Fundamentals of enzyme kinetics:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
London
Portland Press
2004
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| Ausgabe: | 3. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVI, 422 S. graph. Darst. |
| ISBN: | 1855781581 |
Internformat
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Datensatz im Suchindex
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| adam_text | FUNDAMENTALS OF ENZYME KINETICS THIRD EDITION BY ATHEL CORNISH-BOWDEN
UNIVERSITATS-UND LANDESBIBLIOTHEK BIBLIOTHEK BIOLOGIE SCHNITTSPAHNSTR.
10, 64287 DARMSTADT LNV,NR. PORTLAND PRESS CONTENTS PREFACE TO THE THIRD
EDITION XV BASIC PRINCIPLES OF CHEMICAL KINETICS 1.1 ABBREVIATIONS AND
SYMBOLS 1 1.2 ORDER OF A REACTION 2 1.2.1 ORDER AND MOLECULARITY 2 1.2.2
DETERMINATION OF THE ORDER OF A REACTION 6 1.3 DIMENSIONS OF RATE
CONSTANTS 8 1.4 REVERSIBLE REACTIONS 9 1.5 DETERMINATION OF FIRST-ORDER
RATE CONSTANTS 10 1.6 CATALYSIS . 12 1.7 THE INFLUENCE OF TEMPERATURE
AND PRESSURE ON RATE CONSTANTS 13 1.7.1 THE ARRHENIUS EQUATION 13 1.7.2
ELEMENTARY COLLISION THEORY 15 1.7.3 TRANSITION-STATE THEORY 16 1.7.4
EFFECTS OF HYDROSTATIC PRESSURE ON RATE CONSTANTS 20 PROBLEMS 21
INTRODUCTION TO ENZYME KINETICS 2.1 THE IDEA OF AN ENZYME-SUBSTRATE
COMPLEX 23 2.2 THE MICHAELIS-MENTEN EQUATION 25 2.3 THE STEADY STATE OF
AN ENZYME-CATALYSED REACTION 29 2.3.1 THE BRIGGS-HALDANE TREATMENT 29
2.3.2 THE MICHAELIS-MENTEN EQUATION 30 2.3.3 UNITS OF ENZYME ACTIVITY 31
2.3.4 THE CURVE DEFINED BY THE MICHAELIS-MENTEN EQUATION 32 2.3.5 MUTUAL
DEPLETION KINETICS 34 2.3.6 WAYS OF WRITING THE MICHAELIS-MENTEN
EQUATION 35 2.4 SPECIFICITY 36 CONTENTS 2.5 VALIDITY OF THE STEADY-STATE
ASSUMPTION 39 2.6 GRAPHS OF THE MICHAELIS-MENTEN EQUATION 41 2.6.1
PLOTTING V AGAINST A 41 2.6.2 THE DOUBLE-RECIPROCAL PLOT 42 2.6.3 THE
PLOT OF A/V AGAINST A 44 2.6.4 THE PLOT OF V AGAINST VIA 45 2.6.5 THE
DIRECT LINEAR PLOT 46 2.7 THE REVERSIBLE MICHAELIS-MENTEN MECHANISM 48
2.7.1 THE REVERSIBLE RATE EQUATION 48 2.7.2 THE HALDANE RELATIONSHIP 52
2.7.3 ONE-WAY ENZYMES 53 2.8 PRODUCT INHIBITION 55 2.9 INTEGRATION OF
ENZYME RATE EQUATIONS 57 2.9.1 MICHAELIS-MENTEN EQUATION WITHOUT PRODUCT
INHIBITION 57 2.9.2 EFFECT OF PRODUCT INHIBITION ON THE PROGRESS CURVE
58 2.9.3 ACCURATE ESTIMATION OF INITIAL RATES 60 2.9.4 TIME COURSES FOR
OTHER MECHANISMS 63 2.10 ARTIFICIAL ENZYMES, RNA ENZYMES AND CATALYTIC
ANTIBODIES 64 2.10.1 ALTERNATIVE ENZYMES 64 2.10.2 ARTIFICIAL ENZYMES
