Fundamentals of biochemistry: life at the molecular level
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| Main Authors: | , , |
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| Format: | Book |
| Language: | English |
| Published: |
New York [u.a.]
Wiley
2006
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| Edition: | 2. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | 3. Aufl. u.d.T.: Voet, Donald: Principles of biochemistry |
| Physical Description: | getr. Zählung Ill., graph. Darst. |
| ISBN: | 0471214957 |
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EDITION UNDAMENTALS OF BIOCHEMISTRY LIFE AT THE MOLECULAR LEVEL
UNIVERSITSTS-UND LANDESBIBLIOTHEK BIBLIOTHEK BIOLOGIE SCHNITTSPAHNSTR.
10, 64287 DARMSTADT DONALD VOET UNIVERSITY OF PENNSYLVANIA JUDITH G.
VOET SWARTHMORE COLLEGE CHARLOTTE W. PRATT SEATTLE, WASHINGTON WILEY
JOHN WILEY & SONS, INC. BRIEF CONTENTS PARTI INTRODUCTION CHAPTER 1
INTRODUCTION TO THE CHEMISTRY OF LIFE 2 CHAPTER 2 F J WATER 22 PART II
BIOMOLECULES CHAPTER 3 NUCLEOTIDES, NUCLEIC ACIDS, AND GENETIC
INFORMATION 40 CHAPTER 4 AMINO ACIDS 76 CHAPTER 5 PROTEINS: PRIMARY
STRUCTURE 94 CHAPTER 6 PROTEINS: THREE-DIMENSIONAL STRUCTURE 129 CHAPTER
7 PROTEIN FUNCTION: MYOGLOBIN AND HEMOGLOBIN ISI CHAPTER 8 CARBOHYDRATES
206 CHAPTER 9 LIPIDS AND BIOLOGICAL MEMBRANES 233 CHAPTER 10 MEMBRANE
TRANSPORT 284 PART III ENZYMES CHAPTER 11 ENZYMATIC CATALYSIS 312
CHAPTER 12 ENZYME KINETICS, INHIBITION, AND REGULATION 357 PART IV
METABOLISM CHAPTER 13 INTRODUCTION TO METABOLISM 395 CHAPTER 14 GLUCOSE
CATABOLISM 427 CHAPTER 15 GLYCOGEN METABOLISM AND GLUCONEOGENESIS 472
CHAPTER 16 CITRIC ACID CYCLE 514 CHAPTER 17 ELECTRON TRANSPORT AND
OXIDATIVE PHOSPHORYLATION 545 CHAPTER 18 PHOTOSYNTHESIS 590 CHAPTER 19
LIPID METABOLISM 627 CHAPTER 20 AMINO ACID METABOLISM 682 CHAPTER 21
MAMMALIAN FUEL METABOLISM: INTEGRATION AND REGULATION 743 CHAPTER 22
NUCLEOTIDE METABOLISM 787 PART V GENE EXPRESSION AND REPLICATION CHAPTER
23 NUCLEIC ACID STRUCTURE 817 CHAPTER 24 DNA REPLICATION, REPAIR, AND
RECOMBINATION 867 CHAPTER 25 TRANSCRIPTION AND RNA PROCESSING 919
CHAPTER 26 TRANSLATION 960 CHAPTER 27 REGULATION OF GENE EXPRESSION 1010
CHAPTER 28 PROTEIN FUNCTION PART II: CYTOSKELETAL AND MOTOR PROTEINS AND
ANTIBODIES 1072 APPENDIX BIOINFORMATICS EXERCISES 1115 ANSWERS TO
BIOINFORMATICS EXERCISES 1124 SOLUTIONS TO PROBLEMS SP-I GLOSSARY G-I
GUIDE TO MEDIA RESOURCES GMR-I INDEX 1-1 IX CONTENTS PARTI INTRODUCTION
PART II BIOMOLECULES CHAPTER 1 INTRODUCTION TO THE CHEMISTRY OF LIFE 2
1. THE ORIGIN OF LIFE 3 A. THE PREBIOTIC WORLD 3 B. CHEMICAL EVOLUTION 4
2. CELLULAR ARCHITECTURE 6 A. THE EVOLUTION OF CELLS 6 B. PROKARYOTES
AND EUKARYOTES 8 3. ORGANISMAL EVOLUTION 9 A. TAXONOMY AND PHYLOGENY 9
B. THE ORIGINS OF COMPLEXITY 10 C. HOW DO ORGANISMS EVOLVE? 11 4.
THERMODYNAMICS 12 A. THE FIRST LAW OF THERMODYNAMICS: ENERGY IS
CONSERVED 12 B. THE SECOND LAW OF THERMODYNAMICS: ENTROPY TENDS TO
INCREASE 13 C. FREE ENERGY 14 D. CHEMICAL EQUILIBRIA AND THE STANDARD
STATE 15 E. LIFE OBEYS THE LAWS OF THERMODYNAMICS 17 BOX 1-1
PERSPECTIVES IN BIOCHEMISTRY: BIOCHEMICAL CONVENTIONS 13 CHAPTER 2 WATER
22 1. PHYSICAL PROPERTIES OF WATER 23 A. STRUCTURE OF WATER 23 B. WATER
AS A SOLVENT 26 C. THE HYDROPHOBIC EFFECT 27 D. OSMOSIS AND DIFFUSION 29
2. CHEMICAL PROPERTIES OF WATER 31 A. LONIZATION OF WATER 31 B.
ACID-BASE CHEMISTRY 33 C. BUFFERS 35 BOX 2-1 PERSPECTIVES IN
BIOCHEMISTRY: DIFFUSION RATES AND THE SIZES OF ORGANISMS 31 BOX 2-2
BIOCHEMISTRY IN HEALTH AND DISEASE: THE BLOOD BUFFERING SYSTEM 37
CHAPTER 3 NUCLEOTIDES, NUCLEIC ACIDS, AND GENETIC INFORMATION 40 1.
