Pharmacotherapy in chronic obstructive pulmonary disease:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
New York [u.a.]
Dekker
2004
|
| Series: | Lung biology in health and disease
182 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XVII, 354 S. graph. Darst. |
| ISBN: | 0824740297 |
Staff View
MARC
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Record in the Search Index
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|---|---|
| adam_text | Introduction Claude Lenfant, M.D. Hi
Preface v
Contributors ix
Part One THE APPLICATION OF CLINICAL
ASSESSMENT TO THE DRUG
DEVELOPMENT PROCESS
1. Providing Evidence of Therapeutic Benefit in Clinical
Drug Development 1
Steven Kesten and Theodore J. Witek
I. Introduction 1
II. Regulation in the Development of Drugs 2
III. Key Considerations in Clinical Program Designs 3
IV. Key Considerations in Endpoints: Application
to COPD 6
V. Summary 14
References 15
xi
xii Contents
Part Two MEASURING OUTCOMES
A. Physiology
2. Use of Expiratory Airflows and Lung Volumes to Assess
Outcomes in COPD 19
Gary T. Ferguson
I. Introduction 19
II. Expiratory Airflows 19
III. Lung Volumes 25
IV. Other Measures 31
V. Bronchodilator Reversibility and Airway
Hyperreactivity 32
VI. Clinical Relevance 32
VII. Conclusion and Recommendations 37
References 38
3. Exercise Testing 45
Denis E. O Donnell and Katherine A. Webb
I. Introduction 45
II. Exercise Limitation in COPD 46
III. Exercise Testing: Field Tests 54
IV. Exercise Testing: Laboratory Tests 56
V. Failure to Improve Exercise Performance After
Bronchodilators 57
VI. Evaluating Mechanisms of Functional Improvement 58
VII. Utility of Constant Load Exercise Testing: Examples 61
VIII. Summary 65
References 66
4. Sleep Related Breathing Disturbances in COPD 73
Walter T. McNicholas
I. Introduction 73
II. Effects of Sleep on Respiration 74
III. Sleep in Chronic Obstructive Pulmonary Disease 76
IV. Mechanisms of Nocturnal Oxygen Desaturation in
COPD 76
V. Consequences of Nocturnal Hypoxaemia in COPD 77
VI. Sleep Quality in COPD 78
Contents xiii
VII. Contrasts with Exercise 79
VIII. Investigation of Sleep Related Breathing
Disturbances in COPD 79
IX. Management of Respiratory Abnormalities During
Sleep in COPD 80
X. Pharmacological Therapy 81
XI. Conclusion 84
References 84
5. Airway and Alveolar Determinants of Airflow Limitation in
COPD 89
Noe Zamel
I. Introduction 89
II. Large Airways Airflow Limitation 89
III. Small Airways Airflow Limitation 91
IV. Alveolar Airflow Limitation 93
References 94
6. Gas Exchange 95
Antoni Ferrer, Joan Albert Barberd,
and Roberto Rodriguez Roisin
I. Introduction 95
II. Bronchodilators 96
HI. Glucocorticosteroids 106
IV. Vasodilators 108
V. Other Drugs 110
References 110
B. Laboratory
7. Genetics of COPD 119
Jian Qing He, Ikuma Kasuga, and Peter D. Pare
I. Introduction 119
II. Evidence of Genetic Risk 120
III. Methods to Identify Susceptibility Genes 120
IV. Phenotypes 122
V. Candidate Genes in COPD 123
xiv Contents
VI. Therapeutic Implications of COPD Genetics 134
VII. Pharmacogenetics of COPD 134
VIII. Conclusion 135
References 136
C. Health Outcomes
8. Dyspnea 145
Donald A. Mahler
I. Introduction 145
II. The Measurement of Dyspnea 146
III. Responsiveness 151
IV. Summary 154
References 154
9. Exacerbations of COPD 159
Jadwiga A. Wedzicha
I. Definition of a COPD Exacerbation 159
II. Exacerbation Frequency 160
III. Goals of Exacerbation Therapy 161
IV. Therapy of the Acute Exacerbation 161
V. Prevention of COPD Exacerbation 166
VI. Conclusion 170
References 170
10. Health Status Measurement in COPD 175
Paul W. Jones
I. Introduction: The Multifactorial Nature of COPD 175
II. Measuring the Overall Effect of Treatment 177
III. Health Status Questionnaires 177
IV. Thresholds for Clinical Significance 180
V. Health Status Changes Following Treatment 180
VI. Longitudianl Trends in Health Status 182
VII. Implications for Practice 182
VIII. Assessment of Individual Patient Benefit 183
IX. Summary 184
References 184
Contents xv
11. Health Resource Utilization 189
Mitchell Friedman
I. COPD—The Challenge 189
II. Helath Care Utilization in COPD 191
III. Economic Burden of COPD 194
References 199
Part Three SPECIFIC THERAPY
12. Anticholinergics 201
Peter J. Barnes
I. Introduction 201
II. Rationale for Anticholinergic Therapy in COPD 202
III. Muscarinic Receptor Subtypes in the Airways 203
IV. The Search for Selective Anticholinergics 207
V. Tiotropuim Bromide 207
VI. Pharmacokinetics 209
VII. Side Effects 210
VIII. Future Prospects 211
References 212
13. P Adrtnergic Receptor Agonist Bronchodilators in the
Treatment of COPD 217
Stephen I. Rennard
I. Introduction 217
II. Mechanism of Action 218