65 2.10.3 CATALYTIC RNA 66 2.10.4 CATALYTIC ANTIBODIES 67 PROBLEMS 68
PRACTICAL ASPECTS,OF KINETIC STUDIES 3.1 ENZYME ASSAYS 71 3.1.1
DISCONTINUOUS AND CONTINUOUS ASSAYS 71 3.1.2 ESTIMATING THE INITIAL RATE
72 3.1.3 INCREASING THE STRAIGHTNESS OF THE PROGRESS CURVE 73 3.1.4
COUPLED ASSAYS 75 3.2 DETECTING ENZYME INACTIVATION 78 3.3 EXPERIMENTAL
DESIGN 81 3.3.1 CHOICE OF SUBSTRATE CONCENTRATIONS 81 3.3.2 CHOICE OF
PH, TEMPERATURE AND OTHER CONDITIONS 83 3.3.3 USE OF REPLICATE
OBSERVATIONS 84 3.4 TREATMENT OF IONIC EQUILIBRIA , 86 PROBLEMS 89
CONTENTS DERIVING STEADY-STATE RATE EQUATIONS 4.1 INTRODUCTION 4.2 THE
PRINCIPLE OF THE KING-ALTMAN METHOD 4.3 THE METHOD OF KING AND ALTMAN
4.4 THE METHOD OF WONG AND HANES 4.5 MODIFICATIONS TO THE KING-ALTMAN
METHOD 4.6 REACTIONS CONTAINING STEPS AT EQUILIBRIUM 4.7 ANALYSING
MECHANISMS BY INSPECTION 4.7.1 TOPOLOGICAL REASONING 4.7.2 MECHANISMS
WITH ALTERNATIVE ROUTES 4.7.3 DEAD-END STEPS 4.8 DERIVATION OF RATE
EQUATIONS BY COMPUTER PROBLEMS 91 91 95 99 100 103 106 106 107 107 108
111 REVERSIBLE INHIBITION AND ACTIVATION 5.1 INTRODUCTION 113 5.2 LINEAR
INHIBITION 114 5.2.1 COMPETITIVE INHIBITION 114 5.2.2 MIXED INHIBITION
116 5.2.3 UNCOMPETITIVE INHIBITION 119 5.2.4 SUMMARY OF LINEAR
INHIBITION TYPES 120 5.3 PLOTTING INHIBITION RESULTS 121 5.3.1 SIMPLE
PLOTS 121 5.3.2 COMBINATION PLOTS 124 5.4 MULTIPLE INHIBITORS 125 5.5
RELATIONSHIP BETWEEN INHIBITION CONSTANTS AND THE CONCENTRATION FOR
HALF-INHIBITION 126 5.6 INHIBITION BY A COMPETING SUBSTRATE 127 5.6.1
COMPETITION BETWEEN SUBSTRATES 127 5.6.2 TESTING IF TWO REACTIONS OCCUR
AT THE SAME SITE 128 5.7 ENZYME ACTIVATION 130 5.7.1 MISCELLANEOUS USES
OF THE TERM ACTIVATION 130 5.7.2 ESSENTIAL ACTIVATION 131 5.7.3
HYPERBOLIC ACTIVATION AND INHIBITION 133 5.8 DESIGN OF INHIBITION
EXPERIMENTS 135 5.9 INHIBITORY EFFECTS OF SUBSTRATES 137 5.9.1
NON-PRODUCTIVE BINDING 137 5.9.2 SUBSTRATE INHIBITION 140 PROBLEMS 141
CONTENTS TIGHT-BINDING AND IRREVERSIBLE INHIBITORS 6.1 TIGHT-BINDING
INHIBITORS 145 6.2 IRREVERSIBLE INHIBITORS 148 6.2.1 NON-SPECIFIC
IRREVERSIBLE INHIBITION 148 6.2.2 SPECIFIC IRREVERSIBLE INHIBITION 148
6.3 SUBSTRATE PROTECTION EXPERIMENTS 150 6.4 CHEMICAL MODIFICATION AS A
MEANS OF IDENTIFYING ESSENTIAL GROUPS 151 6.4.1 KINETIC ANALYSIS OF
CHEMICAL MODIFICATION 151 6.4.2 REMAINING ACTIVITY AS A FUNCTION OF
DEGREE OF MODIFICATION 153 PROBLEMS 155 REACTIONS OF MORE THAN ONE
SUBSTRATE 7.1 INTRODUCTION 157 7.2 CLASSIFICATION OF MECHANISMS 158