NUCLEOTIDES 41 2. INTRODUCTION TO NUCLEIC ACID STRUCTURE 44 A. THE BASE
COMPOSITION OF DNA 45 B. THE DOUBLE HELIX 46 C. SINGLE-STRANDED NUCLEIC
ACIDS 49 3. OVERVIEW OF NUCLEIC ACID FUNCTION 49 A. DNA CARRIES GENETIC
INFORMATION 50 B. GENES DIRECT PROTEIN SYNTHESIS 51 4. NUCLEIC ACID
SEQUENCING 52 A. RESTRICTION ENDONUCLEASES 52 B. ELECTROPHORESIS AND
RESTRICTION MAPPING 54 C. THE CHAIN-TERMINATOR METHOD OF DNA SEQUENCING
56 D. GENOME SEQUENCING 60 E. SEQUENCES, MUTATION, AND EVOLUTION 61 5.
MANIPULATING DNA 62 A. CLONING TECHNIQUES 63 B. DNA LIBRARIES 66 C. DNA
AMPLIFICATION BY THE POLYMERASE CHAIN REACTION 68 D. APPLICATIONS OF
RECOMBINANT DNA TECHNOLOGY 70 BOX 3-1 PERSPECTIVES IN BIOCHEMISTRY:
RESTRICTION FRAGMENT LENGTH POLYMORPHISMS 55 BOX 3-2 PATHWAYS OF
DISCOVERY: FRANCIS COLLINS AND THE GENE FOR CYSTIC FIBROSIS 59 BOX 3-3
PERSPECTIVES IN BIOCHEMISTRY: ETHICAL ASPECTS OF RECOMBINANT DNA
TECHNOLOGY 72 CHAPTER 4 AMINO ACIDS 76 1. AMINO ACID STRUCTURE 77 A.
GENERAL PROPERTIES 77 B. PEPTIDE BONDS 80 C. CLASSIFICATION AND
CHARACTERISTICS 8I D. ACID-BASE PROPERTIES 84 E. A FEW WORDS ON
NOMENCLATURE 85 2. STEREOCHEMISTRY 86 3. AMINO ACID DERIVATIVES 89 A.
SIDE CHAIN MODIFICATIONS IN PROTEINS 89 B. BIOLOGICALLY ACTIVE AMINO
ACIDS 90 BOX 4-1 PATHWAYS OF DISCOVERY: WILLIAM C. ROSE AND THE
DISCOVERY OF THREONINE SO BOX 4-2 PERSPECTIVES IN BIOCHEMISTRY: THE RS
SYSTEM 88 BOX 4-3 PERSPECTIVES IN BIOCHEMISTRY: GREEN FLUORESCENT
PROTEIN 90 CONTENTS XI CHAPTER 5 PROTEINS: PRIMARY STRUCTURE 94 1.
POLYPEPTIDE DIVERSITY 95 2. PROTEIN PURIFICATION AND ANALYSIS 97 A.
GENERAL APPROACH TO PURIFYING PROTEINS 98 B. PROTEIN SOLUBILITY 101 C.
CHROMATOGRAPHY 102 D. ELECTROPHORESIS 105 E. ULTRACENTRIFUGATION 107 3.
PROTEIN SEQUENCING 108 A. PRELIMINARY STEPS 110 B. POLYPEPTIDE CLEAVAGE
113 C. EDMAN DEGRADATION 115 D. SEQUENCING BY MASS SPECTROMETRY 116 E.
RECONSTRUCTING THE PROTEIN'S SEQUENCE 1 IS 4. PROTEIN EVOLUTION 120 A.
PROTEIN SEQUENCE EVOLUTION 120 B. GENE DUPLICATION AND PROTEIN FAMILIES
124 C. PROTEIN MODULES 125 BOX 5-1 PERSPECTIVES IN BIOCHEMISTRY:
COMBINATORIAL PEPTIDE LIBRARIES 96 BOX 5- 2 PATHWAYS OF DISCOVERY:
FREDERICK SANGER AND PROTEIN SEQUENCING 109 CHAPTER 6 PROTEINS:
THREE-DIMENSIONAL STRUCTURE 129 1. SECONDARY STRUCTURE 130 A. THE
PEPTIDE GROUP 130 B. REGULAR SECONDARY STRUCTURE: THE A HELIX AND THE (3
SHEET 133 C. FIBROUS PROTEINS 138 D. NONREPETITIVE PROTEIN STRUCTURE 142
2. TERTIARY STRUCTURE 144 A. DETERMINING PROTEIN STRUCTURES 144 B. SIDE
CHAIN LOCATION AND POLARITY 149 C. SUPERSECONDARY STRUCTURES AND DOMAINS
150 D. PROTEIN FAMILIES 154 3. QUATERNARY STRUCTURE AND SYMMETRY 155 4.
PROTEIN STABILITY 156 A. FORCES THAT STABILIZE PROTEIN STRUCTURE 157 B.
PROTEIN DYNAMICS 159 C. PROTEIN DENATURATION AND RENATURATION 159 5.
PROTEIN FOLDING I6I A. PROTEIN FOLDING PATHWAYS I6I B. PROTEIN DISULFIDE
ISOMERASE 162 C. MOLECULAR CHAPERONES 164 D. DISEASES CAUSED BY PROTEIN
MISFOLDING 170 6. STRUCTURAL BIOINFORMATICS 174 BOX 6-1 PATHWAYS OF
DISCOVERY: LINUS PAULING AND STRUCTURAL BIOCHEMISTRY 134 BOX 6-2
BIOCHEMISTRY IN HEALTH AND DISEASE: COLLAGEN DISEASES 141 BOX 6-3
PERSPECTIVES IN BIOCHEMISTRY: THERMOSTABLE PROTEINS 160 BOX 6-4
PERSPECTIVES IN BIOCHEMISTRY: PROTEI N STRUCTURE PREDICTION AND PROTEIN
DESIGN 164 CHAPTER 7 PROTEIN FUNCTION: MYOGLOBIN AND HEMOGLOBIN ISI 1.
MYOGLOBIN 182 A. MYOGLOBIN STRUCTURE 182 B. MYOGLOBIN FUNCTION 183 2.
HEMOGLOBIN 185 A. HEMOGLOBIN STRUCTURE 186 B. OXYGEN BINDING TO
HEMOGLOBIN 190 3. COOPERATIVITY 192 A. MECHANISM OF COOPERATIVITY IN
HEMOGLOBIN 192 B. ALLOSTERIC PROTEINS 199 4. ABNORMAL HEMOGLOBINS 200
BOX 7-1 PERSPECTIVES IN BIOCHEMISTRY: OTHER OXYGEN-TRANSPORT PROTEINS
186 BOX 7-2 PATHWAYS OF DISCOVERY: MAX PERUTZ AND THE STRUCTURE AND
FUNCTION OF HEMOGLOBIN 187 BOX 7-3 BIOCHEMISTRY IN HEALTH AND DISEASE:
HIGH-ALTITUDE ADAPTATION 198 CHAPTER 8 CARBOHYDRATES 206 1.
MONOSACCHARIDES 207 A. CLASSIFICATION OF MONOSACCHARIDES 207 B.
CONFIGURATION AND CONFORMATION 209 C. SUGAR DERIVATIVES 212 2.
