 71
3.2 Regulation of membrane tethering and fusion 73
3.3 Rabs and membrane microdomains 75
3.4 Organelle transport 76
3.5 The roles of Rab GTPases in signaling pathways 77
4 Rab proteins in disease and development 78
5 Perspective 78
Acknowledgements 80
References 80
Tethering proteins in membrane traffic 89
Sarah Chu and Wei Guo 89
Abstract 89
1 Introduction 89
2 Tethering proteins in various traffic stages 91
2.1 TRAPP 91
2.2 pi 15 93
2.3Usolp 94
2.4 The COG complex 95
2.5 The exocyst 96
2.6EEA1 98
2.7 HOPS 100
2.8 The GARP/VFT complex 101
3 Postulated functions of the tethering proteins 102
4 Emerging common features of the tethering proteins 103
5 Regulations of the tethering proteins 105
6 Tethering proteins and sorting 105
7 Future studies 106
Acknowledgment 106
References 106
The function of Secl/Muncl8 proteins Solution of the mystery
in sight? 115
Maria Kauppi, Jussi Jantti, and Vesa M. Olkkonen 115
Abstract 115
1 Introduction 115
2 Genetic studies indicate an essential positive function for SM proteins in
vesicle transport 117
2 Genetic studies indicate an essential positive function for SM proteins in
vesicle transport 118
3 The structure of SM proteins 120
4 SM proteins display different binding modes to SNARE molecules 121
5 Are the data suggesting an inhibitory role for SM proteins
physiologically relevant? 123
6 At what stage of the vesicle tethering docking fusion process do SM
proteins exert their effects? 125
7 Evidence for a role of SM proteins in transport and stability
of syntaxins 127
8 Protein phosphorylation regulates interactions of SM proteins with
syntaxins 128
9 Non syntaxin interaction partners of SM proteins 129
9.1 Interactions of SM proteins with transport vesicle tethering
complexes 129
9.2 Interaction partners that regulate the SM protein syntaxin
association 131
9.3 The Mint proteins 133
10 Do the SM proteins share a conserved function despite the different
modes of interaction with SNAREs? 134
Acknowledgements 135
References 135
Regulation of SNARE assembly by protein phosphorylation 145
Adina Weinberger and Jeffrey E. Gerst 145
Abstract 145
1 Introduction 145
2 Phosphorylation and control of the exocytic machinery 147
2.1 Mammalian syntaxins 147
2.2 Yeast syntaxins 151
2.3 Arabidopsis syntaxin 152
2.4 SNAP 25 and SNAP 23 152
2.5 VAMP/Synaptobrevins 155
2.6 SM Proteins 155
2.7 Synaptotagmin 157
3 Protein phosphorylation in the endocytic pathway 158
3.1 Yeast Tig 1,2 and Vps45 158
3.2 VAMP4 159
3.3 Rabs 4 and 5 159
4 Protein phosphorylation in the early secretory pathway 160
5 Conclusions 161
Acknowledgments 162
References 162
Phosphoinositides and membrane traffic in health and disease 171
Anna Godi, Antonella Di Campli, and Maria Antonietta De Matteis 171
Abstract 171
1 Pis metabolism 171
2 The PI kinases: their subcellular localization and role in the secretory
pathway 173
2.1 The Ptdlns 3 kinases 173
2.2 The Ptdlns 4 kinases 175
2.3 The Ptdlns monophosphate kinases 177
3 The PI phosphatases: localization and function in the secretory
pathway 179
3.1 The PI 3 phosphatases 179
3.2 The PI 4 phosphatases 181
3.3 The PI 5 phosphatases 181
4 PI metabolism and disease 182
4.1 PTEN and human cancers 182
4.2 Myotubular myopathy and Charcot Marie Tooth disease 183
4.3 Lowe syndrome 184
5 Conclusions 185
Acknowledgements 185
References 185
Regulation of exocytotic events by centrosome analogous structures 193
Christof Taxis and Michael Knop 193
Abstract 193
1 MTOCs: a brief overview 193
2 Spindle pole bodies and plasma membrane biogenesis in yeast
meiosis 195
2.1 PSM initiation 196
2.2 Growth and shaping of the PSM 199
2.3 Closure of the PSM 200
3 The IMC in Apicomplexa 200
4 Centrioles, basal bodies and plasma membrane 204
5 Conclusion 204
Acknowledgement 205
References 205
Index 209
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| spelling | Regulatory mechanisms of intracellular membrane transport Sirkka Keränen ; Jussi Jäntti (eds.) Berlin [u.a.] Springer 2004 X, 214 S. Ill., graph. Darst. 235 mm x 155 mm txt rdacontent n rdamedia nc rdacarrier Topics in Current Genetics 10 Celbiologie gtt Genetica gtt Membranen gtt Transporteiwitten gtt Biological transport Cell membranes Cellular control mechanisms Eukaryotic Cells metabolism Intracellular Membranes physiology Protein Transport physiology Membrantransport (DE-588)4038575-9 gnd rswk-swf Genregulation (DE-588)4122166-7 gnd rswk-swf Intrazellulärer Transport (DE-588)4313701-5 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Membrantransport (DE-588)4038575-9 s Intrazellulärer Transport (DE-588)4313701-5 s Genregulation (DE-588)4122166-7 s DE-604 Keränen, Sirkka Sonstige oth Jäntti, Jussi Sonstige oth Topics in Current Genetics 10 (DE-604)BV035420113 10 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012870809&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Regulatory mechanisms of intracellular membrane transport Topics in Current Genetics Celbiologie gtt Genetica gtt Membranen gtt Transporteiwitten gtt Biological transport Cell membranes Cellular control mechanisms Eukaryotic Cells metabolism Intracellular Membranes physiology Protein Transport physiology Membrantransport (DE-588)4038575-9 gnd Genregulation (DE-588)4122166-7 gnd Intrazellulärer Transport (DE-588)4313701-5 gnd |
| subject_GND | (DE-588)4038575-9 (DE-588)4122166-7 (DE-588)4313701-5 (DE-588)4143413-4 |
| title | Regulatory mechanisms of intracellular membrane transport |
| title_auth | Regulatory mechanisms of intracellular membrane transport |
| title_exact_search | Regulatory mechanisms of intracellular membrane transport |
| title_full | Regulatory mechanisms of intracellular membrane transport Sirkka Keränen ; Jussi Jäntti (eds.) |
| title_fullStr | Regulatory mechanisms of intracellular membrane transport Sirkka Keränen ; Jussi Jäntti (eds.) |
| title_full_unstemmed | Regulatory mechanisms of intracellular membrane transport Sirkka Keränen ; Jussi Jäntti (eds.) |
| title_short | Regulatory mechanisms of intracellular membrane transport |
| title_sort | regulatory mechanisms of intracellular membrane transport |
| topic | Celbiologie gtt Genetica gtt Membranen gtt Transporteiwitten gtt Biological transport Cell membranes Cellular control mechanisms Eukaryotic Cells metabolism Intracellular Membranes physiology Protein Transport physiology Membrantransport (DE-588)4038575-9 gnd Genregulation (DE-588)4122166-7 gnd Intrazellulärer Transport (DE-588)4313701-5 gnd |
| topic_facet | Celbiologie Genetica Membranen Transporteiwitten Biological transport Cell membranes Cellular control mechanisms Eukaryotic Cells metabolism Intracellular Membranes physiology Protein Transport physiology Membrantransport Genregulation Intrazellulärer Transport Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012870809&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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