Drug localization in tissues and cells: receptor microscopic autoradiography ; a basis for tissue and cellular pharmacokinetics, drug targeting, delivery, and prediction
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Chapel Hill, NC
IDDC Press
2003
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XIV, 170 S. Ill., graph. Darst. |
| ISBN: | 0974051500 |
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| adam_text | DRUG LOCALIZATION IN TISSUES AND CELLS RECEPTOR MICROSCOPIC
AUTORADIOGRAPHY A BASIS FOR TISSUE AND CELLULAR PHARMACOKINETICS, DRUG
TARGETING, DELIVERY, AND PREDICTION WALTER E. STUMPF CONTENTS
ACKNOWLEDGMENTS XI PREFACE XIII 1. INTRODUCTION 1 A. GENERAL
CONSIDERATIONS 1 B. HISTORY 5 1. MACRO AU TORADIOGRAPHY * APPOSITION
(SANDWICH) TECHNIQUES 5 2. RECEPTOR MICROSCOPIC (MICRO) AUTORADIOGRAPHY
6 2. DESIGN AND INTRODUCTION OF EXPERIMENTS A. PLANNING 8 B.
PILOTSTUDIES 10 C. INTRODUCTORY EXPERIMENT TO ESTABLISH THE
AUTORADIOGRAPHIC PROCEDURE 11 3. EMULSION COATING OF SLIDES 13 A.
GENERAL CONSIDERATIONS 13 B. DIPPING PROCEDURE 13 C.
CONTROLO/EMULSIONBACKGROUND 16 1. INITIAL BACKGROUND COUNT 16 2.
EXPERIMENTAL BACKGROUND COUNT 16 4. RADIOLABELED COMPOUNDS 18 A. GENERAL
CONSIDERATIONS 18 B. CHOTEE OF RADIOISOTOPE 18 1. TRITIUM( 3 H) 18 2.
RADIOCARBON ( I4 C) 19 3. RADIOIODINE ( 125 I) 20 VI CONTENTS C. PURITY
OFLABELED COMPOUND 20 D.HIGHSPECIFICACTIVITY 20 E. DOSE AND ROUTE OF
APPLICATION 21 F. CHARACTERIZATION OF RADIOACTIVITY IN TISSUES AND
SPECIFICITY OFBINDING 22 5. PROCUREMENT OF TISSUE 23 A. ARRANGEMENTS 23
B. DISSECTION AND PLACEMENT OF SAMPLES 23 C. SAMPLES FOR PARALLEL
ALTERNATE STUDIES 24 6. FREEZING OF TISSUES, FREEZE-MOUNTING, AND
STORAGE 26 A. FREEZING AND CONTROL OFLCE CRYSTAL FORMATION 26 B.
FREEZING PROCEDURE 27 C. FREEZE-MOUNTING 28 D. MODIFICATIONS OF FREEZING
PROCEDURE 31 7. FROZEN TISSUE SECTIONING AND THAW-MOUNTING 32 A.
TRANSFER OF FROZEN SPECIMEN FROM STORAGE TO MICROTOME-CRYOSTAT 32 B.
ORIENTATION OF SPECIMEN AND TRIMMING 32 C. CUTTING TEMPERATURE 33 D.
FROZEN SECTIONING 35 E. FROZEN SECTION THAW-MOUNTING ON EMULSION-COATED
SLIDE 37 F. CONSIDERATION OF MODIFICATIONS 38 8. PHOTOGRAPHIC EXPOSURE
AND DEVELOPMENT 40 A. STORAGE OFSLIDES IN DESICCATOR BOXES 40 B.
EXPOSURE TIME 41 C. PHOTOGRAPHIC DEVELOPMENT AND FIXATION 43 D.
HISTOLOGICAL FIXATION 45 CONTENTS VII 9. STAINING 47 A. GENERAL
CONSIDERATIONS 47 B. SELECTING THE STAIN 48 C. PREPARING AND APPLYING
THE STAIN 48 1. METHYLENE BLUE * BASIC FUCHSIN STAIN (MBBF) 49 2. METHYL
GREEN * PYRONIN STAIN (MGP) 49 D. TESTING AND STABILITY OF THE STAIN 51
10. EVALUATION OF AUTORADIOGRAMS 52 A. UNDERSTANDING LOCALIZED
RADIOACTIVITY 52 B. RELATIONSHIPS BETWEEN SILVER GRAINS AND TISSUE
STRUCTURES 53 C. REPRODUCIBILITY AND AUTHENTICITY OF RESULTS 54 D.
PROBLEMS OF INTERPRETATION OF RESULTS 54 E. IMPORTAME OF PICTORIAL
EVIDENCE 56 11. QUANTIFICATION 57 A. GENERAL CONSIDERATIONS 57 B.