POLYSACCHARIDES 214 A. DISACCHARIDES 215 B. STRUCTURAL POLYSACCHARIDES:
CELLULOSE AND CHITIN 215 C. STORAGE POLYSACCHARIDES: STARCH AND GLYCQGEN
218 D. GLYCOSAMINOGLYCANS 219 3. GLYCOPROTEINS 222 A. PROTEOGLYCANS 222
B. BACTERIAL CELL WALLS 223 C. GLYCOSYLATED PROTEINS 225 D. FUNCTIONS OF
OLIGOSACCHARIDES 228 BOX 8-1 BIOCHEMISTRY IN HEALTH AND DISEASE: LACTOSE
INTOLERANCE 215 BOX 8-2 PERSPECTIVES IN BIOCHEMISTRY: ARTIFICIAL
SWEETENERS 216 BOX 8-3 BIOCHEMISTRY IN HEALTH AND DISEASE:
PEPTIDOGLYCAN-SPECIF IC ANTIBIOTICS 225 CHAPTER 9 LIPIDS AND BIOLOGICAL
MEMBRANES 233 1. LIPID CLASSIFICATION 234 A. FATTY ACIDS 234 B.
TRIACYLGLYCEROLS 236 C. GLYCEROPHOSPHOLIPIDS 237 D. SPHINGOLIPIDS 240 E.
STEROIDS 242 F. OTHER LIPIDS 245 XII CONTENTS 2. LIPID BILAYERS 248 A.
WHY BILAYERS FORM 248 B. LIPID MOBILITY 249 3. MEMBRANE PROTEINS 251 A.
INTEGRAL MEMBRANE PROTEINS 251 B. LIPID-LINKED PROTEINS 257 C.
PERIPHERAL MEMBRANE PROTEINS 258 4. MEMBRANE STRUCTURE AND ASSEMBLY 259
A. THE FLUID MOSAIC MODEL 259 B. THE MEMBRANE SKELETON 261 C. LIPID
ASYMMETRY 264 D. THE SECRETORY PATHWAY 267 E. VESICLE TRAFFICKING 272 F.
VESICLE FUSION 278 BOX 9-1 BIOCHEMISTRY IN HEALTH AND DISEASE: LUNG
SURFACTANT 239 BOX 9-2 PATHWAYS OF DISCOVERY: RICHARD HENDERSON AND THE
STRUCTURE OF BACTERIORHODOPSIN 254 CHAPTER 10 MEMBRANE TRANSPORT 284 1.
THERMODYNAMICS OF TRANSPORT 285 2. PASSIVE-MEDIATED TRANSPORT 286 A.
LONOPHORES 286 B. PORINS 288 V C. ION CHANNELS 289 D. AQUAPORINS 29S' E.
TRANSPORT PROTEINS 299 3. ACTIVE TRANSPORT 303 A. (NA + -K + )-ATPASE
303 B. CA 2+ -ATPASE 305 C. ION GRADIENT-DRIVEN ACTIVE TRANSPORT 307 BOX
10-1 PERSPECTIVES IN BIOCHEMISTRY: GAP JUNCTIONS 300 BOX 10-2
PERSPECTIVES IN BIOCHEMISTRY: DIFFERENTIATING MEDIATED AND NONMEDIATED
TRANSPORT 302 BOX 10-3 BIOCHEMISTRY IN HEALTH AND DISEASE: THE ACTION OF
CARDIAC GLYCOSIDES 306 PART III ENZYMES CHAPTER 11 ENZYMATIC CATALYSIS
312 1. GENERAL PROPERTIES OF ENZYMES 313 A. ENZYME NOMENCLATURE 314 B.
SUBSTRATE SPECIFICITY 315 C. COFACTORS AND COENZYMES 316 2. ACTIVATION
ENERGY AND THE REACTION COORDINATE 319 3. CATALYTIC MECHANISMS 321 A.
ACID-BASE CATALYSIS 323 B. COVALENT CATALYSIS 325 C. METAL ION CATALYSIS
326 D. CATALYSIS THROUGH PROXIMITY AND ORIENTATION EFFECTS 327 E.
CATALYSIS BY PREFERENTIAL TRANSITION STATE BINDING 329 4. LYSOZYME 331
A. ENZYME STRUCTURE 332 B. CATALYTIC MECHANISM 336 5. SERINE PROTEASES
340 A. THE ACTIVE SITE 340 B. X-RAY STRUCTURES 342 C. CATALYTIC
MECHANISM 346 D. ZYMOGENS 351 BOX 11-1 PERSPECTIVES IN BIOCHEMISTRY:
EFFECTS OF PH ON ENZYME ACTIVITY 323 BOX 11 -2 PERSPECTIVES IN
BIOCHEMISTRY: OBSERVING ENZYME ACTION BY X-RAY CRYSTALLOGRAPHY 334 BOX
11 -3 BIOCHEMISTRY IN HEALTH AND DISEASE: NERVE POISONS 342 BOX 11 -4
BIOCHEMISTRY IN HEALTH AND DISEASE: THE BLOOD COAGULATION CASCADE 352
CHAPTER 12 ENZYME KINETICS, INHIBITION, AND REGULATION 357 1. REACTION
KINETICS 358 A. CHEMICAL KINETICS 358 B. ENZYME KINETICS 360 C. ANALYSIS
OF KINETIC DATA 367 D. BISUBSTRATE REACTIONS 369 2. ENZYME INHIBITION
370 A. COMPETITIVE INHIBITION 371 B. UNCOMPETITIVE INHIBITION 375 C.
MIXED INHIBITION 376 3. ALLOSTERIC REGULATION OF ENZYME ACTIVITY 380 4.
DRUG DESIGN 385 A. DRUG DISCOVERY 386 B. BIOAVAILABILITY AND TOXICITY
387 C. CLINICAL TRIALS 388 D. CYTOCHROME P450 AND ADVERSE DRUG REACTIONS
389 BOX 12-1 PERSPECTIVES IN BIOCHEMISTRY: ISOTOPIC LABELING 361 BOX
12-2 PATHWAYS OF DISCOVERY: J.B.S . HALDANE AND ENZYME ACTION 363 BOX
12-3 PERSPECTIVES IN BIOCHEMISTRY: KINETICS AND TRANSITION STATE THEORY
366 BOX 12-4 BIOCHEMISTRY IN HEALTH AND DISEASE: HIV ENZYME INHIBITORS
378 CONTENTS XIII PART IV METABOLISM CHAPTER 13 INTRODUCTION TO
METABOLISM 395 1. OVERVIEW OF METABOLISM 396 A. TROPHIC STRATEGIES 396
B. METABOLIC PATHWAYS 397 C. THERMODYNAMIC CONSIDERATIONS 401 D. CONTROL
OF METABOLIC FLUX 402 2. "HIGH-ENERGY" COMPOUNDS 404 A. ATP AND
PHOSPHORYL GROUP TRANSFER 406 B. COUPLED REACTIONS 407 C. OTHER
PHOSPHORYLATED COMPOUNDS 410 D. THIOESTERS 413 3. OXIDATION-REDUCTION
REACTIONS 414 A. NAD + AND FAD 414 B. THE NERNST EQUATION 415 C.
