Stress, the brain and depression:
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Cambridge [u.a]
Cambridge Univ. Press
2004
|
| Edition: | 1. publ. |
| Subjects: | |
| Online Access: | Publisher description Table of contents Inhaltsverzeichnis |
| Item Description: | Includes bibliographical references and indexes |
| Physical Description: | XII, 283 S. Ill. |
| ISBN: | 052162147X |
Staff View
MARC
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| 100 | 1 | |a Praag, Herman M. van |d 1929- |e Verfasser |0 (DE-588)122677560 |4 aut | |
| 245 | 1 | 0 | |a Stress, the brain and depression |c H.M. Van Praag ; E.R. De Kloet ; J. Van Os |
| 250 | |a 1. publ. | ||
| 264 | 1 | |a Cambridge [u.a] |b Cambridge Univ. Press |c 2004 | |
| 300 | |a XII, 283 S. |b Ill. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Includes bibliographical references and indexes | ||
| 650 | 4 | |a Cerveau - Effets du stress sur le | |
| 650 | 7 | |a Cerveau - Effets du stress |2 ram | |
| 650 | 7 | |a Depressies (psychiatrie) |2 gtt | |
| 650 | 4 | |a Dépression - Pathgénèse | |
| 650 | 7 | |a Dépression nerveuse - Étiologie |2 ram | |
| 650 | 7 | |a Hersenen |2 gtt | |
| 650 | 4 | |a Stress - Complications et séquelles | |
| 650 | 7 | |a Stress - Complications |2 ram | |
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| 650 | 0 | 7 | |a Stress |0 (DE-588)4058047-7 |2 gnd |9 rswk-swf |
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Record in the Search Index
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| adam_text | Contents
Preface page xi
1 Diagnosing depression ]
1.1 Diagnosing and classifying 1
1.2 Diagnosing depression 1
1.2.1 The nosological approach 1
1.2.2 Problems inherent to nosological systems 2
1.2.3 The syndromal approach 5
1.2.4 Problems inherent to the syndromal approach 6
1.2.5 The dimensional/functional approach 6
1.3 Multi tier diagnosing 7
1.4 Conclusions 8
2 Traumatic life events: general issues ] 2
2.1 History 12
2.2 Definitions 13
2.2.1 The stress syndrome 13
2.2.2 Coping with the stress syndrome 14
2.3 Life events and psychiatric classification 15
2.4 Life events and abnormal mental states 16
2.5 Life events and personality structure 18
2.6 Genetic and environmental variables influencing exposure
to life events 19
2.6.1 Life events do not occur capriciously 19
2.6.2 Genes and environment 19
2.7 Conclusions 21
3 Life events and depression: preliminary issues 24
3.1 The agenda 24
3.2 Border issues 24
v
vi Contents
3.2.1 Distress versus depression 24
3.2.2 Chronic depression versus personality related
depressive traits 26
3.3 Meaning of the term life event 27
3.3.1 Definition 27
3.3.2 Heterogeneity 27
External events 27
Internal events 28
Dependent and independent life events 28
Controllability 29
Type of event 29
Conclusion 30
3.4 How to assess life events? 30
3.4.1 Checklists 30
3.4.2 Structured interviews 31
3.4.3 De subjectivation 32
3.4.4 Conclusion 33
3.5 What is meant with the term causation? 33
3.6 Conclusions 34
4 Life events and depression: is there a causal connection? 38
4.1 What kind of evidence is needed? 38
4.2 Life events preceding depression 38
4.2.1 Acute events 38
4.2.2 Chronic difficulties 40
4.3 Vulnerability 41
4.4 Life events, personality and depression 43
4.4.1 A triad? 43
4.4.2 Depression and personality 43
4.4.3 Life events and personality 45
4.4.4 Congruence 46
4.4.5 Conclusions 47
4.5 Early adversity, life events, personality and depression 47
4.6 Genes, life events, personality and depression 48
4.7 Lite events and recovery from depression 50
4.8 Conclusions 51
5 Genetics or depression 59
5.1 Introduction 59
5.2 Genetics of depression 59
5.2.1 Genetic epidemiology of depression 59
5.2.2 Molecular genetics of depression 60
vii Contents
5.3 Genes and environment 63
5.4 The depression exophenotype 64
5.4.1 Depression as a discrete and a continuous trait 65
5.4.2 Genetics of the qualitative phenotype 65
Family studies 65
Twin studies 66
5.4.3 Genetics of the quantitative phenotype 67
5.4.4 Genetics of the comorbid phenotype 69
5.5 The depression endophenotype 69
5.6 The genetics of personality and depression 70
5.7 Development and genes 70
5.8 Molecular genetic findings 71
5.9 Do environmental factors create enduring liabilities to depression? 7 I
5.10 Conclusion 72
6 Gene—environment correlation and interaction in depression 78
6.1 Gene environment relationships 78
6.1.1 Correlation: genes influence environmental exposure 78
6.1.2 Synergism: genes and environment co participate in the
same cause 79