SPECIAL CONSIDERATIONS 59 1. IDENTIFICATION OFCELLTYPES 59 2. CELL
COMPARTMENT SIZE AND DENSITY OF SILVER GRAINS 60 3. TISSUE
SELF-ABSORPTION OFRADIATION 60 4. SELECTIVE EVALUATION OFLABELED CELLS
AND COMPARTMENTS 60 5. NUMBER OF CELLS COUNTED 61 6. SUBTRACTION OF
BACKGROUND COUNTS 61 7. CHARACTERIZATION OF RADIOACTIVITY ASSOCIATED
WITH CERTAIN TISSUE STRUCTURES AND COMPARTMENTS 62 C. HIERARCHY OF
RECEPTOR BINDING IN TARGET TISSUES 63 D. ESTIMATION OF NUMBER
OFMOLECULES 64 IUE CONTENTS 12. COLOCALIZATION*COMBINED AUTORADIOGRAPHY
AND IMMUNOHISTOCHEMISTRY 66 A. GENERAL CONSIDERATIONS 66 B. PROCEDURE 67
1. FIXATION OFEXPOSED SLIDES PRIOR TO AUTORADIOGRAPHIC DEVELOPMENT 67 2.
AUTORADIOGRAPHIC DEVELOPMENT 67 3. IMMUNOCYTOCHEMICAL STAINING 67 13. IN
VITRO EXPERIMENTS 70 A. GENERAL CONSIDERATIONS 70 B. DIFFUSION 70 C.
HANDLING TISSUE SLICES 71 D. INCUBATION 72 E. CELL SUSPENSIONS 73 1.
SPREADS 73 2. PELLETS 73 14. ARTIFACTS 74 A. GENERAL CONSIDERATIONS 74
B. MULTIPLE SOURCES OFPOSSIBLE ARTIFACTS 74 C. ARTIFACTS RELATED TO IN
VITRO INCUBATION 77 15. CONTROLS 78 A. CONTROLS AGAINST POSITIVE
CHEMOGRAPHY AND MECHANICAL ARTIFACTS 78 B. CONTROLS AGAINST NEGATIVE
CHEMOGRAPHY 78 C. CONTROLS WITHOUT RADIOACTIVITY 79 D. COMPETITION
CONTROLS FOR CHARACTERIZATION OFLOCALIZED RADIOACTIVITY 80 E. EXTERNAL
POSITIVE CONTROLS 80 F. CONTROL OFTHAW-MOUNTINGBYDRY-MOUNTING 81
CONTENTS IX 16. ALTERNATE PROCEDURES FOR DIFFUSIBLE COMPOUNDS 83 A.
GENERAL CONSIDERATIONS 83 B. DRY-MOUNTING OF FROZEN SECTIONS 83 C.
DRY-MOUNTING OF FREEZE-DRIED SECTIONS 84 D. PROBLEMS WITH HARD AND
SPONGY TISSUES 88 1. FROZEN SECTION THAW-MOUNTING 88 2. FROZEN
SECTIONING AFTER BACKING WITH SCOTCH TAPE OR PLASTIC FOIL 89 3. FROZEN
SECTIONING OFACRYLAMIDE-INFILTRATED TISSUE 90 E. REGIONAL HIGH
RESOLUTION AUTORADIOGRAPHY 91 F. IN VITRO LABELING AUTORADIOGRAPHY 92
ADDENDUM 93 1. EXAMPLES OF AUTORADIOGRAMS 95 PIATE 1. 3
H-MESOBILIRUBINOGEN, LIVER 98 PIATE 2. 3 H-ESTRADIOL, UTERUS, BRAIN 100
PIATE 3. STRIA TERMINALIS, ESTROGEN TARGET NEURON CIRCUIT,
ALLOCORTEX-BRAINSTEM-CORE (ABC) CIRCUITRY 102 PIATE 4. 3 H-PROGESTERONE,
UTERINE CERVIX; 3 H-ORG 2058, BRAIN 104 PIATE 5. 3 H-L,25(OH) 2 VITAMIN
D 3 , BRAIN, SPINAL CORD 106 PIATE 6. 3 H-L,25(OH) 2 VITAMIN D 3 ,
PITUITARY 108 PIATE 7. 3 H-L,25(OH) 2 VITAMIN D 3 , PARATHYROID, THYROID
110 PIATE 8. 3 H-L,25(OH) 2 VITAMIN D 3 , HEART 112 PIATE 9. 3
H-L,25(OH) 2 VITAMIN D 3 , SPLEEN 114 PIATE 10. 3 H-L,25(OH) 2 VITAMIN D
3 , ADRENAL 116 PIATE 11. 3 H-L,25(OH) 2 VITAMIN D 3 , STOMACH 118 PIATE
12. 3 H-L,25(OH) 2 VITAMIN D 3 , PYLORUS, DUODENUM 120 PIATE 13. 3
H-L,25(OH) 2 VITAMIN D 3 , SMALL INTESTINE 122 PIATE 14. 3 H-L,25(OH) 2
VITAMIN D 3 , PANCREAS 124 PIATE 15. 3 H-L,25(OH) 2 VITAMIN D 3 ,
TESTIS, KIDNEY 126 PIATE 16. 3 H-OXA-CALCITRIOL (OCT), BONE 128 PIATE
17. 3 H-OXA-CALCITRIOL (OCT), CANCER XENOGRAFT, SKIN 130 PIATE 18.