MEASUREMENTS OF REDUCTION POTENTIAL DIFFERENCES 417 4. EXPERIMENTAL
APPROACHES TO THE STUDY OF METABOLISM 419 A. TRACING METABOLIC FATES 420
B. PERTURBING THE SYSTEM 421 C. DNA MICROARRAYS 422 D. PROTEOMICS 424
BOX 1 3-1 PERSPECTIVES IN BIOCHEMISTRY: OXIDATION STATES OF CARBON BOX
13-2 PERSPECTIVES IN BIOCHEMISTRY: MAPPING METABOLIC PATHWAYS 399 BOX
13-3 PATHWAYS OF DISCOVERY: FRITZ LIPMANN AND "HIGH-ENERGY 1 COMPOUNDS
405 BOX 13-4 PERSPECTIVES IN BIOCHEMISTRY: ATP AND AG 407 CHAPTER 14
GLUCOSE CATABOLISM 427 1. OVERVIEW OF GLYCOLYSIS 428 2. THE REACTIONS OF
GLYCOLYSIS 431 A. HEXOKINASE: FIRST USE OF ATP 431 B. PHOSPHOGLUCOSE
ISOMERASE 432. C. PHOSPHOFRUCTOKINASE: SECOND USE OF ATP 433 D. ALDOLASE
434 E. TRIOSE PHOSPHATE ISOMERASE 436 F. GLYCERALDEHYDE-3-PHOSPHATE
DEHYDROGENASE: FIRST "HIGH-ENERGY" INTERMEDIATE FORMATION 439 G.
PHOSPHOGLYCERATE KINASE: FIRST ATP GENERATION 441 H. PHOSPHOGLYCERATE
MUTASE 441 I. ENOLASE: SECOND "HIGH-ENERGY" INTERMEDIATE FORMATION 442
J. PYRUVATE KINASE: SECOND ATP GENERATION 443 3. FERMENTATION: THE
ANAEROBIC FATE OF PYRUVATE 446 A. HOMOLACTIC FERMENTATION 447 B.
ALCOHOLIC FERMENTATION 448 C. ENERGETICS OF FERMENTATION 451 4. CONTROL
OF GLYCOLYSIS 452 A. PHOSPHOFRUCTOKINASE: THE MAJOR FLUX-CONTROLLING
ENZYME OF GLYCOLYSIS IN MUSCLE 453 B. SUBSTRATE CYCLING 456 5.
METABOLISM OF HEXOSES OTHER THAN GLUCOSE 458 A. FRUCTOSE 458 B.
GALACTOSE 460 C. MANNOSE 462 6. THE PENTOSE PHOSPHATE PATHWAY 462 A.
STAGE 1: OXIDATIVE REACTIONS OF NADPH PRODUCTION 464 B. STAGE 2:
ISOMERIZATION AND EPIMERIZATION OF RIBULOSE-5- PHOSPHATE 465 C. STAGE 3:
CARBON-CARBON BOND CLEAVAGE AND FORMATION REACTIONS 465 D. CONTROL OF
THE PENTOSE PHOSPHATE PATHWAY 466 BOX 14-1 PATHWAYS OF DISCOVERY: OTTO
WARBURG AND STUDIES OF METABOLISM 429 BOX 14-2 PERSPECTIVES IN
BIOCHEMISTRY: SYNTHESIS OF 2,3- BISPHOSPHOGLYCERATE IN ERYTHROCYTES AND
ITS EFFECT ON THE OXYGEN CARRYING CAPACITY OF THE BLOOD 444 BOX 14-3
PERSPECTIVES IN BIOCHEMISTRY: GLYCOLYTIC ATP PRODUCTION IN MUSCLE 453
BOX 14-4 BIOCHEMISTRY IN HEALTH AND DISEASE: GLUCOSE-6-PHOSPHATE
DEHYDROGENASE DEFICIENCY 468 XIV CONTENTS CHAPTER 15 GLYCOGEN METABOLISM
AND GLUCONEOGENESIS 472 1. GLYCOGEN BREAKDOWN 474 A. GLYCOGEN
PHOSPHORYLASE 475 B. GLYCOGEN DEBRANCHING ENZYME 479 C.
PHOSPHOGLUCOMUTASE 480 2. GLYCOGEN SYNTHESIS 481 A. UDP*GLUCOSE
PYROPHOSPHORYLASE 484 B. GLYCOGEN SYNTHASE 485 C. GLYCOGEN BRANCHING
ENZYMES 487 3. CONTROL OF GLYCOGEN METABOLISM 487 A. DIRECT ALLOSTERIC
CONTROL OF GLYCOGEN PHOSPHORYLASE AND GLYCOGEN SYNTHASE 487 B. COVALENT
MODIFICATION OF GLYCOGEN PHOSPHORYLASE AND GLYCOGEN SYNTHASE 489 C.
HORMONAL EFFECTS ON GLYCOGEN METABOLISM 497 4. GLUCONEOGENESIS 500 A.
PYRUVATE TO PHOSPHOENOLPYRUVATE 500 B. HYDROLYTIC REACTIONS 505 C.
REGULATION OF GLUCONEOGENESIS 505 5. OTHER CARBOHYDRATE BIOSYNTHETIC
PATHWAYS 507 BOX 15-1 PATHWAYS OF DISCOVERY: CARL AND GERTY CORI AND
GLUCOSE METABOLISM 475 BOX 1 5-2 BIOCHEMISTRY IN HEALTH AND DISEASE:
GLYCOGEN STORAGE DISEASES 482 BOX 15-3 PERSPECTIVES IN BIOCHEMISTRY:
OPTIMIZING GLYCOGEN STRUCTURE 488 BOX 15-4 PERSPECTIVES IN BIOCHEMISTRY:
LACTOSE SYNTHESIS 508 CHAPTER 16 CITRIC ACID CYCLE 514 1. OVERVIEW OF
THE CITRIC ACID CYCLE 515 2. SYNTHESIS OF ACETYL-COENZYME A 517 A. THE
PYRUVATE DEHYDROGENASE MULTIENZYME COMPLEX 519 B. THE REACTIONS OF THE
PYRUVATE DEHYDROGENASE COMPLEX 521 3. ENZYMES OF THE CITRIC ACID CYCLE
524 A. CITRATE SYNTHASE 525 B. ACONITASE 526 C. NAD + -DEPENDENT
ISOCITRATE DEHYDROGENASE 527 D. A-KETOGLUTARATE DEHYDROGENASE 528 E.