Models describing gene environment synergism 80
6.1.3 Genes and environment add to each other s effect 82
6.1.4 Genes and environment multiply each other s effects 82
6.2 Research findings on gene environment interaction and
correlation 83
6.2.1 Gene environment correlation 83
6.2.2 Gene environment interaction 84
6.3 Conclusion 87
7 Monoamines and depression 91
7.1 The beginnings 91
7.2 Serotonin and depression 92
7.2.1 Localization of serotonergic circuits 92
7.2.2 Serotonin metabolism 92
7.2.3 In vivo receptor studies 96
5 HT receptors and depression 96
5 HTia receptors 99
5 HTnM). receptors 102
5 HT2 receptors 102
5 HT receptors and therapeutic activity of present day
antidepressants 103
5 HT transporter 104
viii Contents
7.2.4 Postmortem receptor studies 104
7.2.5 Genetic studies 105
7.2.6 Conclusions 107
7.3 Noradrenaline and depression 107
7.3.1 Localization 107
7.3.2 Noradrenaline metabolism 108
7.3.3 Noradrenaline receptor studies 110
7.3.4 Conclusions 113
7.4 Dopamine and depression 114
7.4.1 Localization 114
7.4.2 Dopamine metabolism 114
7.4.3 DA receptor studies 116
7.4.4 DA and antidepressant action 117
7.4.5 Conclusions 117
7.5 Behavioural correlates of the monoaminergic disturbances in
depression 118
7.6 Some animal data on 5 HT ergic regulation anxiety and aggression 123
7.7 Conclusions 127
8 Stress hormones and depression 144
8.1 Stress and stress response 144
8.2 Stress and the HPA system 145
8.2.1 The stress response 145
8.2.2 The hypothalamic pituitary adrenal response 146
8.2.3 Cortisol: permissive, feedback and preparatory actions 148
8.2.4 Brain corticosteroid receptors 150
8.2.5 Heterogeneity of the stress response 154
8.2.6 The pacemaker 155
8.3 Depression and the HPA system 155
8.4 CRH and HPA axis abnormalities: stress related or
depression related? 161
8.4.1 How should the question be phrased? 161
8.4.2 Antidepressants and the HPA axis 162
8.4.3 CRH, a depressogenic substance? 163
CRH localization and CRH receptors 163
Effects of CRH in animals 164
CRH and depression 166
CRH, corticosteroids, depression and brain morphology 167
8.4.4 CRH, corticosteroids and early life stress in animals 171
Early life stress and stressor responsivity 171
ix Contents
Mechanisms underlying immediate and long term effects
of maternal separation 173
Persistent effects of mother pup interaction 176
8.4.5 The behavioural effects of early life stress in humans 179
Behavioural effects of childhood adversity 180
Childhood adversity and dysfunction of the HPA axis 183
Posttraumatic stress disorder 185
Childhood adversity and structural changes in the brain 187
8.4.6 Cortisol and the functioning of monoaminergic systems 189
HPA axis and serotonin 189
HPA axis and noradrenalin 193
HPA axis and dopamine 195
Conclusions 196
8.4.7 Glucocorticoids and antidepressant action 197
8.5 Conclusions 200
9 Stress, the brain and depression 225
9.1 The stress syndrome and depression: psychopathological and
biological overlap 225
9.2 Depression, anxiety and aggression: the concept of comorbidity 227
9.3 Comorbidity of depression, anxiety and aggression: some numbers 229
9.3.1 Intercorrelation of the symptoms of mood lowering,
anxiety and aggressivity 229
9.3.2 Comorbidity of mood disorders and anxiety disorders 229
9.3.3 Comorbidity of depression and personality disorder 230
9.4 Comorbidity of anxiety and depression: ways the problem has
been approached 231
9.4.1 Hierarchical exclusion rules 231
9.4.2 Combination diagnoses 232
Atypical depression 232
Mixed anxiety depression disorder 234
9.5 Relationship between anxiety and mood disorders 236
9.6 Anxiety and aggression as pacemakers of depression 236
9.6.1 Anxiety, aggression and mood 236
9.6.2 Anxiety/aggression and depression: psychopathological
aspects 236
9.6.3 Anxiety/aggression and depression: biological aspects 238
Serotonin 238
Stress (CRH/cortisol) serotonin interactions 238
Psychopharmacological observations 239
x Contents
9.6.4 Anxiety/aggression driven depression: aspects of
personality structure 239
9.6.5 Anxiety/aggression driven depression: a
psycho bio psychopathological bridge hypothesis 243
9.6.6 Anxiety/aggression driven depression: therapeutic
expectations 245
9.7 Anxiety/aggression driven depression: diagnostic implications 246
9.7.1 Diagnostic acuity: a condition sine qua non for biological
stress research 246
9.7.2 Functionalization of psychiatric diagnosing 247
9.7.3 Importance of functionalization for the diagnostic process
in psychiatry 248
9.7.4 Functionalization of diagnosis and the construct of