VITAMIN D RECEPTOR DRUG HOMUNCULUS 132 PIATE 19. VITAMIN D (SOLTRIOL)
BIOLOGICAL ROLE 134 PIATE 20. 3 H-OXA-CALCITRIOL (OCT), WHOLE BODY
AUTORADIOGRAMS 136 PIATE 21. MICROTOME-CRYOSTATS 138 X CONTENTS 2.
LESSONS LEARNED 141 3. CHRONOLOGY OF DEVELOPMENT OF TECHNIQUES,
APPLICATIONS, AND DISCOVERIES 145 HIGHLIGHTS 145 TIMELINE OF DEVELOPMENT
OFMETHOD, RELATED DISCOVERIES, AND NEW CONCEPTS 147 4. REFERENCES FOR
AUTORADIOGRAPHY OF DIFFUSIBLE COMPOUNDS 155 SELECTED PUBLICATIONS BY
THEAUTHOR 155 ADDITIONAL REFERENCES 166 5. ABOUT THE AUTHOR 169
|
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| indexdate | 2024-07-09T19:57:06Z |
| institution | BVB |
| isbn | 0974051500 |
| language | English |
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| spelling | Stumpf, Walter E. Verfasser aut Drug localization in tissues and cells receptor microscopic autoradiography ; a basis for tissue and cellular pharmacokinetics, drug targeting, delivery, and prediction Walter E. Stumpf Chapel Hill, NC IDDC Press 2003 XIV, 170 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Autoradiography Autoradiography methods Laboratory Manuals Drug receptors Research Methodology Drug targeting Research Methodology Drugs Research Methodology Microscopy Microscopy methods Laboratory Manuals Pharmacokinetics Research Methodology Radiopharmaceuticals pharmacokinetics Laboratory Manuals Receptors, Drug Laboratory Manuals GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012768070&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Stumpf, Walter E. Drug localization in tissues and cells receptor microscopic autoradiography ; a basis for tissue and cellular pharmacokinetics, drug targeting, delivery, and prediction Autoradiography Autoradiography methods Laboratory Manuals Drug receptors Research Methodology Drug targeting Research Methodology Drugs Research Methodology Microscopy Microscopy methods Laboratory Manuals Pharmacokinetics Research Methodology Radiopharmaceuticals pharmacokinetics Laboratory Manuals Receptors, Drug Laboratory Manuals |
| title | Drug localization in tissues and cells receptor microscopic autoradiography ; a basis for tissue and cellular pharmacokinetics, drug targeting, delivery, and prediction |
| title_auth | Drug localization in tissues and cells receptor microscopic autoradiography ; a basis for tissue and cellular pharmacokinetics, drug targeting, delivery, and prediction |
| title_exact_search | Drug localization in tissues and cells receptor microscopic autoradiography ; a basis for tissue and cellular pharmacokinetics, drug targeting, delivery, and prediction |
| title_full | Drug localization in tissues and cells receptor microscopic autoradiography ; a basis for tissue and cellular pharmacokinetics, drug targeting, delivery, and prediction Walter E. Stumpf |
| title_fullStr | Drug localization in tissues and cells receptor microscopic autoradiography ; a basis for tissue and cellular pharmacokinetics, drug targeting, delivery, and prediction Walter E. Stumpf |
| title_full_unstemmed | Drug localization in tissues and cells receptor microscopic autoradiography ; a basis for tissue and cellular pharmacokinetics, drug targeting, delivery, and prediction Walter E. Stumpf |
| title_short | Drug localization in tissues and cells |
| title_sort | drug localization in tissues and cells receptor microscopic autoradiography a basis for tissue and cellular pharmacokinetics drug targeting delivery and prediction |
| title_sub | receptor microscopic autoradiography ; a basis for tissue and cellular pharmacokinetics, drug targeting, delivery, and prediction |
| topic | Autoradiography Autoradiography methods Laboratory Manuals Drug receptors Research Methodology Drug targeting Research Methodology Drugs Research Methodology Microscopy Microscopy methods Laboratory Manuals Pharmacokinetics Research Methodology Radiopharmaceuticals pharmacokinetics Laboratory Manuals Receptors, Drug Laboratory Manuals |
| topic_facet | Autoradiography Autoradiography methods Laboratory Manuals Drug receptors Research Methodology Drug targeting Research Methodology Drugs Research Methodology Microscopy Microscopy methods Laboratory Manuals Pharmacokinetics Research Methodology Radiopharmaceuticals pharmacokinetics Laboratory Manuals Receptors, Drug Laboratory Manuals |
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