SUCCINYL-COA SYNTHETASE 528 F. SUCCINATE DEHYDROGENASE 530 G. FUMARASE
531 H. MALATE DEHYDROGENASE 531 4. REGULATION OF THE CITRIC ACID CYCLE
531 A. REGULATION OF PYRUVATE DEHYDROGENASE 532 B. THE RATE-CONTROLLING
ENZYMES OF THE CITRIC ACID CYCLE 533 5. REACTIONS RELATED TO THE CITRIC
ACID CYCLE 535 A. PATHWAYS THAT USE CITRIC ACID CYCLE INTERMEDIATES 536
B. REACTIONS THAT REPLENISH CITRIC ACID CYCLE INTERMEDIATES 537 C. THE
GLYOXYLATE CYCLE 538 BOX 16-1 PATHWAYS OF DISCOVERY: HANS KREBS AND THE
CITRIC'ACID CYCLE 518 BOX 16-2 BIOCHEMISTRY IN HEALTH AND DISEASE:
ARSENIC POISONING 525 BOX 16-3 PERSPECTIVES IN BIOCHEMISTRY: EVOLUTION
OF THE CITRIC ACID CYCLE 540 CHAPTER 17 ELECTRON TRANSPORT AND OXIDATIVE
PHOSPHORYLATION 545 1. THE MITOCHONDRION 546 A. MITOCHONDRIAL ANATOMY
547 B. MITOCHONDRIAL TRANSPORT SYSTEMS 548 2. ELECTRON TRANSPORT 549 A.
THERMODYNAMICS OF ELECTRON TRANSPORT 550 B. THE SEQUENCE OF ELECTRON
TRANSPORT 551 C. COMPLEX I (NADH-COENZYME Q OXIDOREDUCTASE) 554 D.
COMPLEX II (SUCCINATE-COENZYME Q OXIDOREDUCTASE) 558 E. COMPLEX III
(COENZYME Q-CYTOCHROME C OXIDOREDUCTASE) 560 F. COMPLEX IV (CYTOCHROME
COXIDASE) 564 3. OXIDATIVE PHOSPHORYLATION 567 A. THE CHEMIOSMOTIC
THEORY 568 B. ATP SYNTHASE 571 C. THE P/0 RATIO 577 D. UNCOUPLING
OXIDATIVE PHOSPHORYLATION 578 4. CONTROL OF OXIDATIVE METABOLISM 579 A.
CONTROL OF OXIDATIVE PHOSPHORYLATION 579 B. COORDINATED CONTROL OF
OXIDATIVE METABOLISM 582 C. PHYSIOLOGICAL IMPLICATIONS OF AEROBIC
METABOLISM 582 BOX 17-1 PERSPECTIVES IN BIOCHEMISTRY: CYTOCHROME S ARE
ELECTRON- TRANSPORT HEME PROTEINS 558 BOX 17-2 PATHWAYS OF DISCOVERY:
PETER MITCHELL AND THE CHEMIOSMOTIC THEORY 569 BOX 17-3 PERSPECTIVES IN
BIOCHEMISTRY: BACTERIAL ELECTRON TRANSPORT AND OXIDATIVE PHOSPHORYLATION
570 BOX 17-4 PERSPECTIVES IN BIOCHEMISTRY: UNCOUPLING IN BROWN ADIPOSE
TISSUE GENERATES HEAT 580 BOX 1 7-5 BIOCHEMISTRY IN HEALTH AND DISEASE:
OXYGEN DEPRIVATION IN HEART ATTACK AND STROKE 584 CHAPTER 18
PHOTOSYNTHESIS 590 1. CHLOROPLASTS 591 A. CHLOROPLAST ANATOMY 592 B.
LIGHT-ABSORBING PIGMENTS 592 2. THE LIGHT REACTIONS 596 A. THE
INTERACTION OF LIGHT AND MATTER 596 B. ELECTRON TRANSPORT IN
PHOTOSYNTHETIC BACTERIA 597 C. TWO-CENTER ELECTRON TRANSPORT 600 S D.
PHOTOPHOSPHORYLATION 612 3. THE DARK REACTIONS 613 A. THE CALVIN CYCLE
613 B. CARBOHYDRATE SYNTHESIS 6IS C. CONTROL OF THE CALVIN CYCLE 619 D.
PHOTORESPIRATION 621 BOX 18-1 PERSPECTIVES IN BIOCHEMISTRY: SEGREGATION
OF PSI AND PSII 611 CONTENTS XV CHAPTER 19 LIPID METABOLISM 627 1. LIPID
DIGESTION, ABSORPTION, AND TRANSPORT 628 A. DIGESTION AND ABSORPTION 628
B. LIPID TRANSPORT 630 2. FATTY ACID OXIDATION 635 A. FATTY ACID
ACTIVATION 636 B. TRANSPORT ACROSS THE MITOCHONDRIAL MEMBRANE 636 C. (3
OXIDATION 638 D. OXIDATION OF UNSATURATED FATTY ACIDS 640 E. OXIDATION
OF ODD-CHAIN FATTY ACIDS 642 F. PEROXISOMAL (3 OXIDATION 648 3. KETONE
BODIES 649 4. FATTY ACID BIOSYNTHESIS 650 A. TRANSPORT OF MITOCHONDRIAL
ACETYL-COA INTO THE CYTOSOL 65I B. ACETYL-COA CARBOXYLASE 651 C. FATTY
ACID SYNTHASE 653 D. ELONGASES AND DESATURASES 657 E. SYNTHESIS OF
TRIACYLGLYCEROLS 658 5. REGULATION OF FATTY ACID METABOLISM 660 6.
SYNTHESIS OF OTHER LIPIDS 663 A. GLYCEROPHOSPHOLIPIDS 663 B.
SPHINGOLIPIDS 666 C. PROSTAGLANDINS 669 7. CHOLESTEROL METABOLISM 671 A.
CHOLESTEROL BIOSYNTHESIS 671 B. REGULATION OF CHOLESTEROL SYNTHESIS 674
C. CHOLESTEROL TRANSPORT AND ATHEROSCLEROSIS 677 BOX 19-1 BIOCHEMISTRY
IN HEALTH AND DISEASE: VITAMIN B12 DEFICIENCY 644 BOX 19-2 PATHWAYS OF
DISCOVERY: DOROTHY CROWFOOT HODGKIN AND THE STRUCTURE OF VITAMIN B12 647
BOX 19-3 PERSPECTIVES IN BIOCHEMISTRY: TRICLOSAN: AN INHIBITOR OF FATTY
ACID SYNTHESIS 658 BOX 19-4 BIOCHEMISTRY IN HEALTH AND DISEASE:
SPHINGOLIPID DEGRADATION AND LIPID STORAGE DISEASES 668 CHAPTER 20 AMINO
ACID METABOLISM 682 1. PROTEIN DEGRADATION 683 A. LYSOSOMAL DEGRADATION
683 B. UBIQUITIN 684 C. THE PROTEASOME 685 2. AMINO ACID DEAMINATION 688
A. TRANSAMINATION 688 B. OXIDATIVE DEAMINATION 692 3. THE UREA CYCLE 692
A. REACTIONS OF THE UREA CYCLE 693 B. REGULATION OF THE UREA CYCLE 697
4. BREAKDOWN OF AMINO ACIDS 697 A. ALANINE, CYSTEINE, GLYCINE, SERINE,
AND THREONINE ARE DEGRADED TO PYRUVATE 698 B. ASPARAGINE AND ASPARTATE
ARE DEGRADED TO OXALOACETATE 701 C. ARGININE, GLUTAMATE, GLUTAMINE,
HISTIDINE, AND PROLINE ARE DEGRADED TO A-KETOGLUTARATE 701 D.