7.2.1 TERNARY-COMPLEX MECHANISMS 158 7.2.2 SUBSTITUTED-ENZYME MECHANISMS
161 7.2.3 COMPARISON BETWEEN CHEMICAL AND KINETIC CLASSIFICATIONS 163
7.2.4 SCHEMATIC REPRESENTATION OF MECHANISMS 165 7.3 RATE EQUATIONS 166
7.3.1 COMPULSORY-ORDER TERNARY-COMPLEX MECHANISM 166 7.3.2 RANDOM-ORDER
TERNARY-COMPLEX MECHANISM 169 7.3.3 SUBSTITUTED-ENZYME MECHANISM 169
7.3.4 CALCULATION OF RATE CONSTANTS FROM KINETIC PARAMETERS 170 7.4
INITIAL-RATE MEASUREMENTS IN THE ABSENCE OF PRODUCTS 171 7.4.1 MEANINGS
OF THE PARAMETERS 171 7.4.2 APPARENT MICHAELIS-MENTEN PARAMETERS 173
7.4.3 PRIMARY PLOTS FOR TERNARY-COMPLEX MECHANISMS 174 7.4.4 SECONDARY
PLOTS 175 7.4.5 PLOTS FOR THE SUBSTITUTED-ENZYME MECHANISM 1 77 7.5
SUBSTRATE INHIBITION 178 7.5.1 WHY SUBSTRATE INHIBITION OCCURS 178 7.5.2
COMPULSORY-ORDER TERNARY-COMPLEX MECHANISM 179 7.5.3 RANDOM-ORDER
TERNARY-COMPLEX MECHANISM 179 7.5.4 SUBSTITUTED-ENZYME MECHANISM 180
7.5.5 DIAGNOSTIC VALUE OF SUBSTRATE INHIBITION 180 CONTENTS 7.6 PRODUCT
INHIBITION 181 7.7 DESIGN OF EXPERIMENTS 184 7.8 REACTIONS WITH THREE OR
MORE SUBSTRATES 185 PROBLEMS 188 8 USE OF ISOTOPES FOR STUDYING ENZYME
MECHANISMS 8.1 ISOTOPE EXCHANGE AND ISOTOPE EFFECTS 191 8.2 PRINCIPLES
OF ISOTOPE EXCHANGE 192 8.3 ISOTOPE EXCHANGE AT EQUILIBRIUM 194 8.4
ISOTOPE EXCHANGE IN SUBSTITUTED-ENZYME MECHANISMS 196 8.5
NON-EQUILIBRIUM ISOTOPE EXCHANGE 197 8.5.1 CHEMIFLUX RATIOS 197 8.5.2
ISOMERASE KINETICS 200 8.5.3 TRACER PERTURBATION 203 8.6 THEORY OF
KINETIC ISOTOPE EFFECTS 204 8.6.1 PRIMARY ISOTOPE EFFECTS 204 8.6.2
SECONDARY ISOTOPE EFFECTS 206 8.6.3 EQUILIBRIUM ISOTOPE EFFECTS 207 8.7
PRIMARY ISOTOPE EFFECTS IN ENZYME KINETICS 207 8.8 SOLVENT ISOTOPE
EFFECTS 209 PROBLEMS 211 9 EFFECT OF PH ON ENZYME ACTIVITY 9.1 ENZYMES
AND PH 213 9.2 ACID-BASE PROPERTIES OF PROTEINS 214 9.3 LONIZATION OF A
DIBASIC ACID 216 9.3.1 EXPRESSION IN TERMS OF GROUP DISSOCIATION
CONSTANTS 216 9.3.2 MOLECULAR DISSOCIATION CONSTANTS 217 9.3.3
BELL-SHAPED CURVES 219 9.4 EFFECT OF PH ON ENZYME KINETIC CONSTANTS 221
9.4.1 UNDERLYING ASSUMPTIONS 221 9.4.2 PH DEPENDENCE OF V AND V/K M 222
9.4.3 PH-INDEPENDENT PARAMETERS AND THEIR RELATIONSHIP TO APPARENT
PARAMETERS 223 9.4.4 PH DEPENDENCE OF K M 224 9.4.5 EXPERIMENTAL DESIGN
225 9.5 LONIZATION OF THE SUBSTRATE 226 CONTENTS 9.6 MORE COMPLICATED PH
EFFECTS 228 PROBLEMS 228 1_0 TEMPERATURE EFFECTS ON ENZYME ACTIVITY 10.1
TEMPERATURE DENATURATION 231 10.2 TEMPERATURE OPTIMUM 233 10.3
APPLICATION OF THE ARRHENIUS EQUATION TO ENZYMES 234 10.4