III. Clinical Response 225
IV. Adverse Effects of (i Agonists 228
V. Clinical Assessment of the COPD patient 229
VI. Effect of Dyspnea 229
VII. Effect on Exercise 230
VIII. Quality of Life 230
IX. Exacerbations 230
X. Use of (3 Agonist Bronchodilators in Clinical
Practice 231
XI. Summary 232
References 233
xvi Contents
14. Theophylline and Phosphodiesterase Inhibitors
in COPD 239
Alicia R. ZuWallack and Richard L. ZuWallack
I. Introduction 239
II. Molecular Mechanisms of Action of Theophylline
and Other PDE Inhibitors 240
III. Pharmacological Effects of Theophylline 242
IV. Pharmacokinetics 243
V. Dosing and Monitoring of Theophylline 245
VI. Toxicity 248
VII. The Effectiveness of Theophylline on Important
Outcomes for COPD 248
VIII. Selective Phosphodiesterase Inhibitors in the
Treatment of COPD 254
IX. The Role of Theophylline in the Acute
Exacerbation of COPD 257
X. Theophylline and Phosphodiesterase Inhibitors Use
in COPD: Where Does It Fit In? 257
References 259
15. Corticosteroids in COPD 265
Mario Cazzola, Maria Gabriella Matera,
and Romain Pauwels
I. Introduction 265
II. Impact of Corticosteroids on Inflammation in
COPD 268
III. Clinical Effects of Corticosteroids in COPD 269
IV. Adverse Effects 281
V. Corticosteroids and Guidelines 282
VI. Combining an Inhaled Corticosteroid and a
Long Acting p2 Agonist in COPD 287
VII. Conclusion 290
References 291
16. Antioxidants and Protease Inhibitors 299
Mario Cazzola and Maria Gabriella Matera
I. Introduction 299
II. Oxidative Stress and COPD 299
Contents xvii
III. Proteases and COPD 312
IV. Conclusions 318
References 318
17. An Integrated Approach to the Pharmacological Therapy of
COPD 327
Bartolome R. Celli
I. Introduction 327
II. Change in Paradigm: A Constructive Analogy with
Systemic Hypertension 328
III. Proof of Concept 330
IV. COPD: A Pulmonary Disease with Systemic
Consequences 331
V. General Principles of Pharmacological Therapy in
COPD 333
VI. Initiation of Drug Therapy 334
VII. Use of Corticosteroids 337
VIII. Other Medications 338
IX. Management of Acute Exacerbations 339
X. Summary and Conclusion 341
References 341
Index 347
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| spelling | Pharmacotherapy in chronic obstructive pulmonary disease Ed. by Bartolome R. Celli New York [u.a.] Dekker 2004 XVII, 354 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Lung biology in health and disease 182 Poumons - Maladies obstructives - Chimiothérapie Drug Evaluation Lungs Diseases, Obstructive Chemotherapy Pulmonary Disease, Chronic Obstructive drug therapy Obstruktive Ventilationsstörung (DE-588)4213128-5 gnd rswk-swf Pharmakotherapie (DE-588)4076066-2 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Obstruktive Ventilationsstörung (DE-588)4213128-5 s Pharmakotherapie (DE-588)4076066-2 s DE-604 Celli, Bartolome R. Sonstige (DE-588)143000543 oth Lung biology in health and disease 182 (DE-604)BV000008326 182 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010725767&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Pharmacotherapy in chronic obstructive pulmonary disease Lung biology in health and disease Poumons - Maladies obstructives - Chimiothérapie Drug Evaluation Lungs Diseases, Obstructive Chemotherapy Pulmonary Disease, Chronic Obstructive drug therapy Obstruktive Ventilationsstörung (DE-588)4213128-5 gnd Pharmakotherapie (DE-588)4076066-2 gnd |
| subject_GND | (DE-588)4213128-5 (DE-588)4076066-2 (DE-588)4143413-4 |
| title | Pharmacotherapy in chronic obstructive pulmonary disease |
| title_auth | Pharmacotherapy in chronic obstructive pulmonary disease |
| title_exact_search | Pharmacotherapy in chronic obstructive pulmonary disease |
| title_full | Pharmacotherapy in chronic obstructive pulmonary disease Ed. by Bartolome R. Celli |
| title_fullStr | Pharmacotherapy in chronic obstructive pulmonary disease Ed. by Bartolome R. Celli |
| title_full_unstemmed | Pharmacotherapy in chronic obstructive pulmonary disease Ed. by Bartolome R. Celli |
| title_short | Pharmacotherapy in chronic obstructive pulmonary disease |
| title_sort | pharmacotherapy in chronic obstructive pulmonary disease |
| topic | Poumons - Maladies obstructives - Chimiothérapie Drug Evaluation Lungs Diseases, Obstructive Chemotherapy Pulmonary Disease, Chronic Obstructive drug therapy Obstruktive Ventilationsstörung (DE-588)4213128-5 gnd Pharmakotherapie (DE-588)4076066-2 gnd |
| topic_facet | Poumons - Maladies obstructives - Chimiothérapie Drug Evaluation Lungs Diseases, Obstructive Chemotherapy Pulmonary Disease, Chronic Obstructive drug therapy Obstruktive Ventilationsstörung Pharmakotherapie Aufsatzsammlung |
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