ISOLEUCINE, METHIONINE, AND VALINE ARE DEGRADED TO SUCCINYL-COA 702 E.
LEUCINE AND LYSINE ARE DEGRADED ONLY TO ACETYL-COA AND/OR ACETOACETATE
708 F. TRYPTOPHAN IS DEGRADED TO ALANINE AND ACETOACETATE 708 G.
PHENYLALANINE AND TYROSINE ARE DEGRADED TO FUMARATE AND ACETOACETATE 710
5. AMINO ACID BIOSYNTHESIS 713 A. BIOSYNTHESIS OF THE NONESSENTIAL AMINO
ACIDS 714 B. BIOSYNTHESIS OF THE ESSENTIAL AMINO ACIDS 719 6. OTHER
PRODUCTS OF AMINO ACID METABOLISM 724 A. HEME BIOSYNTHESIS AND
DEGRADATION 724 B. BIOSYNTHESIS OF PHYSIOLOGICALLY ACTIVE AMINES 730 C.
NITRIC OXIDE 731 7. NITROGEN FIXATION 732 BOX 20-1 BIOCHEMISTRY IN
HEALTH AND DISEASE: HOMOCYSTEINE, A MARKER OF DISEASE 706 BOX 20-2
BIOCHEMISTRY IN HEALTH AND DISEASE: PHENYLKETONURIA AND ALCAPTONURIA
RESULT FROM DEFECTS IN PHENYLALANINE DEGRADATION 712 BOX 20-3
BIOCHEMISTRY IN HEALTH AND DISEASE: THE PORPHYRIAS 728 BOX 20-4
PERSPECTIVES IN BIOCHEMISTRY: ANAMMOX BACTERIA 738 CHAPTER 21 MAMMALIAN
FUEL METABOLISM: INTEGRATION AND REGULATION 743 1. ORGAN SPECIALIZATION
744 A. THE BRAIN 746 B. MUSCLE 746 C. ADIPOSE TISSUE 748 D. LIVER 749 E.
KIDNEY 751 F. INTERORGAN METABOLIC PATHWAYS 751 2. HORMONAL CONTROL OF
FUEL METABOLISM 752 3. SIGNAL TRANSDUCTION 756 A. G PROTEIN-COUPLED
RECEPTORS 757 B. HETEROTRIMERIC G PROTEINS 759 C. ADENYLATE CYCLASE 761
D. RECEPTOR TYROSINE KINASES 764 E. PROTEIN PHOSPHATASES 769 F. THE
PHOSPHOINOSITIDE PATHWAY 771 4. DISTURBANCES IN FUEL METABOLISM 774 A.
STARVATION 774 B. DIABETES MELLITUS 779 C. OBESITY 782 BOX 21-1
BIOCHEMISTRY IN HEALTH AND DISEASE: DRUGS AND TOXINS THAT AFFECT CELL
SIGNALING 763 BOX 21-2 BIOCHEMISTRY IN HEALTH AND DISEASE: ONCOGENES AND
CANCER 768 BOX 21-3 BIOCHEMISTRY IN HEALTH AND DISEASE: ANTHRAX 776 BOX
21-4 PATHWAYS OF DISCOVERY: FREDERICK BANTING AND CHARLES BEST AND THE
DISCOVERY OF INSULIN 780 XVI CONTENTS CHAPTER 22 NUCLEOTIDE METABOLISM
787 1. SYNTHESIS OF PURINE RIBONUCLEOTIDES 788 A. SYNTHESIS OF INOSINE
MONOPHOSPHATE 789 B. SYNTHESIS OF ADENINE AND GUANINE RIBONUCLEOTIDES
792 C. REGULATION OF PURINE NUCLEOTIDE BIOSYNTHESIS 794 D. SALVAGE OF
PURINES 795 2. SYNTHESIS OF PYRIMIDINE RIBONUCLEOTIDES 795 A. SYNTHESIS
OF UMP 796 B. SYNTHESIS OF UTP AND CTP 798 C. REGULATION OF PYRIMIDINE
NUCLEOTIDE BIOSYNTHESIS 798 3. FORMATION OF DEOXYRIBONUCLEOTIDES 799 A.
PRODUCTION OF DEOXYRIBOSE RESIDUES 799 B. ORIGIN OF THYMINE 804 4.
NUCLEOTIDE DEGRADATION 809 A. CATABOLISM OF PURINES 809 B. FATE OF URIC
ACID SN C. CATABOLISM OF PYRIMIDINES 814 BOX 22-1 BIOCHEMISTRY IN HEALTH
AND DISEASE: INHIBITION OF THYMIDYLATE SYNTHESIS IN CANCER THERAPY 807
PART V GENE EXPRESSION AND REPLICATION CHAPTER 23 NUCLEIC ACID STRUCTURE
817 1. THE DNA HELIX SIS A. THE GEOMETRY OF DNA 818 B. FLEXIBILITY OF
DNA 824 C. SUPERCOILED DNA 826 2. FORCES STABILIZING NUCLEIC ACID
STRUCTURES 835 A. DENATURATION AND RENATURATION 835 B. BASE PAIRING 836
C. BASE STACKING AND HYDROPHOBIC INTERACTIONS 837 D. IONIC INTERACTIONS
837 E. RNA STRUCTURE 838 3. FRACTIONATION OF NUCLEIC ACIDS 842 A.
CHROMATOGRAPHY 842 B. ELECTROPHORESIS 842 C. ULTRACENTRIFUGATION 844 4.
DNA-PROTEIN INTERACTIONS 845 A. RESTRICTION ENDONUCLEASES 846 B.
PROKARYOTIC TRANSCRIPTIONAL CONTROL MOTIFS 847 C. EUKARYOTIC
TRANSCRIPTION FACTORS 850 5. EUKARYOTIC CHROMOSOME STRUCTURE 853 A.