ENTROPY-ENTHALPY COMPENSATION 235 PROBLEMS 237 11 CONTROL OF ENZYME
ACTIVITY 11.1 FUNCTION OF COOPERATIVE AND ALLOSTERIC INTERACTIONS 239
11.1.1 FUTILE CYCLES 239 11.1.2 INADEQUACY OF MICHAELIS-MENTEN KINETICS
FOR REGULATION 240 11.1.3 COOPERATIVITY 241 11.1.4 ALLOSTERIC
INTERACTIONS 242 11.2 THE DEVELOPMENT OF MODELS TO EXPLAIN COOPERATIVITY
243 11.2.1 THE HILL EQUATION 243 11.2.2 AN ALTERNATIVE INDEX OF
COOPERATIVITY 245 11.2.3 ASSUMPTION OF EQUILIBRIUM BINDING IN
COOPERATIVE KINETICS 246 11.2.4 THE ADAIR EQUATION 247 11.2.5
MECHANISTIC AND OPERATIONAL DEFINITIONS OF COOPERATIVITY 252 11.3
ANALYSIS OF BINDING EXPERIMENTS 254 11.3.1 EQUILIBRIUM DIALYSIS 254
11.3.2 THE SCATCHARD PLOT 255 11.4 INDUCED FIT 257 11.5 THE SYMMETRY
MODEL OF MONOD, WYMAN AND CHANGEUX 260 11.5.1 BASIC POSTULATES OF THE
SYMMETRY MODEL 260 11.5.2 ALGEBRAIC ANALYSIS 261 11.5.3 PROPERTIES
IMPLIED BY THE BINDING EQUATION 262 11.5.4 HETEROTROPIC EFFECTS 265 11.6
THE SEQUENTIAL MODEL OF KOSHLAND, NEMETHY AND FILMER 266 11.6.1
POSTULATES 266 11.6.2 ALGEBRAIC ANALYSIS 268 11.6.3 PROPERTIES IMPLIED
BY THE BINDING EQUATION 270 CONTENTS 11.7 ASSOCIATION-DISSOCIATION
MODELS OF COOPERATIVITY 272 11.8 KINETIC COOPERATIVITY 273 PROBLEMS 275
12 KINETICS OF MULTI-ENZYME SYSTEMS 12.1 ENZYMES IN THEIR PHYSIOLOGICAL
CONTEXT 277 12.1.1 ENZYMES AS COMPONENTS OF SYSTEMS 277 12.1.2 MOIETY
CONSERVATION 278 12.1.3 CHARACTERIZATION OF ENZYMES IN PERMEABILIZED
CELLS 279 12.2 METABOLIC CONTROL ANALYSIS 280 12.3 ELASTICITIES 282
12.3.1 DEFINITION OF ELASTICITY 282 12.3.2 COMMON PROPERTIES OF
ELASTICITIES 285 12.3.3 ENZYME KINETICS VIEWED FROM CONTROL ANALYSIS 286
12.3.4 RATES AND CONCENTRATIONS AS EFFECTS, NOT CAUSES 287 12.4 CONTROL
COEFFICIENTS 290 12.4.1 DEFINITIONS 290 12.4.2 THE PERTURBING PARAMETER
292 12.5 SUMMATION RELATIONSHIPS 293 12.6 RELATIONSHIPS BETWEEN
ELASTICITIES AND CONTROL COEFFICIENTS 295 12.6.1 CONNECTIVITY PROPERTIES
295 12.6.2 CONTROL COEFFICIENTS IN A THREE-STEP PATHWAY 297 12.6.3
EXPRESSION OF SUMMATION AND CONNECTIVITY RELATIONSHIPS IN MATRIX FORM
298 12.6.4 CONNECTIVITY RELATIONSHIP FOR A METABOLITE NOT INVOLVED IN
FEEDBACK 299 12.6.5 THE FLUX CONTROL COEFFICIENT OF AN ENZYME FOR THE
FLUX THROUGH ITS OWN REACTION 300 12.7 RESPONSE COEFFICIENTS: THE
PARTITIONED RESPONSE 301 12.8 CONTROL AND REGULATION 302 12.9 MECHANISMS
OF REGULATION 305 12.9.1 METABOLITE CHANNELLING 306 12.9.2
INTERCONVERTIBLE ENZYME CASCADES 308 12.9.3 THE METABOLIC ROLE OF
ADENYLATE KINASE 310 12.10 COMPUTER MODELLING OF METABOLIC SYSTEMS 312