anxiety/aggression driven depression 249
9.7.5 Verticalization of psychiatric diagnosing 249
9.7.6 Approaches towards verticalization of psychiatric diagnoses 249
9.7.7 Importance of verticalization for the diagnostic process in
psychiatry 250
9.8 Consequences of diagnostic renewal for biological psychiatric and
psychopharmacological research 251
9.9 Conclusions 252
Epilogue 260
Stress induced depression 260
Vulnerabilities 261
Recognizability 262
Diagnostic strategies 263
Name index 265
Subject index 274
|
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| indexdate | 2024-07-09T19:59:36Z |
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| language | English |
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| physical | XII, 283 S. Ill. |
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| spelling | Praag, Herman M. van 1929- Verfasser (DE-588)122677560 aut Stress, the brain and depression H.M. Van Praag ; E.R. De Kloet ; J. Van Os 1. publ. Cambridge [u.a] Cambridge Univ. Press 2004 XII, 283 S. Ill. txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and indexes Cerveau - Effets du stress sur le Cerveau - Effets du stress ram Depressies (psychiatrie) gtt Dépression - Pathgénèse Dépression nerveuse - Étiologie ram Hersenen gtt Stress - Complications et séquelles Stress - Complications ram Stress gtt aDepression, Mental xPathogenesis aStress (Physiology) xComplications aBrain xEffect of stress on Physiologische Psychologie (DE-588)4076126-5 gnd rswk-swf Traumatische Neurose (DE-588)4185961-3 gnd rswk-swf Stress (DE-588)4058047-7 gnd rswk-swf Depression (DE-588)4011474-0 gnd rswk-swf Stress (DE-588)4058047-7 s Depression (DE-588)4011474-0 s Physiologische Psychologie (DE-588)4076126-5 s DE-604 Traumatische Neurose (DE-588)4185961-3 s b DE-604 Kloet, Edo Ronald de Sonstige oth Os, Jim van Sonstige oth http://www.loc.gov/catdir/description/cam041/2003055889.html Publisher description http://www.loc.gov/catdir/toc/cam041/2003055889.html Table of contents HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012869490&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Praag, Herman M. van 1929- Stress, the brain and depression Cerveau - Effets du stress sur le Cerveau - Effets du stress ram Depressies (psychiatrie) gtt Dépression - Pathgénèse Dépression nerveuse - Étiologie ram Hersenen gtt Stress - Complications et séquelles Stress - Complications ram Stress gtt aDepression, Mental xPathogenesis aStress (Physiology) xComplications aBrain xEffect of stress on Physiologische Psychologie (DE-588)4076126-5 gnd Traumatische Neurose (DE-588)4185961-3 gnd Stress (DE-588)4058047-7 gnd Depression (DE-588)4011474-0 gnd |
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| title | Stress, the brain and depression |
| title_auth | Stress, the brain and depression |
| title_exact_search | Stress, the brain and depression |
| title_full | Stress, the brain and depression H.M. Van Praag ; E.R. De Kloet ; J. Van Os |
| title_fullStr | Stress, the brain and depression H.M. Van Praag ; E.R. De Kloet ; J. Van Os |
| title_full_unstemmed | Stress, the brain and depression H.M. Van Praag ; E.R. De Kloet ; J. Van Os |
| title_short | Stress, the brain and depression |
| title_sort | stress the brain and depression |
| topic | Cerveau - Effets du stress sur le Cerveau - Effets du stress ram Depressies (psychiatrie) gtt Dépression - Pathgénèse Dépression nerveuse - Étiologie ram Hersenen gtt Stress - Complications et séquelles Stress - Complications ram Stress gtt aDepression, Mental xPathogenesis aStress (Physiology) xComplications aBrain xEffect of stress on Physiologische Psychologie (DE-588)4076126-5 gnd Traumatische Neurose (DE-588)4185961-3 gnd Stress (DE-588)4058047-7 gnd Depression (DE-588)4011474-0 gnd |
| topic_facet | Cerveau - Effets du stress sur le Cerveau - Effets du stress Depressies (psychiatrie) Dépression - Pathgénèse Dépression nerveuse - Étiologie Hersenen Stress - Complications et séquelles Stress - Complications Stress aDepression, Mental xPathogenesis aStress (Physiology) xComplications aBrain xEffect of stress on Physiologische Psychologie Traumatische Neurose Depression |
| url | http://www.loc.gov/catdir/description/cam041/2003055889.html http://www.loc.gov/catdir/toc/cam041/2003055889.html http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012869490&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT praaghermanmvan stressthebrainanddepression AT kloetedoronaldde stressthebrainanddepression AT osjimvan stressthebrainanddepression |