HISTONES 854 B. NUCLEOSOMES 855 C. HIGHER LEVELS OF CHROMATIN
ORGANIZATION 858 BOX 23-1 PATHWAYS OF DISCOVERY: ROSALIND FRANKLIN AND
THE STRUCTURE OF DNA 822 BOX 23-2 BIOCHEMISTRY IN HEALTH AND DISEASE: I
N H I B ITORS OF TOPOISOMERASES AS ANTIBIOTICS AND ANTICANCER
CHEMOTHERAPEUTIC AGENTS 834 BOX 23-3 PERSPECTIVES IN BIOCHEMISTRY: THE
RNA WORLD 841 BOX 23-4 PERSPECTIVES IN BIOCHEMISTRY: PACKAGING VIRAL
NUCLEIC ACIDS 862 CHAPTER 24 DNA REPLICATION, REPAIR, AND RECOMBINATION
867 1. OVERVIEW OF DNA REPLICATION 868 2. PROKARYOTIC DNA REPLICATION
871 A. DNA POLYMERASES 871 B. INITIATION OF REPLICATION 877 C. SYNTHESIS
OF THE LEADING AND LAGGING STRANDS 879 D. TERMINATION OF REPLICATION 882
E. FIDELITY OF REPLICATION 884 3. EUKARYOTIC DNA REPLICATION 884 A.
EUKARYOTIC DNA POLYMERASES 885 B. INITIATION AND ELONGATION OF
EUKARYOTIC DNA REPLICATION 886 C. TELOMERES AND TELOMERASE 888 4. DNA
DAMAGE 891 A. MUTAGENESIS 892 B. CARCINOGENS 895 5. DNA REPAIR 896 A.
DIRECT REVERSAL OF DAMAGE 896 B. BASE EXCISION REPAIR 896 C. NUCLEOTIDE
EXCISION REPAIR 898 D. MISMATCH REPAIR 900 E. ERROR-PRONE REPAIR 900 6.
RECOMBINATION 902 A. THE MECHANISM OF HOMOLOGOUS RECOMBINATION 903 B.
RECOMBINATION REPAIR 908 C. TRANSPOSITION 910 BOX 24-1 PATHWAYS OF
DISCOVERY: ARTHUR KORNBERG AND DNA POLYMERASE I 872 BOX 24-2
PERSPECTIVES IN BIOCHEMISTRY: REVERSE TRANSCRIPTASE 886 BOX 24-3
BIOCHEMISTRY IN HEALTH AND DISEASE: TELOMERASE, AGING, AND CANCER 89I
BOX 24-4 PERSPECTIVES IN BIOCHEMISTRY: DNA METHYLATION 894 BOX 24-5
PERSPECTIVES IN BIOCHEMISTRY: WHY DOESN'T DNA CONTAIN URACIL? 898
CONTENTS XVII CHAPTER 25 TRANSCRIPTION AND RNA PROCESSING 919 1. RNA
POLYMERASE 920 A. ENZYME STRUCTURE 920 B. TEMPLATE BINDING 921 C. CHAIN
ELONGATION 924 D. CHAIN TERMINATION 927 2. TRANSCRIPTION IN EUKARYOTES
928 A. EUKARYOTIC RNA POLYMERASES 929 B. EUKARYOTIC PROMOTERS 933 C.
TRANSCRIPTION FACTORS 936 3. POSTTRANSCRIPTIONAL PROCESSING 940 A.
MESSENGER RNA PROCESSING 940 B. RIBOSOMAL RNA PROCESSING 951 C. TRANSFER
RNA PROCESSING 955 BOX 25-1 PERSPECTIVES IN BIOCHEMISTRY: COLLISIONS
BETWEEN DNA POLYMERASE AND RNA POLYMERASE 926 BOX 25-2 BIOCHEMISTRY IN
HEALTH AND DISEASE: INHIBITORS OF TRANSCRIPTION 930 BOX 25-3 PATHWAYS OF
DISCOVERY: RICHARD ROBERTS AND PHILLIP SHARP AND THE DISCOVERY OF
INTRONS 943 CHAPTER 26 TRANSLATION 960 1. THE GENETIC CODE 961 A. CODONS
ARE TRIPLETS THAT ARE READ SEQUENTIALLY 962 B. DECIPHERING THE GENETIC
CODE 963 C. THE NATURE OF THE GENETIC CODE 964 2. TRANSFER RNA AND ITS
AMINOACYLATION 967 A. TRNA STRUCTURE 967 B. AMINOACYL*TRNA SYNTHETASES
969 C. CODON*ANTICODON INTERACTIONS 974 3. RIBOSOMES 977 A. THE
PROKARYOTIC RIBOSOME 977 B. THE EUKARYOTIC RIBOSOME 983 4. TRANSLATION
984 A. CHAIN INITIATION 986 B. CHAIN ELONGATION 991 C. CHAIN TERMINATION
1001 5. POSTTRANSLATIONAL PROCESSING 1004 A. PROTEIN FOLDING 1004 B.
COVALENT MODIFICATION 1005 BOX 26-1 PERSPECTIVES IN BIOCHEMISTRY:
EVOLUTION OF THE GENETIC CODE 966 BOX 26-2 PERSPECTIVES IN BIOCHEMISTRY:
EXPANDING THE GENETIC CODE 976 BOX 26-3 BIOCHEMISTRY IN HEALTH AND
DISEASE: THE EFFECTS OF ANTIBIOTICS ON PROTEIN SYNTHESIS 1000 CHAPTER 27
REGULATION OF GENE EXPRESSION 1010 1. GENOME ORGANIZATION A. GENE NUMBER
B. GENE CLUSTERS 1011 1012 1015 C. REPETITIVE DNA SEQUENCES 1016 2.
REGULATION OF PROKARYOTIC GENE EXPRESSION 1021 A. THE /ACREPRESSOR 1021
B. CATABOLITE REPRESSION: AN EXAMPLE OF GENE ACTIVATION 1025 C.
ATTENUATION 1026 D. RIBOSWITCHES 1029 3. REGULATION OF EUKARYOTIC GENE
EXPRESSION 1030 A. CHROMATIN STRUCTURE AND GENE EXPRESSION 1030 B.
CONTROL OF TRANSCRIPTION IN EUKARYOTES 1043 C. POSTTRANSCRIPTIONAL
CONTROL MECHANISMS 1050 D. THE CELL CYCLE, CANCER, AND APOPTOSIS 1054 E.
THE MOLECULAR BASIS OF DEVELOPMENT 1062 BOX 27-1 BIOCHEMISTRY IN HEALTH
AND DISEASE: TRINUCLEOTIDE REPEAT DISEASES 1018 BOX 27-2 PERSPECTIVES IN
BIOCHEMISTRY: INFERRIN G GENEALOGY FROM DNA SEQUENCES 1021 BOX 27-3
PERSPECTIVES IN BIOCHEMISTRY: X-CHROMOSOME INACTIVATION 1031 BOX 27-4
PERSPECTIVES IN BIOCHEMISTRY: NONSENSE-MEDIATED DECAY 1051 CHAPTER 28
PROTEIN FUNCTION PART II: CYTOSKELETAL AND MOTOR PROTEINS AND ANTIBODIES
1072 1. ACTIN AND MICROFILAMENTS 1073 A. ACTIN STRUCTURE 1074 B.