PROBLEMS 315 CONTENTS 13 FAST REACTIONS 13.1 LIMITATIONS OF STEADY-STATE
MEASUREMENTS 317 13.1.1 THE TRANSIENT STATE 317 13.1.2 THE RELAXATION
TIME 318 13.1.3 SLOW AND FAST STEPS IN MECHANISMS 318 13.1.4
AMBIGUITIES IN THE STEADY-STATE ANALYSIS OF SYSTEMS WITH INTERMEDIATE
ISOMERIZATION 320 13.1.5 ILL-CONDITIONING 321 13.2 PRODUCT RELEASE
BEFORE COMPLETION OF THE CATALYTIC CYCLE 323 13.2.1 BURST KINETICS 323
13.2.2 ACTIVE SITE TITRATION 325 13.3 EXPERIMENTAL TECHNIQUES - 326
13.3.1 CLASSES OF METHOD 326 13.3.2 CONTINUOUS FLOW 328 13.3.3 STOPPED
FLOW 329 13.3.4 QUENCHED FLOW 330 13.3.5 FLASH PHOTOLYSIS 332 13.3.6
MAGNETIC RESONANCE METHODS 334 13.3.7 RELAXATION METHODS 334 13.4
TRANSIENT-STATE,KINETICS 336 13.4.1 SYSTEMS FAR FROM EQUILIBRIUM 336
13.4.2 SIMPLIFICATION OF COMPLICATED MECHANISMS 340 13.4.3 SYSTEMS CLOSE
TO EQUILIBRIUM 343 PROBLEMS 345 14 ESTIMATION OF KINETIC CONSTANTS 14.1
THE EFFECT OF EXPERIMENTAL ERROR ON KINETIC ANALYSIS 347 14.2
LEAST-SQUARES FIT TO THE MICHAELIS-MENTEN EQUATION 350 14.2.1
INTRODUCTION OF ERROR IN THE MICHAELIS-MENTEN EQUATION 350 14.2.2
ESTIMATION OF THE-MICHAELIS-MENTEN PARAMETERS 352 14.2.3 CORRESPONDING
RESULTS FOR A UNIFORM STANDARD DEVIATION IN THE RATES 354 14.3
STATISTICAL ASPECTS OF THE DIRECT LINEAR PLOT 355 14.3.1 COMPARISON
BETWEEN CLASSICAL AND DISTRIBUTION-FREE STATISTICS 355 14.3.2
APPLICATION TO THE DIRECT LINEAR PLOT 357 14.3.3 LACK OF NEED FOR
WEIGHTING 358 CONTENTS 14.3.4 INSENSITIVITY TO OUTLIERS 359 14.3.5
HANDLING OF NEGATIVE PARAMETER ESTIMATES 359 14.4 PRECISION OF ESTIMATED
KINETIC PARAMETERS 361 14.5 RESIDUAL PLOTS AND THEIR USES 367 PROBLEMS
372 REFERENCES , 375 SOLUTIONS AND NOTES TO PROBLEMS 399 INDEX 407
|
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| author | Cornish-Bowden, Athel 1943- |
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| dewey-ones | 547 - Organic chemistry |
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| dewey-tens | 540 - Chemistry and allied sciences |
| discipline | Chemie / Pharmazie Biologie Chemie |
| edition | 3. ed. |
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| id | DE-604.BV018977828 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T19:39:00Z |
| institution | BVB |
| isbn | 1855781581 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-011748551 |
| oclc_num | 249426640 |
| open_access_boolean | |
| owner | DE-91G DE-BY-TUM DE-355 DE-BY-UBR DE-19 DE-BY-UBM DE-634 DE-83 DE-91S DE-BY-TUM DE-11 DE-703 |
| owner_facet | DE-91G DE-BY-TUM DE-355 DE-BY-UBR DE-19 DE-BY-UBM DE-634 DE-83 DE-91S DE-BY-TUM DE-11 DE-703 |
| physical | XVI, 422 S. graph. Darst. |
| publishDate | 2004 |
| publishDateSearch | 2004 |
| publishDateSort | 2004 |
| publisher | Portland Press |
| record_format | marc |
| spelling | Cornish-Bowden, Athel 1943- Verfasser (DE-588)1047958619 aut Fundamentals of enzyme kinetics by Athel Cornish-Bowden 3. ed. London Portland Press 2004 XVI, 422 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Cinética larpcal Cinétique enzymatique Dynamica gtt Enzimas larpcal Enzymen gtt Reactiekinetiek gtt Enzyme kinetics Enzymes Kinetics Reaktionskinetik (DE-588)4048655-2 gnd rswk-swf Enzym (DE-588)4014988-2 gnd rswk-swf Enzymkinetik (DE-588)4133166-7 gnd rswk-swf Enzymkinetik (DE-588)4133166-7 s DE-604 Enzym (DE-588)4014988-2 s Reaktionskinetik (DE-588)4048655-2 s 1\p DE-604 HEBIS Datenaustausch Darmstadt application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=011748551&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Cornish-Bowden, Athel 1943- Fundamentals of enzyme kinetics Cinética larpcal Cinétique enzymatique Dynamica gtt Enzimas larpcal Enzymen gtt Reactiekinetiek gtt Enzyme kinetics Enzymes Kinetics Reaktionskinetik (DE-588)4048655-2 gnd Enzym (DE-588)4014988-2 gnd Enzymkinetik (DE-588)4133166-7 gnd |
| subject_GND | (DE-588)4048655-2 (DE-588)4014988-2 (DE-588)4133166-7 |
| title | Fundamentals of enzyme kinetics |
| title_auth | Fundamentals of enzyme kinetics |
| title_exact_search | Fundamentals of enzyme kinetics |
| title_full | Fundamentals of enzyme kinetics by Athel Cornish-Bowden |
| title_fullStr | Fundamentals of enzyme kinetics by Athel Cornish-Bowden |
| title_full_unstemmed | Fundamentals of enzyme kinetics by Athel Cornish-Bowden |
| title_short | Fundamentals of enzyme kinetics |
| title_sort | fundamentals of enzyme kinetics |
| topic | Cinética larpcal Cinétique enzymatique Dynamica gtt Enzimas larpcal Enzymen gtt Reactiekinetiek gtt Enzyme kinetics Enzymes Kinetics Reaktionskinetik (DE-588)4048655-2 gnd Enzym (DE-588)4014988-2 gnd Enzymkinetik (DE-588)4133166-7 gnd |
| topic_facet | Cinética Cinétique enzymatique Dynamica Enzimas Enzymen Reactiekinetiek Enzyme kinetics Enzymes Kinetics Reaktionskinetik Enzym Enzymkinetik |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=011748551&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT cornishbowdenathel fundamentalsofenzymekinetics |