MICROFILAMENT DYNAMICS 1075 2. MUSCLE CONTRACTION IOSO A. STRUCTURE OF
STRIATED MUSCLE IOSO B. THE ACTIN*MYOSIN REACTION CYCLE 1086 C.
UNCONVENTIONAL MYOSIN V 1088 3. TUBULIN AND MICROTUBULES 1091 A. THE
TUBULIN DIMER 1091 B. MICROTUBULE DYNAMICS 1092 4. MICROTUBULE MOTORS
1094 A. KINESINS 1095 B. DYNEINS 1099 5. ANTIBODIES 1104 A. OVERVIEW OF
THE IMMUNE SYSTEM 1104 B. ANTIBODY STRUCTURE 1105 C. ANTIGEN-ANTIBODY
BINDING 1106 D. GENERATING ANTIBODY DIVERSITY 1108 BOX 28-1 PATHWAYS OF
DISCOVERY: HUGH HUXLEY AND THE SLIDING FILAMENT MODEL 1082 BOX 28-2
BIOCHEMISTRY IN HEALTH AND DISEASE: MYOSIN MUTATIONS AND DEAFNESS 1090
BOX 28-3 BIOCHEMISTRY IN HEALTH AND DISEASE: DRUGS THAT BIND
MICROTUBULES 1096 BOX 28-4 PERSPECTIVES IN BIOCHEMISTRY: MONOCLONAL
ANTIBODIES 1108 BOX 28-5 BIOCHEMISTRY IN HEALTH AND DISEASE: AUTOIMMUNE
DISEASES 1110 XVIII CONTENTS APPENDIX BIOINFORMATICS EXERCISES 1115
ANSWERS TO BIOINFORMATICS EXERCISES 1124 SOLUTIONS TO PROBLEMS SP-I
GLOSSARY G-I GUIDE TO MEDIA RESOURCES GMR-I INDEX 1-1 |
| any_adam_object | 1 |
| author | Voet, Donald 1938- Voet, Judith G. Pratt, Charlotte W. |
| author_GND | (DE-588)132545799 (DE-588)132546159 (DE-588)124312233 |
| author_facet | Voet, Donald 1938- Voet, Judith G. Pratt, Charlotte W. |
| author_role | aut aut aut |
| author_sort | Voet, Donald 1938- |
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| building | Verbundindex |
| bvnumber | BV019341206 |
| callnumber-first | Q - Science |
| callnumber-label | QD415 |
| callnumber-raw | QD415 |
| callnumber-search | QD415 |
| callnumber-sort | QD 3415 |
| callnumber-subject | QD - Chemistry |
| classification_rvk | WD 4010 |
| classification_tum | CHE 800f |
| ctrlnum | (OCoLC)58845396 (DE-599)BVBBV019341206 |
| dewey-full | 572 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 572 - Biochemistry |
| dewey-raw | 572 |
| dewey-search | 572 |
| dewey-sort | 3572 |
| dewey-tens | 570 - Biology |
| discipline | Biologie Chemie |
| edition | 2. ed. |
| format | Book |
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| genre | (DE-588)4123623-3 Lehrbuch gnd-content |
| genre_facet | Lehrbuch |
| id | DE-604.BV019341206 |
| illustrated | Illustrated |
| indexdate | 2025-03-12T13:02:43Z |
| institution | BVB |
| isbn | 0471214957 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-012805728 |
| oclc_num | 58845396 |
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| owner | DE-703 DE-1102 DE-M49 DE-BY-TUM DE-91G DE-BY-TUM DE-19 DE-BY-UBM DE-634 DE-11 DE-188 DE-578 |
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| physical | getr. Zählung Ill., graph. Darst. |
| publishDate | 2006 |
| publishDateSearch | 2006 |
| publishDateSort | 2006 |
| publisher | Wiley |
| record_format | marc |
| spelling | Voet, Donald 1938- Verfasser (DE-588)132545799 aut Fundamentals of biochemistry life at the molecular level Donald Voet ; Judith G. Voet ; Charlotte W. Pratt Biochemistry 2. ed. New York [u.a.] Wiley 2006 getr. Zählung Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier 3. Aufl. u.d.T.: Voet, Donald: Principles of biochemistry Biochmistry cabt Biochimie Biochemistry Textbooks CD-ROM (DE-588)4139307-7 gnd rswk-swf Biochemie (DE-588)4006777-4 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf (DE-588)4123623-3 Lehrbuch gnd-content Molekularbiologie (DE-588)4039983-7 s DE-604 Biochemie (DE-588)4006777-4 s CD-ROM (DE-588)4139307-7 s 1\p DE-604 Voet, Judith G. Verfasser (DE-588)132546159 aut Pratt, Charlotte W. Verfasser (DE-588)124312233 aut HEBIS Datenaustausch Darmstadt application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012805728&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Voet, Donald 1938- Voet, Judith G. Pratt, Charlotte W. Fundamentals of biochemistry life at the molecular level Biochmistry cabt Biochimie Biochemistry Biochemistry Textbooks CD-ROM (DE-588)4139307-7 gnd Biochemie (DE-588)4006777-4 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| subject_GND | (DE-588)4139307-7 (DE-588)4006777-4 (DE-588)4039983-7 (DE-588)4123623-3 |
| title | Fundamentals of biochemistry life at the molecular level |
| title_alt | Biochemistry |
| title_auth | Fundamentals of biochemistry life at the molecular level |
| title_exact_search | Fundamentals of biochemistry life at the molecular level |
| title_full | Fundamentals of biochemistry life at the molecular level Donald Voet ; Judith G. Voet ; Charlotte W. Pratt |
| title_fullStr | Fundamentals of biochemistry life at the molecular level Donald Voet ; Judith G. Voet ; Charlotte W. Pratt |
| title_full_unstemmed | Fundamentals of biochemistry life at the molecular level Donald Voet ; Judith G. Voet ; Charlotte W. Pratt |
| title_short | Fundamentals of biochemistry |
| title_sort | fundamentals of biochemistry life at the molecular level |
| title_sub | life at the molecular level |
| topic | Biochmistry cabt Biochimie Biochemistry Biochemistry Textbooks CD-ROM (DE-588)4139307-7 gnd Biochemie (DE-588)4006777-4 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| topic_facet | Biochmistry Biochimie Biochemistry Biochemistry Textbooks CD-ROM Biochemie Molekularbiologie Lehrbuch |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012805728&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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